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Microdynamic mechanical properties and fracture evolution mechanism of monzogabbro with a true triaxial multilevel disturbance method
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作者 Zhi Zheng Bin Deng +3 位作者 Hong Liu Wei Wang Shuling Huang Shaojun Li 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第3期385-411,共27页
The far-field microdynamic disturbance caused by the excavation of deep mineral resources and underground engineering can induce surrounding rock damage in high-stress conditions and even lead to disasters.However,the... The far-field microdynamic disturbance caused by the excavation of deep mineral resources and underground engineering can induce surrounding rock damage in high-stress conditions and even lead to disasters.However,the mechanical properties and damage/fracture evolution mechanisms of deep rock induced by microdynamic disturbance under three-dimensional stress states are unclear.Therefore,a true triaxial multilevel disturbance test method is proposed,which can completely simulate natural geostress,excavation stress redistribution(such as stress unloading,concentration and rotation),and subsequently the microdynamic disturbance triggering damaged rock failure.Based on a dynamic true triaxial test platform,true triaxial microdynamic disturbance tests under different frequency and amplitudes were carried out on monzogabbro.The results show that increasing amplitude or decreasing frequency diminishes the failure strength of monzogabbro.Deformation modulus gradually decreases during disturbance failure.As frequency and amplitude increase,the degradation rate of deformation modulus decreases slightly,disturbance dissipated energy increases significantly,and disturbance deformation anisotropy strengthens obviously.A damage model has been proposed to quantitatively characterize the disturbance-induced damage evolution at different frequency and amplitude under true triaxial stress.Before disturbance failure,the micro-tensile crack mechanism is dominant,and the micro-shear crack mechanism increases significantly at failure.With the increase of amplitude and frequency,the micro-shear crack mechanism increases.When approaching disturbance failure,the acoustic emission fractal dimension changes from a stable value to local large oscillation,and finally increases sharply to a high value at failure.Finally,the disturbance-induced failure mechanism of surrounding rock in deep engineering is clearly elucidated. 展开更多
关键词 True triaxial disturbance test Mechanical properties fracture evolution mechanism Disturbance-induced damage evolution Failure mechanism and precursor
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A multi-mechanism numerical simulation model for CO_(2)-EOR and storage in fractured shale oil reservoirs
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作者 Yuan-Zheng Wang Ren-Yi Cao +3 位作者 Zhi-Hao Jia Bin-Yu Wang Ming Ma Lin-Song Cheng 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期1814-1828,共15页
Under the policy background and advocacy of carbon capture,utilization,and storage(CCUS),CO_(2)-EOR has become a promising direction in the shale oil reservoir industry.The multi-scale pore structure distribution and ... Under the policy background and advocacy of carbon capture,utilization,and storage(CCUS),CO_(2)-EOR has become a promising direction in the shale oil reservoir industry.The multi-scale pore structure distribution and fracture structure lead to complex multiphase flow,comprehensively considering multiple mechanisms is crucial for development and CO_(2) storage in fractured shale reservoirs.In this paper,a multi-mechanism coupled model is developed by MATLAB.Compared to the traditional Eclipse300 and MATLAB Reservoir Simulation Toolbox(MRST),this model considers the impact of pore structure on fluid phase behavior by the modified Peng—Robinson equation of state(PR-EOS),and the effect simultaneously radiate to Maxwell—Stefan(M—S)diffusion,stress sensitivity,the nano-confinement(NC)effect.Moreover,a modified embedded discrete fracture model(EDFM)is used to model the complex fractures,which optimizes connection types and half-transmissibility calculation approaches between non-neighboring connections(NNCs).The full implicit equation adopts the finite volume method(FVM)and Newton—Raphson iteration for discretization and solution.The model verification with the Eclipse300 and MRST is satisfactory.The results show that the interaction between the mechanisms significantly affects the production performance and storage characteristics.The effect of molecular diffusion may be overestimated in oil-dominated(liquid-dominated)shale reservoirs.The well spacing and injection gas rate are the most crucial factors affecting the production by sensitivity analysis.Moreover,the potential gas invasion risk is mentioned.This model provides a reliable theoretical basis for CO_(2)-EOR and sequestration in shale oil reservoirs. 展开更多
关键词 CO_(2)-EOR CO_(2)storage Shale oil reservoir Complex fracture model Multiple mechanisms
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Effect mechanism of seepage force on the hydraulic fracture propagation
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作者 Haiyang Wang Desheng Zhou +1 位作者 Yi Zou Peng Zheng 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第3期223-240,共18页
