Modulatory Effects of Compound Polysaccharide Erweikang on the Immune Function o f Mice

In order to study the modulatory effects of compound polysaccharide Erweikang on the immune function of the immunosuppressive mice, the positive immune modulati on of Erweikang at different doses and different time points was compared when n ormal saline and cyclophosphamide served as controls. The results showed that di fferent doses of Erweikang could effectively reverse the decreased induction lev els of NK, IL 2, γ IFN and the contents of TNF and IgG of the immunosu ppressive mice after administration of Erweikang for 7 to 14 days. It was sugges ted that compound polysaccharide Erweikang presents positive immune modulation i n dose and time dependent manners.

Stability of Boundary Feedback Control Based on Weighted Lyapunov Function in Networks of Open Channels

Lyapunov 功能在串联为二条开的隧道的盒子基于熵的加权的和被构造，它被 Saint-Venant 方程描述。边界反馈控制器的一个班被介绍借助于 Lyapunov 设计途径在平衡点的一位邻居保证本地靠近环的 asymptotic 稳定性。

Early rehabilitation improves neurofunctional outcome after surgery in children with spinal tumors

To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients （1-17 years old） who received spinal tumor surgical removal. The peddiatric patients received rahabilitation treatment at 4 （range, 2-7） days after surgery for 10 （range, 7-23） days. Results from the Modified McCormick Scale, Functional Independence Measure for Chil- dren, American Spinal Injury Association Impairment Scale and Karnofsky Performance Status Scale demonstrated that the sensory function, motor function and activity of daily living of pedi- atric children who received early rehabilitation were significantly improved. Results also showed that tumor setting and level localization as well as patients＇s clinical symptoms have no influences on neurofunctional outcomes.

Generalized Gr?tzsch ring function and generalized elliptic integrals

Abstract. In this paper, we study the quotient of hypergeometric functions μα （r） in the theory of Ramanujan＇s generalized modular equation for α ∈（0, 1/2]. Several new inequalities are given for this and related functions. Our main results complement and generalize some known results in the literature.

Command functions of open loop galvanometer scanners with optimized duty cycles

The paper approaches the problem of the command functions of galvanometer-based scanners （GS） that are necessary to produce the linear plus parabolic scanning function of the GS, which we have proved previously to produce the highest possible duty cycle （i.e., time efficiency） of the device. We have completed this theoretical aspect （which contradicted what has been stated previously in the literature, where it has been considered that the linear plus sinusoidal scanning function was the best） with the experimental study of the most used scanning functions of the GSs （sawtooth, sinusoidal and triangular）, with applications in biomedical imaging, in particular in optical coherence tomography, demonstrating that the triangular function is always the best one to be applied, from both an optical and a mechanical point of view. In the present study the input voltage/command function which should be applied to the GS to produce the desired triangular scanning function （with controlled non-linearity for the fastest possible stop-and-turn portions） was determined analytically, in relationship with the active torque that drives the device. This command function is analyzed with regard to the specific, respectively required parameters of the GS： natural frequency and damping factor, respectively scan speed and amplitude. The modeling in an open loop control structure of the GS is finally discussed as a trade-off between using the highest possible duty cycle and minimizing the maximum peaks of the input voltage.

Beneficial Effects of Delayed Opening the Infarct - related Artery on Late Phase Left Ventricular Function in Acute Anterior Myocardial Infarction

Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction. Methods 64 patients with initial Q - wave anterior myocardial infarction and the infarct - related arteries were total occluded conformed by angiogram at 2 to 14 days after onset were divided into successful PCI group and control group ( not re- ceiving PCI or the IRA not re - opened). 2 - DE was performed at early phase ( about 3 weeks) , 2 and 6 months after onset of AMI respectively to detect the left ventricular function and left ventricular wall motion ab- normality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up. Re- sults VWMA scores, left ventricular ejection frac- tion (LVEF) , left ventricular end - diastolic and end - systolic volume indices ( LVEDVI and LVDSVI) were similar in 2 groups at early phase and 2 months. There were no differences between early phase and 2 months in each group too. VWMA scores and LVEF did not changed at 6 months in each group compared with the early phase and 2 months ( P > 0. 05 ). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than in the control group (P < 0.01, P < 0. 05). The congestive heart failure events were taken place in 19% of patients in control group com- pared with 2% in successful PCI group ( P > 0. 05 ). Conclusions Although the infarct size does not changed, delayed opening the IRA has beneficial effect to the late phase left ventricular dilatation after acuteanterior myocardial infarction.

