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Isolation and Characterization of Contaminating Bacteria from Garcinia cambogia Extract: Methods to Reduce Microbial Load and Its Anti-Obesity Effect in Wistar Rats
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作者 Raj Kumar Bhosale Sasidharan Sakkan +7 位作者 Srinivasa Murthy Venkatramanappa Shivaswamy Mathada Rudraiah Kumaraswamy Rampur Arulmozhi Sathiyanarayanan Deepa Mandlik Sanman Kolhe Sadanand Yewale Sriram Padmanabhan 《Natural Resources》 CAS 2022年第7期147-170,共24页
Objectives: This study aimed to identify the contaminating bacteria in the extract of Garcinia cambogia, which is regularly used as a dietary supplement for addressing obesity in humans. Methods: The Garcinia cambogia... Objectives: This study aimed to identify the contaminating bacteria in the extract of Garcinia cambogia, which is regularly used as a dietary supplement for addressing obesity in humans. Methods: The Garcinia cambogia extract was used and experiments were conducted to isolate the contaminating bacteria and antibiotic susceptibility was tested. The organism was identified using BIOLOG system. Such an extract was used in a placebo-controlled animal study when 6 eight adult male rats weighing between 200 and 220 g were randomly distributed into three groups (n = 3) and in test group 1, a single dose of 100 mg/kg bw of Garcinia cambogia extract was given while in the test group 2, 100 mg Garcinia cambogia extract + 116 mg Picrorhiza kurroa extract were administered through oral gavage. The normal control rats were given distilled water, and the treatment lasted for 30 days. Blood plasma and liver tissues were prepared for biochemical analysis and histology studies. Results: Nearly ~10<sup>3</sup> cfu/g of Bacillus atrophaeus was present in the Garcinia cambogia extract and we demonstrate >99% reduction in the microbial load with tetracycline. Such an extract at a dose of 100 mg/kg, showed weight loss in Wistar rats when administered orally for 1 month with no significant changes in liver histopathology. Picrorhiza kurroa, also known for its hepatoprotective properties, has been administered at a dose of 116 mg/kg along with Garcinia extract at 100 mg/kg orally and found to improve levels of hepatic enzymes as similar to control animals, although not statistically significant. Conclusions: The study revealed that Garcinia cambogia could prevent weight gain in Wistar rats when given orally and the weight gain in Garcinia-treated animals was almost 4 times less (7.31%), as against weight gain of 25.36% seen in vehicle control animals. The antibiotic susceptibility data indicated that the isolated bacterium is resistant to many antibiotics with a strong susceptibility to tetracycline. 展开更多
关键词 garcinia cambogia Hydroxy Citric Acid Picrorhiza kurroa Liver Health ATP Citrate Lyase
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Garcinia Cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation 被引量:3
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作者 Young-Je Kim Myung-Sook Choi +3 位作者 Yong Bok Park Sang Ryong Kim Mi-Kyung Lee Un Ju Jung 《World Journal of Gastroenterology》 SCIE CAS 2013年第29期4689-4701,共13页
AIM: To investigate long-term effects of Garcinia Cambogia (GC), weight-loss supplement, on adiposity and non-alcoholic fatty liver disease in obese mice. METHODS: Obesity-prone C57BL/6J mice were fed a high-fat diet ... AIM: To investigate long-term effects of Garcinia Cambogia (GC), weight-loss supplement, on adiposity and non-alcoholic fatty liver disease in obese mice. METHODS: Obesity-prone C57BL/6J mice were fed a high-fat diet (HFD, 45 kcal% fat) with or without GC (1%, w/w) for 16 wk. The HFD contained 45 kcal% fat, 20 kcal% protein and 35 kcal% carbohydrate. They were given free access to food and distilled water, and food consumption and body weight were measured daily and weekly, respectively. Data were expressed as the mean ± SE. Statistical analyses were performed using the statistical package for the social science software program. Student's t test was used to assess the differences between the groups. Statistical significance was considered at P < 0.05. RESULTS: There were no significant changes in body weight and food intake between the groups. However, the supplementation of GC significantly lowered visceral fat accumulation and adipocyte size via inhibition of fatty acid synthase activity and its mRNA expression in visceral adipose tissue, along with enhanced enzymatic activity and gene expression involved in adipose fatty acid β-oxidation. Moreover, GC supplementation resulted in significant reductions in glucose intolerance and the plasma resistin level in the HFD-fed mice. However, we first demonstrated that it increased hepatic collagen accumulation, lipid peroxidation and mRNA levels of genes related to oxidative stress (superoxide dismutase and glutathione peroxidase) and inflammatory responses (tumor necrosis factor-α and monocyte chemoattractant protein-1) as well as plasma alanine transaminase and aspartate transaminase levels, although HFD-induced hepatic steatosis was not altered. CONCLUSION: GC protects against HFD-induced obesity by modulating adipose fatty acid synthesis and β-oxidation but induces hepatic fibrosis, inflammation and oxidative stress. 展开更多
