Based on the reconstructed MODIS data and ECMWF reanalysis data from 2003 to 2021,spatial correlations between chlorophyll a(Chl a)and sea surface temperature(SST),photosynthetically available radiation(PAR),aerosol o...Based on the reconstructed MODIS data and ECMWF reanalysis data from 2003 to 2021,spatial correlations between chlorophyll a(Chl a)and sea surface temperature(SST),photosynthetically available radiation(PAR),aerosol optical thickness(AOT),and wind speed(WS)in the Bohai Sea were analyzed from the perspective of time domain and frequency domain.Results indicate that the frequency domain analysis was more conducive to revealing the correlations between Chl a and environmental factors.The spatial pattern of time-domain correlations was similar to the isobaths of the Bohai Sea,which was positive in shallow waters and negative in deep waters for SST,PAR,and AOT,and was reversed for WS.Frequency-domain correlations were obtained by performing Fourier Transform and were higher than correlations in time domain.The spatial distributions indicated that the effects of SST and PAR on Chl a were greater than AOT and WS in the Bohai Sea.Additionally,cross-spectrum analysis was applied to explore the response relationships.A depth-dependent pattern was shown in correlations and time lags,indicating that the influential mechanism of environmental factors on Chl-a concentration is related to seawater depth.展开更多
Channel equalization plays a pivotal role within the reconstruction phase of passive radar reference signals.In the context of reconstructing digital terrestrial multimedia broadcasting(DTMB)signals for low-slow-small...Channel equalization plays a pivotal role within the reconstruction phase of passive radar reference signals.In the context of reconstructing digital terrestrial multimedia broadcasting(DTMB)signals for low-slow-small(LSS)target detection,a novel frequency domain block joint equalization algorithm is presented in this article.From the DTMB signal frame structure and channel multipath transmission characteristics,this article adopts a unconventional approach where the delay and frame structure of each DTMB signal frame are reconfigured to create a circular convolution block,facilitating concurrent fast Fourier transform(FFT)calculations.Following equalization,an inverse fast Fourier transform(IFFT)-based joint output and subsequent data reordering are executed to finalize the equalization process for the DTMB signal.Simulation and measured data confirm that this algorithm outperforms conventional techniques by reducing signal errors rate and enhancing real-time processing.In passive radar LSS detection,it effectively suppresses multipath and noise through frequency domain equalization,reducing false alarms and improving the capabilities of weak target detection.展开更多
Seismic inversion can be divided into time-domain inversion and frequency-domain inversion based on different transform domains.Time-domain inversion has stronger stability and noise resistance compared to frequencydo...Seismic inversion can be divided into time-domain inversion and frequency-domain inversion based on different transform domains.Time-domain inversion has stronger stability and noise resistance compared to frequencydomain inversion.Frequency domain inversion has stronger ability to identify small-scale bodies and higher inversion resolution.Therefore,the research on the joint inversion method in the time-frequency domain is of great significance for improving the inversion resolution,stability,and noise resistance.The introduction of prior information constraints can effectively reduce ambiguity in the inversion process.However,the existing modeldriven time-frequency joint inversion assumes a specific prior distribution of the reservoir.These methods do not consider the original features of the data and are difficult to describe the relationship between time-domain features and frequency-domain features.Therefore,this paper proposes a high-resolution seismic inversion method based on joint data-driven in the time-frequency domain.The method is based on the impedance and reflectivity samples from logging,using joint dictionary learning to obtain adaptive feature information of the reservoir,and using sparse coefficients to capture the intrinsic relationship between impedance and reflectivity.The optimization result of the inversion is achieved through the regularization term of the joint dictionary sparse representation.We have finally achieved an inversion method that combines constraints on time-domain features and frequency features.By testing the model data and field data,the method has higher resolution in the inversion results and good noise resistance.展开更多
The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults.Whether targeting this pathway is beneficial to b...The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults.Whether targeting this pathway is beneficial to brain injury remains unclear.In this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral deficits.Pharmacological inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology domain.Mechanistically,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin pathway.These findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.展开更多
The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the bloo...The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly understood.The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier function.It plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain barrier.Furthermore,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain barrier.This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier permeability.This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to date.This will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic monitoring.In addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier leakage in various diseases and the research progress on cross-blood-brain barrier drug delivery are summarized.This review may contribute to the development of new approaches for the treatment of neurological diseases.展开更多
