The article introduces Prof.Weijia’s experience in using Fengchi(GB 20)totreat gastric ulcer,bronchial asthma,sciatica,and alopecia,etc.He considers that the point has seven general functions of dispelling pathogenic...The article introduces Prof.Weijia’s experience in using Fengchi(GB 20)totreat gastric ulcer,bronchial asthma,sciatica,and alopecia,etc.He considers that the point has seven general functions of dispelling pathogenic wind,purging pathogenic fire,relieving the depressedliver-Qi,resolving the phlegm,activating the blood,tranquilizing the mind,and checking spasm andconvulsion.It also introduces some common diseases treated with needling Fengchi and adjunctpoints,manipulations,and precautions,etc.It Is a comparatively comprehensive summary of Prof.Wei Jia’s individual experience in wonderfully using Fengchi.展开更多
The article introduces the writers’ experience in using Fengchi(GB 20) to treat sciatica,gastric ulcer and bronchial asthma, etc. The writers consider that the point has seven general functions of dispelling pathogen...The article introduces the writers’ experience in using Fengchi(GB 20) to treat sciatica,gastric ulcer and bronchial asthma, etc. The writers consider that the point has seven general functions of dispelling pathogenic wind, purging pathogenic fire, relieving the depressed liver-qi, resolvingthe phlegm, activating the blood, tranquilizing the mind, and checking spasm and c0nvulsion. It alsointroduces the manipulations and precautions of needling Fengchi.展开更多
OBJECTIVE:To study the effect of acupuncture at Fengchi(GB 20) on the activation of myosin light chain kinase(MLCK) in the middle meningeal artery of migraine modeled rats.METHODS:Forty-four clean grade healthy female...OBJECTIVE:To study the effect of acupuncture at Fengchi(GB 20) on the activation of myosin light chain kinase(MLCK) in the middle meningeal artery of migraine modeled rats.METHODS:Forty-four clean grade healthy female Sprague-Dawley(SD) rats were randomly divided into four groups:the control group,blank control group,Fengchi(GB 20) acupuncture group,and Fengchi(GB 20) prevention group.Neurogenic inflammation of these rats was induced by electrical stimulation.The γ-^(32)P infiltration method was then used to detect MLCK activation in the middle meningeal artery,and immunocytochemistry was applied to detect the structural protein expression of MLCK.RESULTS:The migraine model was successfully established in the rats.Compared with the control group,MLCK activation was significantly decreased in the blank control group(P < 0.01).CONCLUSION:The activation of MLCK in the middle meningeal artery was increased by acupuncture at Fengchi(GB 20),indicating its effectiveness in preventing and curing on acute migraine attacks.展开更多
