Objective:To investigate the effect of Fuhe decoction on the behavior and levels of monoamine neurotransmitters in different brain regions in a depression rat model induced by chronic unpredictable mild stimulation(CU...Objective:To investigate the effect of Fuhe decoction on the behavior and levels of monoamine neurotransmitters in different brain regions in a depression rat model induced by chronic unpredictable mild stimulation(CUMS)combined with social isolation.Methods:Fifty male SD rats were randomly divided into a blank group,model group,fluoxetine group,Chaiqinwendan decoction group,and Fuhe decoction group.Chronic unpredictable mild stimulation combined with a social isolation method was used to replicate the depression rat model.After 42 days of administration,a tail suspension test and high-performance liquid electrochemical detection(HPLC-ECD)were used to detect the behavioral changes and changes in the content of monoamine neurotransmitters norepinephrine(NE),dopamine(DA),5-hydroxytrytamine(5-HT),and metabolites in different brain regions of rats in each group before and after treatment.Results:Compared with the model group,the epinephrine(E)content in the Fuhe decoction group was highly significantly increased(P<.01).Compared with the model group,the 5-HT content of the prefrontal cortex in rats in the Fuhe decoction group was highly significantly increased(P<.01).Furthermore,compared with the model group,the 5-HT content in the hippocampus of rats in the Fuhe decoction group was significantly increased(P<.05).Conclusion:Fuhe decoction can improve the depression-like behaviors of model rats,and its antidepressant effect may be related to the increase in 5-HT content in the prefrontal cortex and hippocampus of rats.展开更多
为加强河流生态流量阈值及保障率计算对天然水文情势变化的适应性,提出了基于水文集合分位数的生态流量计算方法。根据河流长序列实测径流数据,在年际和年内划分不同水文情景,基于生态流量水文集合的中位数和下四分位数确定年内汛期、...为加强河流生态流量阈值及保障率计算对天然水文情势变化的适应性,提出了基于水文集合分位数的生态流量计算方法。根据河流长序列实测径流数据,在年际和年内划分不同水文情景,基于生态流量水文集合的中位数和下四分位数确定年内汛期、非汛期生态流量阈值下限,以丰、平水年组的计算结果分别作为平、枯水年组的生态流量理想值,结合生态流量中长期和短期保障率,计算分析河流在不同时间尺度下的生态流量保障程度。抚河下游应用结果表明:综合水情变化的生态流量阈值和多时间尺度保障率分析方法能够更好地适应天然河流年际和年内水情变化,更准确识别河流水文健康状况;丰、平、枯水年组抚河下游年均生态流量阈值下限分别为156.49、90.43、29.54 m 3/s;不同时间尺度下抚河下游生态流量的保障程度均较低,中长期保障率大于短期保障率,中长期和短期保障率分别为63.64%~93.11%、42.50%~91.85%。展开更多
Nineteen surface sediment samples collected from Baiyangdian Lake and its inflowing river （Fuhe River） in North China were analyzed for polybrominated diphenyl ethers （PBDEs） and decabromodiphenylethane （DBDPE）....Nineteen surface sediment samples collected from Baiyangdian Lake and its inflowing river （Fuhe River） in North China were analyzed for polybrominated diphenyl ethers （PBDEs） and decabromodiphenylethane （DBDPE）. The concentrations of PBDEs and DBDPE in sediments ranged from 5.5 to 300.7 ng/g dry weight （dw） and 1.1 to 68.2 ng/g dw, respectively. Their levels in sediments in Fuhe River were significantly higher than those in Balyandian Lake. Compared to data from other regions, the PBDE levels in surface sediments from Baiyangdian Lake and Fuhe River were in the medium to lower range. Among the PBDE congeners, BDE209 was predominant, with contributions to the total PBDEs ranging from 79.4% to 97.3% in sediment samples. For the lowly brominated congeners （tri- to hepta-BDE）, BDE47 and BDE99 were the most abundant, which contributed 52.1% and 44.1% to the sum of tri- to hepta-BDEs in the sediments from Baiyangdian Lake and Fuhe River, respectively. The compositional patterns of PBDEs in Baiyangdian Lake sediments indicated that technical deca-BDE mixture was the major pollutant sources with a minor contribution of penta-BDE mixture. The present study suggested that the importance of Fuhe River as a possibly potential sources of PBDEs contamination in Baiyangdian Lake.展开更多
The Soil and Water Assessment Tool(SWAT)model was used to assess the impacts of different land use scenarios on hydrological processes in the Fuhe watershed in Poyang Lake Basin,East China.A total of 12 model paramete...The Soil and Water Assessment Tool(SWAT)model was used to assess the impacts of different land use scenarios on hydrological processes in the Fuhe watershed in Poyang Lake Basin,East China.A total of 12 model parameters were calibrated with observed monthly runoff data for 1982-1988 and validated for 1991-1998 for baseline conditions.The baseline test results of R2 and Nash-Sutcliffe model efficiency(NSE)values ranged between 0.88 and 0.94 across the calibration and validation periods,indicating that SWAT accurately replicated the Fuhe watershed streamflow.Several different land use scenarios were then simulated with the model,focusing on the impacts of land use change on the hydrology of the watershed.The results of hypothetical scenario simulations revealed that surface runoff declined while groundwater recharge and evapotranspiration(ET)increased,as forest land,agriculture land and/or grassland areas increased,as well as when paddy field and urban areas decreased.These results further showed that forest land has a higher capacity to conserve the water as compared to pasture land.The results of the real scenario simulations revealed that urbanization is the strongest contributor to changes in surface runoff,water yield,and ET.Urbanization can be considered as a potential major environmental stressor controlling hydrological components.展开更多
基金the Foundation of new teachers of Beijing University of Traditional Chinese Medicine(2019-JYB-XJSJJ-001)。
文摘Objective:To investigate the effect of Fuhe decoction on the behavior and levels of monoamine neurotransmitters in different brain regions in a depression rat model induced by chronic unpredictable mild stimulation(CUMS)combined with social isolation.Methods:Fifty male SD rats were randomly divided into a blank group,model group,fluoxetine group,Chaiqinwendan decoction group,and Fuhe decoction group.Chronic unpredictable mild stimulation combined with a social isolation method was used to replicate the depression rat model.After 42 days of administration,a tail suspension test and high-performance liquid electrochemical detection(HPLC-ECD)were used to detect the behavioral changes and changes in the content of monoamine neurotransmitters norepinephrine(NE),dopamine(DA),5-hydroxytrytamine(5-HT),and metabolites in different brain regions of rats in each group before and after treatment.Results:Compared with the model group,the epinephrine(E)content in the Fuhe decoction group was highly significantly increased(P<.01).Compared with the model group,the 5-HT content of the prefrontal cortex in rats in the Fuhe decoction group was highly significantly increased(P<.01).Furthermore,compared with the model group,the 5-HT content in the hippocampus of rats in the Fuhe decoction group was significantly increased(P<.05).Conclusion:Fuhe decoction can improve the depression-like behaviors of model rats,and its antidepressant effect may be related to the increase in 5-HT content in the prefrontal cortex and hippocampus of rats.
