AIM:To determine the association between serum levels of growth-related gene product β(GROβ) and clinical parameters in esophageal squamous cell carcinoma(ESCC).METHODS:Using enzyme-linked immunosorbent assay,serum ...AIM:To determine the association between serum levels of growth-related gene product β(GROβ) and clinical parameters in esophageal squamous cell carcinoma(ESCC).METHODS:Using enzyme-linked immunosorbent assay,serum GROβ levels were measured in ESCC patients(n = 72) and healthy volunteers(n = 83).The association between serum levels of GROβ and clinical parameters of ESCC was analyzed statistically.RESULTS:The serum GROβ levels were much higher in ESCC patients than in healthy controls(median:645 ng/L vs 269 ng/L,P < 0.05).Serum GROβ levels were correlated positively with tumor size,lymph node metastasis,and tumor-node-metastasis(TNM) staging,but not with gender or the histological grade of tumors in ESCC patients.The sensitivity and specificity of the assay for serum GROβ were 73.61% and 56.63%,respectively.CONCLUSION:GROβ may function as an oncogene product and contribute to tumorigenesis and metastasis of ESCC.展开更多
GRO(Global Navigation satellite system Radio Occultation)和LRO(Low Earth Orbit Radio Occultation)联合组网探测地球大气是无线电掩星探测技术的主要发展方向.本文根据掩星事件的数学判据,仿真分析了LEO卫星主要轨道参数对CRO和LR...GRO(Global Navigation satellite system Radio Occultation)和LRO(Low Earth Orbit Radio Occultation)联合组网探测地球大气是无线电掩星探测技术的主要发展方向.本文根据掩星事件的数学判据,仿真分析了LEO卫星主要轨道参数对CRO和LRO掩星事件数量和全球分布情况的影响.研究表明:卫星轨道越低GRO掩星事件越多:轨道倾角在30°和75°之间时,GRO掩星事件较多.全球覆盖率也较大;利用极轨卫星进行LRO掩星探测时.LRO掩星事件较均匀地分布在各纬度带.研究成果对GRO和LRO联合星座设计具有参考价值.展开更多
The Ti 5.6Al 4.8Sn 2Zr 1Mo 0.32Si 1Nd(Ti 60) high temperature titanium alloy heat treated in β phase region was studied. The results of electronic probe analysis show that no elemental accumulation at grain b...The Ti 5.6Al 4.8Sn 2Zr 1Mo 0.32Si 1Nd(Ti 60) high temperature titanium alloy heat treated in β phase region was studied. The results of electronic probe analysis show that no elemental accumulation at grain boundaries is detected by EMP 810Q instrument. The main reason for obstruction of grain growth is that the rare earth rich phases hinder the movement of grain boundaries.展开更多
The spin period variations and hard X-ray spectral properties of the Be/Xray pulsar GRO J1008-57 are studied with INTEGRAL observations during two out- bursts in 2004 June and 2009 March. The pulsation periods of -93....The spin period variations and hard X-ray spectral properties of the Be/Xray pulsar GRO J1008-57 are studied with INTEGRAL observations during two out- bursts in 2004 June and 2009 March. The pulsation periods of -93.66 s in 2004 and - 93.73 s in 2009 are determined. Pulse profiles of GRO J1008-57 during out- bursts are strongly energy dependent with a double-peaked profile from 3-7 keV and a single-peaked profile in hard X-rays above 7 keV. Combined with previous measure- ments, we find that GRO J1008-57 has undergone a spin-down trend from 1993 - 2009 with a rate of - 4.1 × 10^-5 s d^-1, and could have changed into a spin-up trend after 2009. We find a relatively soft spectrum in the early phase of the 2009 outburst with cutoff energy ~ 13keV. Above a hard X-ray flux of - 10^-9 erg cm^-2 s^-1, the spectra of GRO J1008-57 during outbursts need an enhanced hydrogen absorption with column density ~ 6 x 1022 cm-2. The observed dip-like pulse profile of GRO J1008-57 in soft X-ray bands could be caused by this intrinsic absorption. Around the outburst peaks, a possible cyclotron resonance scattering feature at - 74 keV is detected in the spectra of GRO J1008-57 which is consistent with the feature that was reported in MAXI/GSC observations, making the source a neutron star with the highest known magnetic field （- 6.6 × 10^12 G） among accreting X-ray pulsars. This marginal feature is supported by the