Although full waveform inversion in the frequency domain can overcome the local minima problem in the time direction, such problem still exists in the space direction because of the media subsurface complexity. Based ...Although full waveform inversion in the frequency domain can overcome the local minima problem in the time direction, such problem still exists in the space direction because of the media subsurface complexity. Based on the optimal steep descent methods, we present an algorithm which combines the preconditioned bi-conjugated gradient stable method and the multi-grid method to compute the wave propagation and the gradient space. The multiple scale prosperity of the waveform inversion and the multi-grid method can overcome the inverse problems local minima defect and accelerate convergence. The local inhomogeneous three-hole model simulated results and the Marmousi model certify the algorithm effectiveness.展开更多
Air-gun arrays are used in marine-seismic exploration. Far-field wavelets in subsurface media represent the stacking of single air-gun ideal wavelets. We derived single air-gun ideal wavelets using near-field wavelets...Air-gun arrays are used in marine-seismic exploration. Far-field wavelets in subsurface media represent the stacking of single air-gun ideal wavelets. We derived single air-gun ideal wavelets using near-field wavelets recorded from near-field geophones and then synthesized them into far-field wavelets. This is critical for processing wavelets in marine- seismic exploration. For this purpose, several algorithms are currently used to decompose and synthesize wavelets in the time domain. If the traveltime of single air-gun wavelets is not an integral multiple of the sampling interval, the complex and error-prone resampling of the seismic signals using the time-domain method is necessary. Based on the relation between the frequency-domain phase and the time-domain time delay, we propose a method that first transforms the real near-field wavelet to the frequency domain via Fourier transforms; then, it decomposes it and composes the wavelet spectrum in the frequency domain, and then back transforms it to the time domain. Thus, the resampling problem is avoided and single air-gun wavelets and far-field wavelets can be reliably derived. The effect of ghost reflections is also considered, while decomposing the wavelet and removing the ghost reflections. Modeling and real data processing were used to demonstrate the feasibility of the proposed method.展开更多
The boundary identification and quantitative thickness prediction of channel sand bodies are always difficult in seismic exploration.We present a new method for boundary identification and quantitative thickness predi...The boundary identification and quantitative thickness prediction of channel sand bodies are always difficult in seismic exploration.We present a new method for boundary identification and quantitative thickness prediction of channel sand bodies based on seismic peak attributes in the frequency domain.Using seismic forward modeling of a typical thin channel sand body,a new seismic attribute-the ratio of peak frequency to amplitude was constructed.Theoretical study demonstrated that seismic peak frequency is sensitive to the thickness of the channel sand bodies,while the amplitude attribute is sensitive to the strata lithology.The ratio of the two attributes can highlight the boundaries of the channel sand body.Moreover,the thickness of the thin channel sand bodies can be determined using the relationship between seismic peak frequency and thin layer thickness.Practical applications have demonstrated that the seismic peak frequency attribute can depict the horizontal distribution characteristics of channels very well.The ratio of peak frequency to amplitude attribute can improve the identification ability of channel sand body boundaries.Quantitative prediction and boundary identification of channel sand bodies with seismic peak attributes in the frequency domain are feasible.展开更多
This paper deals with the problem of H∞ fault estimation for linear time-delay systems in finite frequency domain.First a generalized coordinate change is applied to the original system such that in the new coordinat...This paper deals with the problem of H∞ fault estimation for linear time-delay systems in finite frequency domain.First a generalized coordinate change is applied to the original system such that in the new coordinates all the time-delay terms are injected by the system's input and output.Then an observer-based H∞ fault estimator with input and output injections is proposed for fault estimation with known frequency range.With the aid of Generalized Kalman-Yakubovich-Popov lemma,sufficient conditions on the existence of the H∞ fault estimator are derived and a solution to the observer gain matrices is obtained by solving a set of linear matrix inequalities.Finally,a numerical example is given to illustrate the effectiveness of the proposed method.展开更多
This paper is to explore further results for total measurable fault information-based residual(ToMFIR) approach to fault detection in dynamic systems.The ToMFIR contains the essential fault information and remains u...This paper is to explore further results for total measurable fault information-based residual(ToMFIR) approach to fault detection in dynamic systems.The ToMFIR contains the essential fault information and remains unaffected by control actions in a closed-loop system.It is composed of controller residual and output residual and some of further results are developed in frequency domain.Besides the ability of detecting actuator and sensor faults,it is able to detect faults/failures resulting from the computer used for control purpose that generates control signals.Currently,all of existing fault detection schemes cannot achieve the same task at all.A practical DC motor example,with a PID controller,is used to demonstrate the effectiveness of the ToMFIR-based fault detection.A comparison with the standard observer-based technique is also provided.展开更多
