AIM: To compare the cleansing quality of polyethylene glycol electrolyte solution and sodium phosphate with different schedules of administration, and to evaluate whether the timing of the administration of bowel prep...AIM: To compare the cleansing quality of polyethylene glycol electrolyte solution and sodium phosphate with different schedules of administration, and to evaluate whether the timing of the administration of bowel preparation affects the detection of polyps. METHODS: One hundred and seventy-seven consecutive outpatients scheduled for colonoscopy were randomized in one of four groups to receive polyethylene glycol electrolyte solution or oral sodium phosphate with two different timing schedules. Quality of cleansing, polyp detection, and tolerance were evaluated. RESULTS: Patients receiving polyethylene glycol or sodium phosphate on the same day as the colonoscopy, obtained good to excellent global cleansing scores more frequently than patients who received polyethylene glycol or sodium phosphate on the day prior to the procedure (P < 0.001). Flat lesions, but not flat adenomas, were more frequent in patients prepared on the same day (P = 0.02). CONCLUSION: The quality of colonic cleansing and the detection of flat lesions are significantly improved when the preparation is taken on the day of the colonoscopy.展开更多
Objective:The accurate prediction of tumor response to neoadjuvant chemoradiotherapy(nCRT)remains challenging.Few studies have investigated pathologic complete response(ypCR)prediction in patients with residual flat m...Objective:The accurate prediction of tumor response to neoadjuvant chemoradiotherapy(nCRT)remains challenging.Few studies have investigated pathologic complete response(ypCR)prediction in patients with residual flat mucosal lesions after treatment.This study aimed to identify variables for predicting ypCR in patients with residual flat mucosal lesions after nCRT for locally advanced rectal cancer(LARC).Methods:Data of patients with residual flat mucosal lesions after nCRT who underwent radical resection between 2009 and 2015 were retrospectively collected from the LARC database at Peking University Cancer Hospital.Univariate and multivariate analyses of the association between clinicopathological factors and ypCR were performed,and a nomogram was constructed by incorporating the significant predictors.Results:Of the 246 patients with residual flat mucosal lesions included in the final analysis,56(22.8%)had ypCR.Univariate and multivariate analyses showed that pretreatment cT stage(pre-cT)≤T2(P=0.016),magnetic resonance tumor regression grade(MR-TRG)1-3(P=0.001)and residual mucosal lesion depth=0 mm(P<0.001)were associated with a higher rate of ypCR.A nomogram was developed with a concordance index(C-index)of0.759 and the calibration curve showed that the nomogram model had good predictive consistency.The follow-up time ranged from 3.0 to 113.3 months,with a median follow-up time of 63.77 months.The multivariate Cox regression model showed that the four variables in the nomogram model were not risk factors for disease-free survival(DFS)or overall survival(OS).Conclusions:Completely flat mucosa,early cT stage and good MR-TRG were predictive factors for ypCR instead of DFS or OS in patients with LARC with residual flat mucosal lesions after nCRT.Endoscopic mucosal re-evaluation before surgery is important,as it may contribute to decision-making and facilitate nonoperative management or organ preservation.展开更多
目的:对胃平坦型病变进行富士能智能分光染色内镜(Fujinon intelligent chromoendoscopy,FICE)放大内镜观察,对比FICE放大内镜与病理检查的一致性,探讨FICE放大内镜在胃平坦型病变诊断中的应用价值.方法:2012-09/2014-08对江汉大学附属...目的:对胃平坦型病变进行富士能智能分光染色内镜(Fujinon intelligent chromoendoscopy,FICE)放大内镜观察,对比FICE放大内镜与病理检查的一致性,探讨FICE放大内镜在胃平坦型病变诊断中的应用价值.方法:2012-09/2014-08对江汉大学附属医院发现的248个胃黏膜平坦性病变进行富士能FICE放大内镜检查.在FICE及放大模式观察病灶腺管开口与毛细血管形态,对其形态进行分型,并结合整体内镜下表现预测病理诊断.将FICE放大内镜下的内镜判定结果与病理组织学结果进行对比,评价其一致性与关联性.FICE内镜与病理诊断的一致性评价采用Kappa检验.结果:萎缩在FICE内镜下主要表现为C、D、E型胃小凹形态;肠上皮化生在F I C E内镜下主要表现为D、E型胃小凹形态;高级别上皮内瘤变及早期癌在FICE内镜下主要表现为E、F型胃小凹形态.FICE放大内镜技术判定萎缩、肠上皮化生、异型增生及早期癌的结果与病理诊断的结果具有较好的一致性.结论:FICE放大内镜技术有助于对病变性质如炎症、萎缩、肠上皮化生、上皮内瘤变及早期癌等的判断,有较好的临床应用价值.展开更多
基金Supported by Grants from the Instituto de Salud Carlos III (C03/02), and from the Consejería de Educación, Cultura y Deportes, Gobierno de Canarias, No.PI2002/138
文摘AIM: To compare the cleansing quality of polyethylene glycol electrolyte solution and sodium phosphate with different schedules of administration, and to evaluate whether the timing of the administration of bowel preparation affects the detection of polyps. METHODS: One hundred and seventy-seven consecutive outpatients scheduled for colonoscopy were randomized in one of four groups to receive polyethylene glycol electrolyte solution or oral sodium phosphate with two different timing schedules. Quality of cleansing, polyp detection, and tolerance were evaluated. RESULTS: Patients receiving polyethylene glycol or sodium phosphate on the same day as the colonoscopy, obtained good to excellent global cleansing scores more frequently than patients who received polyethylene glycol or sodium phosphate on the day prior to the procedure (P < 0.001). Flat lesions, but not flat adenomas, were more frequent in patients prepared on the same day (P = 0.02). CONCLUSION: The quality of colonic cleansing and the detection of flat lesions are significantly improved when the preparation is taken on the day of the colonoscopy.
