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Values of macular ganglion cell-inner plexiform layer and 10-2 visual field measurements in detecting and evaluating glaucoma
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作者 Hai-Jian Hu Ping Li +7 位作者 Bin Tong Yu-Lian Pang Hong-Dou Luo Fei-Fei Wang Chan Xiong Yu-Lin Yu Hai He Xu Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第5期852-860,共9页
AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced glaucoma.METHODS:T... AIM:To assess the performance of macular ganglion cell-inner plexiform layer thickness(mGCIPLT)and 10-2 visual field(VF)parameters in detecting early glaucoma and evaluating the severity of advanced glaucoma.METHODS:Totally 127 eyes from 89 participants(36 eyes of 19 healthy participants,45 eyes of 31 early glaucoma patients and 46 eyes of 39 advanced glaucoma patients)were included.The relationships between the optical coherence tomography(OCT)-derived parameters and VF sensitivity were determined.Patients with early glaucoma were divided into eyes with or without central 10°of the VF damages(CVFDs),and the diagnostic performances of OCT-derived parameters were assessed.RESULTS:In early glaucoma,the mGCIPLT was significantly correlated with 10-2 VF pattern standard deviation(PSD;with average mGCIPLT:β=-0.046,95%CI,-0.067 to-0.024,P<0.001).In advanced glaucoma,the mGCIPLT was related to the 24-2 VF mean deviation(MD;with average mGCIPLT:β=0.397,95%CI,0.199 to 0.595,P<0.001),10-2 VF MD(with average mGCIPLT:β=0.762,95%CI,0.485 to 1.038,P<0.001)and 24-2 VF PSD(with average mGCIPLT:β=0.244,95%CI,0.124 to 0.364,P<0.001).Except for the minimum and superotemporal mGCIPLT,the decrease of mGCIPLT in early glaucomatous eyes with CVFDs was more severe than that of early glaucomatous eyes without CVFDs.The area under the curve(AUC)of the average mGCIPLT(AUC=0.949,95%CI,0.868 to 0.982)was greater than that of the average circumpapillary retinal nerve fiber layer thickness(cpRNFLT;AUC=0.827,95%CI,0.674 to 0.918)and rim area(AUC=0.799,95%CI,0.610 to 0.907)in early glaucomatous eyes with CVFDs versus normal eyes.CONCLUSION:The 10-2 VF and mGCIPLT parameters are complementary to 24-2 VF,cpRNFLT and ONH parameters,especially in detecting early glaucoma with CVFDs and evaluating the severity of advanced glaucoma in group level. 展开更多
关键词 10-2 visual field ganglion cell-inner plexiform layer retinal nerve fiber layer thickness GLAUCOMA
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Comparisons of ganglion cell-inner plexiform layer loss patterns and its diagnostic performance between normal tension glaucoma and primary open angle glaucoma: a detailed, severity-based study 被引量:2
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作者 Xiao-Yu Xu Kun-Bei Lai +3 位作者 Hui Xiao Yi-Quan Lin Xin-Xing Guo Xing Liu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第1期71-78,共8页
AIM: To evaluate the patterns of macular ganglion cell-inner plexiform layer(GCIPL) loss in normal tension glaucoma(NTG) and primary open angle glaucoma(POAG) in a detailed, disease severity-matched way;and to assess ... AIM: To evaluate the patterns of macular ganglion cell-inner plexiform layer(GCIPL) loss in normal tension glaucoma(NTG) and primary open angle glaucoma(POAG) in a detailed, disease severity-matched way;and to assess the diagnostic capabilities of GCIPL thickness parameters in discriminating NTG or POAG from normal subjects.METHODS: A total of 157 eyes of 157 subjects, including 57 normal eyes, 51 eyes with POAG and 49 eyes with NTG were enrolled and strictly matched in age, refraction, and disease severity between POAG and NTG groups. The average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL thickness, and the average, superior, temporal, inferior, and nasal retinal nerve fiber layer(RNFL) thickness were obtained by Cirrus optical coherence tomography(OCT). The diagnostic capabilities of OCT parameters were assessed by area under receiver operating characteristic(AUROC) curves. RESULTS: Among all the OCT thickness parameters, no statistical significant difference between NTG group and POAG group was found(all P>0.05). In discriminating NTG or POAG from normal subjects, the average and inferior RNFL thickness, and the minimum GCIPL thickness had better diagnostic capabilities. There was no significant difference in AUROC curve between the best GCIPL thickness parameter(minimum GCIPL) and the best RNFL thickness parameter in discriminating NTG(inferior RNFL;P=0.076) and indiscriminating POAG(average RNFL;P=0.913) from normal eyes.CONCLUSION: Localized GCIPL loss, especially in the inferior and inferotemporal sectors, is more common in NTG than in POAG. Among all the GCIPL thickness parameters, the minimum GCIPL thickness has the best diagnostic performance in differentiating NTG or POAG from normal subjects, which is comparable to that of the average and inferior RNFL thickness. 展开更多
关键词 normal tension glaucoma primary open angle glaucoma spectral domain optical coherence tomography ganglion cell-inner plexiform layer thickness PATTERN
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Retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in children with obesity 被引量:1
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作者 Selim Demir Samet ozer +3 位作者 Sait Alim Alper Günes Hüseyin Ortak Resul Yilmaz 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第3期434-438,共5页
AIM:To evaluate retinal nerve fiber layer(RNFL)thickness analysis of peripapillary optic nerve head(PONH) and macula as well as ganglion cell-inner plexiform layer(GCIPL) thickness in obese children.· METH... AIM:To evaluate retinal nerve fiber layer(RNFL)thickness analysis of peripapillary optic nerve head(PONH) and macula as well as ganglion cell-inner plexiform layer(GCIPL) thickness in obese children.· METHODS:Eighty-five children with obesity and 30 controls were included in the study.The thicknesses of the PONH and macula of each subject's right eye were measured by high-resolution spectral-domain optic coherence tomography(OCT).· RESULTS:The RNFL thicknesses of central macular and PONH were similar between the groups(all P 〉0.05).The GCIPL thickness was also similar between the groups.However,the RNFL thickness of temporal outer macula were 261.7±13.7 and 268.9±14.3 μm for the obesity and the control group,respectively(P =0.034).· CONCLUSION:Obesity may cause a reduction in temporal outer macular RNFL thickness. 展开更多
关键词 ganglion cell-inner plexiform layer retinalnerve fiber layer thickness optical coherence tomography OBESITY
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Different damage patterns of retinal nerve fiber layer and ganglion cell-inner plexiform layer between early glaucoma and non-glaucomatous optic neuropathy 被引量:1
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作者 Hui Xiao Xing Liu +2 位作者 Ping Lian Ling-Ling Liao Yi-Min Zhong 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第6期893-901,共9页
AIM:To compare the damage pattern of the peripapillary retinal nerve fiber layer(pRNFL)and the macular ganglion cell-inner plexiform layer(mGCIPL)between early glaucomatous and non-glaucomatous optic neuropathy(EGON a... AIM:To compare the damage pattern of the peripapillary retinal nerve fiber layer(pRNFL)and the macular ganglion cell-inner plexiform layer(mGCIPL)between early glaucomatous and non-glaucomatous optic neuropathy(EGON and NGON).METHODS:It is a cross-sectional study.Thirty-eight healthy controls,74 EGONs and 70 NGONs with comparable average pRNFL loss were included.The NGON group included 23 eyes of optic neuritis(ON),13 eyes of hereditary optic neuropathy(HON),19 eyes of toxic optic neuropathy(TON)and 15 eyes of compressive neuropathy(CON).The sectoral pRNFL and mGCIPL thickness obtained by high definition optical coherence tomography were analyzed.RESULTS:Compared to normal controls,the pRNFL thickness in all quadrants showed a decrease in both EGON and NGON group(P<0.001),but the average pRNFL