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A Fiber Tractography Study of Social-Emotional Related Fiber Tracts in Children and Adolescents with Autism Spectrum Disorder 被引量:5
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作者 Yun Li Hui Fang +7 位作者 Wenming Zheng Lu Qian Yunhua Xiao Qiaorong Wu Chen Chang Chaoyong Xiao Kangkang Chu Xiaoyan Ke 《Neuroscience Bulletin》 SCIE CAS CSCD 2017年第6期722-730,共9页
The symptoms of autism spectrum disorder(ASD) have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity'' hypothesis has been used to explain chara... The symptoms of autism spectrum disorder(ASD) have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity'' hypothesis has been used to explain characteristic impairments in ‘‘socio-emotional'' function.Therefore, in this study we compared the facial emotional recognition(FER) feature and the integrity of socialemotional-related white-matter tracts between children and adolescents with high-functioning ASD(HFA) and their typically developing(TD) counterparts. The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders. Compared with the TD group,FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group(P / 0.01). In conclusion, the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities. 展开更多
关键词 Autism spectrum disorder Facial emotional recognition Social-emotional related white matter fiber tracts Diffusion tensor imaging Tractography
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Brain gliomas Biological characteristics and correlation with the status of adjacent corticospinal tracts
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作者 Chaoshi Niu Xiaorui Fei +3 位作者 Changxin Wang Jiaming Mei Ying Liu Min Ding 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第17期1347-1352,共6页
Malignant behaviors of brain gliomas include proliferation and infiltration.It remains unclear which behavior influences the status of adjacent corticospinal tracts.Diffusion tensor imaging can show the status of brai... Malignant behaviors of brain gliomas include proliferation and infiltration.It remains unclear which behavior influences the status of adjacent corticospinal tracts.Diffusion tensor imaging can show the status of brain white matter fiber tracts.Ki-67 and CD44/matrix metalloproteinase 9 are sensitive markers for reflecting the proliferation and infiltration of tumor cells.The present study analyzed pre-operative diffusion tensor images of 24 patients with pathologically confirmed World Health Organization glioma(Ⅰ-Ⅳ).We observed lapse,infiltration and destruction of the peri-tumor corticospinal tract following reconstruction,and simultaneously detected the expression of Ki-67,CD44/matrix metalloproteinase 9 in samples.Expression of CD44 and matrix metalloproteinase 9was not significantly correlated to the status of the peri-tumor corticospinal tract(r = 1.597,4.859;P = 0.450,0.088),while Ki-67 expression significantly correlated to its status(r= 6.590,P = 0.037).These findings demonstrate that highly proliferative gliomas result in damage to the peripheral corticospinal tract. 展开更多
关键词 brain gliomas corticospinal tracts diffusion tensor imaging fiber tract PATHOLOGY BIOLOGY
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A new computational approach for modeling diffusion tractography in the brain
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作者 Harsha T.Garimella Reuben H.Kraft 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第1期23-26,共4页
Computational models provide additional tools for studying the brain,however,many techniques are currently disconnected from each other.There is a need for new computational approaches that span the range of physics o... Computational models provide additional tools for studying the brain,however,many techniques are currently disconnected from each other.There is a need for new computational approaches that span the range of physics operating in the brain.In this review paper,we offer some new perspectives on how the embedded element method can fill this gap and has the potential to connect a myriad of modeling genre.The embedded element method is a mesh superposition technique used within finite element analysis.This method allows for the incorporation of axonal fiber tracts to be explicitly represented.Here,we explore the use of the approach beyond its original goal of predicting axonal strain in brain injury.We explore the potential application of the embedded element method in areas of electrophysiology,neurodegeneration,neuropharmacology and mechanobiology.We conclude that this method has the potential to provide us with an integrated computational framework that can assist in developing improved diagnostic tools and regeneration technologies. 展开更多
关键词 embedded elements finite element analysis computational biomechanics explicit axonal fiber tracts neural regeneration diffusion tractography
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Dynamic radiological change of gliomas located in the paralimbic system and its clinical significance
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作者 CHEN Xu-zhu JIANG Tao +2 位作者 LI Shao-wu AI Lin DAI Jian-ping 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第8期713-715,共3页
Background The paralimbic system, which is composed of three parts, is an important functional unit. Gliomas located in the region remain a challenge for clinical treatment. However, the dynamic change of gliomas in t... Background The paralimbic system, which is composed of three parts, is an important functional unit. Gliomas located in the region remain a challenge for clinical treatment. However, the dynamic change of gliomas in the area has not been well documented. The purpose of this study was to identify the growth tendency of gliomas located in the paralimbic system and to obtain some suggestions for clinical treatment. Methods Eleven cases of gliomas located in the paralimbic system were recruited in the study. All of them were proven by pathology. Analysis of the serial radiological examinations in each patient was performed from the initial to the final examination, taking into consideration the following items: initial tumor location, final location and the growth tendency. Results In the initial and final examinations the ratios of insula involvement were 64% and 100%, respectively. On the other hand, the ratios of gliomas located in two or more parts of paralimbic system increased from 64% to 100% during the dynamic examination. Conclusions Even though the paralimbic system is composed of three independent anatomical parts, gliomas tend to involve all three parts, especially the insula. Therapeutic plans should aim at the whole region of the system, even during the early stages of gliomas. 展开更多
关键词 paralimbic system GLIOMA white matter fiber tracts
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