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Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image
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作者 Yiwei Chen Yi He +3 位作者 Hong Ye Lina Xing Xin Zhang Guohua Shi 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第3期105-113,共9页
The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image processing.Prediction comprises estimating FFA from fundus camera im... The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image processing.Prediction comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from SLO.Although many deep learning models are available,a single model can only perform one or two of these prediction tasks.To accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial network.The three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test set.By comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our proposal.The high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error. 展开更多
关键词 fundus fluorescein angiography image fundus structure image image translation unified deep learning model generative adversarial networks
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Application of non-mydriatic fundus photography-assisted telemedicine in diabetic retinopathy screening 被引量:1
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作者 Wan Zhou Xiao-Jing Yuan +4 位作者 Jie Li Wei Wang Hao-Qiang Zhang Yuan-Yuan Hu Shan-Dong Ye 《World Journal of Diabetes》 SCIE 2024年第2期251-259,共9页
BACKGROUND Early screening and accurate staging of diabetic retinopathy(DR)can reduce blindness risk in type 2 diabetes patients.DR’s complex pathogenesis involves many factors,making ophthalmologist screening alone ... BACKGROUND Early screening and accurate staging of diabetic retinopathy(DR)can reduce blindness risk in type 2 diabetes patients.DR’s complex pathogenesis involves many factors,making ophthalmologist screening alone insufficient for prevention and treatment.Often,endocrinologists are the first to see diabetic patients and thus should screen for retinopathy for early intervention.AIM To explore the efficacy of non-mydriatic fundus photography(NMFP)-enhanced telemedicine in assessing DR and its various stages.METHODS This retrospective study incorporated findings from an analysis of 93 diabetic patients,examining both NMFP-assisted telemedicine and fundus fluorescein angiography(FFA).It focused on assessing the concordance in DR detection between these two methodologies.Additionally,receiver operating characteristic(ROC)curves were generated to determine the optimal sensitivity and specificity of NMFP-assisted telemedicine,using FFA outcomes as the standard benchmark.RESULTS In the context of DR diagnosis and staging,the kappa coefficients for NMFPassisted telemedicine and FFA were recorded at 0.775 and 0.689 respectively,indicating substantial intermethod agreement.Moreover,the NMFP-assisted telemedicine’s predictive accuracy for positive FFA outcomes,as denoted by the area under the ROC curve,was remarkably high at 0.955,within a confidence interval of 0.914 to 0.995 and a statistically significant P-value of less than 0.001.This predictive model exhibited a specificity of 100%,a sensitivity of 90.9%,and a Youden index of 0.909.CONCLUSION NMFP-assisted telemedicine represents a pragmatic,objective,and precise modality for fundus examination,particularly applicable in the context of endocrinology inpatient care and primary healthcare settings for diabetic patients.Its implementation in these scenarios is of paramount significance,enhancing the clinical accuracy in the diagnosis and therapeutic management of DR.This methodology not only streamlines patient evaluation but also contributes substantially to the optimization of clinical outcomes in DR management. 展开更多
