Background: Studies have shown a strong correlation between the growth of E2 in serum and estrone-3-glucuronide (E1-3G) in urine during ovarian stimulation. Thus, we developed theoretical models for using urinary E1-3...Background: Studies have shown a strong correlation between the growth of E2 in serum and estrone-3-glucuronide (E1-3G) in urine during ovarian stimulation. Thus, we developed theoretical models for using urinary E1-3G in ovarian stimulation and focused on their experimental verification and analysis. Methods: A prospective, observational pilot study was conducted involving 54 patients who underwent 54 cycles of ovarian stimulation. The goal was to establish the growth rate of urinary E1-3G during the course of stimulation and to determine the daily upper and lower limits of growth rates at which stimulation is appropriate and safe. Controlled ovarian stimulation was performed using two different stimulation protocols—an antagonist protocol in 25 cases and a progestin-primed ovarian stimulation protocol (PPOS) in 29 cases, with fixed doses of gonadotropins. From the second day of stimulation, patients self-measured their daily urine E1-3G levels at home using a portable analyzer. In parallel, a standard ultrasound follow-up protocol accompanied by a determination of E2, LH, and P levels was applied to optimally control stimulation. Results: The average daily growth rates in both groups were about 50%. The daily increase in E1-3G for the antagonist protocol ranged from 14% to 79%, while they were 28% to 79% for the PPOS protocol. Conclusion: This is the first study to analyze the dynamics of E1-3G in two different protocols and to estimate the limits of its increase during the entire course of the stimulation. The results confirm our theoretical model for the viability of using urinary E1-3G for monitoring ovarian stimulation.展开更多
Nowadays,the widespread application of 5G has promoted rapid development in different areas,particularly in the Internet of Things(IoT),where 5G provides the advantages of higher data transfer rate,lower latency,and w...Nowadays,the widespread application of 5G has promoted rapid development in different areas,particularly in the Internet of Things(IoT),where 5G provides the advantages of higher data transfer rate,lower latency,and widespread connections.Wireless sensor networks(WSNs),which comprise various sensors,are crucial components of IoT.The main functions of WSN include providing users with real-time monitoring information,deploying regional information collection,and synchronizing with the Internet.Security in WSNs is becoming increasingly essential because of the across-the-board nature of wireless technology in many fields.Recently,Yu et al.proposed a user authentication protocol forWSN.However,their design is vulnerable to sensor capture and temporary information disclosure attacks.Thus,in this study,an improved protocol called PSAP-WSNis proposed.The security of PSAP-WSN is demonstrated by employing the ROR model,BAN logic,and ProVerif tool for the analysis.The experimental evaluation shows that our design is more efficient and suitable forWSN environments.展开更多
The industrial Internet of Things(IIoT)is a new indus-trial idea that combines the latest information and communica-tion technologies with the industrial economy.In this paper,a cloud control structure is designed for...The industrial Internet of Things(IIoT)is a new indus-trial idea that combines the latest information and communica-tion technologies with the industrial economy.In this paper,a cloud control structure is designed for IIoT in cloud-edge envi-ronment with three modes of 5G.For 5G based IIoT,the time sensitive network(TSN)service is introduced in transmission network.A 5G logical TSN bridge is designed to transport TSN streams over 5G framework to achieve end-to-end configuration.For a transmission control protocol(TCP)model with nonlinear disturbance,time delay and uncertainties,a robust adaptive fuzzy sliding mode controller(AFSMC)is given with control rule parameters.IIoT workflows are made up of a series of subtasks that are linked by the dependencies between sensor datasets and task flows.IIoT workflow scheduling is a non-deterministic polynomial(NP)-hard problem in cloud-edge environment.An adaptive and non-local-convergent particle swarm optimization(ANCPSO)is designed with nonlinear inertia weight to avoid falling into local optimum,which can reduce the makespan and cost dramatically.Simulation and experiments demonstrate that ANCPSO has better performances than other classical algo-rithms.展开更多