In order to assess gastric motility, a new noninvasive method was addressed. Firstly, bio-impedance and stomach electric signals were recorded from the healthy control group and the pathologic stomach group. Wavelet t...In order to assess gastric motility, a new noninvasive method was addressed. Firstly, bio-impedance and stomach electric signals were recorded from the healthy control group and the pathologic stomach group. Wavelet transform was used to remove the influence of the heart activity signals. By analyzing and processing the two signals of the time domain and frequency domain, we get the corresponding parameters of the two groups. According to all the parameters, several verification tests have been carried out, from the result of the statistics, we can find that in both time and frequency domains, impedance signal and synchronize EGG (electrogastrogram) have some similar features. However synchronize EGG cannot be totally instead by gastric motility, especially in morbid state, EGG is not correspondence to impedance signal. The gastric contraction or gastric emptying is a complex procedure including electrical and mechanical activity. Electrical impedance (EIP) and the synchronous EGG should be analyzed together. In conclusion, the parameters have the value to evaluate gastric motility.展开更多
For many years a soil water content sensor with low cost, reliability and sufficient accuracy has been desirable. Thus, an improved measurement method based on the frequency domain (FD) principle for determining soil ...For many years a soil water content sensor with low cost, reliability and sufficient accuracy has been desirable. Thus, an improved measurement method based on the frequency domain (FD) principle for determining soil water content was considered. Unlike other measurement principles, a new measurable index, η, which was independent of the output impedance and the amplitude of the oscillator while relying on the electrical impedance of a multi-pin probe, was pro- posed. Moreover, a model for processing the impedance of the multi-pin soil probe was developed, and several important electrical parameters for establishing their operating ranges applicable to this probe were evaluated. In order to confirm the theoretical analysis, an experiment was conducted with a 4-pin probe. Using the developed model, the relationship between the proposed index η and soil volumetric water content was shown to be linear (R2 = 0.9921). Thus, as the measurable index, η seemed satisfactory.展开更多
Due to the strong electromagnetic interferences and human interference,traditional electromagnetic methods cannot obtain high quality resistivity data of mineral deposits in Chinese mines.The wide field electromagneti...Due to the strong electromagnetic interferences and human interference,traditional electromagnetic methods cannot obtain high quality resistivity data of mineral deposits in Chinese mines.The wide field electromagnetic method(WFEM),in which the pseudo-random signal is taken as the transmitter source,can extract high quality resistivity data in areas with sever interference by only measuring the electric field component.We use the WFEM to extract the resistivity information of the Dongguashan mine in southeast China.Compared with the audio magnetotelluric(AMT)method,and the controlled source audio-frequency magnetotelluric(CSAMT) method,the WFEM can obtain data with higher quality and simpler operations.The inversion results indicate that the WFEM can accurately identify the location of the main ore-body,which can be used for deep mine exploration in areas with strong interference.展开更多
This paper proposes a novel sampled-data asynchronous fuzzy output feedback control approach for active suspension systems in restricted frequency domain.In order to better investigate uncertain suspension dynamics,th...This paper proposes a novel sampled-data asynchronous fuzzy output feedback control approach for active suspension systems in restricted frequency domain.In order to better investigate uncertain suspension dynamics,the sampleddata Takagi-Sugeno(T-S)fuzzy half-car active suspension(HCAS)system is considered,which is further modelled as a continuous system with an input delay.Firstly,considering that the fuzzy system and the fuzzy controller cannot share the identical premises due to the existence of input delay,a reconstructed method is employed to synchronize the time scales of membership functions between the fuzzy controller and the fuzzy system.Secondly,since external disturbances often belong to a restricted frequency range,a finite frequency control criterion is presented for control synthesis to reduce conservatism.Thirdly,given a full information of state variables is hardly available in practical suspension systems,a two-stage method is proposed to calculate the static output feedback control gains.Moreover,an iterative algorithm is proposed to compute the optimum solution.Finally,numerical simulations verify the effectiveness of the proposed controllers.展开更多
In this paper, we propose a hybrid PML (H-PML) combining the normal absorption factor of convolutional PML (C-PML) with tangential absorption factor of Mutiaxial PML (M-PML). The H-PML boundary conditions can be...In this paper, we propose a hybrid PML (H-PML) combining the normal absorption factor of convolutional PML (C-PML) with tangential absorption factor of Mutiaxial PML (M-PML). The H-PML boundary conditions can better suppress the numerical instability in some extreme models, and the computational speed of finite-element method and the dynamic range are greatly increased using this HPML. We use the finite-element method with a hybrid PML to model the acoustic reflection of the interface when wireline and well logging while drilling (LWD), in a formation with a reflector outside the borehole. The simulation results suggests that the PS- and SP- reflected waves arrive at the same time when the inclination between the well and the outer interface is zero, and the difference in arrival times increases with increasing dip angle. When there are fractures outside the well, the reflection signal is clearer in the subsequent reflection waves and may be used to identify the fractured zone. The difference between the dominant wavelength and the model scale shows that LWD reflection logging data are of higher resolution and quality than wireline acoustic reflection logging.展开更多