thickness of EGON group was not different to that of NGON group(P=0.94).The inferior and superior pRNFL was thinner in EGON group compared to NGON group(P<0.001).The temporal pRNFL was thinner in NGON group compared to EGON group(P<0.001).No statistically significant difference was found in nasal pRNFL between EGON and NGON.While the nasal pRNFL was thinner in CON than other three types of NGON(P=0.01),no statistically significant difference was found in other three quadrantal pRNFL among the four types of NGON(P>0.05).The mGCIPL of EGON and NGON group were thinner than control group(P<0.001).In EGON group the severest sites of mGCIPL reduction was located at inferotemporal and inferior sectors.While,compared to EGON group,the average mGCIPL of NGON groupwere significantly thinner,especially in superonasal and inferonasal sectors(P<0.001).CONCLUSION:The damage pattern of pRNFL and mGCIPL caused by glaucoma is distinct from other NGON such as ON,TON,HON and CON,and this characteristic damage pattern is helpful in differentiating early glaucoma from other NGON. 展开更多
关键词 GLAUCOMA optic neuropathy retinal nerve fiber layer ganglion cell-inner plexiform layer optical coherence tomography
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Retinal ganglion cell-inner plexiform and nerve fiber layers in neuromyelitis optica 被引量:1
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作者 Sai-Jing Hu Pei-Rong Lu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第1期89-93,共5页
AIM: To determine the thickness of the retinal ganglion cell-inner plexiform layer(GCIPL) and the retinal nerve fiber layer(RNFL) in patients with neuromyelitis optica(NMO).METHODS: We conducted a cross-sectio... AIM: To determine the thickness of the retinal ganglion cell-inner plexiform layer(GCIPL) and the retinal nerve fiber layer(RNFL) in patients with neuromyelitis optica(NMO).METHODS: We conducted a cross-sectional study that included 30 NMO patients with a total of 60 eyes. Based on the presence or absence of optic neuritis(ON), subjects were divided into either the NMO-ON group(30 eyes) or the NMO-ON contra group(10 eyes). A detailed ophthalmologic examination was performed for each group; subsequently, the GCIPL and the RNFL were measured using highdefinition optical coherence tomography(OCT). RESULTS: In the NMO-ON group, the mean GCIPL thickness was 69.28±21.12 μm, the minimum GCIPL thickness was 66.02±10.02 μm, and the RNFL thickness were 109.33±11.23, 110.47±3.10, 64.92±12.71 and 71.21±50.22 μm in the superior, inferior, temporal and nasal quadrants, respectively. In the NMO-ON contra group, the mean GCIPL thickness was 85.12±17.09 μm, the minimum GCIPL thickness was 25.39±25.1 μm, and the RNFL thicknesses were 148.33±23.22, 126.36±23.45, 82.21±22.30 and 83.36±31.28 μm in the superior, inferior, temporal and nasal quadrants, respectively. In the control group, the mean GCIPL thickness was 86.98±22.37 μm, the minimum GCIPL thickness was 85.28±10.75 μm, and the RNFL thicknesses were 150.22±22.73, 154.79±60.23, 82.33±7.01 and 85.62±13.81 μm in the superior, inferior, temporal and nasal quadrants, respectively. The GCIPL and RNFL were thinner in the NMO-ON contra group than in the control group(P〈0.05); additionally, the RNFL was thinner in the inferior quadrant in the NMO-ON group than in the control group(P〈0.05). Significant correlations were observed between the GCIPL and RNFL thickness measurements as well as between thickness measurements and the two visual field parameters of mean deviation(MD) and corrected pattern standard deviation(PSD) in the NMO-ON group(P〈0.05). CONCLUSION: The thickness of the GCIPL and RNFL, as measured using OCT, may indicate optic nerve damage in patients with NMO. 展开更多
关键词 neuromyelitis optica retinal nerve fiber layer thickness ganglion cell-inner plexiform layer optical coherence tomography
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Discriminating performance of macular ganglion cellinner plexiform layer thicknesses at different stages of glaucoma 被引量:3
