●AIM:To study if one of the two molecules could lead to a lower number of follow up visits and intra-vitreous injection(IVI)with the same efficacy.●METHODS:ELU(or"elected"in French)study is a retrospective...●AIM:To study if one of the two molecules could lead to a lower number of follow up visits and intra-vitreous injection(IVI)with the same efficacy.●METHODS:ELU(or"elected"in French)study is a retrospective study conducted in real life in patients presenting suboptimal response after ranibizumab IVI(phase 1)and secondary switched to aflibercept(phase 2).The number of follow up visits and IVI were compared in both phases.Visual acuity(VA)evolution and"switching"reasons were secondary analyzed.●RESULTS:We retrospectively included data of 33 patients(38 eyes)with age-related macular degeneration(AMD;mean age:77±7.7 y).The number of monthly follow up visits[median(Q1;Q3)]:was significantly lower with aflibercept(phase 2),respectively 1.0(0.81;1.49)visits in phase 1,versus 0.79(0.67;0.86)visits in phase 2.The median number of monthly IVI also significantly decreased in phase 2,respectively 0.67(0.55;0.90)IVI in phase 1,versus 0.55(0.45;0.67)IVI in phase 2.The mean VA evolution(VA final-VA initial)was similar in both phases,(P>0.05).Whatever the reason for"switching"(loss of efficacy,tachyphylaxis,tolerance problems),there was no incidence on VA evolution over the time.●CONCLUSION:Our results show that switching from ranibizumab to aflibercept in"suboptimal"patients significantly reduce the number of follow up visits and IVI,with a comparable efficacy.This decrease in visit number could improve patients’quality of life and reduce surgical risk by reducing the number of injections.展开更多
目的:为提高捐精志愿者回访率,改变传统纸质记录模式,优化工作流程,借助信息化手段设计一套人类精子库志愿者随访管理系统。方法:该系统基于三层B/S结构,采用SQL Server 2019数据库和Visual Studio 2013开发工具,并应用.NET MVC模式进...目的:为提高捐精志愿者回访率,改变传统纸质记录模式,优化工作流程,借助信息化手段设计一套人类精子库志愿者随访管理系统。方法:该系统基于三层B/S结构,采用SQL Server 2019数据库和Visual Studio 2013开发工具,并应用.NET MVC模式进行设计。系统包括志愿者管理、电话管理、系统管理3个功能模块。结果:基于精子库信息管理平台的业务数据,成功实现了捐精志愿者全流程的随访管理。通过将志愿者回访与工作人员绩效挂钩,回访率提升近60%。结论:该系统简化了工作流程,提高了随访效率,有效满足了精子库日常工作需求,展现出较高的实用价值。展开更多
文摘●AIM:To study if one of the two molecules could lead to a lower number of follow up visits and intra-vitreous injection(IVI)with the same efficacy.●METHODS:ELU(or"elected"in French)study is a retrospective study conducted in real life in patients presenting suboptimal response after ranibizumab IVI(phase 1)and secondary switched to aflibercept(phase 2).The number of follow up visits and IVI were compared in both phases.Visual acuity(VA)evolution and"switching"reasons were secondary analyzed.●RESULTS:We retrospectively included data of 33 patients(38 eyes)with age-related macular degeneration(AMD;mean age:77±7.7 y).The number of monthly follow up visits[median(Q1;Q3)]:was significantly lower with aflibercept(phase 2),respectively 1.0(0.81;1.49)visits in phase 1,versus 0.79(0.67;0.86)visits in phase 2.The median number of monthly IVI also significantly decreased in phase 2,respectively 0.67(0.55;0.90)IVI in phase 1,versus 0.55(0.45;0.67)IVI in phase 2.The mean VA evolution(VA final-VA initial)was similar in both phases,(P>0.05).Whatever the reason for"switching"(loss of efficacy,tachyphylaxis,tolerance problems),there was no incidence on VA evolution over the time.●CONCLUSION:Our results show that switching from ranibizumab to aflibercept in"suboptimal"patients significantly reduce the number of follow up visits and IVI,with a comparable efficacy.This decrease in visit number could improve patients’quality of life and reduce surgical risk by reducing the number of injections.
文摘目的:为提高捐精志愿者回访率,改变传统纸质记录模式,优化工作流程,借助信息化手段设计一套人类精子库志愿者随访管理系统。方法:该系统基于三层B/S结构,采用SQL Server 2019数据库和Visual Studio 2013开发工具,并应用.NET MVC模式进行设计。系统包括志愿者管理、电话管理、系统管理3个功能模块。结果:基于精子库信息管理平台的业务数据,成功实现了捐精志愿者全流程的随访管理。通过将志愿者回访与工作人员绩效挂钩,回访率提升近60%。结论:该系统简化了工作流程,提高了随访效率,有效满足了精子库日常工作需求,展现出较高的实用价值。
