CLINICAL OBSERVATION ON 32 CASES OF FUNCTIONAL ENURESIS TREATED WITH ACUPUNCTURE AT BAIHUI(GV 20)

Acupuncture at Baihui（GV 20）was employed in treating 32 cases of functionalenuresis.As a result,the curative rate reached 81.25％,but that in control group of 32 cases withoutneedling Baihui point was 56.25％.There was a significant difference in statistics（P【0.05）.It indi- cates that Baihui can enhance the therapeutic effect of acupuncture on treating enuresis.

A COMPARATIVE STUDY ON THE TREATMENT OF VASCULAR DEMENTIA BY PUNCTURING BAIHUI (GV20), SHUIGOU (GV26) AND SHENMEN (HT7)

Objective: To observe the relative specialty of the therapeutic effect of acupuncture of Baihui (百会 GV 20), Shuigou (水沟 GV 26) a nd Shenmen (神门 HT 7) in the treatment of vascular dementia (VD) patients. Methods: F ifty VD patients were randomly divided into routine treatment group (control gro up), Baihui (GV 20) group (GV 20 group), Shuigou (GV 26) group (GV 26 gr oup), Shenmen (HT 7) group (HT 7 group) a nd GV 20+GV 26+HT 7 group (joint treatment group), with 10 cases in ea ch group. In control group, acupoints used were Jianyu (肩NFDA1 LI 15), Quchi (曲池 L I 11), Waiguan (外关 TE 5), etc. (which were also used in the other four groups) on the paralyzed side. The treatment was conducted once a day except weekends, 20 session s all together. Clinical Dementia Rating Scale (CDR), Mini-Mental State Examin at ion (MMSE) test, Blessed Dementia Rating Scale (BDR) and Clinical Neurological D eficit Rating (CNDR) were used to assess the patients’ intelligence state befor e and after acupuncture treatment. Results: After acupuncture tr eatment, the VD patients’ intelligence in all the five groups was improved at different degrees . Additional acupuncture of each of GV 20, GV 26 and HT 7 had a remarkable e ffec t in improving the VD patients’ fluid intelligence, and could obviously promote their abilities of temporal orientation, spatial orientation and figure drawing ; and additional joint acupuncture of the three acupoints could improve their co gnitive and non-cognitive functions, such as reducing the severity of dementia , raising the temporal orientation, spatial orientation, calculation, short-term m emory and figure drawing abilities, and improving their activities of daily livi ng and personality. Besides, acupuncture of GV 20 could improve the abilities of calculation and short term memory, and correct the personality change of VD pat ients, while acupuncture of GV 26 could improve the abilities of naming and sh or t-term memory. Conclusion: Acupuncture of GV 20, GV 26 and HT 7 all had a certai n therapeutic effect in improving VD; the therapeutic effects of acupuncture of GV 20 and GV 26 were better than that of acupuncture of HT 7; and the effica cy of the three points used in combination was the best.

Acupuncture through Baihui (DU20) to Qubin (GB7) mitigates neurological impairment after intracerebral hemorrhage

Inflammation plays an important role in nerve defects caused by intracerebral hemorrhage. Repairing brain damage by inhibiting the macrophage-inducible C-type lectin/spleen tyrosine kinase （Mincle/Syk） signaling pathway is a potential new target for treating cerebral hemorrhage. In this study, we aimed to determine whether acupuncture through Baihui （DU20） to Qubin （GBT） is an effective treatment for intracerebral hemorrhage through the Mincle/Syk signaling pathway. An intracerebral hemorrhage rat model was established by autol- ogous blood infusion into the caudate nucleus. Acupuncture through Baihui to Qubin was performed for 30 minutes, once every 12 hours, for a total of three times. Piceatannol （34.62 mg/kg）, a Syk inhibitor, was intraperitoneally injected as a control. Modified neurological severity score was used to assess neurological function. Brain water content was measured. Immunohistochemistry and western blot assay were used to detect immunoreactivity and protein expression levels of Minde, Syk, and CARD9. Real-time polymerase chain reaction was used to determine interleukin-1[~ mRNA levels. Hematoxylin-eosin staining was performed to observe histopathological changes. Our re- suits showed that acupuncture through Baihui to Qubin remarkably improved neurological function and brain water content, and inhibited immunoreactivity and expression of Mincle, Syk, CARDg, and interkeukin-1β Moreover, this effect was similar to piceatannol. These find- ings suggest that acupuncture through Baihui to Qubin can improve neurological impairment after cerebral hemorrhage by inhibiting the Mincle/Syk signaling pathway.