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作者 Melih Ustaoglu Nilgun Solmaz Feyza Onder 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第3期464-471,共8页
AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to... AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer(RNFL) parameters and optic nerve head(ONH) parameters.METHODS: Totally 147 eyes(40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography(OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve(AUC) of the receiver operating characteristics. RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients(P<0.017, for all). Also, minimum, inferotemporal and inferonasal GC-IPL parameters discriminated early glaucoma patients from glaucoma suspects, whereas no RNFL or ONH parameter could discriminate between the two. The best parameters to discriminate glaucoma suspects from subjects with healthy eyes were superonasal GC-IPL, superior RNFL and average c/d ratio(AUC=0.746, 0.810 and 0.746, respectively). Discriminating performances of all the parameters for early glaucoma vs glaucoma suspect comparison were lower than that of the other consecutive group comparisons, with the bestGC-IPL parameters being minimum and inferotemporal(AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, average RNFL, and rim area(AUC=0.900, 0.858, 0.768, respectively) were the best parameters for discriminating moderate-to-severe glaucoma patients from early glaucoma patients.CONCLUSION: GC-IPL parameters can discriminate glaucoma suspect patients from subjects with healthy eyes, and also all the consecutive stages of glaucoma from each other(from glaucoma suspect to moderate-tosevere glaucoma). Further, the discriminating performance of GC-IPL thicknesses is comparable to that. 展开更多
关键词 retinal NERVE fiber layer optic NERVE head cirrus HD-OCT ganglion cell-inner plexiform layer GLAUCOMA SUSPECT
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Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial
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作者 Xiangjun Li Chunyan Li +5 位作者 Hai Huang Dan Bai Jingyi Wang Anqi Chen Yu Gong Ying Leng 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期923-928,共6页
The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic mac... The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser photocoagulation.However,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many patients.This might result from the incomplete recovery of retinal ganglion cell injury.Therefore,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision recovery.In this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their combination.All patients will be followed up for 12 months.The primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after treatment.The secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after treatment.Safety measure is the incidence of adverse events at 1,3,6,9,and 12 months after treatment.The study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up period.The trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal ganglion cells and best-corrected visual acuity.The trial protocol was approved by the Medical Ethics Committee of the Affiliated Hospital of Beihua University with approval No.(2023)(26)on April 25,2023,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR2300072478,June 14,2023,protocol version:2.0). 展开更多
关键词 choroidal thickness diabetic macular edema laser photocoagulation retinal ganglion cell-inner plexiform layer thickness retinal ganglion cells retinal nerve fiber layer thickness thickness of the macular area vascular endothelial growth factor visual acuity
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Structural measurements and vessel density of spectraldomain optic coherence tomography in early,moderate,and severe primary angle-closure glaucoma 被引量:2
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作者 Wei Jiang Nan Jiang +3 位作者 Gui-Bo Liu Jing Lin Cui Li Gui-Qiu Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第7期1100-1109,共10页