Amplitude variations with offset or incident angle (AVO/AVA) inversion are typically combined with statistical methods, such as Bayesian inference or deterministic inversion. We propose a joint elastic inversion met...Amplitude variations with offset or incident angle (AVO/AVA) inversion are typically combined with statistical methods, such as Bayesian inference or deterministic inversion. We propose a joint elastic inversion method in the time and frequency domain based on Bayesian inversion theory to improve the resolution of the estimated P- and S-wave velocities and density. We initially construct the objective function using Bayesian inference by combining seismic data in the time and frequency domain. We use Cauchy and Gaussian probability distribution density functions to obtain the prior information for the model parameters and the likelihood function, respectively. We estimate the elastic parameters by solving the initial objective function with added model constraints to improve the inversion robustness. The results of the synthetic data suggest that the frequency spectra of the estimated parameters are wider than those obtained with conventional elastic inversion in the time domain. In addition, the proposed inversion approach offers stronger antinoising compared to the inversion approach in the frequency domain. Furthermore, results from synthetic examples with added Gaussian noise demonstrate the robustness of the proposed approach. From the real data, we infer that more model parameter details can be reproduced with the proposed joint elastic inversion.展开更多
A frequency and spatial domain decomposition method (FSDD) for operational modal analysis (OMA) is presented in this paper, which is an extension of the complex mode indicator function (CMIF) method for experime...A frequency and spatial domain decomposition method (FSDD) for operational modal analysis (OMA) is presented in this paper, which is an extension of the complex mode indicator function (CMIF) method for experimental modal analysis (EMA). The theoretical background of the FSDD method is clarified, Singular value decomposition is adopted to separate the signal space from the noise space. Finally, an enhanced power spectrum density (PSD) is proposed to obtain more accurate modal parameters by curve fitting in the frequency domain. Moreover, a simulation case and an application case are used to validate this method.展开更多
The traditional compressed sensing method for improving resolution is realized in the frequency domain.This method is aff ected by noise,which limits the signal-to-noise ratio and resolution,resulting in poor inversio...The traditional compressed sensing method for improving resolution is realized in the frequency domain.This method is aff ected by noise,which limits the signal-to-noise ratio and resolution,resulting in poor inversion.To solve this problem,we improved the objective function that extends the frequency domain to the Gaussian frequency domain having denoising and smoothing characteristics.Moreover,the reconstruction of the sparse refl ection coeffi cient is implemented by the mixed L1_L2 norm algorithm,which converts the L0 norm problem into an L1 norm problem.Additionally,a fast threshold iterative algorithm is introduced to speed up convergence and the conjugate gradient algorithm is used to achieve debiasing for eliminating the threshold constraint and amplitude error.The model test indicates that the proposed method is superior to the conventional OMP and BPDN methods.It not only has better denoising and smoothing eff ects but also improves the recognition accuracy of thin interbeds.The actual data application also shows that the new method can eff ectively expand the seismic frequency band and improve seismic data resolution,so the method is conducive to the identifi cation of thin interbeds for beach-bar sand reservoirs.展开更多
On the basis of ice- induced forced vibration model, ice- induced displacement responses of offshore fixed platforms are investigated in both time domain and frequency domain. The relationships of ice-induced displace...On the basis of ice- induced forced vibration model, ice- induced displacement responses of offshore fixed platforms are investigated in both time domain and frequency domain. The relationships of ice-induced displacement responses with ice breaking modes, ice acting directions and platform structures are analyzed and determined. The results lead to an important conclusion obtained for the first time that ice breaking frequency and the natural frequency of the first mode of the platform are the two main factors that dominate the degree of vibration. The present work provides a firm basis for both design and operation of fixed platforms against ice loading.展开更多
基金Supported by the Key Research and Development Program of 14 th Five year Plan of China(No.2021YFC3200401-04)the Major Scientific and Technological Projects of Tianjin(No.18 ZXRHSF00270)。
文摘Based on the reconstructed MODIS data and ECMWF reanalysis data from 2003 to 2021,spatial correlations between chlorophyll a(Chl a)and sea surface temperature(SST),photosynthetically available radiation(PAR),aerosol optical thickness(AOT),and wind speed(WS)in the Bohai Sea were analyzed from the perspective of time domain and frequency domain.Results indicate that the frequency domain analysis was more conducive to revealing the correlations between Chl a and environmental factors.The spatial pattern of time-domain correlations was similar to the isobaths of the Bohai Sea,which was positive in shallow waters and negative in deep waters for SST,PAR,and AOT,and was reversed for WS.Frequency-domain correlations were obtained by performing Fourier Transform and were higher than correlations in time domain.The spatial distributions indicated that the effects of SST and PAR on Chl a were greater than AOT and WS in the Bohai Sea.Additionally,cross-spectrum analysis was applied to explore the response relationships.A depth-dependent pattern was shown in correlations and time lags,indicating that the influential mechanism of environmental factors on Chl-a concentration is related to seawater depth.