present detections in GRO J1008-57 following the correlation between the fundamental line energies and cutoff energies in accret- ing X-ray pulsars. Finally we discovered two modulation periods at - 124.38 d and 248.78d using RXTE/ASM light curves of GRO J1008-57. Two flare peaks ap- pearing in the folded light curve had different spectral properties. The normal outburst lasting 0,1 of an orbital phase had a hard spectrum and could not be significantly de- tected below 3 keV. The second flare lasting ten days showed a very soft spectrum without significant detections above 5 keV. GRO J1008-57 is a good candidate of an accreting system with an equatorial circumstellar disk around the companion star. The neutron star passing the disk of the Be star near periastron and apastron produces two X-ray flares. The soft spectral properties in the secondary flares still need further detailed studies with soft X-ray spectroscopy.展开更多
In this paper an approach of a synoptic classification by cluster k-means (CKM) and the European Großwettertypes (GWT) was performed and executed in COST733 package. The methodology used a CKM with nine cluste...In this paper an approach of a synoptic classification by cluster k-means (CKM) and the European Großwettertypes (GWT) was performed and executed in COST733 package. The methodology used a CKM with nine clusters and GWT with 16. The COST733 evaluated a dataset of 30-years since 1986 to 2015. The variables selected were mean sea level pressure (mslp), geopotential height (z500 and z850), wind speed and direction (u10, v10 and u, v at 850 hPa) and relative vorticity (vo) with a 0.75° × 0.75° resolution of the data grid at 00:00, 06:00, 12:00 and 18:00 UTC and 0 steps. These results were evaluated using COST733 to find the quality of measurements by the explained variance (EV) or reduction ratio in error and pseudo F value (PF) to determine the certainty of the results. GWT-16 showed better yearly values in the evaluation with 32.7 (EV) and 354.3 (PF) against the CKM-9 of 54.2 (EV) and 1621.8 (PF). Finally, it was concluded that GWT-16 could be used for classification of synoptic systems over Mexico and the analysis of meteorological phenomena triggers on increases or decreases of atmospheric pollution in areas over Mexico.展开更多
基金Supported by The Grants from International Science & Technology Cooperation and Exchange Programs, No. 2008DFA31130Joint China/South Africa Science and Technology Agreement+1 种基金National Natural Science Foundation of China, No. 81021061, No. 0772507 and No. 30700992State Key Projects for Basic Research of China, No. 2011CB910703
文摘AIM:To determine the association between serum levels of growth-related gene product β(GROβ) and clinical parameters in esophageal squamous cell carcinoma(ESCC).METHODS:Using enzyme-linked immunosorbent assay,serum GROβ levels were measured in ESCC patients(n = 72) and healthy volunteers(n = 83).The association between serum levels of GROβ and clinical parameters of ESCC was analyzed statistically.RESULTS:The serum GROβ levels were much higher in ESCC patients than in healthy controls(median:645 ng/L vs 269 ng/L,P < 0.05).Serum GROβ levels were correlated positively with tumor size,lymph node metastasis,and tumor-node-metastasis(TNM) staging,but not with gender or the histological grade of tumors in ESCC patients.The sensitivity and specificity of the assay for serum GROβ were 73.61% and 56.63%,respectively.CONCLUSION:GROβ may function as an oncogene product and contribute to tumorigenesis and metastasis of ESCC.
文摘GRO(Global Navigation satellite system Radio Occultation)和LRO(Low Earth Orbit Radio Occultation)联合组网探测地球大气是无线电掩星探测技术的主要发展方向.本文根据掩星事件的数学判据,仿真分析了LEO卫星主要轨道参数对CRO和LRO掩星事件数量和全球分布情况的影响.研究表明:卫星轨道越低GRO掩星事件越多:轨道倾角在30°和75°之间时,GRO掩星事件较多.全球覆盖率也较大;利用极轨卫星进行LRO掩星探测时.LRO掩星事件较均匀地分布在各纬度带.研究成果对GRO和LRO联合星座设计具有参考价值.