AIM:To compare the macular ganglion cell-inner plexiform layer(GCIPL)thickness,retinal nerve fiber layer(RNFL)thickness,optic nerve head(ONH)parameters,and retinal vessel density(VD)measured by spectral-domain optical... AIM:To compare the macular ganglion cell-inner plexiform layer(GCIPL)thickness,retinal nerve fiber layer(RNFL)thickness,optic nerve head(ONH)parameters,and retinal vessel density(VD)measured by spectral-domain optical coherence tomography(SD-OCT)and analyze the correlations between them in the early,moderate,severe primary angle-closure glaucoma(PACG)and normal eyes.METHODS:Totally 70 PACG eyes and 20 normal eyes were recruited for this retrospective analysis.PACG eyes were further separated into early,moderate,or severe PACG eyes using the Enhanced Glaucoma Staging System(GSS2).The GCIPL thickness,RNFL thickness,ONH parameters,and retinal VD were measured by SD-OCT,differences among the groups and correlations within the same group were calculated.RESULTS:The inferior and superotemporal sectors of the GCIPL thickness,rim area of ONH,average and inferior sector of the retinal VD were significantly reduced(all P<0.05)in the early PACG eyes compared to the normal and the optic disc area,cup to disc ratio(C/D),and cup volume were significantly higher(all P<0.05);but the RNFL was not significant changes in early and moderate PACG.In severe group,the GCIPL and RNFL thickness were obvious thinning with retinal VD were decreasing as well as C/D and cup volume increasing than other three groups(all P<0.01).In the early PACG subgroup,there were significant positive correlations between retinal VD and GCIPL thickness(except superonasal and inferonasal sectors,r=0.573 to 0.641,all P<0.05),superior sectors of RNFL thickness(r=0.055,P=0.049).More obvious significant positive correlations were existed in moderate PACG eyes between retinal VD and superior sectors of RNFL thickness(r=0.650,P=0.022),and temporal sectors of RNFL thickness(r=0.740,P=0.006).In the severe PACG eyes,neither GCIPL nor RNFL thickness was associated with retinal VD.CONCLUSION:The ONH damage and retinal VD loss appears earlier than RNFL thickness loss in PACG eyes.As the PACG disease progressed from the early to the moderate stage,the correlations between the retinal VD and RNFL thickness increases. 展开更多
关键词 optic coherence tomography primary angle-closure glaucoma ganglion cell-inner plexiform layer retinal nerve fiber layer optic nerve head retinal vessel density
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HD-OCT测量黄斑区神经节细胞层-内丛状层厚度对开角型青光眼诊断的意义 被引量:8
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作者 许小兰 郭竞敏 +3 位作者 陆朵朵 李木 张虹 王军明 《国际眼科杂志》 CAS 2015年第4期608-613,共6页
目的:评估利用高分辨率相干光断层扫描(Cirrus-HD OCT)测量黄斑区神经节细胞层-内丛状层(GCIPL)厚度参数对早期和中晚期青光眼的诊断意义。方法:本研究共纳入20例健康个体,26例早期青光眼患者,29例中晚期青光眼患者。对所有纳入个体均... 目的:评估利用高分辨率相干光断层扫描(Cirrus-HD OCT)测量黄斑区神经节细胞层-内丛状层(GCIPL)厚度参数对早期和中晚期青光眼的诊断意义。方法:本研究共纳入20例健康个体,26例早期青光眼患者,29例中晚期青光眼患者。对所有纳入个体均测量黄斑区GCIPL厚度参数,视盘(ONH)区参数以及视盘周围神经纤维层(RNFL)厚度参数。最后将所有数据利用SPSS 17.0统计学软件进行分析,分别计算各参数诊断早期和中晚期青光眼的AUC值,以比较和评价各参数的诊断意义。结果:对于早期青光眼组,AUC值最高的为RNFL平均值(0.871)和7∶00位值(0.896),GCIPL各参数也表现出较高的AUC值,其中GCIPL平均值和最小值相应的AUC值分别为0.847和0.812。对于中晚期青光眼组,AUC值最高为盘沿面积(0.992),其次为RNFL平均值(0.991),而GCIPL各参数中平均值与最小值的AUC值分别为0.967和0.983。对于早期青光眼诊断,灵敏度最高的指标为RNFL平均值(76.9%),而特异度最高的指标为GCIPL平均值(93.5%)。结论:GCIPL作为诊断青光眼的新指标在诊断早期和中晚期青光眼时,具有与RNFL相似的诊断意义。对于早期青光眼,诊断时应重点观察RNFL平均值,而在筛查时应重点观察GCIPL的平均值。 展开更多
关键词 神经节细胞层-内丛状层厚度 高分辨率相干光断层扫描 青光眼诊断
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分离格栅视觉诱发电位联合HD-OCT对早期原发性开角型青光眼的诊断效能研究 被引量:2
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作者 张恒丽 唐广贤 +4 位作者 李凡 闫晓伟 马丽华 耿玉磊 李兴茹 《临床眼科杂志》 2020年第3期244-248,共5页
