The four-dimensional(4D) printing technology, as a combination of additive manufacturing and smart materials, has attracted increasing research interest in recent years. The bilayer structures printed with smart mater...The four-dimensional(4D) printing technology, as a combination of additive manufacturing and smart materials, has attracted increasing research interest in recent years. The bilayer structures printed with smart materials using this technology can realize complicated deformation under some special stimuli due to the material properties.The deformation prediction of bilayer structures can make the design process more rapid and thus is of great importance. However, the previous works on deformation prediction of bilayer structures rarely study the complicated deformations or the influence of the printing process on deformation. Thus, this paper proposes a new method to predict the complicated deformations of temperature-sensitive 4D printed bilayer structures,in particular to the bilayer structures based on temperature-driven shape-memory polymers(SMPs) and fabricated using the fused deposition modeling(FDM) technology. The programming process to the material during printing is revealed and considered in the simulation model. Simulation results are compared with experiments to verify the validity of the method. The advantages of this method are stable convergence and high efficiency,as the three-dimensional(3D) problem is converted to a two-dimensional(2D) problem.The simulation parameters in the model can be further associated with the printing parameters, which shows good application prospect in 4D printed bilayer structure design.展开更多
An automatic method for measuring the fetal mean abdominal diameter (MAD) or abdominal circumference (AC) with ultrasound is proposed. From a correctly presented abdominal section suitable for MAD or AC measurement, t...An automatic method for measuring the fetal mean abdominal diameter (MAD) or abdominal circumference (AC) with ultrasound is proposed. From a correctly presented abdominal section suitable for MAD or AC measurement, the location of fetal abdomen is detected by image processing. Thereafter, an active contour model is converged along the abdominal boundary for measurement purposes. The validation data set contained 310 images of fetuses with gestational age (GA) from 14 to 41 weeks. The measurement success rate was 88.1%. By manually indicating the location of the abdomen, the success rate was further improved to 95.8% for the failed cases. The correlation between manual and automatic measurements was 0.95 and the intraclass correlation coefficient (ICC) was 0.976 (95% confidence interval (CI);0.969 - 0.981). The average method execution time was 0.3 s. The mean error was lower in young fetuses (0.4%) than in older fetuses (-2.1%). The proposed cross-platform method was implemented on a portable, low-cost ultrasound machine prototype targeted for low- and middle-income countries (LMIC);the results achieved were comparable to those of other state-of-the-art automatic methods.展开更多
The continuous developing features in the design of mechanical product and based on 3D entity model is aimed at, and the extension of the 4-dimensional model with the process of designing, the knowledge described mode...The continuous developing features in the design of mechanical product and based on 3D entity model is aimed at, and the extension of the 4-dimensional model with the process of designing, the knowledge described model on the level of semantic understanding and summarizing the designing process and the way of discovering knowledge from multi-information model are studied. On the basis of designing the broad sensed collaborative system, through discussion of the relationship between the implicit knowledge of the users and the designing knowledge as well as commanding all the designing links, taking advantage of the way of concluding and deducting in the concept of the designers, the synthetic knowledge unit formed in the dynamic process from the conception design t9 the last design is schemed out, and the knowledge discovered principle in the dynamic designing process of the mechanical products and the key technology in its implementation under the milieu of network is brought forward.展开更多