鼻窦内镜辅助下等离子低温射频消融术对腺样体肥大儿童的疗效观察

目的 探究鼻窦内镜下等离子低温射频消融术对腺样体肥大患儿的作用效果。方法 选取2020年1月至2023年12月本院收治的腺样体肥大患儿102例,根据治疗方案分为观察组及对照组各51例。对照组采用动力系统腺样体切除术,观察组采用鼻窦内镜下等离子低温射频消融术。比较两组临床疗效、手术指标及术后恢复情况、鼻通气功能[氧减指数(ODI)、最长呼吸暂停时间(LAT)、呼吸紊乱指数(AHI)、最低夜间血氧饱和度(LSaO_(2))]、鼻阻力[双侧总呼气阻力、鼻腔呼吸量、鼻腔吸气量],统计并发症发生情况。结果 观察组治疗总有效率显著高于对照组,手术时间、通气恢复时间较对照组更短,术中出血量更少且疼痛程度更低(P<0.05)。术后1周,两组双侧总呼气阻力较术前均降低,鼻腔呼吸量、鼻腔吸气量较术前均升高,观察组双侧总呼气阻力显著低于对照组,鼻腔呼吸量及鼻腔吸气量明显高于对照组(P<0.05)。术后3个月,两组ODI、AHI及LAT水平较术前均降低,且LSaO_(2)水平较术前均升高(P<0.05);观察组ODI、AHI及LAT显著低于对照组,LSaO_(2)高于对照组。观察组并发症总发生率低于对照组(P>0.05)。结论 鼻窦内镜下等离子低温射频消融术治疗腺样体肥大患儿,可以显著改善术后通气功能,手术时间更短、出血量更少,具有良好的临床疗效,安全性高。

IL-8、IL-10/TNF-α比值交互作用对支气管扩张症合并肺部感染患者病情评估的价值

目的探究外周血白细胞介素-8(IL-8)、白细胞介素-10(IL-10)/肿瘤坏死因子α(TNF-α)比值交互作用对支气管扩张症(支扩)合并感染患者病情评估的价值,以期为临床诊疗提供参考。方法选取2021年1月至2023年8月信阳市中心医院收治的85例支扩合并肺部感染患者作为感染组,85例单纯支扩患者作为未感染组。比较两组患者的外周血IL-8、IL-10/TNF-α比值。将感染组患者根据支扩严重程度指数(BSI)分为轻度组(20例)、中度组(47例)和重度组(18例),并根据肺部感染评分(CPIS)分为轻度感染组(26例)、中度感染组(44例)和重度感染组(15例),比较感染组不同扩张严重程度、不同感染程度患者的外周血IL-8、IL-10/TNF-α比值及呼吸功能[第1秒最大呼气量(FEV_1)、FEV_1占所有呼气量的比例(FEV_1/FVC)]。采用Pearson、Spearman法分析感染组外周血IL-8、IL-10/TNF-α比值与呼吸功能、感染程度、扩张程度的相关性,采用交互作用系数γ分析外周血IL-8、IL-10/TNF-α比值对支扩患者合并感染的交互作用,采用受试者工作特征(ROC)曲线分析外周血IL-8、IL-10/TNF-α比值诊断支扩合并感染的价值。结果感染组患者的外周血IL-8、IL-10、TNF-α水平及IL-10/TNF-α比值明显高于未感染组,差异均有统计学意义(P<0.05);外周血IL-8、IL-10、TNF-α水平及IL-10/TNF-α比值随扩张程度加重逐渐下降,随感染程度加重逐渐升高,FEV_1、FEV_1/FVC随扩张程度加重逐渐升高,随感染程度加重逐渐下降,差异均有统计学意义(P<0.05);经Pearson法分析,感染组患者外周血IL-8、IL-10/TNF-α比值与FEV_1(r=-0.591、-0.570)、FEV_1/FVC(r=-0.580、-0.538)均呈负相关(P<0.05),经Spearman法分析,感染组患者外周血IL-8、IL-10/TNF-α比值与感染程度(r=0.538、0.570)、扩张程度(r=0.603、0.619)均呈正相关(P<0.05);交互作用分析结果显示,IL-8高水平、IL-10/TNF-α比值高在支扩合并感染中呈正向交互作用(RR=8.038,95%CI:3.403~18.988),且为次相乘模型;ROC分析结果显示,IL-8、IL-10/TNF-α比值联合诊断支扩合并感染的曲线下面积(AUC)为0.907(95%CI:0.853~0.946),优于两指标单独诊断(P<0.05)。结论IL-8、IL-10/TNF-α比值在支扩合并感染患者外周血中均表达上调,且呈正向交互作用,联合检测对支扩合并感染具有一定诊断价值,可作为临床诊断疾病、评估病情的辅助指标,并可指导临床决策。