关键词 DIABETES Diabetic retinopathy Non-mydriatic fundus photography-assisted telemedicine fundus fluorescein angiography
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Fundus photography,fundus fluorescein angiography,and optical coherence tomography of healthy cynomolgus monkey,New Zealand rabbit,Sprague Dawley rat,and BALB/c mouse retinas
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作者 Bikun Xian Minglei Zhao +5 位作者 Yuting Peng Wencong Wang Zhiquan Li Hening Zhang Weihua Li Bing Huang 《Annals of Eye Science》 2023年第3期48-58,共11页
Background:A variety of experimental animal models are used in basic ophthalmological research to elucidate physiological mechanisms of vision and disease pathogenesis.The choice of animal model is based on the measur... Background:A variety of experimental animal models are used in basic ophthalmological research to elucidate physiological mechanisms of vision and disease pathogenesis.The choice of animal model is based on the measurability of specific parameters or structures,the applicability of clinical measurement technologies,and the similarity to human eye function.Studies of eye pathology usually compare optical parameters between a healthy and altered state,so accurate baseline assessments are critical,but few reports have comprehensively examined the normal anatomical structures and physiological functions in these models.Methods:Three cynomolgus monkeys,six New Zealand rabbits,ten Sprague Dawley(SD)rats,and BALB/c mice were examined by fundus photography(FP),fundus fluorescein angiography(FFA),and optical coherence tomography(OCT).Results:Most retinal structures of cynomolgus monkey were anatomically similar to the corresponding human structures as revealed by FP,FFA,and OCT.New Zealand rabbits have large eyeballs,but they have large optic disc and myelinated retinal nerve fibers in their retinas,and the growth pattern of retinal vessels were also different to the human retinas.Unlike monkeys and rabbits,the retinal vessels of SD rats and BALB/c mice were widely distributed and clear.The OCT performance of them were similar with human beings except the macular.Conclusions:Monkey is a good model to study changes in retinal structure associated with fundus disease,rabbits are not suitable for studies on retinal vessel diseases and optic nerve diseases,and rats and mice are good models for retinal vascular diseases.These measures will help guide the choice of model and measurement technology and reduce the number of experimental animals required. 展开更多
关键词 fundus fluorescein angiography(FFA) fundus photography(FP) optical coherence tomography(OCT) experimental animals
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Fundus photography,fluorescein angiography,optical coherence tomography and electroretinography of preclinical animal models of ocular diseases
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作者 Sandeep Kumar 《Annals of Eye Science》 2023年第3期70-76,共7页
