Soil salinity is the most important factor affecting vegetation distribution,and the secondary salinization has affected the development of oasis agriculture.In arid areas the spatial variation of soil moisture and sa...Soil salinity is the most important factor affecting vegetation distribution,and the secondary salinization has affected the development of oasis agriculture.In arid areas the spatial variation of soil moisture and sa lt content is marked-ly affected by groundwater,irratio nal irrigation in artificial oasis.By analyzing the soil moisture,salt content and groundwa-ter table in different areas of old oasis,new oasis and desert in Fukang Oa sis,it is shown that topography and l and use are main factors affecting the change of groundwater table,the redistribution of soil moisture and salt cont ent.When undis-turbed by human,the groundwater tab le rises from mountain to belt of grou nd water spillage,the groundwater t able rises mightily in plain because of the artificial irrigation,and the secondary salinization of soil is very seriou s.In oasis the ground-water table raises compared with that in the natural desert at the same latitude.In old oasis of upper reaches o f river salt has not been concentrated too much in rhizosphere because this area is the belt of groundwater drainage,soil t exture is coarse,the groundwater table is very low,and the salt in soil is drained i nto the groundwater.The new oasis has been the areas of salt accumulation becau se of the artificial irrigation,the salt content in soil is higher than th at in old oasis,so some cultivated fields here had to be thrown out because of the serious s econdary salinization.展开更多
The origin and source of the petroleum in the Jurassic reservoirs within the eastern Fukang sub-depression were geochemically investigated.They show thermal maturities matching the peak generation stage,while the cond...The origin and source of the petroleum in the Jurassic reservoirs within the eastern Fukang sub-depression were geochemically investigated.They show thermal maturities matching the peak generation stage,while the condensates are at the early stage of intense cracking.Oils and condensates may have experienced mild evaporative fractionation,while mixing of severely biodegraded with non-biodegraded oils has occurred.Using biomarkers and isotopes,petroleums were classified into GroupⅠ,ⅡandⅢgenetic groups,with GroupⅢfurther divided intoⅢa andⅢb subgroups.GroupⅠpetroleum displays heavy carbon isotopes,a strong predominance of pristine over phytane,high C_(19)and C_(20)tricyclic and C_(24)tetracyclic terpanes,low gammacerane,and dominant C_(29)steranes,while GroupⅡshows light carbon isotopes,a predominance of phytane over pristine,high C_(21)and C_(23)tricyclic with low C_(24)tetracyclic terpanes,high gammacerane and dominant C_(27)steranes.GroupⅢa petroleum shows mixing compositions of GroupⅠandⅡ,while GroupⅢb displays similar compositions to Group I,but with significantly higher Ts,C_(29)Ts and C_(30)diahopane proportions.Oil-source rock correlation suggests GroupⅠandⅡpetroleums originate from Jurassic and Permian source rocks,respectively,while GroupⅢa are mixtures sourced from these rocks andⅢb are mixtures from Jurassic and Triassic source rocks.展开更多
The deformation pattern and Holocene slip rate along the Fukang fault in Eastern Tianshan, China are analyzed and studied using the data obtained in field investigation. The result indicates that the Fukang fault cons...The deformation pattern and Holocene slip rate along the Fukang fault in Eastern Tianshan, China are analyzed and studied using the data obtained in field investigation. The result indicates that the Fukang fault consists of 4 low-angle south-dipping thrust faults with stepover, displaying recent tectonic activity. The movement along the termination parts of the fault is weaker, with an average vertical slip rate of 0 13～0 33 mm/a in Holocene, and along the middle part of the fault is stronger, with an average vertical slip rate larger than 1.42 mm/a in Holocene. The Holocene deformation pattern along the fault displays generally steady slip, multi-phase intermittent movement along its western segment, and persistent movement along its middle and eastern segments, which have caused rapid dislocation up to the surface in an earlier phase.展开更多
目的:利用网络药理学方法及分子对接技术探析脉管复康片治疗动脉粥样硬化(atherosclerosis,AS)的机制。方法:通过传统中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platfo...目的:利用网络药理学方法及分子对接技术探析脉管复康片治疗动脉粥样硬化(atherosclerosis,AS)的机制。方法:通过传统中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)筛选脉管复康片(丹参、鸡血藤、没药、乳香、郁金)活性成分和靶基因。使用人类基因数据库(the human gene database,GeneCards)、在线人类孟德尔遗传数据库(online mendelian inheritance in man,OMIM)、药物靶标数据库(therapeutic target database,TTD)、遗传药理学与药物基因组学数据库(pharmacogenetics and pharmacogenomics knowledge base,PharmGKB)、DrugBank疾病数据库获得AS相关基因。使用Cytoscape 3.8.2构建“成分-靶点”网络。使用STRING数据库下载蛋白-蛋白互作网络(protein-protein interactions,PPI)数据,导入Cytoscape,使用CytoNCA插件获取核心靶基因。使用R软件进行基因本体(gene ontology,GO)和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)富集分析。对活性成分及核心基因做分子对接。结果:从脉管复康片中共筛选出157个活性成分,对应AS靶基因238个,PPI核心靶基因共20个。GO功能富集显示生物学功能主要涉及脂多糖反应、细菌来源分子反应、金属离子反应、氧化应激反应等;KEGG通路富集显示主要涉及流体剪切应力和AS、AGE-RAGE信号通路、PI3K-Akt信号通路等;分子对接结果提示槲皮素、木犀草素、柚皮素、丹参酮ⅡA、刺芒柄花素、甘草查尔酮A与4个核心蛋白JUN、MAPK1、TP53、STAT3结合稳定。结论:脉管复康片可通过槲皮素、木犀草素等活性成分作用于多种信号通路及多个基因靶点治疗AS。展开更多