目的应用分离格栅视觉诱发电位(IC-VEP)和高清度相干光层析成像术(HD-OCT)分析、评估早期原发性开角型青光眼(POAG)功能和结构变化,为POAG的早期诊断提供依据。方法收集2017年3月至2019年4月在我院就诊的POAG患者(观察组)31例(31只眼),... 目的应用分离格栅视觉诱发电位(IC-VEP)和高清度相干光层析成像术(HD-OCT)分析、评估早期原发性开角型青光眼(POAG)功能和结构变化,为POAG的早期诊断提供依据。方法收集2017年3月至2019年4月在我院就诊的POAG患者(观察组)31例(31只眼),平均年龄(43.11±5.34)岁(24~56岁);正常对照者(对照组)30例(30只眼),平均年龄(42.88±5.15)岁(27~59岁)。所有受试者均行视野、HD-OCT及IC-VEP检测,统计分析两组受试者基线资料,评估各参数的诊断效能。结果两组受试者的性别、年龄、最佳矫正视力、屈光度、中央角膜厚度均无统计学差异(P﹥0.05),视野平均缺损比较P﹤0.01。早期POAG患者IC-VEP及HD-OCT检查的敏感性和特异性分别为83.87%和90%,80.64%和86.67%,两者敏感性及特异性比较均P﹥0.05。IC-VEP检测早期POAG的ROC曲线下面积(AUCs)为0.901,和黄斑区不同部位节细胞内丛状层(GCIPL)的AUCs比较,均无统计学差异(P>0.05),两者的一致性检测率为65.57%。结论IC-VEP联合HD-OCT对早期POAG诊断的效能较高,快捷、简便,能够提高POAG早期诊断率,降低青光眼致盲率。 展开更多
关键词 原发性开角型青光眼 早期诊断 节细胞内丛状层 分离格栅视觉诱发电位 相干光层析成像术
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正常老年人群黄斑内层视网膜厚度和视盘周围神经纤维层的改变 被引量:4
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作者 胡雅斌 郭彦 +1 位作者 王怀洲 霍妍佼 《中华实验眼科杂志》 CAS CSCD 北大核心 2018年第4期274-278,共5页
目的比较Cirrus HD—OCT测得正常老年人群和年轻人群黄斑神经节细胞一内丛状层(mGCIPL)厚度和视盘周围视网膜神经纤维层(pRNFL)厚度之间的差异,从而对青光眼性视神经病变进展分析提供依据。方法采用前瞻性系列病例分析方法。纳入2... 目的比较Cirrus HD—OCT测得正常老年人群和年轻人群黄斑神经节细胞一内丛状层(mGCIPL)厚度和视盘周围视网膜神经纤维层(pRNFL)厚度之间的差异,从而对青光眼性视神经病变进展分析提供依据。方法采用前瞻性系列病例分析方法。纳入2016年6—7月北京同仁医院眼科进行体检的某事业单位退休职工(60-80岁)67人114眼作为老年人群组,另选取同期行体检的20~40岁24人42眼作为年轻人群组。应用CirrusHD—OCT测量各组黄斑区总的及各个区域GCIPL和pRNFL厚度参数并比较。结果除pRNFL鼻侧区域外,老年人群组mGCIPL和pRNFL各参数测量值均较年轻人群组薄,差异均有统计学意义(均P〈0.05),其中年龄影响最大的黄斑内层厚度参数是mGCIPL最小值,老年人群组与年轻人群组比较,差异有统计学意义[(74.02±11.01)μm与(82.74±3.94)μm;t=-7.290,P〈0.001]。在pRNFL厚度参数中,颞侧pRNFL厚度受年龄影响最大,老年人群组与年轻人群组比较差异有统计学意义[(70.83±12.30)μm与(82.10±17.02)μm;t=-3.930,P〈0.001];而鼻侧pRNFL受年龄影响最小,老年人群组鼻侧pRNFL厚度与年轻人群组比较,差异无统计学差异(P=0.056)。结论除pRNFL鼻侧区域外,CirrusHD—OCT测得老年人群mGCIPL厚度参数与pRNFL厚度参数均较年轻人群明显变薄,在青光眼性视神经病变的随访中需要考虑年龄因素的作用。 展开更多
关键词 光学相干断层扫描/方法 神经节细胞-内丛状层/诊断 视网膜神经纤维层 青光眼 黄斑
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Evaluation of spectral domain optical coherence tomography parameters in discriminating preperimetric glaucoma from high myopia 被引量:1
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作者 Xiao-Yu Xu Hui Xiao +1 位作者 Jing-Yi Luo Xing Liu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第1期58-65,共8页
AIM: To evaluate the diagnostic ability of macular ganglion cell-inner plexiform layer(GCIPL) thickness o b t a i n e d b y s p e c t r a l-d o m a i n o p t i c a l c o h e r e n c e tomography(SD-OCT) in discriminat... AIM: To evaluate the diagnostic ability of macular ganglion cell-inner plexiform layer(GCIPL) thickness o b t a i n e d b y s p e c t r a l-d o m a i n o p t i c a l c o h e r e n c e tomography(SD-OCT) in discriminating non-highly myopic eyes with preperimetric glaucoma(PPG) from highly myopic healthy eyes. METHODS: A total of 254 eyes, including 76 normal controls(NC), 116 eyes with high myopia(HM) and 62 non-highly myopic eyes with PPG were enrolled. The diagnostic ability of OCT parameters was accessed by the areas under the receiver operating characteristic(AUROC) curve in two distinguishing groups: PPG eyes with nonglaucomatous eyes including NC and HM(Group 1), and PPG eyes with HM eyes(Group 2). Differences in diagnostic performance between GCIPL and RNFL parameters were evaluated. RESULTS: The minimum(AUROC curve of 0.782), inferotemporal(0.758) and inferior(0.705) GCIPL thickness were the top three GCIPL parameters in discriminating PPG from non-glaucomatous eyes, all of which had statistically significant lower diagnostic ability than average RNFL thickness(0.847). In discriminating PPG from HM, the best GCIPL parameter was minimum(0.689), statistically significant lower in diagnostic ability than average RNFL thickness(0.789) and three other RNFL thickness parameters of temporal and inferotemporal clock-hour sectors. CONCLUSION: The minimum GCIPL thickness is the best GCIPL parameter to detect non-highly myopic PPG from highly myopic eyes, whose diagnostic ability is inferiorto that of average RNFL thickness and RNFL thickness of several temporal and inferotemporal clock-hour sectors. The average RNFL thickness is recommended for discriminating PPG from highly myopic healthy eyes in current clinical practice in a Chinese population. 展开更多
关键词 ganglion cell-inner plexiform layer DIAGNOSTIC ability preperimetric GLAUCOMA high myopia.