The eye is an immune-privileged and sensory organ in humans and animals.Anatomical,physiological,and pathobiological features share significant similarities across divergent species(1).Each compartment of the eye has ... The eye is an immune-privileged and sensory organ in humans and animals.Anatomical,physiological,and pathobiological features share significant similarities across divergent species(1).Each compartment of the eye has a unique structure and function.The anterior and posterior compartments of the eye contain endothelium(cornea),epithelium(cornea,ciliary body,iris),muscle(ciliary body),vitreous and neuronal(retina)tissues,which make the eye suitable to evaluate efficacy and safety of tissue specific drugs(2). 展开更多
关键词 Retinal fundus photography sodium fluorescein and indocyanine green angiography optical coherence tomography(OCT) ELECTRORETINOGRAPHY animal models of ocular diseases
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Fundus autofluorescence in central serous chorioretinopathy: association with spectral-domain optical coherence tomography and fluorescein angiography 被引量:7
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作者 Peng Zhang Hai-Yan Wang +4 位作者 Zi-Feng Zhang Dong-Jie Sun Jin-Ting Zhu Juan Li Yu-Sheng Wang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2015年第5期1003-1007,共5页
and FA for identifying pathological abnormalities in CSC. The characteristics of IA AF in CSC were attributable to the modification of melanin in the RPE. IR- AIM: To evaluate the correlation among changes in fundus a... and FA for identifying pathological abnormalities in CSC. The characteristics of IA AF in CSC were attributable to the modification of melanin in the RPE. IR- AIM: To evaluate the correlation among changes in fundus autofluorescence (AF) measured using infrared fundus AF (IR -AF) and short-wave length fundus AF (SW -AF) with changes in spectral -domain optical coherence tomography (SD -OCT) and fluorescein angiography (FA) in central serous chorioretinopathy (CSC). METHODS: Two hundred and twenty consecutive patients with CSC were included. In addition to AF, patients were assessed by means of SD -OCT and FA. Abnormalities in images of IA -AF, SW -AF, FA were analyzed and correlated with the corresponding outer retinal alterations in SD-OCT findings. RESULTS: Eyes with abnormalities on either IR-AF or SW-AF were found in 256 eyes (58.18%), among them 256 eyes (100%) showed abnormal IR -AF, but SW-AF abnormalities were present only in 213 eyes (83.20%). The hypo-IR-AF corresponded to accumulation of subretinal liquid, collapse of retinal pigment epithelium (APE) or detachment of APE with or without RPE leakage point in the corresponding area. The hyper -IR -AF corresponded to the area with loss of the ellipsoid portion of the inner segments and sub -sensory retinal deposits or focal melanogenesis under sensory retina. The hypo-SW-AF corresponded to accumulation of subretinal liquid or atrophy of RPE. The hyper -SW -AF associated with sub -sensory retinal deposits, detachment of RPE and focal melanogenesis. CONCLUSION: IR-AF was more sensitive than SW-AF AF should be used as a common diagnostic tool for identifying pathological lesion in CSC. 展开更多
关键词 central serous chorioretinopathy fluorescein angiography fundus autofluorescence optical coherence tomography