文摘Soil salinity is the most important factor affecting vegetation distribution,and the secondary salinization has affected the development of oasis agriculture.In arid areas the spatial variation of soil moisture and sa lt content is marked-ly affected by groundwater,irratio nal irrigation in artificial oasis.By analyzing the soil moisture,salt content and groundwa-ter table in different areas of old oasis,new oasis and desert in Fukang Oa sis,it is shown that topography and l and use are main factors affecting the change of groundwater table,the redistribution of soil moisture and salt cont ent.When undis-turbed by human,the groundwater tab le rises from mountain to belt of grou nd water spillage,the groundwater t able rises mightily in plain because of the artificial irrigation,and the secondary salinization of soil is very seriou s.In oasis the ground-water table raises compared with that in the natural desert at the same latitude.In old oasis of upper reaches o f river salt has not been concentrated too much in rhizosphere because this area is the belt of groundwater drainage,soil t exture is coarse,the groundwater table is very low,and the salt in soil is drained i nto the groundwater.The new oasis has been the areas of salt accumulation becau se of the artificial irrigation,the salt content in soil is higher than th at in old oasis,so some cultivated fields here had to be thrown out because of the serious s econdary salinization.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.20CX02108A)the Development Fund of the Key Laboratory of Deep Oil&Gas,China University of Petroleum(East China)。
文摘The origin and source of the petroleum in the Jurassic reservoirs within the eastern Fukang sub-depression were geochemically investigated.They show thermal maturities matching the peak generation stage,while the condensates are at the early stage of intense cracking.Oils and condensates may have experienced mild evaporative fractionation,while mixing of severely biodegraded with non-biodegraded oils has occurred.Using biomarkers and isotopes,petroleums were classified into GroupⅠ,ⅡandⅢgenetic groups,with GroupⅢfurther divided intoⅢa andⅢb subgroups.GroupⅠpetroleum displays heavy carbon isotopes,a strong predominance of pristine over phytane,high C_(19)and C_(20)tricyclic and C_(24)tetracyclic terpanes,low gammacerane,and dominant C_(29)steranes,while GroupⅡshows light carbon isotopes,a predominance of phytane over pristine,high C_(21)and C_(23)tricyclic with low C_(24)tetracyclic terpanes,high gammacerane and dominant C_(27)steranes.GroupⅢa petroleum shows mixing compositions of GroupⅠandⅡ,while GroupⅢb displays similar compositions to Group I,but with significantly higher Ts,C_(29)Ts and C_(30)diahopane proportions.Oil-source rock correlation suggests GroupⅠandⅡpetroleums originate from Jurassic and Permian source rocks,respectively,while GroupⅢa are mixtures sourced from these rocks andⅢb are mixtures from Jurassic and Triassic source rocks.
文摘The deformation pattern and Holocene slip rate along the Fukang fault in Eastern Tianshan, China are analyzed and studied using the data obtained in field investigation. The result indicates that the Fukang fault consists of 4 low-angle south-dipping thrust faults with stepover, displaying recent tectonic activity. The movement along the termination parts of the fault is weaker, with an average vertical slip rate of 0 13～0 33 mm/a in Holocene, and along the middle part of the fault is stronger, with an average vertical slip rate larger than 1.42 mm/a in Holocene. The Holocene deformation pattern along the fault displays generally steady slip, multi-phase intermittent movement along its western segment, and persistent movement along its middle and eastern segments, which have caused rapid dislocation up to the surface in an earlier phase.
文摘目的:利用网络药理学方法及分子对接技术探析脉管复康片治疗动脉粥样硬化(atherosclerosis,AS)的机制。方法:通过传统中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)筛选脉管复康片(丹参、鸡血藤、没药、乳香、郁金)活性成分和靶基因。使用人类基因数据库(the human gene database,GeneCards)、在线人类孟德尔遗传数据库(online mendelian inheritance in man,OMIM)、药物靶标数据库(therapeutic target database,TTD)、遗传药理学与药物基因组学数据库(pharmacogenetics and pharmacogenomics knowledge base,PharmGKB)、DrugBank疾病数据库获得AS相关基因。使用Cytoscape 3.8.2构建“成分-靶点”网络。使用STRING数据库下载蛋白-蛋白互作网络(protein-protein interactions,PPI)数据,导入Cytoscape,使用CytoNCA插件获取核心靶基因。使用R软件进行基因本体(gene ontology,GO)和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)富集分析。对活性成分及核心基因做分子对接。结果:从脉管复康片中共筛选出157个活性成分,对应AS靶基因238个,PPI核心靶基因共20个。GO功能富集显示生物学功能主要涉及脂多糖反应、细菌来源分子反应、金属离子反应、氧化应激反应等;KEGG通路富集显示主要涉及流体剪切应力和AS、AGE-RAGE信号通路、PI3K-Akt信号通路等;分子对接结果提示槲皮素、木犀草素、柚皮素、丹参酮ⅡA、刺芒柄花素、甘草查尔酮A与4个核心蛋白JUN、MAPK1、TP53、STAT3结合稳定。结论:脉管复康片可通过槲皮素、木犀草素等活性成分作用于多种信号通路及多个基因靶点治疗AS。