文摘The Ti 5.6Al 4.8Sn 2Zr 1Mo 0.32Si 1Nd(Ti 60) high temperature titanium alloy heat treated in β phase region was studied. The results of electronic probe analysis show that no elemental accumulation at grain boundaries is detected by EMP 810Q instrument. The main reason for obstruction of grain growth is that the rare earth rich phases hinder the movement of grain boundaries.
基金Supported by the National Natural Science Foundation of China
文摘The spin period variations and hard X-ray spectral properties of the Be/Xray pulsar GRO J1008-57 are studied with INTEGRAL observations during two out- bursts in 2004 June and 2009 March. The pulsation periods of -93.66 s in 2004 and - 93.73 s in 2009 are determined. Pulse profiles of GRO J1008-57 during out- bursts are strongly energy dependent with a double-peaked profile from 3-7 keV and a single-peaked profile in hard X-rays above 7 keV. Combined with previous measure- ments, we find that GRO J1008-57 has undergone a spin-down trend from 1993 - 2009 with a rate of - 4.1 × 10^-5 s d^-1, and could have changed into a spin-up trend after 2009. We find a relatively soft spectrum in the early phase of the 2009 outburst with cutoff energy ~ 13keV. Above a hard X-ray flux of - 10^-9 erg cm^-2 s^-1, the spectra of GRO J1008-57 during outbursts need an enhanced hydrogen absorption with column density ~ 6 x 1022 cm-2. The observed dip-like pulse profile of GRO J1008-57 in soft X-ray bands could be caused by this intrinsic absorption. Around the outburst peaks, a possible cyclotron resonance scattering feature at - 74 keV is detected in the spectra of GRO J1008-57 which is consistent with the feature that was reported in MAXI/GSC observations, making the source a neutron star with the highest known magnetic field （- 6.6 × 10^12 G） among accreting X-ray pulsars. This marginal feature is supported by the present detections in GRO J1008-57 following the correlation between the fundamental line energies and cutoff energies in accret- ing X-ray pulsars. Finally we discovered two modulation periods at - 124.38 d and 248.78d using RXTE/ASM light curves of GRO J1008-57. Two flare peaks ap- pearing in the folded light curve had different spectral properties. The normal outburst lasting 0,1 of an orbital phase had a hard spectrum and could not be significantly de- tected below 3 keV. The second flare lasting ten days showed a very soft spectrum without significant detections above 5 keV. GRO J1008-57 is a good candidate of an accreting system with an equatorial circumstellar disk around the companion star. The neutron star passing the disk of the Be star near periastron and apastron produces two X-ray flares. The soft spectral properties in the secondary flares still need further detailed studies with soft X-ray spectroscopy.
文摘In this paper an approach of a synoptic classification by cluster k-means (CKM) and the European Großwettertypes (GWT) was performed and executed in COST733 package. The methodology used a CKM with nine clusters and GWT with 16. The COST733 evaluated a dataset of 30-years since 1986 to 2015. The variables selected were mean sea level pressure (mslp), geopotential height (z500 and z850), wind speed and direction (u10, v10 and u, v at 850 hPa) and relative vorticity (vo) with a 0.75° × 0.75° resolution of the data grid at 00:00, 06:00, 12:00 and 18:00 UTC and 0 steps. These results were evaluated using COST733 to find the quality of measurements by the explained variance (EV) or reduction ratio in error and pseudo F value (PF) to determine the certainty of the results. GWT-16 showed better yearly values in the evaluation with 32.7 (EV) and 354.3 (PF) against the CKM-9 of 54.2 (EV) and 1621.8 (PF). Finally, it was concluded that GWT-16 could be used for classification of synoptic systems over Mexico and the analysis of meteorological phenomena triggers on increases or decreases of atmospheric pollution in areas over Mexico.