目的 观察针刺百会、曲鬓穴对急性期脑出血(ICH)大鼠白细胞分化抗原36(CD36)、Toll样受体4(TLR4)表达的影响,探讨针刺治疗脑出血的作用机制。方法 选择144只Wistar雄性大鼠,采用随机数字表法分为假手术组、模型组、针刺组、抑制剂组4组...目的 观察针刺百会、曲鬓穴对急性期脑出血(ICH)大鼠白细胞分化抗原36(CD36)、Toll样受体4(TLR4)表达的影响,探讨针刺治疗脑出血的作用机制。方法 选择144只Wistar雄性大鼠,采用随机数字表法分为假手术组、模型组、针刺组、抑制剂组4组,每组36只,每组按1、3、7 d时间点再分为3个亚组,每组12只。采用立体定位自体血注入法建立ICH大鼠模型。模型组仅接受ICH模型制备,不进行任何治疗;假手术组接受类似模型组各项手术操作,但不进行注血制作;抑制剂组造模后6 h,腹腔注射TLR4抑制剂TAK242,3 mg/kg,1次/d,连续5 d;造模12 h后,针刺组各亚组开始接受针刺治疗,穴位选择百会穴(顶骨正中)、右侧曲鬓穴,采用透刺方法,进针深度20 mm,以100 r/min小幅度捻转,持续捻转2 min,每间隔5 min捻针1次,共留针30 min,期间捻转3次,1次/d,针刺组各亚组分别治疗1、3、7 d。分别于治疗后第1、3、7天,采用改良神经功能缺损评分(mNSS)评估大鼠神经功能;检测脑组织血肿体积;采用Western blot法检测脑组织CD36、TLR4蛋白表达水平;采用免疫荧光法观察CD36、TLR4在星形胶质细胞中的表达。结果 (1) mNSS评分:与假手术组同一时间点比较,模型组、针刺组、抑制剂组治疗后1、3、7 d mNSS评分均明显升高(P<0.05);与模型组同一时间点比较,针刺组、抑制剂组治疗后1、3、7 d mNSS评分均明显降低(P<0.05);与针刺组同一时间点比较,抑制剂组治疗后1 d mNSS评分明显降低(P<0.05)。(2)血肿体积:与模型组同一时间点比较,针刺组、抑制剂组治疗后3、7 d脑血肿体积均明显降低,抑制剂组治疗后1、3、7 d脑血肿体积明显降低(P<0.05);与针刺组同一时间点比较,抑制剂组治疗后1、3、7 d脑血肿体积明显降低(P<0.05)。(3) CD36、TLR4蛋白表达水平:与假手术组同一时间点比较,模型组、针刺组、抑制剂组治疗后1、3、7 d CD36、TLR4蛋白表达水平均明显升高(P<0.05);与模型组同一时间点比较,针刺组、抑制剂组治疗后1、3、7 d CD36蛋白表达水平均明显升高(P<0.05),针刺组、抑制剂组治疗后3、7 d TLR4蛋白表达水平均明显降低(P<0.05);与针刺组比较,抑制剂组治疗后1、3、7 d CD36蛋白表达水平均明显升高,TLR4蛋白表达水平均明显降低(P<0.05)。(4) CD36、TLR4在GFAP中的表达水平:假手术组大鼠脑组织内可见少量CD36、TLR4表达。与假手术组同一时间点比较,模型组治疗后1、3、7 d CD36、TLR4在GFAP表达均明显增加(P<0.05);与模型组同一时间点比较,抑制剂组、针刺组治疗后1、3、7 d CD36在GFAP表达明显增加,TLR4在GFAP表达明显降低(P<0.05)。结论 针刺百会、曲鬓穴可以改善急性期ICH大鼠神经功能,减轻脑出血血肿体积,可能与促进CD36蛋白表达、抑制TLR4蛋白表达有关。展开更多
目的:观察风池穴水针刀治疗颈源性头痛(cervicogenic headache,CEH)的临床疗效。方法:选取淄博市中西医结合医院针灸科、脑病科2020年3月至2021年4月收治的CEH患者120例,按照随机数字表法分为治疗组、针刺组和西药组,每组40例。针刺组...目的:观察风池穴水针刀治疗颈源性头痛(cervicogenic headache,CEH)的临床疗效。方法:选取淄博市中西医结合医院针灸科、脑病科2020年3月至2021年4月收治的CEH患者120例,按照随机数字表法分为治疗组、针刺组和西药组,每组40例。针刺组给予常规针刺治疗,西药组给予口服双氯芬酸钠肠溶缓释胶囊治疗,治疗组给予风池穴水针刀治疗。观察3组患者治疗前后颈椎活动度(cervical range of motion,ROM)评分、头痛程度评分、头痛持续时间评分、头痛指数评分变化情况,治疗后3个月随访进行远期疗效评价。结果:3组患者治疗后头痛程度评分、头痛持续时间评分、头痛指数评分均低于治疗前,差异有统计学意义(P<0.01),治疗组和西药组治疗1个疗程、2个疗程后头痛程度评分、头痛持续时间评分、头痛指数均低于针刺组,差异有统计学意义(P<0.01),但治疗组与西药组比较,差异无统计学意义(P>0.05)。3组患者治疗1个疗程、治疗2个疗程后ROM评分均低于治疗前,差异有统计学意义(P<0.01),治疗组治疗1个疗程、治疗2个疗程后ROM评分低于针刺组、西药组,差异有统计学意义(P<0.05),针刺组治疗2个疗程后ROM评分低于西药组,差异有统计学意义(P<0.05)。治疗组有效率为87.5%,针刺组有效率为65.0%,西药组有效率为47.5%,治疗组有效率高于西药组、针刺组,差异具有统计学意义(P<0.01)。结论:水针刀风池穴治疗颈源性头痛即时镇痛效果好,远期临床疗效高,能改善患者颈椎活动度。展开更多
文摘The article introduces Prof.Weijia’s experience in using Fengchi(GB 20)totreat gastric ulcer,bronchial asthma,sciatica,and alopecia,etc.He considers that the point has seven general functions of dispelling pathogenic wind,purging pathogenic fire,relieving the depressedliver-Qi,resolving the phlegm,activating the blood,tranquilizing the mind,and checking spasm andconvulsion.It also introduces some common diseases treated with needling Fengchi and adjunctpoints,manipulations,and precautions,etc.It Is a comparatively comprehensive summary of Prof.Wei Jia’s individual experience in wonderfully using Fengchi.