有学者提出了一种在压缩语音编码过程中进行QIM(Quantization Index Modulation)隐写的方法.该方法可用于在G.729A压缩语音流中高隐蔽性地嵌入秘密信息,研究其隐写分析方法很有必要.本文首先分析了QIM隐写对G.729A码流造成的显著性特征...有学者提出了一种在压缩语音编码过程中进行QIM(Quantization Index Modulation)隐写的方法.该方法可用于在G.729A压缩语音流中高隐蔽性地嵌入秘密信息,研究其隐写分析方法很有必要.本文首先分析了QIM隐写对G.729A码流造成的显著性特征变化,发现该种隐写将使码流中LPC滤波器的量化索引(码字)发生转移,并导致码字分布的不均衡性及相关性特性发生改变.本文设计了统计模型,实现了对码字分布特性的量化特征抽取;结合支持向量机,本文构造了用于隐写检测的集成分类器系统.实验结果显示本文方法能够在低于30ms的时间内,获得超过98%的检测准确率,实现了对QIM隐写的快速有效检测.展开更多
文摘Background: Studies have shown a strong correlation between the growth of E2 in serum and estrone-3-glucuronide (E1-3G) in urine during ovarian stimulation. Thus, we developed theoretical models for using urinary E1-3G in ovarian stimulation and focused on their experimental verification and analysis. Methods: A prospective, observational pilot study was conducted involving 54 patients who underwent 54 cycles of ovarian stimulation. The goal was to establish the growth rate of urinary E1-3G during the course of stimulation and to determine the daily upper and lower limits of growth rates at which stimulation is appropriate and safe. Controlled ovarian stimulation was performed using two different stimulation protocols—an antagonist protocol in 25 cases and a progestin-primed ovarian stimulation protocol (PPOS) in 29 cases, with fixed doses of gonadotropins. From the second day of stimulation, patients self-measured their daily urine E1-3G levels at home using a portable analyzer. In parallel, a standard ultrasound follow-up protocol accompanied by a determination of E2, LH, and P levels was applied to optimally control stimulation. Results: The average daily growth rates in both groups were about 50%. The daily increase in E1-3G for the antagonist protocol ranged from 14% to 79%, while they were 28% to 79% for the PPOS protocol. Conclusion: This is the first study to analyze the dynamics of E1-3G in two different protocols and to estimate the limits of its increase during the entire course of the stimulation. The results confirm our theoretical model for the viability of using urinary E1-3G for monitoring ovarian stimulation.
文摘Nowadays,the widespread application of 5G has promoted rapid development in different areas,particularly in the Internet of Things(IoT),where 5G provides the advantages of higher data transfer rate,lower latency,and widespread connections.Wireless sensor networks(WSNs),which comprise various sensors,are crucial components of IoT.The main functions of WSN include providing users with real-time monitoring information,deploying regional information collection,and synchronizing with the Internet.Security in WSNs is becoming increasingly essential because of the across-the-board nature of wireless technology in many fields.Recently,Yu et al.proposed a user authentication protocol forWSN.However,their design is vulnerable to sensor capture and temporary information disclosure attacks.Thus,in this study,an improved protocol called PSAP-WSNis proposed.The security of PSAP-WSN is demonstrated by employing the ROR model,BAN logic,and ProVerif tool for the analysis.The experimental evaluation shows that our design is more efficient and suitable forWSN environments.
文摘The industrial Internet of Things(IIoT)is a new indus-trial idea that combines the latest information and communica-tion technologies with the industrial economy.In this paper,a cloud control structure is designed for IIoT in cloud-edge envi-ronment with three modes of 5G.For 5G based IIoT,the time sensitive network(TSN)service is introduced in transmission network.A 5G logical TSN bridge is designed to transport TSN streams over 5G framework to achieve end-to-end configuration.For a transmission control protocol(TCP)model with nonlinear disturbance,time delay and uncertainties,a robust adaptive fuzzy sliding mode controller(AFSMC)is given with control rule parameters.IIoT workflows are made up of a series of subtasks that are linked by the dependencies between sensor datasets and task flows.IIoT workflow scheduling is a non-deterministic polynomial(NP)-hard problem in cloud-edge environment.An adaptive and non-local-convergent particle swarm optimization(ANCPSO)is designed with nonlinear inertia weight to avoid falling into local optimum,which can reduce the makespan and cost dramatically.Simulation and experiments demonstrate that ANCPSO has better performances than other classical algo-rithms.
文摘有学者提出了一种在压缩语音编码过程中进行QIM(Quantization Index Modulation)隐写的方法.该方法可用于在G.729A压缩语音流中高隐蔽性地嵌入秘密信息,研究其隐写分析方法很有必要.本文首先分析了QIM隐写对G.729A码流造成的显著性特征变化,发现该种隐写将使码流中LPC滤波器的量化索引(码字)发生转移,并导致码字分布的不均衡性及相关性特性发生改变.本文设计了统计模型,实现了对码字分布特性的量化特征抽取;结合支持向量机,本文构造了用于隐写检测的集成分类器系统.实验结果显示本文方法能够在低于30ms的时间内,获得超过98%的检测准确率,实现了对QIM隐写的快速有效检测.