任务导向训练联合下肢康复机器人对脑卒中偏瘫患者下肢功能的影响

目的:探讨下肢康复机器人联合任务导向训练对脑卒中偏瘫患者的治疗效果。方法:选取我院2023年1月~12月收治的脑卒中偏瘫患者100例,随机分为对照组和观察组各50例。对照组在康复师的辅助下进行任务导向训练,观察组在对照组基础上给予下肢康复机器人训练。观察两组患者治疗前后下肢平衡、下肢肌力、运动功能、踝关节功能、膝关节屈曲活动范围及行走能力。结果:治疗后,两组患者BBS评分、股四头肌评分、腘绳肌评分、FMA-LE评分及AOFAS评分均较治疗前升高(P<0.05),且观察组治疗后的BBS评分、股四头肌评分、腘绳肌评分、FMA-LE评分及AOFAS评分均显著高于对照组(P<0.05);治疗后,两组患者的膝关节屈曲活动范围及6 min步行距离均较治疗前升高(P<0.05),且观察组治疗后的膝关节屈曲活动范围及6 min步行距离显著大于对照组(P<0.05)。结论:在脑卒中患者的临床治疗中,任务导向训练与下肢康复机器人相结合,可有效提高下肢肌力,促进平衡功能的恢复,对运动功能的恢复效果显著,可提高脑卒中患者的行走能力和膝关节屈曲的活动范围,达到较为理想的治疗效果。

基于动态营养风险评估的睡前加餐在肝硬化合并糖尿病患者中的应用效果观察

目的 探讨基于动态营养风险评估的睡前加餐在肝硬化合并糖尿病患者中的应用效果。方法 选择2022年7月至2023年6月我院收治的乙肝肝硬化合并糖尿病患者85例,采用随机数字表法分为观察组43例与对照组42例,对照组给予肝硬化糖尿病常规饮食干预,观察组给予基于动态风险评估的睡前加餐饮食干预。比较两组血清营养学指标、肝功能指标、糖代谢指标及不良反应。结果 观察组白蛋白、前白蛋白、总蛋白高于对照组(P<0.05);天冬氨酸基转移酶、谷丙转氨酶、总胆红素低于对照组(P<0.05);空腹血糖、糖化血红蛋白、空腹胰岛素低于对照组(P<0.05);不良反应11.63%明显低于对照组30.95%(χ^(2)=4.753,P<0.05)。结论 基于动态营养风险评估的睡前加餐能够改善肝硬化合并糖尿病患者营养状况,修复受损肝功能,控制糖代谢水平,降低不良反应的发生。

