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Effects of thawing-induced softening on fracture behaviors of frozen rock 被引量:1
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作者 Ting Wang Hailiang Jia +2 位作者 Qiang Sun Xianjun Tan Liyun Tang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期979-989,共11页
Due to the presence of ice and unfrozen water in pores of frozen rock,the rock fracture behaviors are susceptible to temperature.In this study,the potential thawing-induced softening effects on the fracture behaviors ... Due to the presence of ice and unfrozen water in pores of frozen rock,the rock fracture behaviors are susceptible to temperature.In this study,the potential thawing-induced softening effects on the fracture behaviors of frozen rock is evaluated by testing the tension fracture toughness(KIC)of frozen rock at different temperatures(i.e.-20℃,-15℃,-12℃,-10℃,-8℃,-6℃,-4℃,-2℃,and 0℃).Acoustic emission(AE)and digital image correlation(DIC)methods are utilized to analyze the microcrack propagation during fracturing.The melting of pore ice is measured using nuclear magnetic resonance(NMR)method.The results indicate that:(1)The KIC of frozen rock decreases moderately between-20℃ and-4℃,and rapidly between-4℃ and 0℃.(2)At-20℃ to-4℃,the fracturing process,deduced from the DIC results at the notch tip,exhibits three stages:elastic deformation,microcrack propagation and microcrack coalescence.However,at-4℃e0℃,only the latter two stages are observed.(3)At-4℃e0℃,the AE activities during fracturing are less than that at-20℃ to-4℃,while more small events are reported.(4)The NMR results demonstrate a reverse variation trend in pore ice content with increasing temperature,that is,a moderate decrease is followed by a sharp decrease and-4℃ is exactly the critical temperature.Next,we interpret the thawing-induced softening effect by linking the evolution in microscopic structure of frozen rock with its macroscopic fracture behaviors as follow:from-20℃ to-4℃,the thickening of the unfrozen water film diminishes the cementation strength between ice and rock skeleton,leading to the decrease in fracture parameters.From-4℃ to 0℃,the cementation effect of ice almost vanishes,and the filling effect of pore ice is reduced significantly,which facilitates microcrack propagation and thus the easier fracture of frozen rocks. 展开更多
关键词 frozen sandstone Different thawing temperature Fracture toughness Microcrack propagation process Unfrozen water content
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Artificial Cycle with or without a Depot Gonadotropin-releasing Hormone Agonist for Frozen-thawed Embryo Transfer: An Assessment of Infertility Type that Is Most Suitable 被引量:5
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作者 Di XIE Fan CHEN +4 位作者 Shou-zhen XIE Zhi-lan CHEN Ping TUO Rong ZHOU Juan ZHANG 《Current Medical Science》 SCIE CAS 2018年第4期626-631,共6页
The clinical outcomes of five groups of infertility patients receiving frozen- thawed, cleavage-stage embryo transfers with exogenous hormone protocols with or without a depot gonadotropin-releasing hormone (GnRH) a... The clinical outcomes of five groups of infertility patients receiving frozen- thawed, cleavage-stage embryo transfers with exogenous hormone protocols with or without a depot gonadotropin-releasing hormone (GnRH) agonist were assessed. A retrospective cohort analysis was performed on 1003 cycles undergoing frozen-thawed, cleavage-stage embryo transfers from January 1, 2012 to June 31, 2015 in the Reproductive Medicine Center of Wuhan General Hospital of Guangzhou Military Region. Based on the infertility etiologies of the patients, the 1003 cycles were divided into five groups: tubal infertility, polycystic ovary syndrome (PCOS), endometriosis, male infertility, and unexplained infertility. The main outcome was the live birth rate. Two groups were set up based on the intervention: group A was given a GnRH agonist with exogenous estrogen and progesterone, and group B (control group) was given exogenous estrogen and progesterone only. The results showed that the baseline serum hormone levels and basic characteristics of the patients were not significantly different between groups A and B. The live birth rates in groups A and B were 41.67% and 29.29%, respectively (P〈0.05). The live birth