Electroacupuncture at Baihui (DU20) acupoint upregulates mRNA expression of NeuroD molecules in the brains of newborn rats suffering in utero fetal distress

Neuro D plays a key regulatory effect on differentiation of neural stem cells into mature neurons in the brain.Thus,we assumed that electroacupuncture at Baihui（DU20） acupoint in newborn rats exposed to in utero fetal distress would influence expression of Neuro D.Electroacupuncture at Baihui was performed for 20 minutes on 3-day-old（Day 3） newborn Sprague-Dawley rats exposed to in utero fetal distress;electroacupuncture parameters consisted of sparse and dense waves at a frequency of 2–10 Hz.Real-time fluorescent quantitative PCR results demonstrated that m RNA expression of Neuro D,a molecule that indicates Neuro D,increased with prolonged time in brains of newborn rats,and peaked on Day 22.The level of m RNA expression was similar between Day 16 and Day 35.These findings suggest that electro acupuncture at Baihui acupoint could effectively increase m RNA expression of molecules involved in Neuro D in the brains of newborn rats exposed to in utero fetal distress.

Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints

Preliminary basic research and clinical findings have demonstrated that electroacupuncture ther- apy exhibits positive effects in ameliorating depression. However, most studies of the underlying mechanism are at the single gene level; there are few reports regarding the mechanism at the whole-genome level. Using a rat genomic gene-chip, we profiled hippocampal gene expression changes in rats after electroacupuncture therapy. Electroacupuncture therapy alleviated depres- sion-related manifestations in the model rats. Using gene-chip analysis, we demonstrated that electroacupuncture at Baihui （DU20） and Yintang （EX-HN3） regulates the expression of 21 genes. Real-time PCR showed that the genes Vgf, lgf2, Trnp32, Loc500373, Hifla, Folrl, Nrnb, and Rtn were upregulated or downregulated in depression and that their expression tended to nor- malize after electroacupuncture therapy. These results indicate that electroacupuncture at Baihui and Yintang modulates depression by regulating the expression of particular genes.

百会穴久留针法改善缺血性脑卒中小鼠神经功能的作用及机制

目的研究百会穴久留针法通过脑源性神经营养因子(BDNF)/酪氨酸受体激酶B(TrkB)通路改善缺血性脑卒中小鼠神经功能的作用及机制。方法选择雄性C57BL/6J小鼠48只,随机分为假手术1组、模型1组、久留针1组、普通留针组,每组12只。后3组采用线栓法制备缺血性脑卒中模型,手术造模后第1天起久留针1组和普通留针组分别给予百会穴久留针和普通留针治疗,连续14 d。另选择雄性C57BL/6J小鼠40只,随机分为假手术2组、模型2组、久留针2组、久留针3组,每组10只。后3组采用线栓法制备缺血性脑卒中模型,针灸治疗前分别给予腺相关病毒100μl单次尾静脉注射。采用改良神经功能缺损评分(mNSS)及水迷宫实验的逃避潜伏期、目标象限停留时间、穿越原平台次数评价神经功能。结果与假手术1组比较,模型1组mNSS评分、目标象限停留时间、穿越原平台次数及缺血脑组织BDNF、TrkB表达明显降低,细胞凋亡率及裂解型半胱氨酸天冬氨酸蛋白酶3(Caspase-3)表达明显增加,差异有统计学意义(P<0.05);与模型1组比较,久留针1组和普通留针组mNSS评分、目标象限停留时间、穿越原平台次数及缺血脑组织BDNF、TrkB表达明显增加,细胞凋亡率及裂解型Caspase-3表达明显降低,且久留针1组上述变化较普通留针组更为显著,差异有统计学意义(P<0.05)。与久留针2组比较,久留针3组mNSS评分、目标象限停留时间、穿越原平台次数及缺血脑组织中BDNF表达明显降低(P<0.05),细胞凋亡率及裂解型Caspase-3表达明显增加[(16.41±2.25)%vs(7.59±1.09)%;1.46±0.16 vs 0.94±0.12,P<0.05]。结论百会穴久留针治疗对缺血性脑卒中小鼠神经功能的改善作用更为显著,激活BDNF/TrkB通路是其发挥神经保护作用的相关分子机制。