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Comparison of fundus fluorescein angiography and fundus photography grading criteria for early diabetic retinopathy 被引量:2
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作者 Xin-Yue Li Shu Wang +1 位作者 Li Dong Hong Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2022年第2期261-267,共7页
AIM:To compare the assessment outcomes of the characteristics of mild to moderate non-proliferative diabetic retinopathy(NPDR) established by fundus photography and fundus fluorescein angiography(FFA).METHODS:The fund... AIM:To compare the assessment outcomes of the characteristics of mild to moderate non-proliferative diabetic retinopathy(NPDR) established by fundus photography and fundus fluorescein angiography(FFA).METHODS:The fundus photos and FFA results of 260 patients with diabetes mellitus were reviewed.Diabetic retinopathy(DR) severity was graded based on the international classification standard.The microaneurysms,hemorrhages,and intraretinal microvascular abnormalities(IRMA) in FFA images of patients with mild to moderate NPDR were observed.The differences between the fundus photos and the FFA results were summarized,analyzed,and compared.RESULTS:The counting of intraretinal hemorrhages identified by FFA revealed that only 9 eyes(1.9%) had more than 20 intraretinal hemorrhages in all four quadrants;15 eyes(3.1%) had more than 20 intraretinal hemorrhages in three quadrants;26 eyes(5.4%) had over 20 intraretinal hemorrhages in two quadrants;and 37 eyes(7.7%) had more than 20 intraretinal hemorrhages in only one quadrant.Furthermore,the number of IRMAs appeared ≥4 in 17 eyes,3 in 35 eyes,2 in 69 eyes,and 1 in 93 eyes.CONCLUSION:FFA has higher detection accuracy of retinal angiopathy than fundus photography.FFA grading results are helpful for timely detection and proper treatment of lesions easily missed by fundus photography. 展开更多
关键词 diabetic retinopathy fundus fluorescein angiography grading criteria
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Can Fundus Fluorescein Angiography be Performed for Diabetic Patients on Oral Metformin 被引量:1
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作者 JunhuiDu Rong Li 《Chinese Medical Sciences Journal》 CAS CSCD 2017年第2期119-122,共4页
Metformin is a kind of biguanide hypoglycemic agent that has been widely used in patients with diabetes mellitus. In clinical practice, whether metformin should be stopped before Fundus fluorescein angiography (FFA)... Metformin is a kind of biguanide hypoglycemic agent that has been widely used in patients with diabetes mellitus. In clinical practice, whether metformin should be stopped before Fundus fluorescein angiography (FFA) remains largely unclear. Some endocrinologists suggest stop metformin before FFA. However, ophthalmologists do not always adopt this opinion in their practice. This situation may lead to disputes between physicians and patients. This article analyzed contrast-induced nephropathy(CIN) and the related contrast agent, as well as the adverse reactions of fluorescein angiography. It pointed out that the discrepancy may be caused by misunderstanding of contrast agents used in FFA. For angiography using iodine contrast agent, metformin must be stopped because of the increased possibility of CIN, while for FFA using fluorescein sodium, no CIN has been reported yet. Therefore, the authors believe FFA is safe for diabetic patients with oral metformin and it is unnecessary to stop metformin before the examination. 展开更多