文摘Channel equalization plays a pivotal role within the reconstruction phase of passive radar reference signals.In the context of reconstructing digital terrestrial multimedia broadcasting(DTMB)signals for low-slow-small(LSS)target detection,a novel frequency domain block joint equalization algorithm is presented in this article.From the DTMB signal frame structure and channel multipath transmission characteristics,this article adopts a unconventional approach where the delay and frame structure of each DTMB signal frame are reconfigured to create a circular convolution block,facilitating concurrent fast Fourier transform(FFT)calculations.Following equalization,an inverse fast Fourier transform(IFFT)-based joint output and subsequent data reordering are executed to finalize the equalization process for the DTMB signal.Simulation and measured data confirm that this algorithm outperforms conventional techniques by reducing signal errors rate and enhancing real-time processing.In passive radar LSS detection,it effectively suppresses multipath and noise through frequency domain equalization,reducing false alarms and improving the capabilities of weak target detection.
文摘Seismic inversion can be divided into time-domain inversion and frequency-domain inversion based on different transform domains.Time-domain inversion has stronger stability and noise resistance compared to frequencydomain inversion.Frequency domain inversion has stronger ability to identify small-scale bodies and higher inversion resolution.Therefore,the research on the joint inversion method in the time-frequency domain is of great significance for improving the inversion resolution,stability,and noise resistance.The introduction of prior information constraints can effectively reduce ambiguity in the inversion process.However,the existing modeldriven time-frequency joint inversion assumes a specific prior distribution of the reservoir.These methods do not consider the original features of the data and are difficult to describe the relationship between time-domain features and frequency-domain features.Therefore,this paper proposes a high-resolution seismic inversion method based on joint data-driven in the time-frequency domain.The method is based on the impedance and reflectivity samples from logging,using joint dictionary learning to obtain adaptive feature information of the reservoir,and using sparse coefficients to capture the intrinsic relationship between impedance and reflectivity.The optimization result of the inversion is achieved through the regularization term of the joint dictionary sparse representation.We have finally achieved an inversion method that combines constraints on time-domain features and frequency features.By testing the model data and field data,the method has higher resolution in the inversion results and good noise resistance.
基金supported by the TARCC,Welch Foundation Award(I-1724)the Decherd Foundationthe Pape Adams Foundation,NIH grants NS092616,NS127375,NS117065,NS111776。
文摘The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults.Whether targeting this pathway is beneficial to brain injury remains unclear.In this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral deficits.Pharmacological inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology domain.Mechanistically,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin pathway.These findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.
基金supported by the National Natural Science Foundation of China,No.82104412(to TD)Shaanxi Provincial Key R&D Program,No.2023-YBSF-165(to TD)+1 种基金the Natural Science Foundation of Shaanxi Department of Science and Technology,No.2018JM7022(to FM)Shaanxi Provincial Key Industry Chain Project,No.2021ZDLSF04-11(to PW)。
文摘The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly understood.The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier function.It plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain barrier.Furthermore,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain barrier.This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier permeability.This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to date.This will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic monitoring.In addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier leakage in various diseases and the research progress on cross-blood-brain barrier drug delivery are summarized.This review may contribute to the development of new approaches for the treatment of neurological diseases.
