Generalized linear mixed models (GLMMs) are typically constructed by incorporating random effects into the linear predictor. The random effects are usually assumed to be normally distributed with mean zero and varianc...Generalized linear mixed models (GLMMs) are typically constructed by incorporating random effects into the linear predictor. The random effects are usually assumed to be normally distributed with mean zero and variance-covariance identity matrix. In this paper, we propose to release random effects to non-normal distributions and discuss how to model the mean and covariance structures in GLMMs simultaneously. Parameter estimation is solved by using Quasi-Monte Carlo (QMC) method through iterative Newton-Raphson (NR) algorithm very well in terms of accuracy and stabilization, which is demonstrated by real binary salamander mating data analysis and simulation studies.展开更多
In this article, robust generalized estimating equation for the analysis of partial linear mixed model for longitudinal data is used. The authors approximate the nonparametric function by a regression spline. Under so...In this article, robust generalized estimating equation for the analysis of partial linear mixed model for longitudinal data is used. The authors approximate the nonparametric function by a regression spline. Under some regular conditions, the asymptotic properties of the estimators are obtained. To avoid the computation of high-dimensional integral, a robust Monte Carlo Newton-Raphson algorithm is used. Some simulations are carried out to study the performance of the proposed robust estimators. In addition, the authors also study the robustness and the efficiency of the proposed estimators by simulation. Finally, two real longitudinal data sets are analyzed.展开更多
Territory risk analysis has played an important role in the decision-making of auto insurance rate regulation.Due to the optimality of insurance loss data groupings,clustering methods become the natural choice for suc...Territory risk analysis has played an important role in the decision-making of auto insurance rate regulation.Due to the optimality of insurance loss data groupings,clustering methods become the natural choice for such territory risk classification.In this work,spatially constrained clustering is first applied to insurance loss data to form rating territories.The generalized linear model(GLM)and generalized linear mixed model(GLMM)are then proposed to derive the risk relativities of obtained clusters.Each basic rating unit within the same cluster,namely Forward Sortation Area(FSA),takes the same risk relativity value as its cluster.The obtained risk relativities from GLM or GLMM are used to calculate the performance metrics,including RMSE,MAD,and Gini coefficients.The spatially constrained clustering and the risk relativity estimate help obtain a set of territory risk benchmarks used in rate filings to guide the rate regulation process.展开更多
In this paper, we propose a bias-corrected empirical likelihood （BCEL） ratio to construct a goodness- of-fit test for generalized linear mixed models. BCEL test maintains the advantage of empirical likelihood that i...In this paper, we propose a bias-corrected empirical likelihood （BCEL） ratio to construct a goodness- of-fit test for generalized linear mixed models. BCEL test maintains the advantage of empirical likelihood that is self scale invariant and then does not involve estimating limiting variance of the test statistic to avoid deteri- orating power of test. Furthermore, the bias correction makes the limit to be a process in which every variable is standard chi-squared. This simple structure of the process enables us to construct a Monte Carlo test proce- dure to approximate the null distribution. Thus, it overcomes a problem we encounter when classical empirical likelihood test is used, as it is asymptotically a functional of Gaussian process plus a normal shift function. The complicated covariance function makes it difficult to employ any approximation for the null distribution. The test is omnibus and power study shows that the test can detect local alternatives approaching the null at parametric rate. Simulations are carried out for illustration and for a comparison with existing method.展开更多
For the linear mixed model with skew-normal random effects, this paper gives the density function, moment generating function and independence conditions. The noncentral skew chi-square distribution is defined and its...For the linear mixed model with skew-normal random effects, this paper gives the density function, moment generating function and independence conditions. The noncentral skew chi-square distribution is defined and its density function is shown. The necessary and sufficient conditions under which a quadratic form is distributed as noncentral skew chi-square distribution are obtained. Also, a version of Cochran＇s theorem is given~ which modifies the result of Wang et al. （2009） and is used to set up exact tests for fixed effects and variance components of the proposed model. For illustration, our main results are applied to a real data problem.展开更多