rates in patients with PCOS in groups A and B were 56.25% and 30.61%, respectively (P〈0.05). The clinical pregnancy, implantation and on-going pregnancy rates showed the same trends as the live birth rates between groups A and B. The ectopic pregnancy rate was significantly lower in group A than in group B. We concluded that the live birth rate was higher and other clinical outcomes were more satisfactory with GnRH agonist co- treatment than without GnRH agonist co-treatment for frozen-thawed embryo transfer. The GnRH agonist combined with exogenous estrogen and progesterone worked for all types of infertility tested, especially for women with PCOS. 展开更多
关键词 frozen-thawed embryo transfer gonadotropin-releasing hormone agonist polycystic ovary syndrome
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Improvement of Live Birth Rate Following Frozen-Thawed Blastocyst Transfer by Combination of Prednisolone Administration and Stimulation of Endometrium Embryo Transfer
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作者 Taketo Inoue Yoshiyuki Ono +2 位作者 Yukiko Yonezawa Junji Kishi Nobuyuki Emi 《Open Journal of Obstetrics and Gynecology》 2014年第13期745-750,共6页
The endometrial condition is a significant factor for successful pregnancy. To regulate endometrial function in fertility treatment, prednisolone (PSL) is administered for suppression of increased natural killer cells... The endometrial condition is a significant factor for successful pregnancy. To regulate endometrial function in fertility treatment, prednisolone (PSL) is administered for suppression of increased natural killer cells and stimulation of endometrium embryo transfer (SEET) to enhance communication between embryo and maternal tissues. We attempted to improve the endometrial condition by PSL administration and SEET during frozen–thawed blastocyst transfer (FBT). Patients took PSL (5 mg) 3 times daily for 3 days after ovulation during the FBT cycle. To analyse effects of PSL combined with SEET, we determined rates of chemical pregnancy, clinical pregnancy, foetal heart movement (FHM) and live birth. Rates of chemical pregnancy, clinical pregnancy and FHM were significantly higher in the PSL(+)/SEET(+) (57.7%, 50.0% and 46.2%, respectively) and PSL(+)/SEET(-) (53.3%, 46.7% and 46.7%, respectively) groups than in the PSL(-)/SEET(+) (30.3%, 18.2% and 18.2%, respectively) and PSL(-)/SEET(-) (22.4%, 22.4% and 18.4%;P = 0.0043, 0.0081 and 0.0055, respectively) groups. The live birth rate was significantly higher in the PSL(+)/SEET(+) group than in the PSL(+)/SEET(-), PSL(-)/SEET(+) and PSL(-)/SEET(-) groups (42.3%, 26.7%, 18.2% and 12.2%, respectively;P = 0.0237). PSL combined with SEET may be a useful adjunct to assisted reproductive technology in women who repeatedly fail to conceive by infertility treatment. 展开更多
关键词 frozenthawed BLASTOCYST TRANSFER Infertility Live Birth PREDNISOLONE STIMULATION of ENDOMETRIUM Embryo TRANSFER (SEET)
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Comparison of clinical outcomes of frozen-thawed blastocysts transfer in natural and hormonally controlled cycles
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作者 高辉 孙正怡 +2 位作者 邓成艳 郁琦 何方方 《生殖医学杂志》 CAS 2007年第A01期79-83,共5页
Objectives:To assess the clinical outcomes of frozen-thawed blastocysts transfer in natural and hormonally controlled cycles.Methods:A retrospective analysis of natural and hormonally controlled cycle for 246 frozen-t... Objectives:To assess the clinical outcomes of frozen-thawed blastocysts transfer in natural and hormonally controlled cycles.Methods:A retrospective analysis of natural and hormonally controlled cycle for 246 frozen-thawed blastocyst transfer cycles,the clinical pregnancy rate,implantation rate,early abortion rate were compared.Results:Of the 192 hormonally controlled cycles,the cancel rate,clinical pregnancy rate per ET,implantation rate and abortion rate were 7.3%(14/192),53.9%(96/178),38.8%(131/338)and 11.5%(11/96)respectively,whereas in 54 natural cycles,these rates were 16.7%(9/54),68.9%(31/45),52.9%(45/85)and 16.1%(5/31)respectively.There was no significant difference between the two groups with regard to the clinical pregnancy and abortion rate per ET,but the cancel rate and implantation rate were higher in natural cycles.However,the pregnancy and implantation rates of patients without PCOS in hormonal control cycles(57.2%,40.9%)were similar with those in natural cycles(P>0.05).Conclusion:These findings suggested that both hormonally controlled and natural cycles had similar pregnancy outcomes in frozen-thawed blastocysts transfer. 展开更多