基金supported by grants from the National Natural Science Foundation of China(No.82173156)Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(No.ZYLX202116)。
文摘Objective:The accurate prediction of tumor response to neoadjuvant chemoradiotherapy(nCRT)remains challenging.Few studies have investigated pathologic complete response(ypCR)prediction in patients with residual flat mucosal lesions after treatment.This study aimed to identify variables for predicting ypCR in patients with residual flat mucosal lesions after nCRT for locally advanced rectal cancer(LARC).Methods:Data of patients with residual flat mucosal lesions after nCRT who underwent radical resection between 2009 and 2015 were retrospectively collected from the LARC database at Peking University Cancer Hospital.Univariate and multivariate analyses of the association between clinicopathological factors and ypCR were performed,and a nomogram was constructed by incorporating the significant predictors.Results:Of the 246 patients with residual flat mucosal lesions included in the final analysis,56(22.8%)had ypCR.Univariate and multivariate analyses showed that pretreatment cT stage(pre-cT)≤T2(P=0.016),magnetic resonance tumor regression grade(MR-TRG)1-3(P=0.001)and residual mucosal lesion depth=0 mm(P<0.001)were associated with a higher rate of ypCR.A nomogram was developed with a concordance index(C-index)of0.759 and the calibration curve showed that the nomogram model had good predictive consistency.The follow-up time ranged from 3.0 to 113.3 months,with a median follow-up time of 63.77 months.The multivariate Cox regression model showed that the four variables in the nomogram model were not risk factors for disease-free survival(DFS)or overall survival(OS).Conclusions:Completely flat mucosa,early cT stage and good MR-TRG were predictive factors for ypCR instead of DFS or OS in patients with LARC with residual flat mucosal lesions after nCRT.Endoscopic mucosal re-evaluation before surgery is important,as it may contribute to decision-making and facilitate nonoperative management or organ preservation.
文摘目的:对胃平坦型病变进行富士能智能分光染色内镜(Fujinon intelligent chromoendoscopy,FICE)放大内镜观察,对比FICE放大内镜与病理检查的一致性,探讨FICE放大内镜在胃平坦型病变诊断中的应用价值.方法:2012-09/2014-08对江汉大学附属医院发现的248个胃黏膜平坦性病变进行富士能FICE放大内镜检查.在FICE及放大模式观察病灶腺管开口与毛细血管形态,对其形态进行分型,并结合整体内镜下表现预测病理诊断.将FICE放大内镜下的内镜判定结果与病理组织学结果进行对比,评价其一致性与关联性.FICE内镜与病理诊断的一致性评价采用Kappa检验.结果:萎缩在FICE内镜下主要表现为C、D、E型胃小凹形态;肠上皮化生在F I C E内镜下主要表现为D、E型胃小凹形态;高级别上皮内瘤变及早期癌在FICE内镜下主要表现为E、F型胃小凹形态.FICE放大内镜技术判定萎缩、肠上皮化生、异型增生及早期癌的结果与病理诊断的结果具有较好的一致性.结论:FICE放大内镜技术有助于对病变性质如炎症、萎缩、肠上皮化生、上皮内瘤变及早期癌等的判断,有较好的临床应用价值.