A large amount of progress has achieved in neuroscience,however,there is still a lack of reasonable model for the storage/output(S/O)of life information.The cyclical motion of cardio-and pulmonary-myocyte is a typical...A large amount of progress has achieved in neuroscience,however,there is still a lack of reasonable model for the storage/output(S/O)of life information.The cyclical motion of cardio-and pulmonary-myocyte is a typical process of the life information S/O,while the opening and closing sites of Ca^(2+)ion channels during the motion can form a genetically programmed time-dependent three-dimensional(3D)pattern.Those phenomena indicate a strong correlation of the information S/O model of these myocytes with the time-sequence 3D patterns.Therefore,based on the time-dependent Ca^(2+)fluorescence imaging during the motion of cardio-and pulmonary-myocyte,here we suggest a four-dimensional(4D)code of information S/O model in cell and nervous system.Further from the fact of pulmonary myocyte motion able to be controlled by brain,it is deduced that the 4D code in brain has a role of controlling muscles through a pathway of the central nervous system,peripheral nervous system,neuromuscular junction,and muscle cells.In addition,we also suggested the 4D code of non-innate skill that can be programmed by the learning/training of a long time(~3 years),such as walking,writing,painting,sports,speech,singing,and dancing.Noticeably,this 4D S/O model is reasonable for the ultralow energy consumption of life information transmission.展开更多
This paper addresses the problem of four-dimensional angle and Doppler frequency estimation for bistatic multiple-input multiple-output （MIMO） radar with arbitrary arrays in spatial co- lored noise. A novel method f...This paper addresses the problem of four-dimensional angle and Doppler frequency estimation for bistatic multiple-input multiple-output （MIMO） radar with arbitrary arrays in spatial co- lored noise. A novel method for joint estimation of Doppler fre- quency, two-dimensional （2D） direction of departure and 2D direc- tion of arrival based on the propagator method （PM） for arbitrary arrays is discussed. A special matrix is constructed to eliminate the influence of spatial colored noise. The four-dimensional （4D） angle and Doppler frequency are extracted from the matrix and the three- dimensional （3D） coordinates of the targets are then calculated on the basis of these angles. The proposed algorithm provides a lower computational complexity and has a parameter estimation very close to that of the ESPRIT algorithm and the DOA-matrix al- gorithm in the high signal to noise ratio and the Cramer-Rao bound （CRB） is given. Furthermore, multi-dimensional parameters can be automatically paired by this algorithm to avoid performance degra- dation resulting from wrong pairing. Simulation results demonstrate the effectiveness of the proposed method.展开更多
Time-dependent structure analysis theory has been proved to be more accurate and reliable compared to commonly used methods during construction. However, so far applications are limited to partial period and part of t...Time-dependent structure analysis theory has been proved to be more accurate and reliable compared to commonly used methods during construction. However, so far applications are limited to partial period and part of the structure because of immeasurable artificial intervention. Based on the building informa-tion model (BIM) and four-dimensional (4D) technology, this paper proposes an improves structure analysis method, which can generate structural geometry, resistance model, and loading conditions automatically by a close interlink of the schedule information, architectural model, and material properties. The method was applied to a safety analysis during a continuous and dynamic simulation of the entire construction process. The results show that the organic combination of the BIM, 4D technology, construction simulation, and safety analysis of time-dependent structures is feasible and practical. This research also lays a foundation for further researches on building lifecycle management by combining architectural design, structure analysis, and construction management.展开更多
Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed,self-assembly structures with the ability to transform over time.However,one of the...Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed,self-assembly structures with the ability to transform over time.However,one of the critical challenges of 4D printing is the lack of advanced 4D printing systems that not only meet all the essential requirements of shape change but also possess smart,dynamic capabilities to spatiotemporally and instantly control the shape-transformation process.Here,we present a facile 4D printing platform which incorporates nanomaterials into the conventional stimuli-responsive polymer,allowing the 4D printed object to achieve a dynamic and remote controlled,on-time and position shape transformation.A proof-of-concept 4D printed brain model was created using near-infrared light (NIR) responsive nanocomposite to evaluate the capacity for controllable 4D transformation,and the feasibility of photothermal stimulation for modulating neural stem cell behaviors.This novel 4D printing strategy can not only be used to create dynamic 3D patterned biological structures that can spatiotemporally control their shapes or behaviors of transformation under a human benign stimulus (NIR),but can also provide a potential method for building complex self-morphing objects for widespread applications.展开更多