The flow of fluid through the porous matrix of a reservoir rock applies a seepage force to the solid rock matrix.Although the seepage force exerted by fluid flow through the porous matrix of a reservoir rock has a not... The flow of fluid through the porous matrix of a reservoir rock applies a seepage force to the solid rock matrix.Although the seepage force exerted by fluid flow through the porous matrix of a reservoir rock has a notable influence on rock deformation and failure,its effect on hydraulic fracture(HF)propagation remains ambiguous.Therefore,in this study,we improved a traditional fluid–solid coupling method by incorporating the role of seepage force during the fracturing fluid seepage,using the discrete element method.First,we validated the simulation results of the improved method by comparing them with an analytical solution of the seepage force and published experimental results.Next,we conducted numerical simulations in both homogeneous and heterogeneous sandstone formations to investigate the influence of seepage force on HF propagation.Our results indicate that fluid viscosity has a greater impact on the magnitude and extent of seepage force compared to injection rate,and that lower viscosity and injection rate correspond to shorter hydraulic fracture lengths.Furthermore,seepage force influences the direction of HF propagation,causing HFs to deflect towards the side of the reservoir with weaker cementation and higher permeability. 展开更多
关键词 Hydraulic fracturing Seepage force fracture propagation Discrete element method Reservoir heterogeneity
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Mechanisms of fracture propagation from multi-cluster using a phase field based HMD coupling model in fractured reservoir
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作者 Yun-Jin Wang Bo Wang +6 位作者 Hang Su Tu Chang Ren-Cheng Dong Li-Zhe Li Wei-Yu Tang Ting-Xue Jiang Fu-Jian Zhou 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期1829-1851,共23页
Natural fractures(NFs)are common in shale and tight reservoirs,where staged multi-cluster fracturing of horizontal wells is a prevalent technique for reservoir stimulation.While NFs and stress interference are recogni... Natural fractures(NFs)are common in shale and tight reservoirs,where staged multi-cluster fracturing of horizontal wells is a prevalent technique for reservoir stimulation.While NFs and stress interference are recognized as significant factors affecting hydraulic fracture(HF)propagation,the combined influence of these factors remains poorly understood.To address this knowledge gap,a novel coupled hydromechanical-damage(HMD)model based on the phase field method is developed to investigate the propagation of multi-cluster HFs in fractured reservoirs.The comprehensive energy functional and control functions are established,while incorporating dynamic fluid distribution between multiple perforation clusters and refined changes in rock mechanical parameters during hydraulic fracturing.The HMD coupled multi-cluster HF propagation model investigates various scenarios,including single HF and single NF,reservoir heterogeneity,single HF and NF clusters,and multi-cluster HFs with NF clusters.The results show that the HMD coupling model can accurately capture the impact of approach angle(θ),stress difference and cementation strength on the interaction of HF and NF.The criterion of the open and cross zones is not fixed.The NF angle(a)is not a decisive parameter to discriminate the interaction.According to the relationship between approach angle(θ)and NF angle(a),the contact relationship of HF can be divided into three categories(θ=a,θ<a,andθ>a).The connected NF can increase the complexity of HF by inducing it to form branch fracture,resulting in a fractal dimension of HF as high as2.1280 at angles of±45°.Inter-fracture interference from the heel to the toe of HF shows the phenomenon of no,strong and weak interference.Interestingly,under the influence of NFs,distant HFs from the injection can become dominant fractures.However,as a gradually increases,inter-fracture stress interference becomes the primary factor influencing HF propagation,gradually superseding the dominance of NF induced fractures. 展开更多
关键词 HMD coupling Phase field Natural fracture Flow distribution Hydraulic fracturing Inter-fracture interference
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Prediction and critical transition mechanism for granite fracture:Insights from critical slowing down theory
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作者 WANG Chun-lai ZHOU Bao-kun +6 位作者 LI Chang-feng WEN Zhi-jie BAI Zhi-an ZHU Chao-yang SUN Liang XUE Xu-hui CAO Peng 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2748-2764,共17页