关键词 garcinia cambogia Anti-adiposity Metabolic changes HEPATIC collagen accumulation HEPATIC INFLAMMATION HEPATIC oxidative stress
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Hepatotoxicity associated with Garcinia cambogia: A case report 被引量:2
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作者 Muhammad Nadeem Yousaf Fizah S Chaudhary +1 位作者 Seyed Mohammad Hodanazari Charmian D Sittambalam 《World Journal of Hepatology》 CAS 2019年第11期735-742,共8页
BACKGROUND Herbal supplements(HS)for weight loss are perceived to be“safe”and“natural”,as advertised in ads,however,hepatotoxicity can be associated with consumption of some HS.Use of HS may be missed,as the patie... BACKGROUND Herbal supplements(HS)for weight loss are perceived to be“safe”and“natural”,as advertised in ads,however,hepatotoxicity can be associated with consumption of some HS.Use of HS may be missed,as the patient may not report these unless specifically asked about these products,since they are often not thought of as medications with potential side effects or interaction potential.CASE SUMMARY We reported a case of a 21-year-old female with morbid obesity who presented with abdominal pain for 1 wk associated with nausea,vomiting,anorexia and myalgias.She denied smoking tobacco,drinking alcohol,usage of illicit drugs,hormonal contraceptives,or energy drinks.There was no significant past medical or family illnesses.Her laboratory workup revealed acute liver failure.The workup for possible etiologies of acute liver failure was unremarkable.She was using a weight loss herbal supplement“Garcinia cambogia”for 4 wks.This case demonstrates the association of acute liver failure with Garcinia cambogia.CONCLUSION Medical reconciliation of HS should be performed in patients with suspected acute liver failure and early discontinuation of HS can prevent further progression of drug induced hepatoxicity. 展开更多
关键词 HEPATOTOXICITY Drug induced LIVER injury Acute LIVER failure HERBAL SUPPLEMENTS garcinia cambogia OBESITY Case report
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基于网络药理学及生物信息学探讨藤梨汤治疗结直肠癌的作用机制研究 被引量:1
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作者 罗字呈 杨桃 +4 位作者 陈江 曹一波 胡文婷 曾炼 肖天保 《空军军医大学学报》 CAS 2024年第3期311-318,共8页
目的使用生物信息学技术和网络药理学探讨藤梨汤治疗结直肠癌(CRC)的潜在作用机制及对预后的影响。方法采用TCMSP和SymMap数据库检索藤梨汤的活性成分及靶点。通过GeneCards、TTD、OMIM、DisGeNET数据库等筛选CRC疾病靶点,并基于癌症基... 目的使用生物信息学技术和网络药理学探讨藤梨汤治疗结直肠癌(CRC)的潜在作用机制及对预后的影响。方法采用TCMSP和SymMap数据库检索藤梨汤的活性成分及靶点。通过GeneCards、TTD、OMIM、DisGeNET数据库等筛选CRC疾病靶点,并基于癌症基因组图谱计划数据库集筛选出CRC患者与健康人的差异基因。运用Venny 2.1平台获取藤梨汤与疾病的共有靶点,通过STRING数据库及Cytoscape 3.9.1构建蛋白质蛋白质相互作用(PPI)网络获得该网络核心靶点并构建“药物有效成分靶点作用通路”网络图。借助Metascape数据库对共有靶点进行GO及KEGG功能富集分析。结果获取藤梨汤中30个活性成分,药物靶点622个,疾病靶点27057个,“方病”关键靶点417个;藤梨汤治疗CRC的核心活性成分包括槲皮素、异鼠李素、信阳冬凌草甲素等;PPI网络中筛选前15个核心靶点有AKT1、STAT3、TP53、ESR1、MYC等。结论本研究初步揭示了藤梨汤治疗CRC的潜在作用机制及预后影响,表明该方治疗CRC具有多成分多靶点多通路的药效特点,并可能使患者生存获益,将为今后相关研究提供新思路和依据。 展开更多
关键词 藤梨汤 结直肠癌 网络药理学 生物信息学 预后分析
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藤茶植物饮料指纹图谱建立及主要成分含量测定
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作者 阳晓雪 李鑫 +3 位作者 李雨喜 邓文艺 张全 叶静 《中南药学》 CAS 2024年第9期2420-2423,共4页
目的建立藤茶植物饮料的高效液相色谱指纹图谱分析方法。方法采用HPLC法对10批藤茶植物饮料样品进行分析,通过色谱峰指认,结合相似度评价、主成分分析探讨不同批次间的稳定性,并同时测定了藤茶植物饮料中二氢杨梅素、杨梅苷和杨梅素的... 目的建立藤茶植物饮料的高效液相色谱指纹图谱分析方法。方法采用HPLC法对10批藤茶植物饮料样品进行分析,通过色谱峰指认,结合相似度评价、主成分分析探讨不同批次间的稳定性,并同时测定了藤茶植物饮料中二氢杨梅素、杨梅苷和杨梅素的含量。结果建立了藤茶植物饮料的HPLC指纹图谱,标定了10个共有峰,并指认了3个峰,10批样品的相似度均大于0.9。聚类分析和主成分分析将10批样品分为两类。结论该指纹图谱分析方法可信度高、稳定,可用于藤茶指纹图谱的质量控制及含量测定。 展开更多
关键词 藤茶植物饮料 高效液相色谱法 指纹图谱 含量测定
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Hydroxycitric acid does not promote inflammation or liver toxicity 被引量:2
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作者 Dallas L Clouatre Harry G Preuss 《World Journal of Gastroenterology》 SCIE CAS 2013年第44期8160-8162,共3页