In this study, Fengyun-3 D(FY-3 D) Micro Wave Radiation Imager(MWRI) radiance data were directly assimilated into the Global/Regional Assimilation and Pr Ediction System(GRAPES) four-dimensional variational(4 DVar) sy...In this study, Fengyun-3 D(FY-3 D) Micro Wave Radiation Imager(MWRI) radiance data were directly assimilated into the Global/Regional Assimilation and Pr Ediction System(GRAPES) four-dimensional variational(4 DVar) system. Quality control procedures were developed for MWRI applications by using algorithms from similar microwave instruments. Compared with the FY-3 C MWRI, the bias of FY-3 D MWRI observations did not show a clear node-dependent difference from the numerical weather prediction background simulation. A conventional bias correction approach can therefore be used to remove systematic biases before the assimilation of data. After assimilating the MWRI radiance data into GRAPES, the geopotential height and humidity analysis fields were improved relative to the control experiment. There was a positive impact on the location of the subtropical high, which led to improvements in forecasts of the track of Typhoon Shanshan.展开更多
In order to increase the productivity of construction industry, emerging technologies have been constantly introduced and applied in this traditional industry by pilot researchers. This paper provides an integrated mo...In order to increase the productivity of construction industry, emerging technologies have been constantly introduced and applied in this traditional industry by pilot researchers. This paper provides an integrated model of radio-frequency identification (RFID) and four-dimensional Computer-Aided Design (4D CAD) in construction management. RFID involves the use of tags that collect data and transmit data. RFID can collect data by radio waves instead of light waves. RFID technology is surpassing barcode technology where light waves are easily blocked and barcode labels are easy to fall off or become unreadable due to dust, dirt, or other contaminants. 4D CAD which involves 3D construction models and construction schedules presents visualized construction process. Integration of RFID and 4D CAD in this paper built a dynamic construction management and control system which would reduce the time of capturing data on site and control quality of construction materials efficiently. Pilot test result shows that a construction manager can easily understand how and what a complicated construction project will be accomplished. Although further analysis is necessary, RFID and 4D CAD show promises of being a beneficial technology in construction management.展开更多
目的探讨聚焦超声治疗外阴上皮内非瘤变(nonneoplastic epithelial disorders of vulva,NNEDV)后细胞周期素D 1(Cyclin D 1)和周期素依赖性蛋白激酶4(cyclin-dependent kinase 4,CDK 4)的表达及意义。方法回顾性分析2015年8月至2016年7...目的探讨聚焦超声治疗外阴上皮内非瘤变(nonneoplastic epithelial disorders of vulva,NNEDV)后细胞周期素D 1(Cyclin D 1)和周期素依赖性蛋白激酶4(cyclin-dependent kinase 4,CDK 4)的表达及意义。方法回顾性分析2015年8月至2016年7月西南医科大学附属医院妇产科收治的20例NNEDV患者的皮损标本,设为病例组,经聚焦超声治疗后5~12月(平均8月)在原活检部位再次取材;选取因各种外阴疾病就诊局部活检后经病理证实为正常组织者10例为正常组。采用免疫组织化学法研究NNEDV患者聚焦超声治疗前后皮损中Cyclin D 1和CDK 4蛋白的表达。结果 NNEDV组织中Cyclin D 1和CDK 4蛋白阳性表达组织学评分治疗前高于治疗后及正常组(P<0.05),治疗后与正常组比较差异无统计学意义(P>0.05)。治疗前NNEDV患者Cyclin D 1和CDK 4在上皮组织棘细胞层/基底细胞层阳性表达组织学评分比值均高于治疗后及正常组(P<0.05),治疗后与正常组比较差异无统计学意义(P>0.05)。结论聚焦超声可以有效阻断NNEDV组织中Cyclin D 1、CDK 4的高表达而达到治疗目的,治疗后Cyclin D 1和CDK 4阳性细胞在NNEDV的上皮组织各层中的分布趋于正常。展开更多
In this paper,some basic properties of a new four-dimensional(4 D)continuous autonomous chaotic system,in which each equation contains a cubic cross-product term,are further analyzed.The new system has 9 equilibria di...In this paper,some basic properties of a new four-dimensional(4 D)continuous autonomous chaotic system,in which each equation contains a cubic cross-product term,are further analyzed.The new system has 9 equilibria displaying graceful symmetry with respect to the origin and coordinate planes,and the stability of them are discussed.Then detailed bifurcation analysis is given to demonstrate the evolution processes of the system.Numerical simulations show that the system evolves chaotic motions through period-doubling bifurcation or intermittence chaos while the system parameters vary.We design a new scheme of generalized projective synchronization,so-called unified generalized projective synchronization,whose response signal synchronizes with the linear combination of drive signal.The design has the advantages of containing complete synchronization,anti-synchronization and disorder synchronization over the usual generalized projective synchronization,such that it can provide greater security in secure communication.Based on Lyapunov stability theorem,some sufficient conditions for the new synchronization are inferred.Numerical simulations demonstrate the effectiveness and feasibility of the method by employing the four-wing chaotic system.展开更多