Rock fracture warning is one of the significant challenges in rock mechanics.Many true triaxial and synchronous acoustic emission(AE)tests were conducted on granite samples.The investigation focused on the characteris... Rock fracture warning is one of the significant challenges in rock mechanics.Many true triaxial and synchronous acoustic emission(AE)tests were conducted on granite samples.The investigation focused on the characteristics of AE signals preceding granite fracture,based on the critical slowing down(CSD)theory.The granite undergoes a transition from the stable phase to the fracture phase and exhibits a clear CSD phenomenon,characterized by a pronounced increase in variance and autocorrelation coefficient.The variance mutation points were found to be more identifiable and suitable as the primary criterion for predicting precursor information related to granite fracture,compared to the autocorrelation coefficient.It is noteworthy to emphasize that the CSD factor holds greater potential in elucidating the underlying mechanisms responsible for the critical transition of granite fracture,in comparison to the AE timing parameters.Furthermore,a novel multi-parameter collaborative prediction method for rock fracture was developed by comprehensively analyzing predictive information,including abnormal variation modes and the CSD factor of AE characteristic parameters.This method enhances the understanding and prediction of rock fracture-related geohazards. 展开更多
关键词 GRANITE triaxial compression acoustic emission rock fracture critical slowing down theory
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Fracture behavior and mechanism of highly fragmented steel cylindrical shell under explosive loading
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作者 Kang Wang Peng Chen +5 位作者 Xingyun Sun Yufeng Liu Jiayu Meng Xiaoyuan Li Xiongwei Zheng Chuan Xiao 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第6期122-132,共11页
An in-depth understanding of the fracture behavior and mechanism of metallic shells under internal explosive loading can help develop material designs for warheads and regulate the quantity and mass distribution of th... An in-depth understanding of the fracture behavior and mechanism of metallic shells under internal explosive loading can help develop material designs for warheads and regulate the quantity and mass distribution of the fragments formed.This study investigated the fragmentation performance of a new high-carbon silicon-manganese(HCSiMn)steel cylindrical shell through fragment recovery experiments.Compared with the conventional 45Cr steel shell,the number of small mass fragments produced by the HCSi Mn steel shell was significantly increased with a scale parameter of 0.57 g fitted by the Weibull distribution model.The fragmentation process of the HCSi Mn shell exhibited more brittle tensile fracture characteristics,with the microcrack damage zone on the outer surface being the direct cause of its high fragmentation.On the one hand,the doping of alloy elements resulted in grain refinement by forming metallographic structure of tempered sorbite,so that microscopic intergranular fracture reduces the characteristic mass of the fragments;on the other hand,the distribution of alloy carbides can exert a"pinning"effect on the substrate grains,causing more initial cracks to form and propagate along the brittle carbides,further improving the shell fragmentation.Although the killing power radius for light armored vehicles was slightly reduced by about 6%,the dense killing radius of HCSiMn steel projectile against personnel can be significantly increased by about 26%based on theoretical assessment.These results provided an experimental basis for high fragmentation warhead design,and to some extent,revealed the correlation mechanism between metallographic structure and shell fragmentation. 展开更多
关键词 Projectile fragmentation Fragment mass distribution fracture mode Metallographic structure Damage power
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Failure characteristics and fracture mechanism of overburden rock induced by mining:A case study in China
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作者 Jiawei Li Meng Zhang +2 位作者 Changxiang Wang Changlong Liao Baoliang Zhang 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第3期241-255,共15页
This study employs similar simulation testing and discrete element simulation coupling to analyze the failure and deformation processes of a model coal seam's roof.The caving area of the overburden rock is divided... This study employs similar simulation testing and discrete element simulation coupling to analyze the failure and deformation processes of a model coal seam's roof.The caving area of the overburden rock is divided into three zones:the delamination fracture zone,broken fracture zone,and compaction zone.The caving and fracture zones'heights are approximately 110 m above the coal seam,with a maximum subsidence of 11 m.The delamination fracture zone's porosity range is between 0.2 and 0.3,while the remainder of the roof predominantly exhibits a porosity of less than 0.1.In addition,the numerical model's stress analysis revealed that the overburden rock's displacement zone forms an'arch-beam'structure starting from 160 m,with the maximum and minimum stress values decreasing as the distance of advancement increases.In the stress beam interval of the overburden rock,the maximum value changes periodically as the advancement distance increases.Based on a comparative analysis between observable data from on-site work and numerical simulation results,the stress data from the numerical simulation are essentially consistent with the actual results detected on-site,indicating the validity of the numerical simulation results. 展开更多