关键词 胚泡 临床分析 生殖功能 孕妇
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冻融循环对季冻土区粉质黏土-混凝土界面剪切性能的影响
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作者 王伯昕 高银龙 +1 位作者 王清 刘佳奇 《吉林大学学报(地球科学版)》 CAS CSCD 北大核心 2024年第5期1592-1603,共12页
为探究季冻土区粉质黏土-混凝土界面剪切性能,进行了不同冻融循环次数、土体含水率和法向应力的粉质黏土-混凝土二元体冻融循环试验和直剪试验,探讨了界面抗剪强度、抗剪强度参数和抗剪强度损伤度的变化规律。结果表明:直剪试验得到的应... 为探究季冻土区粉质黏土-混凝土界面剪切性能,进行了不同冻融循环次数、土体含水率和法向应力的粉质黏土-混凝土二元体冻融循环试验和直剪试验,探讨了界面抗剪强度、抗剪强度参数和抗剪强度损伤度的变化规律。结果表明:直剪试验得到的应力-应变曲线均发生应变硬化现象,可分为弹性变形阶段(剪切位移为0~3 mm)和弹塑性变形阶段(剪切位移为4~15 mm);冻融循环对界面抗剪强度有劣化作用,即通过对土体造成损伤,导致界面内摩擦角和黏聚力下降,从而降低界面抗剪强度;随着冻融循环次数增加,界面抗剪强度损伤度增加,当冻融循环进行0、4次,抗剪强度损伤迅速,冻融循环进行12~20次,抗剪强度损伤较缓,最大界面抗剪强度损伤度为25%;土体含水率的增加对抗剪强度有削弱作用,随着土体含水率的增加,界面内摩擦角降低,但黏聚力先增加后减小,当土体含水率为20.7%时,黏聚力达到最大值;法向应力的增加对抗剪强度有增强作用。 展开更多
关键词 混凝土 粉质黏土 界面 剪切性能 冻融循环 抗剪强度 季冻土区
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Coupling of the Calculated Freezing and Thawing Front Parameterization in the Earth System Model CAS-ESM 被引量:3
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作者 Ruichao LI Jinbo XIE +5 位作者 Zhenghui XIE Binghao JIA Junqiang GAO Peihua QIN Longhuan WANG Si CHEN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第9期1671-1688,共18页
The soil freezing and thawing process affects soil physical properties,such as heat conductivity,heat capacity,and hydraulic conductivity in frozen ground regions,and further affects the processes of soil energy,hydro... The soil freezing and thawing process affects soil physical properties,such as heat conductivity,heat capacity,and hydraulic conductivity in frozen ground regions,and further affects the processes of soil energy,hydrology,and carbon and nitrogen cycles.In this study,the calculation of freezing and thawing front parameterization was implemented into the earth system model of the Chinese Academy of Sciences(CAS-ESM)and its land component,the Common Land Model(CoLM),to investigate the dynamic change of freezing and thawing fronts and their effects.Our results showed that the developed models could reproduce the soil freezing and thawing process and the dynamic change of freezing and thawing fronts.The regionally averaged value of active layer thickness in the permafrost regions was 1.92 m,and the regionally averaged trend value was 0.35 cm yr–1.The regionally averaged value of maximum freezing depth in the seasonally frozen ground regions was 2.15 m,and the regionally averaged trend value was–0.48 cm yr–1.The active layer thickness increased while the maximum freezing depth decreased year by year.These results contribute to a better understanding of the freezing and thawing cycle process. 展开更多
关键词 frozen ground freezing and thawing fronts maximum freezing depth active layer thickness earth system model CAS-ESM
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Stabilized effects of L-S cement-mixed batter pile composite foundation for existed warm frozen soil subgrade
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作者 SUN Gao-chen YAO Gang +4 位作者 ZHANG Jian-ming LI Bo LI Jun-qi LIAN Wei-ping WEI Yi 《Journal of Mountain Science》 SCIE CSCD 2023年第2期542-556,共15页
In permafrost regions with warm frozen soil,subgrade thaw-collapse phenomenon commonly occurs,facing thaw collapse problems of the existed frozen soil subgrade,thus it is difficult to use traditional methods such as a... In permafrost regions with warm frozen soil,subgrade thaw-collapse phenomenon commonly occurs,facing thaw collapse problems of the existed frozen soil subgrade,thus it is difficult to use traditional methods such as active cooling and passive protection technology to stabilize the existed warm frozen soil subgrade.This study derives a novel stabilizer method,a long-short(L-S)cement-mixed batter pile composite foundation to stabilize the existed warm frozen soil subgrade.To solve the thawcollapse problems in warm frozen soil subgrade,high water content and large compressibility characteristics were compared between soft soil and warm frozen soils.Theoretical analysis of heat conduction and numerical simulation of finite element