The purpose of this article is to investigate approaches for modeling individual patient count/rate data over time accounting for temporal correlation and non</span><span style="font-family:Verdana;"...The purpose of this article is to investigate approaches for modeling individual patient count/rate data over time accounting for temporal correlation and non</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">constant dispersions while requiring reasonable amounts of time to search over alternative models for those data. This research addresses formulations for two approaches for extending generalized estimating equations (GEE) modeling. These approaches use a likelihood-like function based on the multivariate normal density. The first approach augments standard GEE equations to include equations for estimation of dispersion parameters. The second approach is based on estimating equations determined by partial derivatives of the likelihood-like function with respect to all model parameters and so extends linear mixed modeling. Three correlation structures are considered including independent, exchangeable, and spatial autoregressive of order 1 correlations. The likelihood-like function is used to formulate a likelihood-like cross-validation (LCV) score for use in evaluating models. Example analyses are presented using these two modeling approaches applied to three data sets of counts/rates over time for individual cancer patients including pain flares per day, as needed pain medications taken per day, and around the clock pain medications taken per day per dose. Means and dispersions are modeled as possibly nonlinear functions of time using adaptive regression modeling methods to search through alternative models compared using LCV scores. The results of these analyses demonstrate that extended linear mixed modeling is preferable for modeling individual patient count/rate data over time</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> because in example analyses</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> it either generates better LCV scores or more parsimonious models and requires substantially less time.展开更多
In this paper we introduce an appealing nonparametric method for estimating variance and conditional variance functions in generalized linear models （GLMs）, when designs are fixed points and random variables respect...In this paper we introduce an appealing nonparametric method for estimating variance and conditional variance functions in generalized linear models （GLMs）, when designs are fixed points and random variables respectively, Bias-corrected confidence bands are proposed for the （conditional） variance by local linear smoothers. Nonparametric techniques are developed in deriving the bias-corrected confidence intervals of the （conditional） variance. The asymptotic distribution of the proposed estimator is established and show that the bias-corrected confidence bands asymptotically have the correct coverage properties. A small simulation is performed when unknown regression parameter is estimated by nonparametric quasi-likelihood. The results are also applicable to nonparamctric autoregressive times series model with heteroscedastic conditional variance.展开更多
文摘Generalized linear mixed models (GLMMs) are typically constructed by incorporating random effects into the linear predictor. The random effects are usually assumed to be normally distributed with mean zero and variance-covariance identity matrix. In this paper, we propose to release random effects to non-normal distributions and discuss how to model the mean and covariance structures in GLMMs simultaneously. Parameter estimation is solved by using Quasi-Monte Carlo (QMC) method through iterative Newton-Raphson (NR) algorithm very well in terms of accuracy and stabilization, which is demonstrated by real binary salamander mating data analysis and simulation studies.
基金the Natural Science Foundation of China(10371042,10671038)
文摘In this article, robust generalized estimating equation for the analysis of partial linear mixed model for longitudinal data is used. The authors approximate the nonparametric function by a regression spline. Under some regular conditions, the asymptotic properties of the estimators are obtained. To avoid the computation of high-dimensional integral, a robust Monte Carlo Newton-Raphson algorithm is used. Some simulations are carried out to study the performance of the proposed robust estimators. In addition, the authors also study the robustness and the efficiency of the proposed estimators by simulation. Finally, two real longitudinal data sets are analyzed.
文摘Territory risk analysis has played an important role in the decision-making of auto insurance rate regulation.Due to the optimality of insurance loss data groupings,clustering methods become the natural choice for such territory risk classification.In this work,spatially constrained clustering is first applied to insurance loss data to form rating territories.The generalized linear model(GLM)and generalized linear mixed model(GLMM)are then proposed to derive the risk relativities of obtained clusters.Each basic rating unit within the same cluster,namely Forward Sortation Area(FSA),takes the same risk relativity value as its cluster.The obtained risk relativities from GLM or GLMM are used to calculate the performance metrics,including RMSE,MAD,and Gini coefficients.The spatially constrained clustering and the risk relativity estimate help obtain a set of territory risk benchmarks used in rate filings to guide the rate regulation process.
