A New Hybrid Model of Amino Acid Substitution for Protein Functional Classification

In this paper, a new hybrid model of amino acid substitution is developed and compared with the others in previous works. The results show that the new hybrid model can characterize the protein sequences very well by calculating Fisher weights, which can denote how much the variants contribute to the classification.

FUNCTIONAL CLASSIFICATION OF PITUITARY ADENOMA

Pituitary adenoma may be calssifded in light of the hormones produced. 225 surgical specimens were labeled with anti-sear of GH, PRL. ACTH, TSH, FSH and LH by immunohistochemical technique (ABC method). Data indicated that 100 out of 225 cases (44.5%) were monohormonal adenomas, including 24 GH, 39 PRL, 1 FSH and 9 LH, 77 (34.2%) were multi-hormonal adenomas, including 28 positive for 2 hormones, 30 positive for 3 hormones, 19 positive for 4 or more different hormones, and the remaining 48 (21.3%) were nonfunctional adenomas. In comparison with Kovacs series, factors which might participate in the mechanism of developing monohormonal or multi-hormonal adenomas are discussed.

A NEW FUNCTIONAL CLASSIFICATION OF STOMACH CANCER AND ITS PATHOBIOLOGICAL AND CLINICAL SIGNIFICANCE

The functional differentiations of stomach cancer specimens from 121 patients were investigated by enzyme-,mucin-,affinity-and immunohistochemical methods, and the stomach cancers were divided into five functionally differentiated types : 1 ) Absorptive Function Differentiation Type (AFDT), 19. 8% ; 2) Mucin Secreting Function Differentiation Type(MSFDT) , 24. 0% ; 3) Absorptive and Mucin-Producing Function Differentiation Type(AMPFDT) , 47. 1%; 4 ) Special Function Differentiation Type(SFDT) , 0. 8 %; and 5) Non-Function Differentiation Type(NFDT) , 8. 3%. The results indicate that stomach cancer tissues of the same histological type often display differing functional differentiation, and these functionally differentiated types have different invasive and metastatic characteristics. In addition, the functionally differentiated types have particular organic affinities of metastasis and different clinical prognoses. This study suggests that this new functional classification may supplement histological classification. The mechanisms of liver and ovary metastases of stomach cancer are also dis-cussed.

THE CLASSIFICATION OF INDUSTRIAL FUNCTION OF CHINESE CITIES (INCLUDING ATTACHED COUNTIES)

Represents the first attempt to classify all of China’s295 cities in terms of industrial functions,using 1984 data.Within the framework of economic base theory of urban development,three elements are defined as specialized branch,functional intensity and functional scale.The method used here is based on a combination of the three elements.A number of techniques tried made it possible to base the classification on a composite measure,consisting of the Ward’s Error Method of hierarchical cluster analysis and a supplementary application of Nelson measure.The 295 cities have been grouped into three categories with 19 subcategories and 54 functional groups.The distribution of cities in most of the subcategories are displayed on 8 maps.

Rehabilitation of shoulder paresis caused by herpes zoster according to the International Classification of Functioning, Disability and Health A case report

We describe the case of a 73-year-old man with left shoulder paresis caused by a herpes zoster infection of the left C5 dermatomes. The patient had been affected by pain for 10 days, a skin rash on his left shoulder and back for 5 days, and weakness of his left shoulder for 2 days before admission. Eiectromyography revealed denervation discharges from the left supraspinatus, infraspinatus and deltoid muscles, which was compatible with radiculopathy showing after zoster infection. The patient was examined in accordance with the International Classification of Functioning, Disability and Health, and treated with range-of-movement and strengthening exercises as well as activities of daily living and social participation. At 14 months after the onset of the condition, muscle strength had returned to normal. Electromyography revealed that motor unit action potentials were largely normal. These results indicate that the rehabilitation of paresis caused by herpes zoster can obtain positive results with suitable movement training.