文摘The article introduces the writers’ experience in using Fengchi(GB 20) to treat sciatica,gastric ulcer and bronchial asthma, etc. The writers consider that the point has seven general functions of dispelling pathogenic wind, purging pathogenic fire, relieving the depressed liver-qi, resolvingthe phlegm, activating the blood, tranquilizing the mind, and checking spasm and c0nvulsion. It alsointroduces the manipulations and precautions of needling Fengchi.
基金the Beijing Natural Science Found Program[Fengchi point(GB 20)Controlling Mechanisn of MLCK Signal System of the Migraine,No.7092054
文摘OBJECTIVE:To study the effect of acupuncture at Fengchi(GB 20) on the activation of myosin light chain kinase(MLCK) in the middle meningeal artery of migraine modeled rats.METHODS:Forty-four clean grade healthy female Sprague-Dawley(SD) rats were randomly divided into four groups:the control group,blank control group,Fengchi(GB 20) acupuncture group,and Fengchi(GB 20) prevention group.Neurogenic inflammation of these rats was induced by electrical stimulation.The γ-^(32)P infiltration method was then used to detect MLCK activation in the middle meningeal artery,and immunocytochemistry was applied to detect the structural protein expression of MLCK.RESULTS:The migraine model was successfully established in the rats.Compared with the control group,MLCK activation was significantly decreased in the blank control group(P < 0.01).CONCLUSION:The activation of MLCK in the middle meningeal artery was increased by acupuncture at Fengchi(GB 20),indicating its effectiveness in preventing and curing on acute migraine attacks.