基金the National Natural Science Foundation of China(Nos.52130501 and 52075479)the National Key R&D Program of China(No.2018YFB1700804)。
文摘The four-dimensional(4D) printing technology, as a combination of additive manufacturing and smart materials, has attracted increasing research interest in recent years. The bilayer structures printed with smart materials using this technology can realize complicated deformation under some special stimuli due to the material properties.The deformation prediction of bilayer structures can make the design process more rapid and thus is of great importance. However, the previous works on deformation prediction of bilayer structures rarely study the complicated deformations or the influence of the printing process on deformation. Thus, this paper proposes a new method to predict the complicated deformations of temperature-sensitive 4D printed bilayer structures,in particular to the bilayer structures based on temperature-driven shape-memory polymers(SMPs) and fabricated using the fused deposition modeling(FDM) technology. The programming process to the material during printing is revealed and considered in the simulation model. Simulation results are compared with experiments to verify the validity of the method. The advantages of this method are stable convergence and high efficiency,as the three-dimensional(3D) problem is converted to a two-dimensional(2D) problem.The simulation parameters in the model can be further associated with the printing parameters, which shows good application prospect in 4D printed bilayer structure design.
文摘An automatic method for measuring the fetal mean abdominal diameter (MAD) or abdominal circumference (AC) with ultrasound is proposed. From a correctly presented abdominal section suitable for MAD or AC measurement, the location of fetal abdomen is detected by image processing. Thereafter, an active contour model is converged along the abdominal boundary for measurement purposes. The validation data set contained 310 images of fetuses with gestational age (GA) from 14 to 41 weeks. The measurement success rate was 88.1%. By manually indicating the location of the abdomen, the success rate was further improved to 95.8% for the failed cases. The correlation between manual and automatic measurements was 0.95 and the intraclass correlation coefficient (ICC) was 0.976 (95% confidence interval (CI);0.969 - 0.981). The average method execution time was 0.3 s. The mean error was lower in young fetuses (0.4%) than in older fetuses (-2.1%). The proposed cross-platform method was implemented on a portable, low-cost ultrasound machine prototype targeted for low- and middle-income countries (LMIC);the results achieved were comparable to those of other state-of-the-art automatic methods.
基金Selected from Proceedings of the 7th International Conference on Frontiers of DesignManufacturing(ICFDM'2006)This project is supported by National Natural Science Foundation of China(No.50275100)Key Scientific Technological Projects in Sichuan China(No.2006Z01-001-6).
文摘The continuous developing features in the design of mechanical product and based on 3D entity model is aimed at, and the extension of the 4-dimensional model with the process of designing, the knowledge described model on the level of semantic understanding and summarizing the designing process and the way of discovering knowledge from multi-information model are studied. On the basis of designing the broad sensed collaborative system, through discussion of the relationship between the implicit knowledge of the users and the designing knowledge as well as commanding all the designing links, taking advantage of the way of concluding and deducting in the concept of the designers, the synthetic knowledge unit formed in the dynamic process from the conception design t9 the last design is schemed out, and the knowledge discovered principle in the dynamic designing process of the mechanical products and the key technology in its implementation under the milieu of network is brought forward.
基金supported by the National Key R&D Program of China(Nos.2021YFA1200404 and 2018YFA0208502)the National Natural Science Foundation of China(Nos.51973227,21988102,and T224100002).