model were used to study the freeze–thaw process and evaluate the stabilized effects of the L-S cement-mixed batter piles on the warm frozen soil foundation of the Qinghai-Tibet Highway.Furthermore,the thaw process and mechanical properties of foundation and piles were analyzed by introducing the hydration heat factor in the thermodynamic control equation.The results indicate that the thawing displacement of the existed warm frozen soil subgrade was reduced owing to the“support”and“grasp”effects of the L-S cement-mixed batter piles on the surrounding soil.The composite ground formed by strengthening the warm frozen ground with batter piles could considerably improve the bearing capacity of the existed warm frozen ground,effectively restrain the deformation of the upper embankment,and improve the strength of the ground.The analysis can provide method for the construction design of cement mixing batter pile foundation in cold regions. 展开更多
关键词 Warm frozen soil subgrade thaw collapse Thermal disturbance Long-short cementmixed batter pile Existed frozen soil subgrade
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宫腔镜检查在GnRHa-HRT内膜准备方案冻融胚胎移植中的应用价值研究
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作者 莫莉菁 朱梦霞 +2 位作者 沈春娟 姚秋萍 付伟平 《浙江医学》 CAS 2024年第5期485-489,495,共6页
目的 探讨宫腔镜检查(HS)在促性腺激素释放激素激动剂-激素替代治疗(GnRHa-HRT)内膜准备方案冻融胚胎移植(FET)中的应用价值。方法 选取2022年1至10月在嘉兴市妇幼保健院生殖医学中心既往有1~2次胚胎移植失败史的不孕妇女112例,采用随... 目的 探讨宫腔镜检查(HS)在促性腺激素释放激素激动剂-激素替代治疗(GnRHa-HRT)内膜准备方案冻融胚胎移植(FET)中的应用价值。方法 选取2022年1至10月在嘉兴市妇幼保健院生殖医学中心既往有1~2次胚胎移植失败史的不孕妇女112例,采用随机数字表法分为GnRHa-HRT联合HS组和GnRHa-HRT组,每组各56例。比较两组患者的一般情况以及FET妊娠结局。结果 两组患者年龄、不孕年限、BMI、既往移植失败次数、转化日内膜厚度、移植胚胎数、优质胚胎移植数、优质囊胚移植数、不孕类型、不孕因素比较差异均无统计学意义(均P>0.05)。两组患者生化妊娠率、临床妊娠率、早期流产率、异位妊娠率及活产率比较差异均无统计学意义(均P>0.05),但GnRHa-HRT联合HS组的胚胎着床率高于GnRHa-HRT组(40.20%比26.47%,χ2=4.324,P=0.038),56例GnRH-HS-HRT组患者行HS,HS正常患者26例(46.43%),异常患者30例(53.57%)。GnRH-HS-HRT组HS正常患者与异常患者生化妊娠率、临床妊娠率、胚胎着床率、早期流产率、异位妊娠率及活产率比较差异均无统计学意义(均P>0.05)。结论 既往有胚胎移植失败史的患者,宫腔异常的发生率较高,HS联合子宫内膜搔刮术有助于发现子宫腔细微病变,改善子宫内膜的容受性。在同一个月经周期内进行HS和FET,可以缩短治疗周期,改善妊娠结局。 展开更多
关键词 宫腔镜检查 促性腺激素释放激素激动剂 冻融胚胎移植 子宫内膜容受性 胚胎着床率
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Shear strength of frozen clay under freezing-thawing cycles using triaxial tests 被引量:8
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作者 Wang Miao Meng Shangjiu +1 位作者 Sun Yiqiang Fu Haiqing 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2018年第4期761-769,共9页
Using a new low-temperature dynamic triaxial apparatus, the influence law of freezing-thawing cycles on clay shear strength is studied. In this research, the concept of correction coefficients of freezing-thawing cycl... Using a new low-temperature dynamic triaxial apparatus, the influence law of freezing-thawing cycles on clay shear strength is studied. In this research, the concept of correction coefficients of freezing-thawing cycles on clay static strength, cohesion and internal friction angles is proposed, and the change patterns, correction curves and regressive formulae of clay static strength, cohesion and internal friction angles under freezing-thawing cycles are given. The test results indicate that with increasing numbers of freezing-thawing cycles, the clay static strength and cohesion decrease exponentially but the internal friction angle increases exponentially. The performance of static strength, cohesion and internal friction angles are different with increasing numbers of freezing-thawing cycles, i.e., the static strength decreases constantly until about 30% of the initial static strength prior to the freezing-thawing cycling and then stays basically stable. After 5-7 freezing-thawing cycles, the cohesion decreases gradually to about 70% of the initial cohesion. The internal friction angle increases about 20% after the first freezing-thawing cycle, then increases gradually close to a stable value which is an increase of about 40% of the internal friction angle. The freezing-thawing process can increase the variation of the density of the soil samples; therefore, strict density discreteness standards of frozen soil sample preparation should be established to ensure the reliability of the test results. 展开更多
关键词 seasonally frozen soil freezing-thawing cycles COHESION internal friction angle correction coefficient
