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H pylori exist in the gallbladder mucosa of patients with chronic cholecystitis
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作者 Dong-Feng Chen Lu Hu Ping Yi Wei-Wen Liu Dian-Chun Fang Hong Cao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第10期1608-1611,共4页
AIM:To study whether H pylori locate in the gallbladder mucosa of patients with chronic cholecystitis.METHODS:Using Warthy-Starry(W-S)silver stain and immunohistochemistry stain with anti-H pylori antibodies,we screen... AIM:To study whether H pylori locate in the gallbladder mucosa of patients with chronic cholecystitis.METHODS:Using Warthy-Starry(W-S)silver stain and immunohistochemistry stain with anti-H pylori antibodies,we screened paraffin specimens in 524 cases of cholecystitis.H pylori urease gene A(HPUA)and H pylori urease gene B(HPUB)were analyzed by polymerase chain reaction(PCR)in the fresh tissue specimens from 81 cases of cholecystitis.RESULTS:H pylori-like bacteria were found in 13.55% of the gallbladders of the cholecystitis patients using W-S stain.Meanwhile,bacteria positive for H pylori antibodies were also found in 7.1% of the gallbladders of patients with cholecystitis by immunohistochemistry.Of 81 gallbladders,11 were positive for both HPUA and HPUB,4 were positive for HPUA only and 7 were positive for HPUB only.CONCLUSION:H pylori exist in the gallbladders of patients with chronic cholecystitis. 展开更多
关键词 HPYLORI gallbladder mucosa Chronic cholecystitis Polymerase chain reaction Hpylori urease gene
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H pylori are associated with chronic cholecystitis 被引量:3
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作者 Dong-Feng Chen Lu Hu, Ping Yi Wei-Wen Liu Dian-Chun Fang Hong Cao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第7期1119-1122,共4页
AIM: To study whether H pylon are associated with chronic cholecystitis. METHODS: The subjects were divided into three groups: H pylori-infected cholecystitis group, H pylorinegative cholecystitis group and control... AIM: To study whether H pylon are associated with chronic cholecystitis. METHODS: The subjects were divided into three groups: H pylori-infected cholecystitis group, H pylorinegative cholecystitis group and control group. Pathologic changes of the gallbladder were observed by optic and electronic microscopes and the levels of interleukin-1, 6 and 8 (IL-1, 6 and 8) were detected by radioimmunoassay. RESULTS: Histological evidence of chronic cholecystitis including degeneration, necrosis, inflammatory cell infiltration, were found in the region where H pylori colonized. Levels of IL-1, 6 and 8 in gallbladder mucosa homogenates were significantly higher in H py/oriinfected cholecystitis group than those in Hpylorinegative cholecystitis group and control group. CONCLUSION: H pylon infection may be related to cholecystitis. 展开更多
关键词 H pylori Chronic cholecystitis INTERLEUKIN COLONIZATION gallbladder mucosa
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