MgAl type layered double hydroxide(LDH) obtained by co-precipitation,has been used as precursors to intercalate an antineoplastic agent fluorouracil to prepare an intercalation compound LDH-FLU with ion exchange react...MgAl type layered double hydroxide(LDH) obtained by co-precipitation,has been used as precursors to intercalate an antineoplastic agent fluorouracil to prepare an intercalation compound LDH-FLU with ion exchange reaction.The transformation in structure and crystalline state property from LDH to LDH-FLU has been investigated via XRD,FT-IR,TEM,TG-DSC,and BET-N2 surface area characterizations.The results show that the structure of the intercalation compound is homologous to a monolayer parallel pillar-layer interaction model.Compared with LDH,the crystallinity of this compound is enhanced,the proportion of the inter-lamellar constitution H2O is increased,the thermal decomposition of intermediate crystalline phase complicated,the stack order of grains intensified in c axial,the absorbability of micro-pore decreased,and the pore volume of inter-laminar are reduced evidently.展开更多
1,3-bis[5-(4-ethyoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(A),1-[5-(4-ethoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(B) are synthesized.Their structures are ...1,3-bis[5-(4-ethyoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(A),1-[5-(4-ethoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(B) are synthesized.Their structures are characterized by UV-Vis,IR,1HNMR and MS.The synthesis and separation conditions of the target compounds are studied.The results show that the yield is higher when DMF is used as the solvent at 115 ℃ for 11 h.The products are separated via column chroma to graphy with silica gel(200-300) separation is more satisfactory as the eluent when the column is 3 cm in diameter and 12 cm in height.展开更多
文摘[目的]评价5氟脲嘧啶(5-F luorourac il,5Fu)关节腔注射治疗兔膝骨性关节炎(osteoarthritis,OA)的疗效。[方法]24只兔子制成骨关节炎模型随机分成OA组、5Fu组和对照组,OA组立即处死,5Fu组按5Fu 2mg/kg关节腔注射,每周1次连续4次,对照组注射等量生理盐水,最后1次治疗后1周处死。观察3组滑膜组织的光镜、电镜改变及软骨的光镜、MMP-1免疫组化改变,比较软骨M ank in s评分及关节液中IL-1的浓度。[结果]5Fu组可见软骨破坏减轻,滑膜炎症明显抑制,M ank in s评分明显改善(P<0.01);关节液IL-1浓度降低(P<0.05),关节软骨中MMP-1表达减弱。[结论]5Fu关节腔内注射能抑制滑膜炎症,缓解软骨的破坏。
文摘MgAl type layered double hydroxide(LDH) obtained by co-precipitation,has been used as precursors to intercalate an antineoplastic agent fluorouracil to prepare an intercalation compound LDH-FLU with ion exchange reaction.The transformation in structure and crystalline state property from LDH to LDH-FLU has been investigated via XRD,FT-IR,TEM,TG-DSC,and BET-N2 surface area characterizations.The results show that the structure of the intercalation compound is homologous to a monolayer parallel pillar-layer interaction model.Compared with LDH,the crystallinity of this compound is enhanced,the proportion of the inter-lamellar constitution H2O is increased,the thermal decomposition of intermediate crystalline phase complicated,the stack order of grains intensified in c axial,the absorbability of micro-pore decreased,and the pore volume of inter-laminar are reduced evidently.
文摘1,3-bis[5-(4-ethyoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(A),1-[5-(4-ethoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(B) are synthesized.Their structures are characterized by UV-Vis,IR,1HNMR and MS.The synthesis and separation conditions of the target compounds are studied.The results show that the yield is higher when DMF is used as the solvent at 115 ℃ for 11 h.The products are separated via column chroma to graphy with silica gel(200-300) separation is more satisfactory as the eluent when the column is 3 cm in diameter and 12 cm in height.