文摘A large amount of progress has achieved in neuroscience,however,there is still a lack of reasonable model for the storage/output(S/O)of life information.The cyclical motion of cardio-and pulmonary-myocyte is a typical process of the life information S/O,while the opening and closing sites of Ca^(2+)ion channels during the motion can form a genetically programmed time-dependent three-dimensional(3D)pattern.Those phenomena indicate a strong correlation of the information S/O model of these myocytes with the time-sequence 3D patterns.Therefore,based on the time-dependent Ca^(2+)fluorescence imaging during the motion of cardio-and pulmonary-myocyte,here we suggest a four-dimensional(4D)code of information S/O model in cell and nervous system.Further from the fact of pulmonary myocyte motion able to be controlled by brain,it is deduced that the 4D code in brain has a role of controlling muscles through a pathway of the central nervous system,peripheral nervous system,neuromuscular junction,and muscle cells.In addition,we also suggested the 4D code of non-innate skill that can be programmed by the learning/training of a long time(~3 years),such as walking,writing,painting,sports,speech,singing,and dancing.Noticeably,this 4D S/O model is reasonable for the ultralow energy consumption of life information transmission.
基金supported by the National Natural Science Foundation of China(6137116961179006)+1 种基金the Jiangsu Postdoctoral Research Funding Plan(1301013B)the Nanjing University of Aeronautics and Astronautics Funding(NZ2013208)
文摘This paper addresses the problem of four-dimensional angle and Doppler frequency estimation for bistatic multiple-input multiple-output （MIMO） radar with arbitrary arrays in spatial co- lored noise. A novel method for joint estimation of Doppler fre- quency, two-dimensional （2D） direction of departure and 2D direc- tion of arrival based on the propagator method （PM） for arbitrary arrays is discussed. A special matrix is constructed to eliminate the influence of spatial colored noise. The four-dimensional （4D） angle and Doppler frequency are extracted from the matrix and the three- dimensional （3D） coordinates of the targets are then calculated on the basis of these angles. The proposed algorithm provides a lower computational complexity and has a parameter estimation very close to that of the ESPRIT algorithm and the DOA-matrix al- gorithm in the high signal to noise ratio and the Cramer-Rao bound （CRB） is given. Furthermore, multi-dimensional parameters can be automatically paired by this algorithm to avoid performance degra- dation resulting from wrong pairing. Simulation results demonstrate the effectiveness of the proposed method.
基金the National Natural Science Foundation of China (No. 50478015) the National Technological Support Program for the 11th Five-Year Plan of China (No. 2006BAJ10B07)
文摘Time-dependent structure analysis theory has been proved to be more accurate and reliable compared to commonly used methods during construction. However, so far applications are limited to partial period and part of the structure because of immeasurable artificial intervention. Based on the building informa-tion model (BIM) and four-dimensional (4D) technology, this paper proposes an improves structure analysis method, which can generate structural geometry, resistance model, and loading conditions automatically by a close interlink of the schedule information, architectural model, and material properties. The method was applied to a safety analysis during a continuous and dynamic simulation of the entire construction process. The results show that the organic combination of the BIM, 4D technology, construction simulation, and safety analysis of time-dependent structures is feasible and practical. This research also lays a foundation for further researches on building lifecycle management by combining architectural design, structure analysis, and construction management.
文摘Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed,self-assembly structures with the ability to transform over time.However,one of the critical challenges of 4D printing is the lack of advanced 4D printing systems that not only meet all the essential requirements of shape change but also possess smart,dynamic capabilities to spatiotemporally and instantly control the shape-transformation process.Here,we present a facile 4D printing platform which incorporates nanomaterials into the conventional stimuli-responsive polymer,allowing the 4D printed object to achieve a dynamic and remote controlled,on-time and position shape transformation.A proof-of-concept 4D printed brain model was created using near-infrared light (NIR) responsive nanocomposite to evaluate the capacity for controllable 4D transformation,and the feasibility of photothermal stimulation for modulating neural stem cell behaviors.This novel 4D printing strategy can not only be used to create dynamic 3D patterned biological structures that can spatiotemporally control their shapes or behaviors of transformation under a human benign stimulus (NIR),but can also provide a potential method for building complex self-morphing objects for widespread applications.