Chronic Diseases of Childhood and the International Classification of Functioning, Disability, and Health: A Systematic Review

The increase in chronic diseases in childhood highlights the need for a biopsychosocial approach to deal with the complexity of these health conditions. The International Classification of Functioning, Disability, and Health (ICF) results from the need to implement new explanatory evaluative and therapeutic models. Thus, the present systematic review aims to identify published studies on the use of the ICF in chronic childhood diseases. As a secondary objective, to map the themes that have already been studied in the area to support the discussion on the expansion of the use of this classification in health services. The systematic review followed the PRISMA protocol, and the model was the PICO acronym, where Population was children and adolescents with chronic diseases, Intervention/Exposure was evaluation based on ICF concepts, Comparator was any tool, instrument, or intervention, and outcome was direct or indirect use of the ICF. We selected eight articles, five of which used the ICF as a conceptual tool and three as a classification system, divided into the following themes: quality of life, evaluation of patients (without using coding) and mapping the inclusion of the activity’s results and participation in clinical trials. Thus, use of the ICF in clinical practice is still incipient, although it has been recommended in guidelines. Further studies are necessary to expand the number of contributions by the ICF and to develop the necessary approaches for understanding the classification’s use.

Prognostic factors and its predictive value in patients with metastatic spinal cancer

BACKGROUND The spine is the most common location of metastatic diseases.Treating a metastatic spinal tumor depends on many factors,including patients’overall health and life expectancy.The present study was conducted to investigate prognostic factors and clinical outcomes in patients with vertebral metastases.AIM To investigate prognostic factors and their predictive value in patients with metastatic spinal cancer.METHODS A retrospective analysis of 109 patients with metastatic spinal cancer was conducted between January 2015 and September 2017.The prognoses and survival were analyzed,and the effects of factors such as clinical features,treatment methods,primary lesions and affected spinal segments on the prognosis of patients with metastatic spinal cancer were discussed.The prognostic value of Frankel spinal cord injury functional classification scale,metastatic spinal cord compression(MSCC),spinal instability neoplastic score(SINS)and the revised Tokuhashi score for prediction of prognosis was explored in patients with metastatic spinal tumors.RESULTS Age,comorbidity of metastasis from elsewhere,treatment methods,the number of spinal tumors,patient’s attitude toward tumors and Karnofsky performance scale score have an effect on the prognosis of patients(all P<0.05).With respect to classification of spinal cord injury,before operation,the proportion of grade B and grade C was higher in the group of patients who died than in the group of patients who survived,and that of grade D and grade E was lower in the group of patients who died than in the group of patients who survived(all P<0.05).At 1 mo after operation,the proportion of grade A,B and C was higher in the group of patients who died than in the group of patients who survived,and that of grade E was lower in patients in the group of patients who died than in the group of patients who survived(all P<0.05).MSCC occurred in four(14.3%)patients in the survival group and 17(21.0%)patients in the death group(P<0.05).All patients suffered from intractable pain,dysfunction in spinal cord and even paralysis.The proportion of SINS score of 1 to 6 points was lower in the death group than in the survival group,and the proportion of SINS score of 7 to 12 points was higher in the death group than in the survival group(all P<0.05).The proportion of revised Tokuhashi score of 0 to 8 points and 9 to 11 points were higher in the death group than in the survival group,and the proportion of revised Tokuhashi score of 12 to 15 points was lower in the death group than in the survival group(all P<0.05).Frankel spinal cord injury functional classification scale,MSCC,SINS and revised Tokuhashi score were important factors influencing the surgical treatment of patients with metastatic spinal cancer(all P<0.05).CONCLUSION Frankel spinal cord injury functional classification scale,MSCC,SINS and revised Tokuhashi score were helpful in predicting the prognosis of patients with metastatic spinal cancer.

International Health Classification Family and International Classification of Functioning

The theoretical framework, terminology and coding of the InternationalClassification of Functioning, Disability and Health for Children andYouth are useful tools for content analysis of physical activity guidelines forchildren and adolescents. The guidelines for physical activity for children andadolescents at home and abroad have their own policy background and healthrelated theoretical basis for healthy development. The formulation and implementation of physical activity guidelines for children and adolescents shouldbe based on the national health policy, propose programs suitable for childrenand adolescents, and guide the implementation of the guidelines. This papersummarizes the use in patients with cerebral palsy and those on the autismspectrum. Based on the theoretical framework and methodological systemof research rehabilitation guidelines based on the World Health OrganizationFamily International Classifications, pay attention to the policy backgroundand theoretical basis, activity mode and amount, benefits and influencingfactors of physical activity guidelines for children and adolescents, and provide theoretical basis and methodological guidance for the formulation andimplementation of relevant guidelines.