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Determination of long-term strength of frozen loess after numerous freeze-thaw cycles 被引量:2
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作者 Hong Zhou Ze Zhang +2 位作者 WenJie Feng Jiao Ming ZhongQiong Zhang 《Research in Cold and Arid Regions》 CSCD 2014年第5期494-498,共5页
In order to determine the changing rule of long-term frozen soil strength and elucidate the connection between long-term strength and soil physical properties,frozen loess was subjected to 4,6,8,10,and 50 freeze-thaw ... In order to determine the changing rule of long-term frozen soil strength and elucidate the connection between long-term strength and soil physical properties,frozen loess was subjected to 4,6,8,10,and 50 freeze-thaw cycles,under closed-state conditions in a constant-temperature box.The frozen samples were tested on a spherical template indenter,and the results show that under the effect of repeated freeze-thaw cycles,the long-term strength of frozen loess decreased; changes in the mechanical property indices were highly unstable during the first 10 cycles; the soil strength and density were the greatest at the eighth cycle while the void ratio was the smallest; and after eight cycles all of the indices had less fluctuation and certain rising or falling tendencies.By converting the number of freeze-thaw cycles into elapsed time in the tests,three different forecasting methods of long-term soil strength could be assessed and the soil equivalent cohesive force after 10 years,20 years,or 30 years could be estimated. 展开更多
关键词 frozen loess FREEZE-thaw long-term strength
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冻融胚胎移植前IVF-ET助孕患者的血清E_(2)、孕酮表达情况及其与妊娠结局的相关性分析
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作者 熊维玲 刘梦伊 +2 位作者 魏晓瑞 廖美光 于海微 《临床医学工程》 2024年第7期847-848,共2页
目的分析冻融胚胎移植前体外受精-胚胎移植(IVF-ET)助孕患者的血清雌二醇(E_(2))、孕酮表达情况及其与妊娠结局的相关性。方法选择2020年3月至2022年3月收治的126例IVF-ET助孕患者,冻融胚胎移植前检测血清E_(2)、孕酮表达情况,完成IVF-E... 目的分析冻融胚胎移植前体外受精-胚胎移植(IVF-ET)助孕患者的血清雌二醇(E_(2))、孕酮表达情况及其与妊娠结局的相关性。方法选择2020年3月至2022年3月收治的126例IVF-ET助孕患者,冻融胚胎移植前检测血清E_(2)、孕酮表达情况,完成IVF-ET助孕后统计妊娠结局,比较不同妊娠结局患者冻融胚胎移植前血清E_(2)、孕酮表达,并分析冻融胚胎移植前IVF-ET助孕患者的血清E_(2)、孕酮表达与妊娠结局的相关性。结果126例IVF-ET助孕患者妊娠成功51例,成功率为40.48%。妊娠失败患者冻融胚胎移植前血清E_(2)、孕酮低于妊娠成功患者(P<0.05)。经Logistic回归分析结果显示,血清E_(2)、孕酮表达与妊娠结局有关(P<0.05)。结论IVF-ET助孕患者的妊娠结局与冻融胚胎移植前血清E_(2)、孕酮表达密切相关。 展开更多
关键词 体外受精-胚胎移植 冻融胚胎 雌二醇 孕酮
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Analysis of Factors Influencing Pregnancy Rate in Frozenthawed Embryo Transfer
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作者 Lu LI Xiao-xi SUN Jun-ling CHEN Xiao-hong GAO Yong-wei WANG Jie-wei TAO Li-nan CHENG 《Journal of Reproduction and Contraception》 CAS 2004年第4期239-244,共6页
Objective To analyse factors influencing the outcome of frozen-thawed embryo transfer (FET). Method A retrospective analysis was performed in our center on 129 thawing cycles from March 2001 to April 2003. The relat... Objective To analyse factors influencing the outcome of frozen-thawed embryo transfer (FET). Method A retrospective analysis was performed in our center on 129 thawing cycles from March 2001 to April 2003. The related parameters were compared between conceived and non-conceived cycles. Results There were totally 129 clinical pregnancies in these transfers (pregnancy rate: 27.1%). Frozen-thawed embryos were transferred to natural cycles and CC cycling and hormone replacement treatment had equal success. Groups of IVF and ICSI did not differ significantly in pregnancy rates (P〉0.05). The pregnancy rates for one, two, three and four pre-embryos transfer were 0, 20.0%,44.1% and 75.0%, respectively (P〈0.05). There were statistical differences between pregnancy group or non- pregnancy group in the endometrial thickness, CES, CES/No. of embryo. A higher pregnancy rate was observed in embryo transfers which had at least one 4-cell grade I embryo (d 2)(P〈0.01). Conclusions The most important factors influencing the implantation rate and pregnancy rate of frozen-thawed embryo transfer are age, endometrium thickness, and the number, morphology and growth rate of transferred frozen embryos of women participants. 展开更多
关键词 frozen thaw embryo transfer pregnancy rate
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GnRH-a降调节联合雌孕激素替代疗法在多囊卵巢综合征冻融胚胎移植中的应用效果
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作者 郭磊 《中国社区医师》 2024年第29期24-26,共3页