A Comparative Study on the Acupoints of Specialty of Baihui, Shuigou and Shenmen in Treating Vascular Dementia

Objective： To study the relative specialty of the acupoints of Baihui （DU20）, Shuigou （DU26） and Shenmen （HTT） in treating vascular dementia （VD）. Methods： Fifty patients suffering from VD were divided into 5 groups randomly and treated by conventional acupuncture for hemiplegia, or conventional acupuncture plus needling in DU20, DU26, HT7 respectively or simultaneously. Clinical symptoms were observed, and the scales such as Hasegawa＇s dementia scale-recension （HDS-R）, activities of daily living （ADL） and functional activities questionnaire （FAQ） were used for assessment before and after acupuncture treatment. The scores were processed statistically. Results： DU20 and HT7 could improve the abilities of memory, orientation, reaction and reduce adamancy and trance. Bedsides, DU 20 was helpful in improving the abilities of understanding, calculating and social adapting. While DU26 is helpful in treating retardation, failure in daily activities, trance and poor memory. The combination of the 3 acupoints could improve the intelligence and social adapting ability of VD patients. Conclusion： DU20, DU26 and HT7 had its own effect in treating VD, but the effect of three points used in combination was the best.

针刺百会、曲鬓穴对急性期脑出血大鼠的影响及其作用机制研究

目的 观察针刺百会、曲鬓穴对急性期脑出血(ICH)大鼠白细胞分化抗原36(CD36)、Toll样受体4(TLR4)表达的影响,探讨针刺治疗脑出血的作用机制。方法 选择144只Wistar雄性大鼠,采用随机数字表法分为假手术组、模型组、针刺组、抑制剂组4组,每组36只,每组按1、3、7 d时间点再分为3个亚组,每组12只。采用立体定位自体血注入法建立ICH大鼠模型。模型组仅接受ICH模型制备,不进行任何治疗;假手术组接受类似模型组各项手术操作,但不进行注血制作;抑制剂组造模后6 h,腹腔注射TLR4抑制剂TAK242,3 mg/kg,1次/d,连续5 d;造模12 h后,针刺组各亚组开始接受针刺治疗,穴位选择百会穴(顶骨正中)、右侧曲鬓穴,采用透刺方法,进针深度20 mm,以100 r/min小幅度捻转,持续捻转2 min,每间隔5 min捻针1次,共留针30 min,期间捻转3次,1次/d,针刺组各亚组分别治疗1、3、7 d。分别于治疗后第1、3、7天,采用改良神经功能缺损评分(mNSS)评估大鼠神经功能;检测脑组织血肿体积;采用Western blot法检测脑组织CD36、TLR4蛋白表达水平;采用免疫荧光法观察CD36、TLR4在星形胶质细胞中的表达。结果 (1) mNSS评分:与假手术组同一时间点比较,模型组、针刺组、抑制剂组治疗后1、3、7 d mNSS评分均明显升高(P<0.05);与模型组同一时间点比较,针刺组、抑制剂组治疗后1、3、7 d mNSS评分均明显降低(P<0.05);与针刺组同一时间点比较,抑制剂组治疗后1 d mNSS评分明显降低(P<0.05)。(2)血肿体积:与模型组同一时间点比较,针刺组、抑制剂组治疗后3、7 d脑血肿体积均明显降低,抑制剂组治疗后1、3、7 d脑血肿体积明显降低(P<0.05);与针刺组同一时间点比较,抑制剂组治疗后1、3、7 d脑血肿体积明显降低(P<0.05)。(3) CD36、TLR4蛋白表达水平:与假手术组同一时间点比较,模型组、针刺组、抑制剂组治疗后1、3、7 d CD36、TLR4蛋白表达水平均明显升高(P<0.05);与模型组同一时间点比较,针刺组、抑制剂组治疗后1、3、7 d CD36蛋白表达水平均明显升高(P<0.05),针刺组、抑制剂组治疗后3、7 d TLR4蛋白表达水平均明显降低(P<0.05);与针刺组比较,抑制剂组治疗后1、3、7 d CD36蛋白表达水平均明显升高,TLR4蛋白表达水平均明显降低(P<0.05)。(4) CD36、TLR4在GFAP中的表达水平:假手术组大鼠脑组织内可见少量CD36、TLR4表达。与假手术组同一时间点比较,模型组治疗后1、3、7 d CD36、TLR4在GFAP表达均明显增加(P<0.05);与模型组同一时间点比较,抑制剂组、针刺组治疗后1、3、7 d CD36在GFAP表达明显增加,TLR4在GFAP表达明显降低(P<0.05)。结论 针刺百会、曲鬓穴可以改善急性期ICH大鼠神经功能,减轻脑出血血肿体积,可能与促进CD36蛋白表达、抑制TLR4蛋白表达有关。