Repetitive transcranial magnetic stimulation for hallucination in schizophrenia spectrum disorders A meta-analysis

OBJECTIVE： This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES： Online literature retrieval was conducted using PubMed, ISI Web of Science, EMBASE, Medline and Cochrane Central Register of Controlled Trials databases from January 1985 to May 2012. Key words were ＂transcranial magnetic stimulation＂, ＂TMS＂, ＂repetitive tran- scranial magnetic stimulation＂, and ＂hallucination＂. STUDY SELECTION： Selected studies were randomized controlled trials assessing therapeutic ef- ficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders. Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders. Control groups received sham stimulation. MAIN OUTCOME MEASURES： The primary outcome was total scores of Auditory Hallucinations Rating Scale, Auditory Hallucination Subscale of Psychotic Symptom Rating Scale, Positive and Negative Symptom Scale-Auditory Hallucination item, and Hallucination Change Scale. Secondary outcomes included response rate, global mental state, adverse effects and cognitive function. RESULTS： Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened, with controls receiving sham stimulation. All data were completely effective, involving 398 patients. Overall mean weighted effect size for repeti- tive transcranial magnetic stimulation versus sham stimulation was statistically significant （MD = -0.42, 95%C/： -0.64 to -0.20, P = 0.000 2）. Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation （OR = 2.94, 95%C/： 1.39 to 6.24, P =0.005）. No significant differences were found between active repetitive transcranial magnetic stimulation and sham stimulation for positive or negative symptoms. Compared with sham stimulation, active repeti- tive transcranial magnetic stimulation had equivocal outcome in cognitive function and commonly caused headache and facial muscle twitching. CONCLUSION： Repetitive transcranial magnetic stimulation is a safe and effective treatment for auditory hallucination in schizophrenia spectrum disorders,

Laplace Transformation and Ergodic Potential Kernel for q-Process in Random Environment

This paper introduces some concepts such as q- process in random environment, Laplace transformation, ergodic potential kernel, error function and some basic lemmas.We study the continuity and Laplace transformation of random transition function. Finally, we give the sufficient condition for the existence of ergodic potential kernel for homogeneous q- processes in random environments.

A reliability study of springback on the sheet metal forming process under probabilistic variation of prestrain and blank holder force

This work deals with a reliability assessment of springback problem during the sheet metal forming process. The effects of operative parameters and material properties, blank holder force and plastic prestrain, on springback are in- vestigated. A generic reliability approach was developed to control springback. Subsequently, the Monte Carlo simula- tion technique in conjunction with the Latin hypercube sam- pling method was adopted to study the probabilistic spring- back. Finite element method based on implicit/explicit al- gorithms was used to model the springback problem. The proposed constitutive law for sheet metal takes into account the adaptation of plastic parameters of the hardening law for each prestrain level considered. Rackwitz-Fiessler al- gorithm is used to find reliability properties from response surfaces of chosen springback geometrical parameters. The obtained results were analyzed using a multi-state limit reli- ability functions based on geometry compensations.

APPLICATIONS OF HYPERGEOMETRIC SUMMATION THEOREMS OF KUMMER AND DIXON INVOLVING DOUBLE SERIES

Using series iteration techniques identities and apply each of these identities in we derive a number of general double series order to deduce several hypergeometric reduction formulas involving the Srivastava-Daoust double hypergeometric function. The results presented in this article are based essentially upon the hypergeometric summation theorems of Kummer and Dixon.

Ten Reflections on 5G

5G takes the concept of service-oriented architecture to replace the priority principle of network efficiency in the Internet to meet requirements of the industrial Internet and smart cities,such as high reliability and low latency.On the other hand,in order to adapt to the uncertainty of future business,5G features the openness of services and the Internet protocols,different from the closeness of traditional telecommunication networks.Although 5G tries to have the advantages of both the Internet and telecommunication network,its realization still faces many challenges.In this paper,ten major issues concerning 5G networking and service offering are discussed.