Corticoreticular tract lesion in children with developmental delay presenting with gait dysfunction and trunk instability

The corticoreticular tract （CRT） is known to be involved in walking and postural control. Using diffusion tensor tractography （DTT）, we investigated the relationship between the CRT and gait dysfunction, includ- ing trunk instability, in pediatric patients. Thirty patients with delayed development and 15 age-matched, typically-developed （TD） children were recruited. Fifteen patients with gait dysfunction （bilateral trunk instability） were included in the group A, and the other 15 patients with gait dysfunction （unilateral trunk instability） were included in the group B. The Growth Motor Function Classification System, Functional Ambulation Category scale, and Functional Ambulation Category scale were used for measurement of functional state. Fractional anisotropy, apparent diffusion coefficient, fiber number, and tract integrity of the CRT and corticospinal tract were measured. Diffusion parameters or integrity of corticospinal tract were not significantly different in the three study groups. However, CRT results revealed that both CRTs were disrupted in the group A, whereas CRT disruption in the hemispheres contralateral to clinical mani- festations was observed in the group B. Fractional anisotropy values and fiber numbers in both CRTs were decreased in the group A than in the group TD. The extents of decreases of fractional anisotropy values and fiber numbers on the ipsilateral side relative to those on the contralateral side were greater in the group B than in the group TD. Functional evaluation data and clinical manifestations were found to show strong correlations with CRT status, rather than with corticospinal tract status. These findings suggest that CRT status appears to be clinically important for gait function and trunk stability in pediatric patients and DTT can help assess CRT status in pediatric patients with gait dysfunction.

Multi－variate Stepwise Discriminant Analysis Research Affecting Portal Hypertension＇s Grade Factors of Liver Function

The idtal time for selecting portal hypertension operation is the accurate judgement of the grade of liver function.yet the present criterion in grading liver functicn is controversial.tco pztitnts vith 20 factoxs related to poxttl hypeitersor wexe undergone stepwise discriminant analysis by using SAS software on the IBM/PC computer(significance levtl α=0.05).The results show that ascites degree prothrombin tmie(PT),serum total bilirubin,serum albumin content,main portal vein flow are significant fators.In the light of above variates contributing to grading liver function as to estblish a discriminant eqation,it was found that the total agreement rate between replaceable discimination and original Child-Pugh classification is 86%.A test for agieement was performed between discriminant and original classificaton,showing that the two kinds of classification methods have a good agreement rates (Kppa=0.7856),indicating the discriminant classification is of practica values.

Integrating urban morphology and land surface temperature characteristics for urban functional area classification

The classification of urban functional areas plays an important role in urban planning and resource management.Although previous studies have confirmed that different urban func-tional areas have different morphological structures and Land Surface Temperature(LST)characteristics,these two types of characteristics have rarely been fully integrated and used for functional area classification.In this paper,a new framework for classifying urban functional areas is proposed by combining urban morphological features and LST features.First,metrics are constructed from three levels,namely,building,road and region,which are used to portray urban morphology;LST is retrieved using thermal infrared remote sensing to reflect LST features with four metrics:the average temperature,maximum temperature,temperature difference and standard deviation of temperature.Then,the functional areas are classified into four categories:service/public land,commercial land,residential land and industrial land.A random forest algorithm is used to effectively fuse the features of these two categories and classify the functional areas.The effectiveness of the proposed framework is tested in the study area of Shenzhen City,Guangdong Province.The results show that the combined classification accuracy of the proposed classification method is 0.85,which is 0.26 higher than that of the classification model based on urban morphology and 0.1 higher than that of the classification model based on LST features.The proposed framework verifies that the integration of LST features into urban functional area classification is reliable and effectively combines urban morphology and LST features for functional area classification.

The value of real-time three-dimensional echocardiography in evaluating left ventricular function for different degrees of heart failure