关键词 fracture development characteristics Similar simulation experiment Layer porosity Discrete element numerical simulation
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FRACTURE序列在中轴型脊柱关节炎骶髂关节结构性病变中的诊断价值
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作者 章忆惠 程艺璇 +4 位作者 徐磊 徐凌霄 谈文峰 王梦悦 祁良 《放射学实践》 CSCD 北大核心 2024年第7期929-934,共6页
目的:评估限制回波间隔的快速梯度回波类CT成像(FRACTURE)序列在检测中轴型脊柱关节炎(SpA)骶髂关节结构病变中的诊断价值。方法:回顾性分析83例确诊中轴型SpA患者在2021年12月-2022年8月进行骶髂关节MRI和CT检查的影像资料。评估图像包... 目的:评估限制回波间隔的快速梯度回波类CT成像(FRACTURE)序列在检测中轴型脊柱关节炎(SpA)骶髂关节结构病变中的诊断价值。方法:回顾性分析83例确诊中轴型SpA患者在2021年12月-2022年8月进行骶髂关节MRI和CT检查的影像资料。评估图像包括FRACTURE、T_(1)WI序列和CT平扫图像。对骶髂关节的影像图像进行结构性病变评分:关节间隙变化(0~5分)、骨质侵蚀(0~3分)和骨质硬化(0~2分)。根据修改后的纽约标准评分系统对骶髂关节炎进行综合评分。结果:总共有166个骶髂关节图像(83名受试者)可供分析。以CT图像作为参考标准,FRACTURE序列在关节间隙改变、骨质侵蚀、骨质硬化和骶髂关节炎综合评分与CT结果表现出较高的一致性,AUC分别为0.908、0.943、0.918和0.944。与T_(1)WI相比,FRACTURE在关节间隙变化(91.8%vs.70.5%)、骨质侵蚀(93.3%vs.56.4%)、骨质硬化(94%vs.77.6%)和骶髂关节炎综合评分(98.9%vs.75.3%)方面具有更高的诊断准确性。结论:FRACTURE成像可以评估中轴型SpA患者骶髂关节的结构性病变,并显示出良好的诊断性能。 展开更多
关键词 fracture序列 骶髂关节 脊柱关节病 磁共振成像 体层摄影术 X线计算机
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A two-phase type-curve method with multiscale fluid transport mechanisms in hydraulically fractured shale reservoirs 被引量:1
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作者 Feng-Yuan Zhang Lin-Jun Zou +3 位作者 Zhen-Hua Rui Hamid Emami-Meybodi Luis F.Ayala Zheng-Xin Zhang 《Petroleum Science》 SCIE EI CAS CSCD 2023年第4期2253-2267,共15页
The quantitative understanding of hydraulic fracture(HF)properties guides accurate production forecasts and reserve estimation.Type curve is a powerful technique to characterize HF and reservoir properties from flowba... The quantitative understanding of hydraulic fracture(HF)properties guides accurate production forecasts and reserve estimation.Type curve is a powerful technique to characterize HF and reservoir properties from flowback and long-term production data.However,two-phase flow of water and hydrocarbon after an HF stimulation together with the complex transport mechanisms in shale nanopores exacerbate the nonlinearity of the transport equation,causing errors in type-curve analysis.Accordingly,we propose a new two-phase type-curve method to estimate HF properties,such as HF volume and permeability of fracture,through the analysis of flowback data of multi-fractured shale wells.The proposed type curve is based on a semianalytical solution that couples the two-phase flow from the matrix with the flow in HF by incorporating matrix influx,slippage effect,stress dependence,and the spatial variation of fluid properties in inorganic and organic pores.For the first time,multiple fluid transport mechanisms are considered into two-phase type-curve analysis for shale reservoirs.We analyze the flowback data from a multi-fractured horizontal well in a shale gas reservoir to verify the field application of the proposed method.The results show that the fracture properties calculated by the type-curve method are in good agreement with the long-time production data. 展开更多
关键词 Type curve Two-phase flow Flowback analysis Fluid transport mechanisms Shale reservoir
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A modified 3D mean strain energy density criterion for predicting shale mixed-mode Ⅰ/Ⅲ fracture toughness
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作者 Kun Zheng Chaolin Wang +2 位作者 Yu Zhao Jing Bi Haifeng Liu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第7期2411-2428,共18页
The fracture toughness of rocks is a critical fracturing parameter in geo-energy exploitation playing a significant role in fracture mechanics and hydraulic fracturing.The edge-notched disk bending(ENDB)specimens are ... The fracture toughness of rocks is a critical fracturing parameter in geo-energy exploitation playing a significant role in fracture mechanics and hydraulic fracturing.The edge-notched disk bending(ENDB)specimens are employed to measure the entire range of mixed-modeⅠ/Ⅲfracture toughness of Longmaxi shale.To theoretically interpret the fracture mechanisms,this research first introduces the detailed derivations of three established fracture criteria.By distinguishing the volumetric and distortional strain energy densities,an improved three-dimensional mean strain energy density(MSED)criterion is proposed.As the critical volumetric to distortional MSED ratio decreases,the transition from tensiondominated fracture to shear-dominated fracture is observed.Our results indicate that both peak load and applied energy increase significantly with the transition from pure mode I(i.e.,tension)to pure modeⅢ(i.e.,torsion or tearing)since mode-Ⅲcracking happens in a twisted manner and mode-Ⅰcracking occurs in a coplanar manner.The macroscopic fracture signatures are consistent with those of triaxial hydraulic fracturing.The average ratio of pure mode-Ⅲfracture toughness to pure mode-Ⅰfracture toughness is 0.68,indicating that the obtained mode-Ⅲfracture resistance for a tensionbased loading system is apparent rather than true.Compared to the three mainstream fracture criteria,the present fracture criterion exhibits greater competitiveness and can successfully evaluate and predict mixed-modeⅠ/Ⅲfracture toughness of distinct materials and loading methods. 展开更多
关键词 Longmaxi shale Hydraulic fracturing fracture mechanisms fracture criteria Mixed-modeⅠ/Ⅲfracture toughness Edge-notched disk bending