H_∞ Optimal Model Reduction for Singular Fast Subsystems

In this paper, H∞ optimal model reduction for singular fast subsystems will be inves-tigated. First, error system is established to measure the error magnitude between the original andreduced systems, and it is demonstrated that the new feature for model reduction of singular systemsis to make H∞ norm of the error system finite and minimal. The necessary and su?cient conditionis derived for the existence of the H∞ suboptimal model reduction problem. Next, we give an exactand practicable algorithm to get the parameters of the reduced subsystems by applying the matrixtheory. Meanwhile, the reduced system may be also impulsive. The advantages of the proposedalgorithm are that it is more ?exible in a straight-forward way without much extra computation, andthe order of the reduced systems is as minimal as possible. Finally, one illustrative example is givento illustrate the e?ectiveness of the proposed model reduction approach.

Statistical significance of non-reproducibility of cross sections measured in dissipative reactions ^(19)F+^(93)Nb

Two independent measurements of cross sections for the 19F+93Nb dissipative heavy-ion collision (DHIC) have been performed at incident energies from 100 to 108 MeV in steps of 250 keV. Two independently prepared targets were used respectively with all other experimental conditions being identical in both experiments. The data indicate non-reproducibility of the non-self-averaging oscillation yields in the two measurements. The statistical analysis of this non-reproducibility supports recent theoretical predictions of spontaneous coherence, slow phase randomization and extreme sensitivity in highly excited quantum many-body systems.

A Linear Immigration-Birth-Death Model and Its Statistical Inference

formula of simulation proccss by In this paper, we employ monmnt generating function to obtain some exact transition probability of inlmigration-birth-death（IBD） model and discuss the of sample path and statistical inference with complete observations of the IBD the exact transition density formula.

Oxygen Molecule Activation on Single-Atom Catalysts with Cu, Ag, and Au: A Cluster Model Study

(M = Au, Ag, Cu;n= 1, 2, 3) clusters were used as a cluster model to study the activation of oxygen molecules on single-atom catalysts. Structures of clusters were studied by density functional calculations with global optimization. For each n, the most stable structures are quite similar for different metal types, and the oxygen molecule prefers to be adsorbed onto M atoms. It is found that the activation degree of oxygen is higher on clusters with non-noble metal Cu than that of Ag or Au containing clusters, by comparing the changes of O-O bond length and vibrational frequency, natural charge population analysis, Fuzzy bond order analysis, and energy barriers of O2 dissociation. CO oxidation was used as a probe reaction to study the reactivity of Cu-containing clusters, and it is found that the reactivity decreases with the increase of the size of silicon-oxygen clusters. Our results give a new aspect to understand the reaction mechanism of non-precious metal single-atom catalyst for oxygen activation with high efficiency.

基于IKAP理论的呼吸专项训练对老年肺癌患者肺康复依从性、希望水平和肺功能的影响

目的探讨基于信息知识信念行为(Information-Knowledge-Attitude-Practice,IKAP)理论的呼吸专项训练对老年肺癌患者肺康复依从性、希望水平和肺功能的影响。方法回顾性选取2022年4月—2024年4月由南京医科大学附属肿瘤医院收治的80例老年肺癌患者为研究对象,按照干预方法的不同分为观察组(42例,基于IKAP理论的呼吸专项训练)和对照组(38例,常规呼吸训练)。对比2组康复依从性、希望水平、肺功能、并发症发生率、护理满意率。结果干预后,观察组患者康复依从率高于对照组(90.48%vs 71.05%,P<0.05);观察组中文版Herth希望量表各维度评分均高于对照组,差异均有统计学意义(P<0.05);观察组患者MVV、FEV1、FVC值均高于对照组,差异均有统计学意义(P<0.05);观察组总并发症发生率低于对照组(7.14%vs 23.68%,P<0.05);观察组护理满意率高于对照组护理满意率(100.00%vs 84.21%,P<0.05)。结论基于IKAP理论的呼吸专项训练可提升老年肺癌患者希望水平,增加其康复依从性,改善其肺功能。