目的:探讨促性腺激素释放激素激动剂(GnRH-a)降调节联合雌孕激素替代疗法在多囊卵巢综合征(PCOS)冻融胚胎移植(FET)中的应用效果。方法:选取2022年1—12月于徐州市妇幼保健院生殖医学科行FET的64例PCOS患者作为研究对象,随机分为联合组(... 目的:探讨促性腺激素释放激素激动剂(GnRH-a)降调节联合雌孕激素替代疗法在多囊卵巢综合征(PCOS)冻融胚胎移植(FET)中的应用效果。方法:选取2022年1—12月于徐州市妇幼保健院生殖医学科行FET的64例PCOS患者作为研究对象,随机分为联合组(n=32)与单用组(n=32)。单用组使用雌孕激素替代疗法治疗,联合组使用GnRH-a降调节联合雌孕激素替代疗法。比较两组患者的性激素水平、移植相关参数及临床结局。结果:治疗前,两组血清促黄体生成激素(LH)、促卵泡生成激素(FSH)、雌二醇(E_2)水平比较,无统计学差异(P>0.05);治疗后,两组LH、FSH、E_2水平显著下降,与单用组比较,联合组E_2、LH、FSH水平更低(P<0.05)。与单用组患者比较,联合组患者雌二醇片使用时间更短、使用剂量更少,胚胎植入时子宫内膜更厚(P<0.05);两组移植优质胚胎数比较,无统计学差异(P>0.05)。与单用组比较,联合组患者胚胎种植成功率更高(P<0.05);两组早期流产率、异位妊娠率比较,无统计学差异(P>0.05)。结论:GnRH-a降调节联合雌孕激素替代疗法在PCOS FET中的应用效果显著,可调控性激素水平,减少雌激素使用时间及剂量,增加患者子宫内膜厚度,提高胚胎种植成功率。 展开更多
关键词 多囊卵巢综合征 冻融胚胎移植 促性腺激素释放激素激动剂降调节 雌孕激素替代疗法
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血清25-羟维生素D水平对冻融胚胎移植妊娠结局的影响 被引量:1
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作者 张静 张富青 +1 位作者 刘敏 王丽娜 《生殖医学杂志》 CAS 2023年第3期364-369,共6页
目的研究血清中25-羟维生素D(25-OH VD)水平对冻融胚胎移植(FET)助孕结局的影响。方法回顾性分析2018年10月至2021年6月于郑州市妇幼保健院生殖中心行FET治疗的471周期临床资料。按照血清25-OH VD水平将患者分为3组:VD严重缺乏组(25-OHV... 目的研究血清中25-羟维生素D(25-OH VD)水平对冻融胚胎移植(FET)助孕结局的影响。方法回顾性分析2018年10月至2021年6月于郑州市妇幼保健院生殖中心行FET治疗的471周期临床资料。按照血清25-OH VD水平将患者分为3组:VD严重缺乏组(25-OHVD<10 ng/ml,n=82)、VD缺乏组(10 ng/ml≤25-OH VD<20 ng/ml,n=287)例及VD非缺乏组(25-OH VD≥20 ng/ml,n=102)。比较各组患者的基础资料、FET内膜准备方案、移植胚胎情况及妊娠结局的差异。结果3组患者间的女方年龄、不孕年限、不孕类型、体质量指数(BMI)、血糖、血清抗苗勒管激素(AMH)水平、FET内膜准备方案、FET日内膜厚度、移植胚胎数目及移植胚胎类型等差异均无统计学意义(P>0.05)。VD严重缺乏组患者的活产率最低,显著低于VD缺乏组(28.05%vs.41.11%)和VD非缺乏组(28.05%vs.47.06%)(P<0.05)。VD非缺乏组患者的胚胎种植率、HCG阳性率及临床妊娠率均最高,但3组间比较差异尚无统计学意义(P>0.05)。VD严重缺乏组的流产率及早产率均较高,但3组间比较差异无统计学意义(分别为28.13%vs.13.87%、9.43%;21.74%vs.11.86%、8.33%;P>0.05)。VD严重缺乏组的新生儿体重最低,与另外两组比较差异有统计学意义[(2.93±0.55)kg vs.(3.22±0.57)kg、(3.12±0.59)kg,P<0.05]。结论血清25-OHVD缺乏降低了冻融胚胎移植周期的活产率,且可能增加流产、早产的风险。 展开更多
关键词 冻融胚胎移植 25-羟维生素D 妊娠结局
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水-冰-水动态变化引起冷冻肉类食品品质变化机理及控制技术研究进展 被引量:7
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作者 芮李彤 刘畅 夏秀芳 《食品科学》 EI CAS CSCD 北大核心 2023年第5期187-196,共10页
低温冷冻是最古老、应用最广泛和最经济有效的肉类食品保鲜方法,但肉类食品经过冻结、冻藏和解冻后,其中80%的水分经历水-冰-水两次相变,冰晶的形成以及后续冰晶的融化会破坏肌细胞结构,使肌肉主要成分如蛋白质和脂肪发生氧化,导致冷冻... 低温冷冻是最古老、应用最广泛和最经济有效的肉类食品保鲜方法,但肉类食品经过冻结、冻藏和解冻后,其中80%的水分经历水-冰-水两次相变,冰晶的形成以及后续冰晶的融化会破坏肌细胞结构,使肌肉主要成分如蛋白质和脂肪发生氧化,导致冷冻肉类食品保水性降低、颜色变暗、组织软塌和营养价值减少或丧失。因此,本文拟从水-冰-水动态变化角度概述冰晶的形成和生长过程(冰晶的成核、生长和重结晶);分析不同温度和过饱和度下冰晶的形态、冻融引起肌肉中发生水-冰-水动态变化的过程;重点综述水-冰-水动态变化迫使冷冻肉微观结构、保水性、氧化稳定性(脂肪氧化、蛋白质氧化和构象改变)以及感官品质(质构、色泽和风味)发生劣变的机理;简述目前一些提升冷冻肉类食品品质的新兴冷冻技术(超声波技术、高压技术、电磁场技术以及添加抗冻剂),为提高冷冻肉类食品品质及工业化生产提供科学理论依据。 展开更多
关键词 --水动态变化 冷冻 解冻 冷冻肉类食品 品质
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Characterization of frozen soil-cement mixture for berm construction in cold regions 被引量:1
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作者 HaoLin Yu XinLei Na ZhaoHui Joey Yang 《Research in Cold and Arid Regions》 CSCD 2015年第4期300-306,共7页
Lagoon berms in western Alaska are difficult to design and build due to limited resources, high cost of construction and materials, and warm permafrost conditions. This paper explores methods to treat locally availabl... Lagoon berms in western Alaska are difficult to design and build due to limited resources, high cost of construction and materials, and warm permafrost conditions. This paper explores methods to treat locally available frozen materials and use them for berm construction. The goal is to find an optimized mix ratio for cement and additives that can be effective in increasing the strength and decreasing the thaw settlement of an ice-rich frozen silty soil. Soil of similar type and ice content to the permafrost found at a project site in Eek, Alaska is prepared in a cold room. The frozen soil is pulverized and cement, additives and fibers are added to the samples for enhancing shear strength and controlling thaw settlement. Thaw settlement and direct shear tests are performed to assess strength and settlement characteristics. This paper presents a sample preparation method, data from thaw settlement and direct shear tests, and analyses of the test results and preliminary conclusions. 展开更多
关键词 frozen soil stabilization thaw settlement shear strength Portland cement
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Numerical simulation and experimental validation of moisture-heat coupling for saturated frozen soils 被引量:2