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Effect of heat treatment on the microstructure,mechanical properties and fracture behaviors of ultra-high-strength SiC/Al-Zn-Mg-Cu composites
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作者 Guonan Ma Shize Zhu +3 位作者 Dong Wang Peng Xue BolüXiao Zongyi Ma 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第10期2233-2243,共11页
A high-zinc composite,12vol%SiC/Al-13.3 Zn-3.27 Mg-1.07Cu(wt%),with an ultra-high-strength of 781 MPa was success-fully fabricated through a powder metallurgy method,followed by an extrusion process.The effects of sol... A high-zinc composite,12vol%SiC/Al-13.3 Zn-3.27 Mg-1.07Cu(wt%),with an ultra-high-strength of 781 MPa was success-fully fabricated through a powder metallurgy method,followed by an extrusion process.The effects of solid-solution and aging heat treat-ments on the microstructure and mechanical properties of the composite were extensively investigated.Compared with a single-stage sol-id-solution treatment,a two-stage solid-solution treatment(470℃/1 h+480℃/1 h)exhibited a more effective solid-solution strengthen-ing owing to the higher degree of solid-solution and a more uniform microstructure.According to the aging hardness curves of the com-posite,the optimized aging parameter(100℃/22 h)was determined.Reducing the aging temperature and time resulted in finer and more uniform nanoscale precipitates but only yielded a marginal increase in tensile strength.The fractography analysis revealed that intergranu-lar cracking and interface debonding were the main fracture mechanisms in the ultra-high-strength SiC/Al-Zn-Mg-Cu composites.Weak regions,such as the SiC/Al interface containing numerous compounds and the precipitate-free zones at the high-angle grain boundaries,were identified as significant factors limiting the strength enhancement of the composite.Interfacial compounds,including MgO,MgZn2,and Cu5Zn8,reduced the interfacial bonding strength,leading to interfacial debonding. 展开更多
关键词 metal matrix composites heat treatment interfacial reaction mechanical properties fracture mechanism
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Research of the molecular mechanism of Hai Honghua medicinal liquor in the treatment of fracture based on network pharmacology combined with molecular docking 被引量:1
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作者 Die Qian Cheng-Xun He +4 位作者 Qing Zhang Xiao-Ting Huang Jun Zhao Chi Xu Hong Zhang 《TMR Integrative Medicine》 2023年第12期1-9,共9页
Background:Hai Honghua medicinal liquor(HHML),a famous hospital formula composed of 19 traditional Chinese medicines,has been successfully applied in treating soft tissue injury,fresh closed fracture,limb dysfunction ... Background:Hai Honghua medicinal liquor(HHML),a famous hospital formula composed of 19 traditional Chinese medicines,has been successfully applied in treating soft tissue injury,fresh closed fracture,limb dysfunction after fracture healing,shoulder,neck and leg pain,knee joint pain and other clinical multiple diseases for 30 years in clinical.However,research on the material basis of HHML for the treatment of fracture healing-related disorders is still in a gap.Therefore,it is particularly important to explore the active ingredients,core targets and potential pharmacological mechanisms of HHML to promote fracture healing.Methods:We screened the core active components of each traditional Chinese medicine in formula and its action targets through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and Encyclopedia of Traditional Chinese Medicine database.The fracture related targets were retrieved from several different public databases,including GeneCards,Online Mendelian Inheritance in Man,DisGeNET and Therapeutic Target Database.Bioinformatics analysis to obtain key bioactive components,underlying targets and signaling pathways,containing the Venn diagram of the intersection with components and diseases gene targets,protein–protein interaction,as well as the Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes analysis,and finally molecular docking.Results:A total of 249 bioactive ingredients of HHML and 325 HHML-fracture-related targets were screened.The network analysis revealed that quercetin,luteolin,kaempferol,Licochalcone A,naringenin and 8-Isopentenyl-kaempferol may be potential candidate agents.Multiple targets are involved including TP53,MAPK3,STAT3,AKT1,MAPK1,HSP90AA1,ESR1 and PIK3CA may be closely linked targets.PI3K-AKT signaling pathway may play a significant role of HHML in treatment of fracture.What’s more,molecular docking suggested that 8-isopentenyl kaempferol,glycyrrhiza chalcone A,and naringenin bound to AKT1,PIK3CA,and ESR1,respectively,exhibiting lower energy and more stable characteristics.Conclusions:The findings indicate the potential active ingredients,target proteins and molecular mechanisms of HHML for the treatment of fractures to provide the exact idea for the next research on the mechanism of action of HHML formula for fracture treatment. 展开更多
关键词 Hai Honghua medicinal liquor fracture healing network pharmacology molecular docking PI3K/AKT signal pathway
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Shared genetic architecture highlights the bidirectional association between major depressive disorder and fracture risk 被引量:1