关键词 fundus fluorescein angiography diabetes mellitus METFORMIN contrast-induced nephropathy
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Risk factors for adverse reactions of fundus fluorescein angiography 被引量:1
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作者 Yi Yang Jingzhuang Mai Jun Wang 《Eye Science》 CAS 2016年第2期86-91,共6页
Background:To explore the difference between the outcomes of correlations between a series of variables and adverse reactions(ARs)to fluorescein from univariate and multivariate analysis and to evaluate the nausea eff... Background:To explore the difference between the outcomes of correlations between a series of variables and adverse reactions(ARs)to fluorescein from univariate and multivariate analysis and to evaluate the nausea effects in different age groups.Methods:A retrospective study of patients undergoing consecutive fluorescein angiography between March2010 and February 2012 was conducted.No patients were excluded on the ground of age,presence of atopy,allergy history,previous procedures without severe allergic ARs,asymptomatic hypertension and kidney failure with serum creatinine levels lower than 250μmol/L or with renal dialysis.Results:A total of 829 patients were enrolled and 22.2%of them had ARs.The majority of reactions were nausea(12.1%)which occurred less when age became old(P<0.0001).When the correlations between a series of variables and ARs were assessed separately,age(P<0.0001),prior reactions(P<0.0001)and motion sickness(P=0.0062)were highly and cardio/cerebrovascular disease(P=0.0015),diabetes(P=0.0001)and renal disease(P=0.0219)were lowly related to ARs.However,when the correlations were assessed simultaneously,only age[odd ratio(OR)0.974;95%confidence interval(CI),0.962–0.986],prior reactions(OR 5.596;95%CI,2.083–15.029)and motion sickness(OR 4.849;95%CI,1.583–14.856)were statistically correlated with ARs.Conclusions:Fluorescein angiography is a safe procedure for patients who are relatively healthy but with a history of any systemic disease.Young age,prior reactions and motion sickness which are highly related to emetic events should be considered in the evaluation of ARs to fluorescein. 展开更多
关键词 不良反应 血管造影 荧光素 危险因素 过敏性疾病 眼底 心脑血管疾病 肾脏疾病
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Daytona超广角激光扫描眼底成像与FFA在老年白内障病人糖尿病性视网膜病变筛查中的一致性分析
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作者 刘戈 刘洋 罗杰 《实用老年医学》 CAS 2024年第11期1148-1152,共5页
目的探讨Daytona超广角激光扫描眼底成像与荧光素眼底血管造影(fundus fluorescein angiography,FFA)筛查老年白内障病人糖尿病性视网膜病变(diabetic retinopathy,DR)的一致性。方法采用横断面研究方法,选取2021年4月至2023年8月在大... 目的探讨Daytona超广角激光扫描眼底成像与荧光素眼底血管造影(fundus fluorescein angiography,FFA)筛查老年白内障病人糖尿病性视网膜病变(diabetic retinopathy,DR)的一致性。方法采用横断面研究方法,选取2021年4月至2023年8月在大庆油田总医院眼科门诊就诊的年龄≥60岁合并糖尿病的老年白内障病人172例(323眼),所有病人均接受Daytona超广角激光扫描眼底成像以及FFA检查,分别记录2种检查方法诊断DR以及DR分期情况。采用卡方检验、加权Kappa一致性检验、Spearman偏回归分析对2种检查结果的相关性进行分析。结果2种检查方法的可阅片率差异无统计学意义(93.8%比94.1%,P=0.869)。Daytona超广角系统检查时间较FFA检查时间明显缩短(Z=16.85,P<0.001)。排除未得到眼底图像25眼,最终153例298眼纳入一致性研究。Daytona超广角系统与FFA检测DR分期完全一致278只眼(93.29%),Kappa值为0.925,95%CI:0.892~0.958。以FFA为金标准,Daytona超广角系统检测增生型DR的敏感度和特异度分别为90.00%、100.00%,Kappa值为0.926;检测非增生型DR的敏感度、特异度分别为94.47%、90.91%,Kappa值为0.900。Daytona超广角系统与FFA检测DR分期结果呈高度正相关(r=0.921)。结论Daytona超广角激光扫描眼底成像对合并糖尿病的老年白内障病人DR筛查效果及分期与FFA有很好的一致性。 展开更多