电针预处理对大鼠脑缺血再灌注后小胶质细胞极化的影响

目的探讨电针预处理对大鼠脑缺血再灌注(IR)后小胶质细胞极化的影响以及与酪氨酸激酶2(JAK2)/信号传导及转录活化因子3(STAT3)通路的关系。方法选择健康清洁级雄性SD大鼠45只,随机分为假手术组、IR组和电针组,每组15只。IR组采用线栓法建立大鼠IR损伤模型,电针组造模前连续5 d行电针刺激百会穴,假手术组仅暴露颈部血管。再灌注后24 h,采用改良神经功能缺损评分(mNSS)观察各组大鼠神经功能损伤程度,氯化三苯四氮唑染色观察脑梗死体积,Western blot检测经典激活型(M1)标志物诱导型一氧化氮合酶(iNOS)和替代激活型(M2)标志物精氨酸酶1(Arg-1)、磷酸化JAK2、JAK2、磷酸化STAT3及STAT3蛋白表达,定量聚合酶链反应检测M1标志物iNOS mRNA和M2标志物Arg-1 mRNA表达,检测肿瘤坏死因子α(TNF-α)、白细胞介素10(IL-10)表达。结果与假手术组比较,IR组和电针组mNSS、脑梗死体积、磷酸化JAK2/JAK2、磷酸化STAT3/STAT3、iNOS蛋白、iNOS mRNA、Arg-1蛋白、Arg-1 mRNA、TNF-α和IL-10表达明显升高,差异有统计学意义(P<0.01)。与IR组比较,电针组mNSS、脑梗死体积、磷酸化JAK2/JAK2、磷酸化STAT3/STAT3、iNOS蛋白、iNOS mRNA、TNF-α表达明显降低(P<0.01),Arg-1蛋白、Arg-1 mRNA、IL-10表达明显升高[2.0±0.2 vs 1.5±0.1,4.2±0.8 vs 3.1±0.3,(49.1±7.1)pg/mg vs(27.9±5.9)pg/mg,P<0.01]。结论电针预处理可促进脑IR后小胶质细胞向M2极化,抑制向M1极化,其机制可能与抑制JAK2/STAT3通路有关。