文摘目的 观察针刺百会、曲鬓穴对急性期脑出血(ICH)大鼠白细胞分化抗原36(CD36)、Toll样受体4(TLR4)表达的影响,探讨针刺治疗脑出血的作用机制。方法 选择144只Wistar雄性大鼠,采用随机数字表法分为假手术组、模型组、针刺组、抑制剂组4组,每组36只,每组按1、3、7 d时间点再分为3个亚组,每组12只。采用立体定位自体血注入法建立ICH大鼠模型。模型组仅接受ICH模型制备,不进行任何治疗;假手术组接受类似模型组各项手术操作,但不进行注血制作;抑制剂组造模后6 h,腹腔注射TLR4抑制剂TAK242,3 mg/kg,1次/d,连续5 d;造模12 h后,针刺组各亚组开始接受针刺治疗,穴位选择百会穴(顶骨正中)、右侧曲鬓穴,采用透刺方法,进针深度20 mm,以100 r/min小幅度捻转,持续捻转2 min,每间隔5 min捻针1次,共留针30 min,期间捻转3次,1次/d,针刺组各亚组分别治疗1、3、7 d。分别于治疗后第1、3、7天,采用改良神经功能缺损评分(mNSS)评估大鼠神经功能;检测脑组织血肿体积;采用Western blot法检测脑组织CD36、TLR4蛋白表达水平;采用免疫荧光法观察CD36、TLR4在星形胶质细胞中的表达。结果 (1) mNSS评分:与假手术组同一时间点比较,模型组、针刺组、抑制剂组治疗后1、3、7 d mNSS评分均明显升高(P<0.05);与模型组同一时间点比较,针刺组、抑制剂组治疗后1、3、7 d mNSS评分均明显降低(P<0.05);与针刺组同一时间点比较,抑制剂组治疗后1 d mNSS评分明显降低(P<0.05)。(2)血肿体积:与模型组同一时间点比较,针刺组、抑制剂组治疗后3、7 d脑血肿体积均明显降低,抑制剂组治疗后1、3、7 d脑血肿体积明显降低(P<0.05);与针刺组同一时间点比较,抑制剂组治疗后1、3、7 d脑血肿体积明显降低(P<0.05)。(3) CD36、TLR4蛋白表达水平:与假手术组同一时间点比较,模型组、针刺组、抑制剂组治疗后1、3、7 d CD36、TLR4蛋白表达水平均明显升高(P<0.05);与模型组同一时间点比较,针刺组、抑制剂组治疗后1、3、7 d CD36蛋白表达水平均明显升高(P<0.05),针刺组、抑制剂组治疗后3、7 d TLR4蛋白表达水平均明显降低(P<0.05);与针刺组比较,抑制剂组治疗后1、3、7 d CD36蛋白表达水平均明显升高,TLR4蛋白表达水平均明显降低(P<0.05)。(4) CD36、TLR4在GFAP中的表达水平:假手术组大鼠脑组织内可见少量CD36、TLR4表达。与假手术组同一时间点比较,模型组治疗后1、3、7 d CD36、TLR4在GFAP表达均明显增加(P<0.05);与模型组同一时间点比较,抑制剂组、针刺组治疗后1、3、7 d CD36在GFAP表达明显增加,TLR4在GFAP表达明显降低(P<0.05)。结论 针刺百会、曲鬓穴可以改善急性期ICH大鼠神经功能,减轻脑出血血肿体积,可能与促进CD36蛋白表达、抑制TLR4蛋白表达有关。
文摘目的:观察风池穴水针刀治疗颈源性头痛(cervicogenic headache,CEH)的临床疗效。方法:选取淄博市中西医结合医院针灸科、脑病科2020年3月至2021年4月收治的CEH患者120例,按照随机数字表法分为治疗组、针刺组和西药组,每组40例。针刺组给予常规针刺治疗,西药组给予口服双氯芬酸钠肠溶缓释胶囊治疗,治疗组给予风池穴水针刀治疗。观察3组患者治疗前后颈椎活动度(cervical range of motion,ROM)评分、头痛程度评分、头痛持续时间评分、头痛指数评分变化情况,治疗后3个月随访进行远期疗效评价。结果:3组患者治疗后头痛程度评分、头痛持续时间评分、头痛指数评分均低于治疗前,差异有统计学意义(P<0.01),治疗组和西药组治疗1个疗程、2个疗程后头痛程度评分、头痛持续时间评分、头痛指数均低于针刺组,差异有统计学意义(P<0.01),但治疗组与西药组比较,差异无统计学意义(P>0.05)。3组患者治疗1个疗程、治疗2个疗程后ROM评分均低于治疗前,差异有统计学意义(P<0.01),治疗组治疗1个疗程、治疗2个疗程后ROM评分低于针刺组、西药组,差异有统计学意义(P<0.05),针刺组治疗2个疗程后ROM评分低于西药组,差异有统计学意义(P<0.05)。治疗组有效率为87.5%,针刺组有效率为65.0%,西药组有效率为47.5%,治疗组有效率高于西药组、针刺组,差异具有统计学意义(P<0.01)。结论:水针刀风池穴治疗颈源性头痛即时镇痛效果好,远期临床疗效高,能改善患者颈椎活动度。