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Ethambutol-induced optic neuropathy with rare bilateral asymmetry onset:A case report 被引量:1
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作者 Wen-Yan Sheng Shuang-Qing Wu +1 位作者 Ling-Ya Su Li-Wei Zhu 《World Journal of Clinical Cases》 SCIE 2022年第2期663-670,共8页
BACKGROUND Ethambutol-induced optic neuropathy(EON)most commonly manifests as bilateral symmetrical loss of vision and often cause serious and irreversible visual impairment because of the lack of early detection and ... BACKGROUND Ethambutol-induced optic neuropathy(EON)most commonly manifests as bilateral symmetrical loss of vision and often cause serious and irreversible visual impairment because of the lack of early detection and effective treatment.We followed a case of EON with rare binocular asymmetric clinical manifestations and observed the changes of visual function and retinal structure after drug withdrawal,so as to further understand the clinical characteristics of this disease.CASE SUMMARY A 54-year-old man complained of gradual visual decline in the left eye.The patient presented with best-corrected visual acuity of 20/20 in the right eye and 20/50 in the left eye.Color vision examination revealed difficulty in reading green color plates in the left eye.The visual field manifested as concentric contraction in the left eye.After nearly a month of drug withdrawal,the right eye had a similar decline in visual function.At the last visit,19 mo after drug withdrawal,the visual function significantly recovered in both eyes.During follow-up optical coherence tomography(OCT)examination,both eyes manifested the thickness of the retinal nerve fiber layer from mild thickening to thinning and finally temporal atrophy,and the ganglion cell-inner plexiform layer showed significant thinning.The difference was that a reversible structural disorder in the outer retina of the nasal macula was detected in the left eye by macular high-definition OCT.CONCLUSION Nephropathy and high blood pressure,which damage the retinal microcirculation,may cause damage to the outer layer of the retina.Ethambutol may influence photoreceptor as well as retinal ganglion cells. 展开更多
关键词 Ethambutol-induced optic neuropathy Retinal nerve fiber layer ganglion cell-inner plexiform layer Optical coherence tomography Asymmetry Case report
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视觉诱发电位和黄斑区神经节细胞内丛状层厚度在原发性开角型青光眼早期诊断中的相关性 被引量:1
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作者 张恒丽 闫晓伟 +3 位作者 耿玉磊 马丽华 李凡 唐广贤 《临床眼科杂志》 2021年第1期9-13,共5页
目的探讨分离格栅视觉诱发电位(IC-VEP)和黄斑区神经节细胞内丛状层(GCIP)厚度改变在原发性开角型青光眼(POAG)早期诊断中的相关性,为提高POAG早期诊断效能和速率提供理论依据。方法病例对照研究。收集2017年3月至2019年4月在石家庄市... 目的探讨分离格栅视觉诱发电位(IC-VEP)和黄斑区神经节细胞内丛状层(GCIP)厚度改变在原发性开角型青光眼(POAG)早期诊断中的相关性,为提高POAG早期诊断效能和速率提供理论依据。方法病例对照研究。收集2017年3月至2019年4月在石家庄市人民医院住院治疗的POAG早期患者(观察组)31例(31只眼),平均年龄(43.11±5.34)岁;正常受试者(对照组)30例(30只眼),平均年龄(42.88±5.15)岁。两组受试者均行Humphrey视野、HD-OCT及IC-VEP检测,统计分析两组受试者基线资料、各参数诊断效能以及SNR和GCIP厚度变化相关性。结果两组受试者性别、年龄、最佳矫正视力、屈光度和中央角膜厚度的差异均无统计学意义(P﹥0.05),视野平均缺损变化(P﹤0.01)。观察组IC-VEP和HD-OCT检测的敏感性及特异性分别占83.87%和90%,80.64%和86.67%,组间比较(均P﹥0.05)。两组受试者的一致性检测率为65.57%。观察组和对照组信噪比(SNR)值分别为(0.92±0.05和1.37±0.16),差异有统计学意义(P﹤0.01)。观察组黄斑区不同部位GCIPL厚度均明显变薄(均P﹤0.05)。观察组SNR和黄斑区不同部位GCIPL均呈正相关(均P﹤0.05)。结论视觉诱发电位和黄斑区神经节细胞内丛状层厚度在POAG早期的一致性变化,将进一步提高POAG早期诊断效能和速率,延缓并降低青光眼盲的发生率。 展开更多
关键词 原发性开角型青光眼 早期诊断 神经节细胞内丛状层 视觉诱发电位 相关性
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The role of optical coherence tomography in neuro-ophthalmology
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作者 John J.Chen Fiona Costello 《Annals of Eye Science》 2018年第1期228-245,共18页