基金supported by the China State Key Science and Technology Project on Marine Carbonate Reservoir Characterization (No. 2011ZX05004-003)the Basic Research Programs of CNPC during the 12th Five-Year Plan Period (NO.2011A-3603)+1 种基金the Natural Science Foundation of China (No.41104066)the RIPED Young Professional Innovation Fund (NO.2010-13-16-02, 2010-A-26-02)
文摘Although full waveform inversion in the frequency domain can overcome the local minima problem in the time direction, such problem still exists in the space direction because of the media subsurface complexity. Based on the optimal steep descent methods, we present an algorithm which combines the preconditioned bi-conjugated gradient stable method and the multi-grid method to compute the wave propagation and the gradient space. The multiple scale prosperity of the waveform inversion and the multi-grid method can overcome the inverse problems local minima defect and accelerate convergence. The local inhomogeneous three-hole model simulated results and the Marmousi model certify the algorithm effectiveness.
基金supported by the Geosciences and Technology Academy of China University of Petroleum(East China)
文摘Air-gun arrays are used in marine-seismic exploration. Far-field wavelets in subsurface media represent the stacking of single air-gun ideal wavelets. We derived single air-gun ideal wavelets using near-field wavelets recorded from near-field geophones and then synthesized them into far-field wavelets. This is critical for processing wavelets in marine- seismic exploration. For this purpose, several algorithms are currently used to decompose and synthesize wavelets in the time domain. If the traveltime of single air-gun wavelets is not an integral multiple of the sampling interval, the complex and error-prone resampling of the seismic signals using the time-domain method is necessary. Based on the relation between the frequency-domain phase and the time-domain time delay, we propose a method that first transforms the real near-field wavelet to the frequency domain via Fourier transforms; then, it decomposes it and composes the wavelet spectrum in the frequency domain, and then back transforms it to the time domain. Thus, the resampling problem is avoided and single air-gun wavelets and far-field wavelets can be reliably derived. The effect of ghost reflections is also considered, while decomposing the wavelet and removing the ghost reflections. Modeling and real data processing were used to demonstrate the feasibility of the proposed method.
基金supported by National Key Science and Technology Special Projects (Grant No.2008ZX05000-004)CNPC Key S and T Special Projects (Grant No.2008E-0610-10)
文摘The boundary identification and quantitative thickness prediction of channel sand bodies are always difficult in seismic exploration.We present a new method for boundary identification and quantitative thickness prediction of channel sand bodies based on seismic peak attributes in the frequency domain.Using seismic forward modeling of a typical thin channel sand body,a new seismic attribute-the ratio of peak frequency to amplitude was constructed.Theoretical study demonstrated that seismic peak frequency is sensitive to the thickness of the channel sand bodies,while the amplitude attribute is sensitive to the strata lithology.The ratio of the two attributes can highlight the boundaries of the channel sand body.Moreover,the thickness of the thin channel sand bodies can be determined using the relationship between seismic peak frequency and thin layer thickness.Practical applications have demonstrated that the seismic peak frequency attribute can depict the horizontal distribution characteristics of channels very well.The ratio of peak frequency to amplitude attribute can improve the identification ability of channel sand body boundaries.Quantitative prediction and boundary identification of channel sand bodies with seismic peak attributes in the frequency domain are feasible.
基金supported in part by the National Natural Science Foundation of China (60774071)the National High Technology Research and Development Program of China (863 Program) (2008AA121302)+1 种基金the Major State Basic Research Development Program of China (973 Program) (2009CB724000)the State Scholarship Fund of China
文摘This paper deals with the problem of H∞ fault estimation for linear time-delay systems in finite frequency domain.First a generalized coordinate change is applied to the original system such that in the new coordinates all the time-delay terms are injected by the system's input and output.Then an observer-based H∞ fault estimator with input and output injections is proposed for fault estimation with known frequency range.With the aid of Generalized Kalman-Yakubovich-Popov lemma,sufficient conditions on the existence of the H∞ fault estimator are derived and a solution to the observer gain matrices is obtained by solving a set of linear matrix inequalities.Finally,a numerical example is given to illustrate the effectiveness of the proposed method.
文摘This paper is to explore further results for total measurable fault information-based residual(ToMFIR) approach to fault detection in dynamic systems.The ToMFIR contains the essential fault information and remains unaffected by control actions in a closed-loop system.It is composed of controller residual and output residual and some of further results are developed in frequency domain.Besides the ability of detecting actuator and sensor faults,it is able to detect faults/failures resulting from the computer used for control purpose that generates control signals.Currently,all of existing fault detection schemes cannot achieve the same task at all.A practical DC motor example,with a PID controller,is used to demonstrate the effectiveness of the ToMFIR-based fault detection.A comparison with the standard observer-based technique is also provided.