基金Supported by the National Natural Science Foundation of China(41675108)National Key Research and Development Program(2018YFC1506700)Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK0105)。
文摘In this study, Fengyun-3 D(FY-3 D) Micro Wave Radiation Imager(MWRI) radiance data were directly assimilated into the Global/Regional Assimilation and Pr Ediction System(GRAPES) four-dimensional variational(4 DVar) system. Quality control procedures were developed for MWRI applications by using algorithms from similar microwave instruments. Compared with the FY-3 C MWRI, the bias of FY-3 D MWRI observations did not show a clear node-dependent difference from the numerical weather prediction background simulation. A conventional bias correction approach can therefore be used to remove systematic biases before the assimilation of data. After assimilating the MWRI radiance data into GRAPES, the geopotential height and humidity analysis fields were improved relative to the control experiment. There was a positive impact on the location of the subtropical high, which led to improvements in forecasts of the track of Typhoon Shanshan.
文摘In order to increase the productivity of construction industry, emerging technologies have been constantly introduced and applied in this traditional industry by pilot researchers. This paper provides an integrated model of radio-frequency identification (RFID) and four-dimensional Computer-Aided Design (4D CAD) in construction management. RFID involves the use of tags that collect data and transmit data. RFID can collect data by radio waves instead of light waves. RFID technology is surpassing barcode technology where light waves are easily blocked and barcode labels are easy to fall off or become unreadable due to dust, dirt, or other contaminants. 4D CAD which involves 3D construction models and construction schedules presents visualized construction process. Integration of RFID and 4D CAD in this paper built a dynamic construction management and control system which would reduce the time of capturing data on site and control quality of construction materials efficiently. Pilot test result shows that a construction manager can easily understand how and what a complicated construction project will be accomplished. Although further analysis is necessary, RFID and 4D CAD show promises of being a beneficial technology in construction management.
文摘目的探讨聚焦超声治疗外阴上皮内非瘤变(nonneoplastic epithelial disorders of vulva,NNEDV)后细胞周期素D 1(Cyclin D 1)和周期素依赖性蛋白激酶4(cyclin-dependent kinase 4,CDK 4)的表达及意义。方法回顾性分析2015年8月至2016年7月西南医科大学附属医院妇产科收治的20例NNEDV患者的皮损标本,设为病例组,经聚焦超声治疗后5~12月(平均8月)在原活检部位再次取材;选取因各种外阴疾病就诊局部活检后经病理证实为正常组织者10例为正常组。采用免疫组织化学法研究NNEDV患者聚焦超声治疗前后皮损中Cyclin D 1和CDK 4蛋白的表达。结果 NNEDV组织中Cyclin D 1和CDK 4蛋白阳性表达组织学评分治疗前高于治疗后及正常组(P<0.05),治疗后与正常组比较差异无统计学意义(P>0.05)。治疗前NNEDV患者Cyclin D 1和CDK 4在上皮组织棘细胞层/基底细胞层阳性表达组织学评分比值均高于治疗后及正常组(P<0.05),治疗后与正常组比较差异无统计学意义(P>0.05)。结论聚焦超声可以有效阻断NNEDV组织中Cyclin D 1、CDK 4的高表达而达到治疗目的,治疗后Cyclin D 1和CDK 4阳性细胞在NNEDV的上皮组织各层中的分布趋于正常。
基金Supported by the National Natural Science Foundation of China(61863022)the Natural Science Foundation of Gansu Province(17JR5RA096)。
文摘In this paper,some basic properties of a new four-dimensional(4 D)continuous autonomous chaotic system,in which each equation contains a cubic cross-product term,are further analyzed.The new system has 9 equilibria displaying graceful symmetry with respect to the origin and coordinate planes,and the stability of them are discussed.Then detailed bifurcation analysis is given to demonstrate the evolution processes of the system.Numerical simulations show that the system evolves chaotic motions through period-doubling bifurcation or intermittence chaos while the system parameters vary.We design a new scheme of generalized projective synchronization,so-called unified generalized projective synchronization,whose response signal synchronizes with the linear combination of drive signal.The design has the advantages of containing complete synchronization,anti-synchronization and disorder synchronization over the usual generalized projective synchronization,such that it can provide greater security in secure communication.Based on Lyapunov stability theorem,some sufficient conditions for the new synchronization are inferred.Numerical simulations demonstrate the effectiveness and feasibility of the method by employing the four-wing chaotic system.