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作者 Pianpian Zhao Zhimin Ying +10 位作者 Chengda Yuan Haisheng Zhang Ao Dong Jianguo Tao Xiangjiao Yi Mengyuan Yang Wen Jin Weiliang Tian David Karasik Geng Tian Houfeng Zheng 《General Psychiatry》 CSCD 2024年第3期352-363,共12页
Background There is limited evidence suggesting that osteoporosis might exacerbate depressive symptoms,while more studies demonstrate that depression negatively affects bone density and increases fracture risk.Aims To... Background There is limited evidence suggesting that osteoporosis might exacerbate depressive symptoms,while more studies demonstrate that depression negatively affects bone density and increases fracture risk.Aims To explore the relationship between major depressive disorder(MDD)and fracture risk.Methods We conducted a nested case-control analysis(32670 patients with fracture and 397017 individuals without fracture)and a matched cohort analysis(16496 patients with MDD and 435492 individuals without MDD)in the same prospective UK Biobank data set.Further,we investigated the shared genetic architecture between MDD and fracture with linkage disequilibrium score regression and the MiXeR statistical tools.We used the conditional/conjunctional false discovery rate approach to identify the specific shared loci.We calculated the weighted genetic risk score for individuals in the UK Biobank and logistic regression was used to confirm the association observed in the prospective study.Results We found that MDD was associated with a 14%increase in fracture risk(hazard ratio(HR)1.14,95%CI 1.14 to 1.15,p<0.001)in the nested case-control analysis,while fracture was associated with a 72%increase in MDD risk(HR 1.72,95%CI 1.64 to 1.79,p<0.001)in the matched cohort analysis,suggesting a longitudinal and bidirectional relationship.Further,genetic summary data suggested a genetic overlap between MDD and fracture.Specifically,we identified four shared genomic loci,with the top signal(rs7554101)near SGIP1.The protein encoded by SGIP1 is involved in cannabinoid receptor type 1 signalling.We found that genetically predicted MDD was associated with a higher risk of fracture and vice versa.In addition,we found that the higher expression level of SGIP1 in the spinal cord and muscle was associated with an increased risk of fracture and MDD.Conclusions The genetic pleiotropy between MDD and fracture highlights the bidirectional association observed in the epidemiological analysis.The shared genetic components(such as SGIP1)between the diseases suggest that modulating the endocannabinoid system could be a potential therapeutic strategy for both MDD and bone loss. 展开更多
关键词 fracture matched OSTEOPOROSIS
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Management and classification of the fracture of lateral process of talus:An overview and literature update 被引量:1
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作者 Chao-Qun Wang Ulrich Stockle +2 位作者 Sheng-Nan Dong Xu-Gui Li Ze-Xi Ling 《World Journal of Clinical Cases》 SCIE 2024年第15期2487-2498,共12页
Fracture of the lateral process of the talus(FLPT)is uncommon in clinical practice and can be easily missed or misdiagnosed.In recent years,as researchers from all over the world have further deepened their research o... Fracture of the lateral process of the talus(FLPT)is uncommon in clinical practice and can be easily missed or misdiagnosed.In recent years,as researchers from all over the world have further deepened their research on FLPT,there has been a breakthrough in the classification,and the methods and principles of clinical management have changed accordingly;however,there is still no standardized guideline for the diagnosis and management of FLPT,and there have been few relevant literature review articles related to this kind of fracture in the past at least 5 years.In this article,we review the clinical classification,classification-based therapeutic recommendations,and prognosis of FLPT,with the aim of providing a reference for the clinical diagnosis and management of this infrequent fracture. 展开更多
关键词 fracture of the lateral process of the talus fracture of the talus Hindfoot injuries Intraarticular fracture Subtalar joint
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Creep constitutive model considering nonlinear creep degradation of fractured rock 被引量:1
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作者 Wang Chunping Liu Jianfeng +3 位作者 Chen Liang Liu Jian Wang Lu Liao Yilin 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第1期105-116,共12页
Stability analysis of underground constructions requires a model study of rock masses’ long-term performance. Creep tests under different stress conditions was conducted on intact granite and granite samples fracture... Stability analysis of underground constructions requires a model study of rock masses’ long-term performance. Creep tests under different stress conditions was conducted on intact granite and granite samples fractured at 30° and 45° angles. The experimental results indicate that the steady creep strain rates of intact and fractured rock present an exponential increase trend with the increase of stress level. A nonlinear creep model is developed based on the experimental results, in which the initial damage caused by fracture together with the damage caused by constant load have been taken into consideration. The fitting analysis results indicated that the model proposed is more accurate at identifying the full creep regions in fractured granite, especially the accelerated stage of creep deformation. The least-square fit error of the proposed creep model is significantly lower than that of Nishihara model by almost an order of magnitude. An analysis of the effects of elastic modulus, viscosity coefficient, and damage factors on fractured rock strain rate and creep strain is conducted. If no consideration is given to the effects of the damage, the proposed nonlinear creep model can degenerate into to the classical Nishihara model. 展开更多