Optical coherence tomography(OCT)is an ocular imaging technique that can complement the neuro-ophthalmic assessment,and inform our understanding regarding functional consequences of neuroaxonal injury in the afferent ... Optical coherence tomography(OCT)is an ocular imaging technique that can complement the neuro-ophthalmic assessment,and inform our understanding regarding functional consequences of neuroaxonal injury in the afferent visual pathway.Indeed,OCT has emerged as a surrogate end-point in the diagnosis and follow up of several demyelinating syndromes of the central nervous system(CNS),including optic neuritis(ON)associated with:multiple sclerosis(MS),neuromyelitis optica spectrum disorder(NMOSD),and anti-myelin oligodendrocyte glycoprotein(MOG)antibodies.Recent advancements in enhanced depth imaging(EDI)OCT have distinguished this technique as a new gold standard in the diagnosis of optic disc drusen(ODD).Moreover,OCT may enhance our ability to distinguish cases of papilledema from pseudopapilledema caused by ODD.In the setting of idiopathic intracranial hypertension(IIH),OCT has shown benefit in tracking responses to treatment,with respect to reduced retinal nerve fiber layer(RNFL)measures and morphological changes in the angling of Bruch’s membrane.Longitudinal follow up of OCT measured ganglion cell-inner plexiform layer thickness may be of particular value in managing IIH patients who have secondary optic atrophy.Causes of compressive optic neuropathies may be readily diagnosed with OCT,even in the absence of overt visual field defects.Furthermore,OCT values may offer some prognostic value in predicting post-operative outcomes in these patients.Finally,OCT can be indispensable in differentiating optic neuropathies from retinal diseases in patients presenting with vision loss,and an unrevealing fundus examination.In this review,our over-arching goal is to highlight the potential role of OCT,as an ancillary investigation,in the diagnosis and management of various optic nerve disorders. 展开更多
关键词 Optical coherence tomography(OCT) retinal nerve fiber layer(RNFL) ganglion cell-inner plexiform layer(GCIP)thickness optic neuritis(ON) optic disc drusen(ODD)
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高分辨率OCT测量神经节细胞-内丛状层厚度在青光眼早期诊断中的作用 被引量:9
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作者 霍妍佼 郭彦 +2 位作者 洪洁 王怀洲 王宁利 《眼科》 CAS 2013年第6期374-377,共4页
目的探讨高分辨率相干光断层扫描(Cirrus-HD OCT)测量黄斑神经节细胞-内丛状层(GCIPL)厚度参数在青光眼早期诊断中的作用。设计诊断技术评价。研究对象30例早期青光眼患者和56例正常对照者。方法应用Cirrus-HD OCT进行黄斑区及其分区域G... 目的探讨高分辨率相干光断层扫描(Cirrus-HD OCT)测量黄斑神经节细胞-内丛状层(GCIPL)厚度参数在青光眼早期诊断中的作用。设计诊断技术评价。研究对象30例早期青光眼患者和56例正常对照者。方法应用Cirrus-HD OCT进行黄斑区及其分区域GCIPL和视盘周围视网膜神经纤维层(RNFL)厚度参数测量。用受试者工作特性曲线下面积(AUC)来评价各参数区分正常眼与青光眼的能力。主要指标GCIPL与RNFL的厚度和两者的AUC值。结果正常人和早期青光眼GCIPL和RNFL各参数测量值之间比较,差异均有统计学意义(P均<0.01)。正常人和早期青光眼患者的平均GCIPL厚度分别为(85.43±5.27)μm和(69.30±7.71)μm;平均RNFL厚度分别为(100.98±7.98)μm和(78.80±10.38)μm(P<0.001)。GCIPL参数中诊断效能最高者是最小值(minimum)和颞上区域(superotemporal),AUC均为0.985;其他AUC较高的参数依次为平均值(average)(0.971)、下方区域(inferior)(0.941)、颞下区域(superotemporal)(0.934)和鼻上区域(0.907)。视盘周围RNFL参数中诊断效能最高者是平均值(0.990)。结论 Cirrus-HD OCT测得的GCIPL厚度参数与视盘周围RNFL厚度参数类似,具有较好的区分正常人和早期青光眼患者的能力,可作为青光眼早期诊断的有用工具。(眼科,2013,22:374-377) 展开更多
关键词 NFL厚度 青光眼患者 早期诊断 神经节细胞 CT测量 高分辨率 丛状 视网膜神经纤维层
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频域OCT测量黄斑区节细胞-内丛状层厚度在青光眼早期诊断中的应用 被引量:17
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作者 刘杏 徐晓宇 《眼科》 CAS CSCD 北大核心 2016年第1期1-5,共5页
SD-OCT测量黄斑区节细胞-内丛状层(GCIPL)厚度有可能较视盘周围视网膜神经纤维层(RNFL)厚度、黄斑区节细胞复合体(GCC)更早地发现青光眼性结构损害。GCIPL在东方人群中鼻上方最厚、下方最薄。年龄及眼轴是影响GCIPL的重要因素。目前GCIP... SD-OCT测量黄斑区节细胞-内丛状层(GCIPL)厚度有可能较视盘周围视网膜神经纤维层(RNFL)厚度、黄斑区节细胞复合体(GCC)更早地发现青光眼性结构损害。GCIPL在东方人群中鼻上方最厚、下方最薄。年龄及眼轴是影响GCIPL的重要因素。目前GCIPL厚度与RNFL厚度具有相似的临床诊断效能。其与视野、RNFL厚度、视盘参数相互整合,是提高青光眼早期检出率的关键。 展开更多
关键词 频域相干光断层扫描 青光眼 早期诊断 节细胞-内丛状层
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OCT测量黄斑内层视网膜厚度在青光眼诊断中的研究进展 被引量:6
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作者 霍妍佼 郭彦 王怀洲 《国际眼科纵览》 2016年第3期150-155,共6页
目前高分辨相干光断层扫描(optical coherence tomography, OCT)的扫描速度及轴向分辨率大幅度提高,尤其是视网膜层间算法的应用,使得黄斑内层视网膜厚度的测量成为可能。近些年来,许多研究关注于视网膜内层厚度在青光眼中改变,... 目前高分辨相干光断层扫描(optical coherence tomography, OCT)的扫描速度及轴向分辨率大幅度提高,尤其是视网膜层间算法的应用,使得黄斑内层视网膜厚度的测量成为可能。近些年来,许多研究关注于视网膜内层厚度在青光眼中改变,发现黄斑结构损害与功能丢失之间的对应关系,并通过多种分析方法,帮助临床医生提高青光眼的诊断效率。 展开更多
关键词 相干光断层扫描 黄斑 视网膜节细胞复合体 视网膜节细胞一内丛状层 青光眼/诊断
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