项七针针刺联合百会压灸治疗颈性眩晕的疗效观察

目的观察项七针针刺联合百会压灸治疗颈性眩晕的临床疗效。方法将90例颈性眩晕患者随机分为治疗组和对照组,每组45例。对照组采用项七针针刺治疗,治疗组在对照组基础上采用百会穴压灸治疗。两组治疗后均采用海特光照射颈枕部。观察两组治疗前后疼痛视觉模拟量表(visual analog scale,VAS)评分、颈性眩晕症状与功能评估量表(evaluation scale for cervical vertigo,ESCV)评分及颈部红外热成像温度的变化情况,比较两组临床疗效。结果两组治疗后ESCV评分及红外热成像温度均较同组治疗前显著升高,VAS评分显著降低,差异均具有统计学意义(P<0.05)。治疗组治疗后ESCV评分及红外热成像温度明显高于对照组,VAS评分明显低于对照组,差异均具有统计学意义(P<0.05)。治疗组治疗后总有效率为93.2%,明显高于对照组的77.8%,差异具有统计学意义(P<0.05)。结论项七针针刺联合百会穴压灸可明显改善颈性眩晕患者的临床症状,缓解疼痛,有助于提高患者生活质量。

通督调神针法影响卒中后癫痫脑血流动力学及氧自由基的临床研究

【目的】探讨通督调神针法对卒中后癫痫(post-strokeepilepsy,PSE)患者的脑血流动力学及氧自由基的效应。【方法】将60例PSE患者随机分为治疗组和对照组,每组各30例。2组患者均给予降脂、控压、控糖、抗血小板等基础治疗,对照组同时给予丙戊酸钠缓释片治疗,治疗组在对照组的基础上给予通督调神针法(以百会、神庭、水沟、风府、风池等为主穴)治疗,1个月为1个疗程,共治疗3个疗程。观察2组患者治疗前后癫痫发作次数、脑电图严重程度和经颅多普勒(TCD)检测的双侧大脑前动脉、大脑中动脉、大脑后动脉收缩期峰值流速(Vs)、舒张期末血流速度(Vd)等脑血流动力学指标以及外周血丙二醛(MDA)、羟自由基(OH)、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)等氧自由基的变化情况,并评价2组患者的临床疗效和安全性。【结果】(1)疗效方面,治疗3个月后,治疗组的总有效率为93.33%(28/30),对照组为73.33%(23/30),组间比较(χ^(2)检验),治疗组的疗效明显优于对照组(P<0.05)。(2)癫痫发作频次方面,治疗后,2组患者的癫痫月平均发作频次均较治疗前减少(P<0.05),且治疗组的减少程度明显优于对照组(P<0.05)。(3)脑电图严重程度分级方面,治疗后,2组患者的脑电图严重程度分级情况均较治疗前明显改善(P<0.05),且治疗组的改善程度明显优于对照组(P<0.05)。(4)氧自由基水平方面,治疗后,2组患者的外周血MDA、OH、LPO水平均较治疗前降低(P<0.05),外周血SOD水平均较治疗前升高(P<0.05),且治疗组对外周血MDA、OH、LPO水平的降低幅度及对外周血SOD水平的升高幅度均明显优于对照组(P<0.05或P<0.01)。(5)脑血流动力学指标方面,治疗后,2组患者的左右侧大脑前动脉、大脑中动脉、大脑后动脉的Vs、Vd值均较治疗前升高(P<0.05),且治疗组的升高幅度均明显优于对照组,差异均有统计学意义(P<0.05)。(6)安全性方面,治疗过程中,2组患者均未出现晕针、滞针、出血及皮疹等情况,具有较高的安全性。【结论】通督调神针法可明显减少PSE发作频率,改善癫痫脑电图严重程度,其治疗机制可能与降低氧自由基水平、改善脑血流动力学相关。

Forty Cases of Insomnia Treated by Suspended Moxibustion at Baihui (GV 20)

Objective： To observe the therapeutic effect of suspended moxibustion at Baihui （GV 20） for insomnia. Methods： 75 cases were divided randomly into two groups, with 40 cases in the treatment group treated by suspended moxibustion over Baihui （GV 20） and 35 cases in the control group treated by oral administration of Estazolam. Results： The difference in therapeutic effect between the two groups was not statistically significant （P〉0.1）. Conelusion： It was concluded that suspended moxibustion at Baihui （GV 20） is as effective as Estazolam for insomnia.