关键词 Daytona超广角激光扫描眼底成像 眼底荧光血管造影检查 糖尿病性视网膜病变 白内障 糖尿病
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光学相干断层扫描血管成像参数诊断非增殖性糖尿病视网膜病变的价值分析
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作者 张琼 吴彦霖 +2 位作者 胡起维 张泽伟 黄守约 《诊断学理论与实践》 2024年第1期67-76,共10页
目的:分析光学相干断层扫描血管成像(optical coherence tomography angiography,OCTA)诊断非增殖性糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)的价值。方法:连续纳入2021年1月至2023年6月期间在我科门诊收治的12... 目的:分析光学相干断层扫描血管成像(optical coherence tomography angiography,OCTA)诊断非增殖性糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)的价值。方法:连续纳入2021年1月至2023年6月期间在我科门诊收治的122例有2型糖尿病病史(包括伴或不伴有视网膜病变)的患者,均接受眼底荧光血管造影(fundus fluorescein angiography,FFA)检查和OCTA定量检查。以FFA结果为金标准,并将患者根据FFA结果分为对照组(无NPDR)、轻度NPDR组、中度NPDR组和重度NPDR组。OCTA观察指标包括,视网膜黄斑区中央视网膜厚度(central macular thickness,CMT)、血管线性密度(vascular density,VD)、血流灌注密度(perfusion density,PD)、黄斑中心凹无血管区面积(foveal avascular zone area,FAZ-A)、黄斑中心凹无血管区周长(foveal avascular zone perimeter,FAZ-P)、圆形指数(foveal avascular zone circularity index,FAZ-CI)。用单因素方差或非参数方法分析比较各组间定量指标的差异,取其中存在显著组间差异的指标纳入多因素Logistic回归模型,分析反映NPDR患病和严重程度的指标,并绘制受试者工作特征(receiver operating characteristic,ROC)曲线分析单独或联合指标对于NPDR的诊断价值。结果:VD在各NPDR组中较对照组均显著下降,重度NPDR组较轻度、中度NPDR组均显著下降(P<0.05);PD在中度和重度NPDR组较对照组均显著下降(P<0.05),在重度NPDR组较轻度和中度NPDR组均显著下降(P<0.05);FAZ-A在各NPDR组中较对照组均显著下降(P<0.05),但在各NPDR组间均无统计学差异;FAZ-P在各NPDR组中较对照组均显著下降(P<0.05),但在各NPDR组间均无统计学差异;FAZ-CI在各组间均无统计学差异。多因素Logistic回归分析结果显示,CMT升高、VD和FAZ-P下降与NPDR患病相关(P=0.03,<0.001和0.001);CMT上升和VD下降与NPDR严重程度相关(P=0.01,<0.001)。ROC曲线分析显示,CMT(>260.00μm)、VD(<16.55/mm2)和FAZ-P(<2.15 mm)对NPDR均具有单独诊断价值(AUC分别为0.63、0.78和0.70),其中VD的诊断效能显著高于CMT(P=0.02),CMT与VD或FAZ-P的诊断效能之间则无统计学差异(P均>0.05)。CMT、VD和FAZ-P指标联合诊断NPDR的诊断效能(AUC=0.86)显著高于任一单项指标的诊断效能(P均<0.05)。结论:OCTA检查参数CMT、VD和FAZ-P均独立具备对NPDR的诊断价值,将三者联合使用则能进一步提高其诊断效能。OCTA血流参数联合黄斑形态参数可有效提高NPDR的临床诊断。 展开更多
关键词 光学相干断层扫描血管成像技术 眼底荧光血管造影 糖尿病视网膜病变
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OCTA在早期糖尿病视网膜病变诊断中的应用及特异度、灵敏度分析
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作者 黄玉苗 林水龙 陈雅珍 《糖尿病新世界》 2024年第9期173-175,共3页
目的分析光学相干断层扫描血管成像(optical coherence tomography angiography,OCTA)对早期糖尿病视网膜病变(diabetic retinopathy,DR)诊断中的价值。方法选取晋江市医院眼科于2023年1月—2024年1月收治的94例(176眼)疑似DR患者为研... 目的分析光学相干断层扫描血管成像(optical coherence tomography angiography,OCTA)对早期糖尿病视网膜病变(diabetic retinopathy,DR)诊断中的价值。方法选取晋江市医院眼科于2023年1月—2024年1月收治的94例(176眼)疑似DR患者为研究对象,均开展OCTA检查和眼底荧光素血管造影(fundus fluorescein angiography,FFA)。将FFA结果作为金标准,评价OCTA对早期DR的诊断价值,通过kappa一致性检验分析OCTA诊断DR与FFA结果的一致性。结果FFA共检出122眼DR,54眼无DR;OCTA共检出119眼DR,57眼无DR。OCTA诊断早期DR的灵敏度、特异度、准确度、阳性预测值、阴性预测值分别为94.26%、92.59%、93.75%、96.64%、87.72%。kappa检验结果可知,OCTA诊断DR与FFA结果的一致性较强(kappa=0.792)。结论OCTA诊断DR与FFA结果的一致性较强,有助于诊断早期DR,具有较高灵敏度、特异度。 展开更多
关键词 光学相干断层扫描血管成像 糖尿病性视网膜病变 眼底荧光素血管造影
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超广域SS-OCTA联合超广角激光扫描眼底成像对糖尿病视网膜病变的诊断价值 被引量:2
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作者 毛明珠 黎梦宇 +4 位作者 韦丁杨 陈丽 刘逸 李杰 钟捷 《眼科新进展》 CAS 北大核心 2024年第4期291-296,共6页
目的 超广域扫频源光学相干断层扫描血管成像(UWF SS-OCTA)联合超广角激光扫描眼底成像(UWF SLO)对糖尿病视网膜病变(DR)患者病变的检出率以及对DR分级诊断价值的研究。方法 横断面研究。招募在四川省人民医院眼科就诊的糖尿病患者。所... 目的 超广域扫频源光学相干断层扫描血管成像(UWF SS-OCTA)联合超广角激光扫描眼底成像(UWF SLO)对糖尿病视网膜病变(DR)患者病变的检出率以及对DR分级诊断价值的研究。方法 横断面研究。招募在四川省人民医院眼科就诊的糖尿病患者。所有参与者都接受了UWF SS-OCTA、UWF SLO和荧光素眼底血管造影(FFA)检查,用于检测DR病变,包括微动脉瘤(MA)、视网膜内出血(IRH)、视网膜无灌注区(NPAs)、视网膜内微血管异常(IRMAs)、视网膜静脉串珠(VB)、视网膜新生血管(NVE)、视盘新生血管(NVD)及玻璃体积血(VH)。联合三类影像检查(以下简称三联影像)结果作为标准对照,对比不同影像两两联合对DR病变的检出率及对DR严重度分级的一致性。结果 共纳入101例175眼。与三联影像结果相比,UWF SS-OCTA联合UWF SLO对MA、IRH、NPAs、IRMAs、NVE、NVD及VH的检出率分别为91%、83%、77%、69%、27%、10%及12%,Kappa依次为0.812、1.000、1.000、1.000、0.986、0.970及1.000。与三联影像结果相比,UWF SS-OCTA联合UWF SLO对DR的严重度分级具有优异一致性(Kappa=0.943)。结论 UWF SS-OCTA联合UWF SLO能准确识别MA、IRH、NPAs、IRMAs、NVE、NVD及VH,对DR筛查及分级诊断准确性高,适用于临床上对DR的大规模筛查与管理。 展开更多