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作者 Zhi Ming Li Jian Chen +1 位作者 Kai Sun Bin Zhang 《Research in Cold and Arid Regions》 CSCD 2017年第3期250-257,共8页
In seasonally frozen regions,freezing-and-thawing action is the main cause responsible for the destruction of canals,which is closely linked to the temperature gradient and water transport.To investigate the behaviour... In seasonally frozen regions,freezing-and-thawing action is the main cause responsible for the destruction of canals,which is closely linked to the temperature gradient and water transport.To investigate the behaviour of soils under freezing-and-thawing actions,many numerical models have been established that consider the important coupling of moisture transport and temperature evolution;but they contain excessive parameters,some of which are rather difficult to determine.Based on the well-known Harlan's theory,a simple moisture-heat coupling model was recently proposed to quantify the coupled moisture-heat transport performance of soils in terms of the central temperature and porosity.The mathematical module of COMSOL Multiphysics was further employed to solve the governing equations numerically.To validate our model,a thorough experimental scheme was carried out in our lab.The measured temperature distribution was found to be consistent with the predicted results. 展开更多
关键词 saturated frozen soil moisture-heat coupling freezing-and-thawing action CANAL
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Response Relationship between the Seasonal Freezing-Thawing Process of Soil and Spatial Factor Changes in the Dayekou Basin of the Qilian Mountains 被引量:2
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作者 Yun Niu Jinling An 《Open Journal of Ecology》 2018年第8期417-431,共15页
Objective: In this study, the influence and response relationship between the seasonal freezing-thawing process of soil and the spatial factor changes in the management and utilization of water resource processes were... Objective: In this study, the influence and response relationship between the seasonal freezing-thawing process of soil and the spatial factor changes in the management and utilization of water resource processes were explored. Methods: The monitoring equipment in this study was arranged at different altitudes, gradients, and slope directions, such as the typical forest sample area in the Dayekou Basin of the Qilian Mountains. The spatial variation characteristics of the seasonal freezing-thawing process of the soil were analyzed, and a regression model was established. Results: 1) The results of this study determined that the rate of the soil’s freezing increased with the altitude in a trend of volatility. However, the rate of the thawing of the frozen soil was found to have an opposite trend. The variation degree of the freezing-thawing process increased with the altitude in a trend of volatility. The end time of the approximate soil freezing with altitude increased in a volatility trend ahead of schedule. However, the opposite was observed in the thawing rate of the frozen soil;2) The rate of the soil’s freezing under the mosses of the spruce forest at an altitude of 3028 m was found to be the lowest. However, in the sub-alpine scrub forest at an altitude of 3300 m, a maximum in the spatial ordering was observed, with an average of 1.9 cm·d-1. The thawing rate of the frozen soil in scrub-spruce forest at an altitude of 3300 m was found to be minimal. However, in the sunny slope grassland at an altitude of 2946 m, a maximum in the spatial ordering was observed, with an average of 1.5 cm·d-1. In the spatial ordering of the variation degree of the process of freezing-thawing with an average of 1.2, the scrub-grassland at an altitude of 2518 m was found to be the lowest, and the scrub-spruce forest at an altitude of 3195 m was also low;3) The soil freezing began on approximately October 20th, and the rate of soil freezing gradually became reduced. The arrival time of the frozen soil of up to 150 cm in depth in sub-alpine scrub forest was first observed at an altitude of 3028 m. However, the scrub-spruce forest at an altitude of 3100 m did not become frozen until approximately January 12th on average. Then, the thawing rate of the frozen soil increased gradually. The end time of the thawing was earliest observed