Objective:To explore the value and feasibility of real-time three-dimensional echocardiography(RT-3DE)in evaluating left ventricular function in patients with different degrees of heart failure.Methods:The 60 heart failure patients in the case group were divided into three subgroups according to the New York Heart Association(NYHA)classification:12 cases of cardiac function gradeⅡ,35 cases of cardiac function gradeⅢ,13 cases of cardiac function grade IV,and the other 30 cases of healthy subjects as control group.Compare the left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF),and left ventricular 16,12,and 6 segments reaching the minimum systolic volume time standard deviation standardized value(Tmsv SD%),left ventricular 16,12 and 6 segments reaching the minimum systolic volume time standardized values of the maximum difference(Tmsv DIF%),analysis of the correlation between the above left ventricular function-related parameters and cardiac function grading.Results:(1)There were statistically significant differences in LVEDV and LVESV between each group(p<0.001).There was no statistically significant difference in LVEF between the cardiac function gradeⅡgroup and the control group,and between the grade IV group and the gradeⅢgroup(p=0.094 and 0.246).(2)compared with the control group,all parameters related to RT-3DE evaluation of left ventricular synchronization were prolonged in the case group,and the difference was statistically significant(p<0.001).The differences of Tmsv 16-SD%and Tmsv 16-DIF%in each subgroup of the case group were statistically significant(p<0.001).(3)LVEF was negatively correlated with NYHA classification of cardiac function(rs=-0.779,p<0.001),and LVEDV,LVESV,Tmsv 16-SD%,Tmsv 12-SD%,Tmsv 6-SD%,Tmsv 16-DIF%,Tmsv 12-DIF%,Tmsv 6-DIF%were positively correlated with NYHA function classification,showing strong correlation(rs=0.710,0.785,0.885,0.675,0.605,0.885,0.695,0.622,p<0.001),among them,Tmsv 16-SD%and Tmsv 16-Dif%have the highest correlation.Conclusion:RT-3DE can comprehensively evaluate the impairment of cardiac function.The measured parameters of left ventricular function are strongly correlated with cardiac function classification,which has impo-rtant application value for clinical judgment of the severity of heartfailure.

Algae functional group characteristics in reservoirs and lakes with different trophic levels in northwestern semi-humid and semi-arid regions in China

In order to study the differences in algae species and their biomass in water bodies in a region, three reservoirs and two lakes at the center of Guanzhong Plain were chosen to identify algae functional groups, measure biomass, and assess water quality, from January2013 to December 2014. The water bodies represented different trophic levels： one oligotrophic, three mesotrophic, and one eutrophic. Based on the Reynolds’ functional groups, they had 10 groups in common—B, P, D, X1, M, MP, F, S1, J, and G, but the algae biomasses and proportions were different. In the oligotrophic reservoir, functional group B reached a peak biomass of 576 × 104 L-1, which accounted for 31.27%. In the eutrophic lake,functional group D reached a peak biomass of 3227 × 104 L-1, which accounted for only13.38%. When samples collected from other water bodies with similar trophic levels were compared, we found differences in the algae species functional groups. The potential reasons for the differences in algae functional group characteristics in the different water bodies in the region were water temperature and nutritional states.

Application of the international classification of functioning, disability and health in China

Implementation of the International Classification of Functioning, Disability and Health （ICF） started in 2001 with the unanimous endorsement of the classification by the 54th World Health Organization （WHO） as a framework for describing and measuring health and disability. In recent years, the ICF has been increasingly applied to research and development in China, and has influenced the policies of the Chinese Disabled Person Enterprise and Chinese Rehabilitation Career. This paper introduces the translation, training and spread of ICF and its application in the fields of medicine, society and education in China.

Strategic Digital Transformation of State-owned Enterprises:Mission Embedding and Mode Selection-A Case Study Based on the Typical Digital Transformation of Three State-owned Enterprises

China’s state-owned enterprises(SOEs)are facing an embedded integration of new functional mission,new classification reform and new digital development.These new tasks require SOEs to embrace digital strategic transformation and innovation for high-quality fulfillment of their national mission.Studying their digital transformation practices,this paper systematically explores the mechanism and path of embedding national mission into SOE digital transformation,and the mode selection of SOE digital transformation under different mission guidance.The findings are:(1)The SOE functional mission focusing on economic development,strategic support and public services in the new era is undertaken by for-profit,strategic and public functional SOEs;(2)the foreign circulation path based on the positioning mechanism-mapping mechanism and the internal consumption connection path for the state capital strategic positioning constitute a double twoway mechanism of embedding the national mission to the SOE digital strategic transformation,leading SOEs to build market-oriented,capacity-oriented and public-oriented digital transformation modes;(3)the three types of reform modes have respectively produced the action mechanism featuring agile strengthening,toughness strengthening and adaptability strengthening,which support the SOE classification performance.This paper attempts to make up for the research gap such as the lack of integration of the SOE digital strategic transformation mode by constructing the theoretical mode of SOE digital strategic transformation under the guidance of national mission,and reveals the intermediary mechanism of digital strategic transformation to support SOEs for fulfilling their functional missions.

Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children:a randomized controlled trial

Background Constipation is a common problem in children with spastic cerebral palsy(sCP)with a prevalence that reaches 75%.We hypothesized that treating constipation in those children will improve their health and shorten time spent in daily care.Our aim was to evaluate the efficacy and safety of oral magnesium sulfate for treating chronic constipation in children with sCP.Methods A prospective,double-blinded randomized control trial was carried out involving 100 children aged 2-12 years with sCP(level Ⅲ-Ⅴ of the Gross Motor Functional Classification system)and chronic constipation.They were followed up in the Pediatric neurology clinic,Children's hospital,Ain Shams University,May 2017-January 2019.The intervention group(O-Mg)received oral magnesium sulfate 1 mL/kg/day daily for 1 month compared to the placebo.Outcome measures were constipation improvement and decrease in bowel evacuation time after 1 month.Results Initially,weekly bowel movements,constipation scores and stool consistency were comparable in both groups.After 1 month of regular administration of oral magnesium sulfate,the constipation score,stool frequency and consistency improved compared to the placebo group(P<0.001).Effective safe treatment was achieved in 31(68%)and 4(9.5%)patients in the O-Mg and placebo groups,respectively(RR,2.95;95%CI 2.0-4.5)(P<0.001).Painful bowel evacuation attempts spent by mothers decreased from 25(55.6%)of the cases initially to 10(22%)cases after one month in the O-Mg group(P=0.001).In contrast,in the placebo group,the decrease went from 21(50%)cases initially to 18(42.9%)after 1 month and was not significant(P=0.5).Conclusions Oral magnesium sulfate seems effective in alleviating chronic constipation and pain experience in children with sCP.Consequently,saving maternal time spent in daily bowel evacuation attempts.

Wind Power Prediction Based on Multi-class Autoregressive Moving Average Model with Logistic Function

The seasonality and randomness of wind present a significant challenge to the operation of modern power systems with high penetration of wind generation. An effective shortterm wind power prediction model is indispensable to address this challenge. In this paper, we propose a combined model, i.e.,a wind power prediction model based on multi-class autoregressive moving average(ARMA). It has a two-layer structure: the first layer classifies the wind power data into multiple classes with the logistic function based classification method;the second layer trains the prediction algorithm in each class. This two-layer structure helps effectively tackle the seasonality and randomness of wind power while at the same time maintaining high training efficiency with moderate model parameters. We interpret the training of the proposed model as a solvable optimization problem. We then adopt an iterative algorithm with a semi-closed-form solution to efficiently solve it. Data samples from open-source projects demonstrate the effectiveness of the proposed model. Through a series of comparisons with other state-of-the-art models, the experimental results confirm that the proposed model improves not only the prediction accuracy,but also the parameter estimation efficiency.

Concept of the integrative aspects of the forest ecosystem services with case study on recreation services assessment in Slovakia

Introduction:This paper presents basic information on the research,classification,and application of the functions of tree species and their communities(mainly forest)in Slovakia.The main aim is a scientific assessment of acquired knowledge regarding the functional effects of forests under real ecological,forest management and socio-economic conditions from various regions in Slovakia;the most up-to-date findings concerning the ecology and economics of natural resources will be applied here.The second part of the paper presents methodological possibilities for valuation of outdoor recreation in forests.Different methods and methodological approaches suitable to a valuation of recreation based on various principles and criteria(preference and non-preference methods,cost-based methods,revenue-based methods,and direct and indirect methods)are analyzed.A practical application of one indirect preference method(travel cost method)is made to evaluate outdoor recreation in forests in Slovakia.Results and conclusions:A new classification system and a methodology of integrative utilization of forest functions for the forest ecosystem services are constructed.Outdoor recreation in forests,besides recreational forests and areas,assumes the character of a public good:its use by individuals has some influence on utilization by other individuals,and single users cannot be excluded from its utilization.Therefore,some stimulation for its production is missing.In principle,there are no markets for these kinds of public goods and services.The total value of outdoor recreation in forests in Slovakia amounted to€163.4 million;if opportunity time costs were included,this amounted to as much as€825.7 million.