关键词 fractured rock DAMAGE CREEP Beishan granite Geological disposal
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Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics 被引量:2
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作者 Qian-Yun Guo Jia-Qi Yang +1 位作者 Xun-Xun Feng Yu-Jie Zhou 《Military Medical Research》 SCIE CAS CSCD 2024年第1期80-97,共18页
Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public hea... Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury. 展开更多
关键词 Heart regeneration Cardiac disease THERAPEUTICS Signaling mechanisms
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The underlying mechanism of variety–water–nitrogen–stubble damage interactions on yield formation in ratoon rice with low stubble height under mechanized harvesting 被引量:2
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作者 Jingnan Zou Ziqin Pang +11 位作者 Zhou Li Chunlin Guo Hongmei Lin Zheng Li Hongfei Chen Jinwen Huang Ting Chen Hailong Xu Bin Qin Puleng Letuma Weiwei Lin Wenxiong Lin 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第3期806-823,共18页
Agronomic measures are the key to promote the sustainable development of ratoon rice by reducing the damage from mechanical crushing to the residual stubble of the main crop, thereby mitigating the impact on axillary ... Agronomic measures are the key to promote the sustainable development of ratoon rice by reducing the damage from mechanical crushing to the residual stubble of the main crop, thereby mitigating the impact on axillary bud sprouting and yield formation in ratoon rice. This study used widely recommended conventional rice Jiafuzhan and hybrid rice Yongyou 2640 as the test materials to conduct a four-factor block design field experiment in a greenhouse of the experimental farm of Fujian Agricultural and Forestry University, China from 2018 to 2019.The treatments included fertilization and no fertilization, alternate wetting and drying irrigation and continuous water flooding irrigation, and plots with and without artificial crushing damage on the rice stubble. At the same time, a 13C stable isotope in-situ detection technology was used to fertilize the pot experiment. The results showed significant interactions among varieties, water management, nitrogen application and stubble status.Relative to the long-term water flooding treatment, the treatment with sequential application of nitrogen fertilizer coupled with moderate field drought for root-vigor and tiller promotion before and after harvesting of the main crop, significantly improved the effective tillers from low position nodes. This in turn increased the effective panicles per plant and grains per panicle by reducing the influence of artificial crushing damage on rice stubble and achieving a high yield of the regenerated rice. Furthermore, the partitioning of 13C assimilates to the residual stubble and its axillary buds were significantly improved at the mature stage of the main crop, while the translocation rate to roots and rhizosphere soil was reduced at the later growth stage of ratooning season rice. This was triggered by the metabolism of hormones and polyamines at the stem base regulated by the interaction of water and fertilizer at this time. We therefore suggest that to achieve a high yield of ratoon rice with low stubble height under mechanized harvesting, the timely application of nitrogen fertilizer is fundamental,coupled with moderate field drying for root-vigor preservation and tiller promotion before and after the mechanical harvesting of the main crop. 展开更多
关键词 mechanized harvesting ratoon rice rice stubble yield attributes
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Complication rates after direct anterior vs posterior approach for hip hemiarthroplasty in elderly individuals with femoral neck fractures 被引量:2
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作者 Tatiana Charles Nicolas Bloemers +1 位作者 Bilal Kapanci Marc Jayankura 《World Journal of Orthopedics》 2024年第1期22-29,共8页
BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with ... BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with no consensus regarding the superiority of any single approach.AIM To compare early postoperative complications after implementing the direct anterior and posterior approaches(PL)for hip hemiarthroplasty after femoral neck fractures.METHODS This is a comparative,retrospective,single-center cohort study conducted at a university hospital.Between March 2008 and December 2018,273 patients(a total of 280 hips)underwent bipolar hemiarthroplasties(n=280)for displaced femoral neck fractures using either the PL(n=171)or the minimally invasive direct anterior approach(DAA)(n=109).The choice of approach was related to the surgeons’practices;the implant types were similar and unrelated to the approach.Dislocation rates and other complications were reviewed after a minimum followup of 6 mo.RESULTS Both treatment groups had similarly aged patients(mean age:82 years),sex ratios,patient body mass indexes,and patient comorbidities.Surgical data(surgery delay time,operative time,and blood loss volume)did not differ significantly between the groups.The 30 d mortality rate was higher in the PL group(9.9%)than in the DAA group(3.7%),but the difference was not statistically significant(P=0.052).Among the one-month survivors,a significantly higher rate of dislocation was observed in the PL group(14/154;9.1%)than in the DAA group(0/105;0%)(P=0.002).Of the 14 patients with dislocation,8 underwent revision surgery for recurrent instability(posterior group),and one of them had 2 additional procedures due to a deep infection.The rate of other complications(e.g.,perioperative and early postoperative periprosthetic fractures and infection-related complications)did not differ significantly between the groups.CONCLUSION These findings suggest that the DAA to bipolar hemiarthroplasty for patients with femoral neck fractures is associated with a lower dislocation rate(<1%)than the PL. 展开更多
关键词 HEMIARTHROPLASTY Femoral neck fracture Direct anterior approach Posterior approach DISLOCATION MORTALITY
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Evaluating the stability and volumetric flowback rate of proppant packs in hydraulic fractures using the lattice Boltzmann-discrete element coupling method 被引量:1
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作者 Duo Wang Sanbai Li +2 位作者 Rui Wang Binhui Li Zhejun Pan 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第6期2052-2063,共12页
The stability and mobility of proppant packs in hydraulic fractures during hydrocarbon production are numerically investigated by the lattice Boltzmann-discrete element coupling method(LB-DEM).This study starts with a... The stability and mobility of proppant packs in hydraulic fractures during hydrocarbon production are numerically investigated by the lattice Boltzmann-discrete element coupling method(LB-DEM).This study starts with a preliminary proppant settling test,from which a solid volume fraction of 0.575 is calibrated for the proppant pack in the fracture.In the established workflow to investigate proppant flowback,a displacement is applied to the fracture surfaces to compact the generated proppant pack as well as further mimicking proppant embedment under closure stress.When a pressure gradient is applied to drive the fluid-particle flow,a critical aperture-to-diameter ratio of 4 is observed,above which the proppant pack would collapse.The results also show that the volumetric proppant flowback rate increases quadratically with the fracture aperture,while a linear variation between the particle flux and the pressure gradient is exhibited for a fixed fracture aperture.The research outcome contributes towards an improved understanding of proppant flowback in hydraulic fractures,which also supports an optimised proppant size selection for hydraulic fracturing operations. 展开更多
关键词 Numerical simulation Hydraulic fracturing Proppant flowback Closure stress Particulate flow
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Effect of fracture fluid flowback on shale microfractures using CT scanning 被引量:1
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作者 Jiale He Zhihong Zhao +6 位作者 Yiran Geng Yuping Chen Jianchun Guo Cong Lu Shouyi Wang Xueliang Han Jun Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第2期426-436,共11页
The field data of shale fracturing demonstrate that the flowback performance of fracturing fluid is different from that of conventional reservoirs,where the flowback rate of shale fracturing fluid is lower than that o... The field data of shale fracturing demonstrate that the flowback performance of fracturing fluid is different from that of conventional reservoirs,where the flowback rate of shale fracturing fluid is lower than that of conventional reservoirs.At the early stage of flowback,there is no single-phase flow of the liquid phase in shale,but rather a gas-water two-phase flow,such that the single-phase flow model for tight oil and gas reservoirs is not applicable.In this study,pores and microfractures are extracted based on the experimental results of computed tomography(CT)scanning,and a spatial model of microfractures is established.Then,the influence of rough microfracture surfaces on the flow is corrected using the modified cubic law,which was modified by introducing the average deviation of the microfracture height as a roughness factor to consider the influence of microfracture surface roughness.The flow in the fracture network is simulated using the modified cubic law and the lattice Boltzmann method(LBM).The results obtained demonstrate that most of the fracturing fluid is retained in the shale microfractures,which explains the low fracturing fluid flowback rate in shale hydraulic fracturing. 展开更多
关键词 SHALE Flowback of fracturing fluid MICROfracture Lattice Boltzmann method(LBM)
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