文摘In order to assess gastric motility, a new noninvasive method was addressed. Firstly, bio-impedance and stomach electric signals were recorded from the healthy control group and the pathologic stomach group. Wavelet transform was used to remove the influence of the heart activity signals. By analyzing and processing the two signals of the time domain and frequency domain, we get the corresponding parameters of the two groups. According to all the parameters, several verification tests have been carried out, from the result of the statistics, we can find that in both time and frequency domains, impedance signal and synchronize EGG (electrogastrogram) have some similar features. However synchronize EGG cannot be totally instead by gastric motility, especially in morbid state, EGG is not correspondence to impedance signal. The gastric contraction or gastric emptying is a complex procedure including electrical and mechanical activity. Electrical impedance (EIP) and the synchronous EGG should be analyzed together. In conclusion, the parameters have the value to evaluate gastric motility.
基金Project supported by the National Natural Science Foundation of China (Nos. 30270775 and 30370823) and the DoctorResearch Foundation of the Ministry of Education of China (No. 20030019012)
文摘For many years a soil water content sensor with low cost, reliability and sufficient accuracy has been desirable. Thus, an improved measurement method based on the frequency domain (FD) principle for determining soil water content was considered. Unlike other measurement principles, a new measurable index, η, which was independent of the output impedance and the amplitude of the oscillator while relying on the electrical impedance of a multi-pin probe, was pro- posed. Moreover, a model for processing the impedance of the multi-pin soil probe was developed, and several important electrical parameters for establishing their operating ranges applicable to this probe were evaluated. In order to confirm the theoretical analysis, an experiment was conducted with a 4-pin probe. Using the developed model, the relationship between the proposed index η and soil volumetric water content was shown to be linear (R2 = 0.9921). Thus, as the measurable index, η seemed satisfactory.
基金Project(2018YFC0807802)supported by the National Key R&D Program of ChinaProject(41874081)supported by the National Natural Science Foundation of China
文摘Due to the strong electromagnetic interferences and human interference,traditional electromagnetic methods cannot obtain high quality resistivity data of mineral deposits in Chinese mines.The wide field electromagnetic method(WFEM),in which the pseudo-random signal is taken as the transmitter source,can extract high quality resistivity data in areas with sever interference by only measuring the electric field component.We use the WFEM to extract the resistivity information of the Dongguashan mine in southeast China.Compared with the audio magnetotelluric(AMT)method,and the controlled source audio-frequency magnetotelluric(CSAMT) method,the WFEM can obtain data with higher quality and simpler operations.The inversion results indicate that the WFEM can accurately identify the location of the main ore-body,which can be used for deep mine exploration in areas with strong interference.
基金supported by the National Natural Science Foundation of China(51705084)the Natural Science Foundation of Guangdong Province of China(2018A030313999,2019A1515011602)+2 种基金the Fundamental Research Funds for the Central Universities(2018MS46,N2003032)the Opening Project of Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing,South China University of Technology(2019kfkt06)the Research Grants of the University of Macao(MYRG2017-00135-FST,MYRG2019-00028-FST)。
文摘This paper proposes a novel sampled-data asynchronous fuzzy output feedback control approach for active suspension systems in restricted frequency domain.In order to better investigate uncertain suspension dynamics,the sampleddata Takagi-Sugeno(T-S)fuzzy half-car active suspension(HCAS)system is considered,which is further modelled as a continuous system with an input delay.Firstly,considering that the fuzzy system and the fuzzy controller cannot share the identical premises due to the existence of input delay,a reconstructed method is employed to synchronize the time scales of membership functions between the fuzzy controller and the fuzzy system.Secondly,since external disturbances often belong to a restricted frequency range,a finite frequency control criterion is presented for control synthesis to reduce conservatism.Thirdly,given a full information of state variables is hardly available in practical suspension systems,a two-stage method is proposed to calculate the static output feedback control gains.Moreover,an iterative algorithm is proposed to compute the optimum solution.Finally,numerical simulations verify the effectiveness of the proposed controllers.