Effect of electroacupuncture at Neiguan(PC 6) and Baihui(GV 20) on CHOP and caspase-12 gene expressions in rats after ischemia-reperfusion injury

Objective： To investigate the effects of electroacupuncture （EA） at Neiguan （PC 6） and Baihui （GV 20） by observing the changes of CCAAT/enhancer-binding protein（C/EBP） homologous protein （CHOP） and caspase-12 gene expressions in rats after cerebral ischemia-reperfusion injury （IRI）, and explore whether the apoptosis pathway of endoplasmic reticulum stress （ERS） is involved in the protective mechanisms of EA. Methods： Sixty rats were randomly assigned to five groups （12 in each group）： a normal control group （group A）, a sham-operation group （group B）, an operation group （group C）, an Edaravone group （group D） and an EA group （group E）. The cerebral IRI rat model was induced by middle cerebral artery occlusion （MCAO） using intraluminal monofilament. 2,3,5-triphenyl tetrazolium chloride （TTC） staining was adopted in the measurement of cerebral infarction volume. Real-time polymerase chain reaction （RT-PCR） was used to determine the mRNA expressions of CHOP and caspase-12. Results： Compared with group A and group B, the volume of cerebral infarction and mRNA expressions of CHOP and caspase-12 in group C, group D and group E were increased, with statistical significances （P〈0.05 or P〈O.01）; compared with group C, the volume of cerebral infarction and mRNA expressions of CHOP and caspase-12 in group D and group E were decreased significantly （P〈0.05 or P〈0.01）; there were no significant differences between group D and group E in comparing the above items （P〉0.05）. Conclusion： EA at Neiguan （PC 6） and Baihui （GV 20） can effectively suppress the volume of cerebral infarction. Furthermore, the underlying mechanism of EA at Neiguan （PC 6） and Baihui （GV 20） is possibly related to the down-regulation of CHOP and caspase-12 mRNA expressions, so as to decrease cell apoptosis.

Effect of long-time needle retaining at Baihui(GV 20) on cognitive impairment in post-stroke patients

Objective： To observe the clinical efficacy of long-time needle retaining at Baihui（GV 20） in treating post-stroke cognitive impairment. Methods： A total of 60 eligible patients with post-stroke cognitive impairment were randomized into a treatment group and a control group by random digital table, 30 cases in each group. The control group was intervened by basic treatment including routine therapy in Neurology department and Western medicine rehabilitation therapy, while the treatment group was intervened by same treatment in the control group combined with long-time needle retaining at Baihui（GV 20）. Mental state of patients was evaluated by National Institute of Health stroke scale（NIHSS） and mini-mental state examination（MMSE） after 4 weeks of treatment. Results： After 4-week treatment, the NIHSS score dropped in both groups, and intra-group comparisons showed statistical significances（both P〈0.05）, and the score in the treatment group was statistically lower than that in the control group（P〈0.01）; the MMSE score in the treatment group was significantly higher than that in the control group, there was a statistical inter-group difference（P〈0.01）; the total effective rate was 93.3%, and the marked effective rate was 50.0% in the treatment group, versus 76.7% and 20.0% in the control group, there were significant differences in the total effective rate and the marked effective rate between the two groups（all P〈0.05）. Conclusion： Long-time needle retaining at Baihui（GV 20） can produce a safe valid therapeutic efficacy in treating post-stroke cognitive impairment.

Clinical Observation on Suspended Moxibustion at Baihui （GV 20） for Insomnia

Insomnia is a common disease with frequently disturbed sleep which can strongly influence the patients＇ daily life, work and study, so it should be treated as early as possible. A more effective and less harmful therapy was recently sought by the clinical researchers due to serious side-effects of drugs. The author treated insomnia with suspended moxibustion at Baihui （GV 20）, the report is as follows.

Clinical Applications of Acupoints Baihui （GV 20） and Sishencong （Ex-HN 1）

Through clinical practice over the last decade, , I have been using Baihui （GV 20） and Sishencong （Ex-HN 1） for treating various diseases or symptoms. It is now reported as follows.