关键词 超广域扫频源光学相干断层扫描血管成像 超广角激光扫描眼底成像 荧光素眼底血管造影 糖尿病性视网膜病变
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多模影像对糖尿病小鼠眼底特征的实验研究 被引量:1
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作者 赵春林 马广成 +4 位作者 陶思翰 陈卓琳 王明月 方祎鸣 施炜 《中国现代医学杂志》 CAS 2024年第11期43-50,共8页
目的观察糖尿病小鼠视网膜影像改变特征,为糖尿病小鼠视网膜病理改变特征提供影像学依据。方法8周龄C57BL/6J小鼠连续5 d腹腔注射链脲佐菌素STZ(50 mg/kg),1周后测量小鼠空腹血糖浓度,模型复制成功的糖尿病小鼠(模型组)与正常小鼠(对照... 目的观察糖尿病小鼠视网膜影像改变特征,为糖尿病小鼠视网膜病理改变特征提供影像学依据。方法8周龄C57BL/6J小鼠连续5 d腹腔注射链脲佐菌素STZ(50 mg/kg),1周后测量小鼠空腹血糖浓度,模型复制成功的糖尿病小鼠(模型组)与正常小鼠(对照组)喂养5个月,5个月后对正常小鼠和糖尿病小鼠进行双眼光学相干断层扫描/光学相干断层扫描血管造影(OCT/OCTA)及眼底荧光血管造影(FFA)检测,采用图湃软件和Image J软件得出眼底视网膜厚度,血管密度、形态及管径大小,以及荧光素渗漏情况等数据,最后用GraphPad Prism进行统计学分析。结果对照组内层内环视网膜厚度大于模型组(P<0.05),对照组内层中、外环及外层内、中、外环厚度与模型组比较,差异均无统计学意义(P>0.05)。对照组表层及深层内、中、外环视网膜血管密度与模型组比较,差异均无统计学意义(P>0.05)。对照组一、二级血管管径值均窄于模型组、(P<0.05)。应用多模影像技术可以明确糖尿病视网膜病变(DR)的具体部位及捕捉DR的病变特征,包括微血管瘤、视网膜薄变、小血管迂曲扩张,以及迂曲扩张的小血管周围毛细血管网间隙增宽和囊样暗腔样改变。结论OCT/OCTA及FFA的多模影像相结合,可以活体监测DR小鼠视网膜早期损伤及毛细血管早期特征改变,对DR基础研究发挥一定作用。 展开更多
关键词 糖尿病视网膜病变 光学相干断层扫描 光学相干断层扫描血管造影 眼底荧光血管造影
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光学成像技术在早产儿视网膜病变筛查中的应用
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作者 张婷 王迪 +1 位作者 梁姗姗 张军 《眼科新进展》 CAS 北大核心 2024年第9期734-738,共5页
早产儿视网膜病变(ROP)是一种视网膜血管增生性疾病,可能会导致患者视网膜脱离和永久性视力丧失。及时筛查和诊断ROP,并给予相应治疗,对于预防早产儿失明和降低致盲率至关重要。近年来,接触式和非接触式眼底照相机、荧光素眼底血管造影... 早产儿视网膜病变(ROP)是一种视网膜血管增生性疾病,可能会导致患者视网膜脱离和永久性视力丧失。及时筛查和诊断ROP,并给予相应治疗,对于预防早产儿失明和降低致盲率至关重要。近年来,接触式和非接触式眼底照相机、荧光素眼底血管造影、光学相干断层扫描等光学技术的进步,极大地丰富了人们对ROP影像学特征的辨识能力。基于这些技术的发展,眼科专家们更新了ROP的影像学诊断标准。本文就光学成像技术在ROP筛查中的应用进行综述,以期为临床实践提供参考。 展开更多
关键词 早产儿视网膜病变 检眼镜 眼底照相机 荧光素眼底血管造影 光学相干断层扫描
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光学相干断层扫描血管成像术在湿性年龄相关性黄斑变性诊断中的临床应用价值
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作者 陈艳玲 周颖 《中外医药研究》 2024年第16期144-146,共3页
目的:探讨光学相干断层扫描血管成像术(OCTA)在湿性年龄相关性黄斑变性(AMD)诊断中的临床应用价值。方法:选取2021年9月—2022年9月中山市人民医院收治的初次诊断为湿性AMD的患者70例为研究对象。所有研究对象接受初始3个月每月玻璃体... 目的:探讨光学相干断层扫描血管成像术(OCTA)在湿性年龄相关性黄斑变性(AMD)诊断中的临床应用价值。方法:选取2021年9月—2022年9月中山市人民医院收治的初次诊断为湿性AMD的患者70例为研究对象。所有研究对象接受初始3个月每月玻璃体腔注射给药1次,后按需给药(PRN),即3+PRN方案治疗,给药3次后复查,进行荧光素眼底血管造影(FFA)、OCTA检查。分析FFA、OCTA结果图像,比较两项检查在视网膜新生血管、黄斑水肿2项眼底病变指标的检出率和检出一致性。结果:两种方法视网膜新生血管、黄斑水肿检出率比较,差异无统计学意义(P>0.05)。FFA与OCTA检出视网膜新生血管、黄斑水肿的一致性良好(Kappa=0.896、0.909,P<0.001)。结论:应用OCTA检查与FFA检查湿性AMD患者视网膜新生血管、黄斑水肿的一致性较高,可用于替代FFA检查。 展开更多
关键词 湿性年龄相关性黄斑变性 荧光素眼底血管造影 光学相干断层扫描血管成像术
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光学相干断层扫描血管造影在视网膜血管性疾病诊疗中的研究进展
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作者 郝相慧 卜子文 胡健艳 《医学综述》 CAS 2024年第12期1457-1462,1467,共7页
光学相干断层扫描血管造影(OCTA)是一种非侵入性的快速成像方式,其扫描能显示视网膜各个层面的血流信息,可在任意方位显示一系列的二维横断面图像,尽可能量化视网膜形态,目前已广泛用于眼科疾病尤其是视网膜血管性疾病的诊断和病情监测... 光学相干断层扫描血管造影(OCTA)是一种非侵入性的快速成像方式,其扫描能显示视网膜各个层面的血流信息,可在任意方位显示一系列的二维横断面图像,尽可能量化视网膜形态,目前已广泛用于眼科疾病尤其是视网膜血管性疾病的诊断和病情监测,并提供了前所未有的深度解析信息。随着OCTA扫描速度和分辨率的不断提高,以及减少伪影、提高图像质量和进行定量测量的软件算法的开发,OCTA的临床应用将得到进一步增强,相信今后无创OCTA有望取代相关的有创检查方法成为眼科影像学检查的重要工具。 展开更多
关键词 视网膜血管性疾病 光学相干断层扫描血管造影 荧光素眼底血管造影
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儿童玻璃体视网膜疾病诊治新进展