基金supported by the National Natural Science Foundation of China(No.41204094)Science Foundation of China University of Petroleum,Beijing(No.2462015YQ0506)
文摘In this paper, we propose a hybrid PML (H-PML) combining the normal absorption factor of convolutional PML (C-PML) with tangential absorption factor of Mutiaxial PML (M-PML). The H-PML boundary conditions can better suppress the numerical instability in some extreme models, and the computational speed of finite-element method and the dynamic range are greatly increased using this HPML. We use the finite-element method with a hybrid PML to model the acoustic reflection of the interface when wireline and well logging while drilling (LWD), in a formation with a reflector outside the borehole. The simulation results suggests that the PS- and SP- reflected waves arrive at the same time when the inclination between the well and the outer interface is zero, and the difference in arrival times increases with increasing dip angle. When there are fractures outside the well, the reflection signal is clearer in the subsequent reflection waves and may be used to identify the fractured zone. The difference between the dominant wavelength and the model scale shows that LWD reflection logging data are of higher resolution and quality than wireline acoustic reflection logging.
基金supported by the National Nature Science Foundation Project(Nos.41604101 and U1562215)the National Grand Project for Science and Technology(No.2016ZX05024-004)+2 种基金the Natural Science Foundation of Shandong(No.BS2014NJ005)Science Foundation from SINOPEC Key Laboratory of Geophysics(No.33550006-15-FW2099-0027)the Fundamental Research Funds for the Central Universities
文摘Amplitude variations with offset or incident angle (AVO/AVA) inversion are typically combined with statistical methods, such as Bayesian inference or deterministic inversion. We propose a joint elastic inversion method in the time and frequency domain based on Bayesian inversion theory to improve the resolution of the estimated P- and S-wave velocities and density. We initially construct the objective function using Bayesian inference by combining seismic data in the time and frequency domain. We use Cauchy and Gaussian probability distribution density functions to obtain the prior information for the model parameters and the likelihood function, respectively. We estimate the elastic parameters by solving the initial objective function with added model constraints to improve the inversion robustness. The results of the synthetic data suggest that the frequency spectra of the estimated parameters are wider than those obtained with conventional elastic inversion in the time domain. In addition, the proposed inversion approach offers stronger antinoising compared to the inversion approach in the frequency domain. Furthermore, results from synthetic examples with added Gaussian noise demonstrate the robustness of the proposed approach. From the real data, we infer that more model parameter details can be reproduced with the proposed joint elastic inversion.
基金China Postdoctoral Science Foundation Under Grant No. 2004035215 Jiangsu Planned Projects for Postdoctoral Research Funds 2004 Aeronautical Science Research Foundation Under Grant No. 04152065
文摘A frequency and spatial domain decomposition method (FSDD) for operational modal analysis (OMA) is presented in this paper, which is an extension of the complex mode indicator function (CMIF) method for experimental modal analysis (EMA). The theoretical background of the FSDD method is clarified, Singular value decomposition is adopted to separate the signal space from the noise space. Finally, an enhanced power spectrum density (PSD) is proposed to obtain more accurate modal parameters by curve fitting in the frequency domain. Moreover, a simulation case and an application case are used to validate this method.
基金National Science and Technology Major Project(No.2016ZX05006-002 and 2017ZX05072-001).
文摘The traditional compressed sensing method for improving resolution is realized in the frequency domain.This method is aff ected by noise,which limits the signal-to-noise ratio and resolution,resulting in poor inversion.To solve this problem,we improved the objective function that extends the frequency domain to the Gaussian frequency domain having denoising and smoothing characteristics.Moreover,the reconstruction of the sparse refl ection coeffi cient is implemented by the mixed L1_L2 norm algorithm,which converts the L0 norm problem into an L1 norm problem.Additionally,a fast threshold iterative algorithm is introduced to speed up convergence and the conjugate gradient algorithm is used to achieve debiasing for eliminating the threshold constraint and amplitude error.The model test indicates that the proposed method is superior to the conventional OMP and BPDN methods.It not only has better denoising and smoothing eff ects but also improves the recognition accuracy of thin interbeds.The actual data application also shows that the new method can eff ectively expand the seismic frequency band and improve seismic data resolution,so the method is conducive to the identifi cation of thin interbeds for beach-bar sand reservoirs.
基金The project was financially supported by China Postdoctor Science Foundationthe Key Project Foundation of the Chinese Academy of Sciences and China National Offshore Oil Corporation
文摘On the basis of ice- induced forced vibration model, ice- induced displacement responses of offshore fixed platforms are investigated in both time domain and frequency domain. The relationships of ice-induced displacement responses with ice breaking modes, ice acting directions and platform structures are analyzed and determined. The results lead to an important conclusion obtained for the first time that ice breaking frequency and the natural frequency of the first mode of the platform are the two main factors that dominate the degree of vibration. The present work provides a firm basis for both design and operation of fixed platforms against ice loading.