in the sunny slope grassland at an altitude of 2946 m. However, the scrub-spruce forest at an altitude of 3100 m was found to be the last to thaw, and averaged approximately July 27th. The average durations of the freezing and thawing of the soil were 77 and 121 days, respectively, and the average duration of the entire process of freezing-thawing was 199 days;4) This study’s established regression models of the duration time of frozen soil’s thaw, and the rate of frozen soil’s thaw, all passed the R test of goodness of fit, F test of variance, and t test. Conclusions: The characteristics of the seasonal freezing-thawing process of the soil with the spatial changes were seasonal. However, the characteristics under the different spatial factor influences were not the same. 展开更多
关键词 FREEZING-thawING SPATIAL FACTOR Seasonal frozen SOIL Dayekou BASIN of the QILIAN Mountains
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Response of Freezing/Thawing Indexes to the Wetting Trend under Warming Climate Conditions over the Qinghai–Tibetan Plateau during 1961–2010:A Numerical Simulation 被引量:3
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作者 Xuewei FANG Zhi LI +5 位作者 Chen CHENG Klaus FRAEDRICH Anqi WANG Yihui CHEN Yige XU Shihua LYU 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第2期211-222,共12页
Since the 1990s,the Qinghai–Tibetan Plateau(QTP)has experienced a strikingly warming and wetter climate that alters the thermal and hydrological properties of frozen ground.A positive correlation between the warming ... Since the 1990s,the Qinghai–Tibetan Plateau(QTP)has experienced a strikingly warming and wetter climate that alters the thermal and hydrological properties of frozen ground.A positive correlation between the warming and thermal degradation in permafrost or seasonally frozen ground(SFG)has long been recognized.Still,a predictive relationship between historical wetting under warming climate conditions and frozen ground has not yet been well demonstrated,despite the expectation that it will become even more important because precipitation over the QTP has been projected to increase continuously in the near future.This study investigates the response of the thermal regime to historical wetting in both permafrost and SFG areas and examines their relationships separately using the Community Land Surface Model version 4.5.Results show that wetting before the 1990s across the QTP mainly cooled the permafrost body in the arid and semiarid zones,with significant correlation coefficients of 0.60 and 0.48,respectively.Precipitation increased continually at the rate of 6.16 mm decade–1 in the arid zone after the 1990s but had a contrasting warming effect on permafrost through a significant shortening of the thawing duration within the active layer.However,diminished rainfall in the humid zone after the 1990s also significantly extended the thawing duration of SFG.The relationship between the ground thawing index and precipitation was significantly negatively correlated(−0.75).The dual effects of wetting on the thermal dynamics of the QTP are becoming critical because of the projected increases in future precipitation. 展开更多
关键词 freezing/thawing indexes numerical modeling wetting process frozen ground Qinghai–Tibetan Plateau
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宫腔灌注G-CSF对薄型子宫内膜患者激素替代周期FET临床结局影响的Meta分析 被引量:1
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作者 郝敏 张宁 《生殖医学杂志》 CAS 2023年第6期912-919,共8页
目的系统评价宫腔灌注粒细胞集落刺激因子(G-CSF)对于采用激素替代治疗(HRT)周期方案进行内膜准备的薄型子宫内膜(TE)患者行冻融胚胎移植(FET)的临床疗效。方法计算机检索Pubmed、中国生物医学文献数据库(CBM)、中国知网、万方等中、英... 目的系统评价宫腔灌注粒细胞集落刺激因子(G-CSF)对于采用激素替代治疗(HRT)周期方案进行内膜准备的薄型子宫内膜(TE)患者行冻融胚胎移植(FET)的临床疗效。方法计算机检索Pubmed、中国生物医学文献数据库(CBM)、中国知网、万方等中、英文数据库,系统搜集关于宫腔灌注G-CSF应用于TE患者FET周期的相关研究,检索时间自建库至2022年8月。由两位研究者独立筛选文献、提取相关资料和评价文献质量后,采用RevMan 5.3统计软件进行Meta分析。结果共纳入7篇研究,累计共842例患者。Meta分析的结果显示:与对照组相比,宫腔灌注G-CSF可以显著改善其子宫内膜厚度[MD=0.92,95%CI(0.63,1.22),P<0.00001]、提高胚胎种植率[RR=1.45,95%CI(1.16,1.81),P=0.001]、提高临床妊娠率[RR=1.36,95%CI(1.03,1.81),P=0.03];而在周期取消率[RR=0.75,95%CI(0.40,1.39),P=0.36]和不良妊娠结局发生率[RR=0.94,95%CI(0.47,1.88),P=0.85]方面,两组差异无统计学意义。结论对于采用HRT方案行FET的TE患者,宫腔灌注G-CSF治疗可以明显改善其子宫内膜厚度,提高胚胎种植率和临床妊娠率,且不会增加不良妊娠结局风险和周期取消率。但鉴于纳入的研究数量和质量有限,后续仍需更多高质量的随机对照试验加以探讨。 展开更多
关键词 粒细胞集落刺激因子 薄型子宫内膜 激素替代周期 冻融胚胎移植 META分析
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