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作者 毛克荣 彭婕 赵培泉 《临床眼科杂志》 2024年第4期365-368,共4页
儿童玻璃体视网膜病变是儿童视力发育不良和儿童盲的主要原因。相较于成人眼底病及其他儿童眼病,儿童玻璃体视网膜病变早期较难发现,其诊断和治疗较困难,且容易导致患儿视功能永久不可逆性的损害。本文总结了近年来在儿童玻璃体视网膜... 儿童玻璃体视网膜病变是儿童视力发育不良和儿童盲的主要原因。相较于成人眼底病及其他儿童眼病,儿童玻璃体视网膜病变早期较难发现,其诊断和治疗较困难,且容易导致患儿视功能永久不可逆性的损害。本文总结了近年来在儿童玻璃体视网膜手术方面取得的多项新技术和新成果,包括两步法眼底血管荧光素造影、分期手术、黏弹剂分离晶状体后纤维增生膜、Coats病两切口激光和24G静脉留置针巩膜外引流、微创外路手术、无灌注晶状体切割辅助晶状体切除术、虹膜穿刺引流术、视网膜下注射抗血管内皮生长因子(VEGF)药物术、虹膜扩张器使用、小儿黄斑裂孔治疗、前部型永存胎儿血管症(AAPFV)命名等。 展开更多
关键词 儿童玻璃体视网膜病变 玻璃体视网膜手术 荧光素钠血管造影
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基于荧光素血管造影图像的处理配准筛查新生儿眼底疾病
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作者 顾璐瑶 张芳艳 +2 位作者 蒲涵 王亚睿 周炜杰 《计算机应用文摘》 2024年第22期160-163,共4页
视觉是人体最重要的感觉功能之一,0~3岁则是儿童视力系统发育的关键时期。此时期的眼病对儿童视力发育危害极大,如果不能得到及时的发现和治疗,将造成眼睛的终身残疾。因此,对婴幼儿进行眼病的筛查,及时发现各种眼疾,使其得到早期治疗,... 视觉是人体最重要的感觉功能之一,0~3岁则是儿童视力系统发育的关键时期。此时期的眼病对儿童视力发育危害极大,如果不能得到及时的发现和治疗,将造成眼睛的终身残疾。因此,对婴幼儿进行眼病的筛查,及时发现各种眼疾,使其得到早期治疗,对儿童的成长发育具有重要意义。文章介绍了一种基于荧光素血管造影图像的处理配准筛查新生儿眼底疾病的方式,为制定科学高效的新生儿眼底疾病诊治和随诊策略提供了依据,可助力提高新生儿眼底疾病防治效力。 展开更多
关键词 荧光素血管造影 新生儿 眼底病变 筛查
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羟苯磺酸钙辅助532 nm眼底激光对糖尿病视网膜病变患者黄斑厚度及视网膜新生血管荧光素渗漏面积的影响
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作者 孙海华 马楠 《反射疗法与康复医学》 2024年第9期119-122,共4页
目的探讨羟苯磺酸钙辅助532 nm眼底激光对糖尿病视网膜病变(DR)患者的影响。方法以2020年5月—2023年5月于我院门诊和住院治疗的150例DR患者为研究对象,按照随机数字表法将其分为对照组和观察组,各75例。对照组实施532 nm眼底激光治疗,... 目的探讨羟苯磺酸钙辅助532 nm眼底激光对糖尿病视网膜病变(DR)患者的影响。方法以2020年5月—2023年5月于我院门诊和住院治疗的150例DR患者为研究对象,按照随机数字表法将其分为对照组和观察组,各75例。对照组实施532 nm眼底激光治疗,观察组在对照且基础上加用羟苯磺酸钙治疗。比较两组视力水平、视网膜新生血管荧光素渗漏面积、黄斑厚度、生活质量、并发症发生情况。结果治疗后,观察组视网膜新生血管荧光素渗漏面积(2.78±0.55)mm^(2)小于对照组,黄斑厚度(305.12±38.46)μm薄于对照组,视力水平(0.75±0.21)及世界卫生组织生存质量测定量表中的环境领域评分(79.88±6.42)分、心理领域评分(80.66±6.97)分、社会关系领域评分(82.13±6.73)分、生理领域评分(79.84±6.63)分均高于对照组,组间差异有统计学意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论羟苯磺酸钙辅助532 nm眼底激光治疗,可明显缩减黄斑厚度,减小渗漏面积,有助于视力改善,且安全性高。 展开更多
关键词 糖尿病视网膜病变 532 nm眼底激光 羟苯磺酸钙 视网膜新生血管荧光素渗漏面积 黄斑厚度
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Changes of Indocyanine Green and Fluorescein Angiography in Multiple Evanescent White-dot Syndrome: A Case Report 被引量:1
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作者 Changxian Yi, Guilin Zhao, Jiexiong Ou, Hong Yan Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China 《Eye Science》 CAS 2003年第3期171-173,200,共4页
Purpose: To study the clinicopathological change on "Multiple Evanescent White-dot Syndrome (MEWDS)"through fundus angiogrphy analyses.Methods:Examing the case with fluorescein angiography (FFA) and indocyan... Purpose: To study the clinicopathological change on "Multiple Evanescent White-dot Syndrome (MEWDS)"through fundus angiogrphy analyses.Methods:Examing the case with fluorescein angiography (FFA) and indocyanine green angiography(ICGA), visual field and following up for 15 months.Results :There exist multiple white dots in the fundus photo and angiography. The changes on ICGA maintain longer than fundus photo and FFA. Papille may be edematous and macula could present with special hypofluorescent flecks.Conclusions:MEWDS has specific angiographic features. Its pathological changes involve deep retinal pigment epithelium(RPE) as well as choroidal capillaries. The prognosis of the visual acuity for MEWDS is very good. 展开更多
关键词 White-dot综合症 荧光眼底血管造影术 靛蓝花青血管造影术 视网膜 色素上皮细胞
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