文摘为加强河流生态流量阈值及保障率计算对天然水文情势变化的适应性,提出了基于水文集合分位数的生态流量计算方法。根据河流长序列实测径流数据,在年际和年内划分不同水文情景,基于生态流量水文集合的中位数和下四分位数确定年内汛期、非汛期生态流量阈值下限,以丰、平水年组的计算结果分别作为平、枯水年组的生态流量理想值,结合生态流量中长期和短期保障率,计算分析河流在不同时间尺度下的生态流量保障程度。抚河下游应用结果表明:综合水情变化的生态流量阈值和多时间尺度保障率分析方法能够更好地适应天然河流年际和年内水情变化,更准确识别河流水文健康状况;丰、平、枯水年组抚河下游年均生态流量阈值下限分别为156.49、90.43、29.54 m 3/s;不同时间尺度下抚河下游生态流量的保障程度均较低,中长期保障率大于短期保障率,中长期和短期保障率分别为63.64%~93.11%、42.50%~91.85%。
基金supported by the National Basic Research Program(973) of China(No. 2006CB403306)the National Natural Science Foundation of China(No.30870311)
文摘Nineteen surface sediment samples collected from Baiyangdian Lake and its inflowing river （Fuhe River） in North China were analyzed for polybrominated diphenyl ethers （PBDEs） and decabromodiphenylethane （DBDPE）. The concentrations of PBDEs and DBDPE in sediments ranged from 5.5 to 300.7 ng/g dry weight （dw） and 1.1 to 68.2 ng/g dw, respectively. Their levels in sediments in Fuhe River were significantly higher than those in Balyandian Lake. Compared to data from other regions, the PBDE levels in surface sediments from Baiyangdian Lake and Fuhe River were in the medium to lower range. Among the PBDE congeners, BDE209 was predominant, with contributions to the total PBDEs ranging from 79.4% to 97.3% in sediment samples. For the lowly brominated congeners （tri- to hepta-BDE）, BDE47 and BDE99 were the most abundant, which contributed 52.1% and 44.1% to the sum of tri- to hepta-BDEs in the sediments from Baiyangdian Lake and Fuhe River, respectively. The compositional patterns of PBDEs in Baiyangdian Lake sediments indicated that technical deca-BDE mixture was the major pollutant sources with a minor contribution of penta-BDE mixture. The present study suggested that the importance of Fuhe River as a possibly potential sources of PBDEs contamination in Baiyangdian Lake.
基金This work was funded by the National Natural Science Foundation of China(41331174,41101415,41301366)Collaborative Innovation Center of Geospatial Technology,Collaborative Innovation Center for Major Ecological Security Issues of Jiangxi Province and Monitoring Implementation(JXS-EW-08)+2 种基金Special Fund by Surveying&Mapping and Geoinformation Research in the Public Interest(201512026),863 Program(2012AA12A304,2012AA12A306)Natural Science Foundation of Hubei Province of China(2015CFB331)Special funds of State Key Laboratory for equipment.Thanks to Jiangxi Provincial Institute of Water Science for providing partial data for this paper.
文摘The Soil and Water Assessment Tool(SWAT)model was used to assess the impacts of different land use scenarios on hydrological processes in the Fuhe watershed in Poyang Lake Basin,East China.A total of 12 model parameters were calibrated with observed monthly runoff data for 1982-1988 and validated for 1991-1998 for baseline conditions.The baseline test results of R2 and Nash-Sutcliffe model efficiency(NSE)values ranged between 0.88 and 0.94 across the calibration and validation periods,indicating that SWAT accurately replicated the Fuhe watershed streamflow.Several different land use scenarios were then simulated with the model,focusing on the impacts of land use change on the hydrology of the watershed.The results of hypothetical scenario simulations revealed that surface runoff declined while groundwater recharge and evapotranspiration(ET)increased,as forest land,agriculture land and/or grassland areas increased,as well as when paddy field and urban areas decreased.These results further showed that forest land has a higher capacity to conserve the water as compared to pasture land.The results of the real scenario simulations revealed that urbanization is the strongest contributor to changes in surface runoff,water yield,and ET.Urbanization can be considered as a potential major environmental stressor controlling hydrological components.