Comparative Study on the Effect of Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） on Cognition of Patients with Vascular Dementia

Objective： To study the relative specificity of Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） in improving the cognitive function of patients with vascular dementia （VD）. Method： Fifty VD cases were randomized into 5 groups, which were treated with routine points, routine points plus Baihui （GV 20）, routine points plus Shuigou （GV 26）, routine points plus Shenmen （HT 7）, and routine points plus the above-mentioned three points together respectively. The scale of elderly cognitive function （SECF） was measured before and after the treatment for statistical management. Results： The total score of SECF was markedly increased after Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） were added to the routine points, more specifically, with addition of Baihui （GV 20）, the patients with VD got increased scores in such aspects as orientation, instant memory, long-term anamnesis, animal names, cancellation and calculation, and classification and analogy; with addition of Shuigou （GV 26）, the patients with VD got increased scores in such aspects as orientation, cancellation and calculation, and classification and analogy; with addition of Shenmen （HT 7）, the patients with VD got increased scores in such aspects as digital scope, animal names, and classification and analogy. Conclusion： Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） could improve the cognitive function of patients with VD, and the combination of the three points got the best result despite their respective specificity.

Clinical observation on moxibustion at Baihui(GV20)plus Tuina for children with postnasal drip syndrome

Objective:To observe the clinical efficacy of moxibustion at Baihui(GV20)plus Tuina(Chinese therapeutic massage)for children with postnasal drip syndrome(PNDS).Methods:A total of 60 cases were divided into an observation group and a control group according to the random number table method,with 30 cases in each group.Cases in the control group received mometasone furoate nasal spray and nasal irrigation with 0.9%normal saline.Cases in the observation group received additional moxibustion at Baihui(GV20)plus Tuina at the head and face.All the cases were treated for four consecutive weeks.The clinical efficacy and traditional Chinese medicine(TCM)symptoms score were compared between the two groups.Results:The total effective rate of the observation group was 93.3%while that of the control group was 70.0%.The difference between the two groups was statistically significant(P<0.05).After treatment,the TCM symptom scores in both groups declined significantly,showing a statistical difference from that before treatment(P<0.05),and the score of the observation group was notably lower than that of the control group(P<0.05).Conclusion:The clinical efficacy of moxibustion at Baihui(GV20)plus Tuina at the head and face on the basis of nasal spray with Western medicine is more significant than that of Western medicine alone for PNDS in children.

温针灸治疗儿童癫痫的疗效观察及对血清PSD-95水平的影响

目的观察温针灸涌泉和百会穴治疗儿童癫痫的临床疗效及对患者神经损伤状态和血清突触后致密区95(postsynaptic density-95,PSD-95)水平的影响。方法对110例癫痫儿童患者展开回顾性研究,根据治疗方法的不同将其分为对照组和观察组,每组55例。对照组采用口服拉莫三嗪治疗,观察组在对照组口服药物基础上采用温针灸涌泉和百会穴治疗。比较两组临床疗效,观察两组治疗前后韦氏儿童智力量表(Wechsler intelligence scale for children-Ⅳ,WISC-Ⅳ)和简易精神状态检查表(mini-mental state examination,MMSE)评分、癫痫发作频率、癫痫持续时间、脑电图指标以及血清S100β、胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)和PSD-95水平的变化。结果观察组总有效率高于对照组(P<0.05)。观察组治疗后WISC-Ⅳ和MMSE评分均高于对照组(P<0.05),癫痫发作频率低于对照组(P<0.05),癫痫持续时间短于对照组(P<0.05)。观察组治疗后脑电图β功率、δ功率、θ功率和α功率均高于对照组(P<0.05)。观察组治疗后血清S100β和GFAP水平均低于对照组(P<0.05),血清PSD-95水平高于对照组(P<0.05)。结论在口服拉莫三嗪治疗基础上,采用温针灸涌泉和百会穴治疗儿童癫痫可改善神经损伤状态,改善认知功能和精神状态,减少癫痫发作次数,缩短发作持续时间,上调血清PSD-95表达量,降低血清S100β和GFAP水平,提高临床疗效。

Treatment of 35 Cases of Parietal Headache with Baihui （GV20） and Taichong （LR 3）

针刺百会和双侧太冲穴，治疗巅顶痛患者35例，痊愈14例，显效13例，好转6例，无效2例，总有效率94．3％。