Two new compounds,(22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one(1) and fusidione(3), along with two known compounds, 5α,8α-epidioxy ergosta-6,22-diene-3β-ol(2) and microperfuranone(4), we...Two new compounds,(22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one(1) and fusidione(3), along with two known compounds, 5α,8α-epidioxy ergosta-6,22-diene-3β-ol(2) and microperfuranone(4), were isolated from the fermentation products of the marine-sourced fungus Acremonium fusidioides RZ01. The structures of compounds 1 and 3 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Both new compounds showed inhibitory activity against HL-60 cells with IC50 values being16.6 and 44.9 μmol·L-1, respectively.展开更多
基金supported by the National Natural Science Foundation of China(No.81502951)
文摘Two new compounds,(22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one(1) and fusidione(3), along with two known compounds, 5α,8α-epidioxy ergosta-6,22-diene-3β-ol(2) and microperfuranone(4), were isolated from the fermentation products of the marine-sourced fungus Acremonium fusidioides RZ01. The structures of compounds 1 and 3 were elucidated by extensive spectroscopic methods, especially 2D NMR, and their absolute configurations were suggested on the basis of the circular dichroism spectral analysis and the NOESY data. Both new compounds showed inhibitory activity against HL-60 cells with IC50 values being16.6 and 44.9 μmol·L-1, respectively.