基金Supported by the National Natural Science Foundation of China(No.10901109)a grant(HKBU2030/07P)from the Research Grants Council of Hong Kong,Hong Kong,China
文摘In this paper, we propose a bias-corrected empirical likelihood （BCEL） ratio to construct a goodness- of-fit test for generalized linear mixed models. BCEL test maintains the advantage of empirical likelihood that is self scale invariant and then does not involve estimating limiting variance of the test statistic to avoid deteri- orating power of test. Furthermore, the bias correction makes the limit to be a process in which every variable is standard chi-squared. This simple structure of the process enables us to construct a Monte Carlo test proce- dure to approximate the null distribution. Thus, it overcomes a problem we encounter when classical empirical likelihood test is used, as it is asymptotically a functional of Gaussian process plus a normal shift function. The complicated covariance function makes it difficult to employ any approximation for the null distribution. The test is omnibus and power study shows that the test can detect local alternatives approaching the null at parametric rate. Simulations are carried out for illustration and for a comparison with existing method.
基金supported by National Natural Science Foundation of China(Grant No.11401148)Ministry of Education of China,Humanities and Social Science Projects(Grant Nos.14YJC910005,10YJC790184)+2 种基金Zhejiang Provincial Natural Science Foundation of China(Grant No.LY14A010030)Zhejiang Provincial Philosophy and Social Science Planning Project of China(Grant No.13NDJC089YB)Houji Scholar Fund of Northwest A and F University,China
文摘For the linear mixed model with skew-normal random effects, this paper gives the density function, moment generating function and independence conditions. The noncentral skew chi-square distribution is defined and its density function is shown. The necessary and sufficient conditions under which a quadratic form is distributed as noncentral skew chi-square distribution are obtained. Also, a version of Cochran＇s theorem is given~ which modifies the result of Wang et al. （2009） and is used to set up exact tests for fixed effects and variance components of the proposed model. For illustration, our main results are applied to a real data problem.
文摘The purpose of this article is to investigate approaches for modeling individual patient count/rate data over time accounting for temporal correlation and non</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">constant dispersions while requiring reasonable amounts of time to search over alternative models for those data. This research addresses formulations for two approaches for extending generalized estimating equations (GEE) modeling. These approaches use a likelihood-like function based on the multivariate normal density. The first approach augments standard GEE equations to include equations for estimation of dispersion parameters. The second approach is based on estimating equations determined by partial derivatives of the likelihood-like function with respect to all model parameters and so extends linear mixed modeling. Three correlation structures are considered including independent, exchangeable, and spatial autoregressive of order 1 correlations. The likelihood-like function is used to formulate a likelihood-like cross-validation (LCV) score for use in evaluating models. Example analyses are presented using these two modeling approaches applied to three data sets of counts/rates over time for individual cancer patients including pain flares per day, as needed pain medications taken per day, and around the clock pain medications taken per day per dose. Means and dispersions are modeled as possibly nonlinear functions of time using adaptive regression modeling methods to search through alternative models compared using LCV scores. The results of these analyses demonstrate that extended linear mixed modeling is preferable for modeling individual patient count/rate data over time</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> because in example analyses</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> it either generates better LCV scores or more parsimonious models and requires substantially less time.
基金Supported by the National Natural Science Foundation of China （No.10471140）.
文摘In this paper we introduce an appealing nonparametric method for estimating variance and conditional variance functions in generalized linear models （GLMs）, when designs are fixed points and random variables respectively, Bias-corrected confidence bands are proposed for the （conditional） variance by local linear smoothers. Nonparametric techniques are developed in deriving the bias-corrected confidence intervals of the （conditional） variance. The asymptotic distribution of the proposed estimator is established and show that the bias-corrected confidence bands asymptotically have the correct coverage properties. A small simulation is performed when unknown regression parameter is estimated by nonparametric quasi-likelihood. The results are also applicable to nonparamctric autoregressive times series model with heteroscedastic conditional variance.