Garcinia cambogia extract(GC)with its active component consisting of hydroxycitric acid(HCA)is widely utilized for weight loss.Various HCA salts are available,including calcium,magnesium,potassium and mixtures of thes... Garcinia cambogia extract(GC)with its active component consisting of hydroxycitric acid(HCA)is widely utilized for weight loss.Various HCA salts are available,including calcium,magnesium,potassium and mixtures of these.Experimentally,these salts exhibit different properties with some,but not all,improving glucose tolerance and blood pressure.Recently,obesity-prone C57BL/6J mice were fed a high-fat diet(HFD,45 kcal%fat)with or without GC(1%,w/w)for 16 wk.The active arm reduced visceral fat,adipocyte size and serum glucose,yet purportedly also exhibited hepatic collagen accumulation,lipid peroxidation and increased mRNA levels of genes related to oxidative stress.The latter findings are at odds with a large body of animal and human studies that have been conducted on the safety and efficacy of HCA.This literature shows HCA to be protective against the liver toxicity associated with ethanol and dexamethasone administration,and to maintain serum aspartate aminotransferase,alanine aminotransferase and alkaline phosphatase at near normal levels.In both animal and clinical literature,elevated intakes of HCA per se have not led to signs of inflammation or hepatotoxicity.The compound has been found to reduce markers of inflammation in brain,intestines,kidney and serum. 展开更多
关键词 garcinia cambogia Hepatic collagen Hepatic inflammation Hepatic oxidative stress Hydroxycitric acid Metabolic syndrome Tumor necrosis factor-α Weight loss
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No evidence demonstrating hepatotoxicity associated with hydroxycitric acid 被引量:2
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作者 Sidney J Stohs Harry G Preuss +4 位作者 Sunny E Ohia Gilbert R Kaats Carl L Keen Lonnie D Williams George A Burdock 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第32期4087-4089,共3页
Although a number of cases of hepatotoxicity are associated with the use of Hydroxycut weight management products, it has been alleged that their effects are primarily due to the presence of hydroxycitric acid (HCA, a... Although a number of cases of hepatotoxicity are associated with the use of Hydroxycut weight management products, it has been alleged that their effects are primarily due to the presence of hydroxycitric acid (HCA, as Super CitriMax) in the formulations. However, while these products contain up to 20 different ingredients, some do not contain HCA. Case studies reported to date have not considered in depth the literature on the numerous animal and human studies that have been conducted on the safety and effi cacy of HCA. No HCA-associated hepatotoxicity or treatment-related adverse effects have been reported in these studies, and thus it is premature to make the assumptions presented in the recent case studies regarding Hydroxycut. If it is established in well controlled studies that the use of these formulations with and/or without HCA can result in the occurrence or progression of hepatotoxicity, additional studies should be conducted to characterize the causative factor(s). 展开更多
关键词 Hydroxycitric acid Super CitriMax Hydroxycitric acid-SX garcinia cambogia Hydroxycut Liver failure HEPATOTOXICITY Safety and efficacy
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Science of weight loss supplements:Compromised by conflicts of interest? 被引量:1
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作者 Ano Lobb 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第38期4880-4882,共3页
Weight loss supplements often contain powerful pharmacoactive ingredients with the potential to cause harm. Trials used to determine product safety and effectiveness, meanwhile,tend to be small, of short duration, and... Weight loss supplements often contain powerful pharmacoactive ingredients with the potential to cause harm. Trials used to determine product safety and effectiveness, meanwhile,tend to be small, of short duration, and frequently lack financial conflict of interest disclosures. These factors could conspire to place consumers at risk, especially when published research cited in advertising cloaks products with the suggestion that their safety and effectiveness have been proven by science. Examples of current and former weight loss products backed by potentially con? icted or low quality research include Metabolife-356, Hydroxycut, Xenadrine and LeptiCore. Published research, especially in the field of weight loss supplements, needs better conflict of interest disclosure, and regulators should consider how research f indings are used in marketing claims. 展开更多
关键词 Weight loss supplements Cissus quadrangularis Hydroxycut Xenadrine Metabolife Lepticore garcinia cambogia Con ict of interest
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离子交换树脂对藤黄果中羟基柠檬酸的分离纯化 被引量:2
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作者 易馨如 封棣 +2 位作者 王泰 张丞林 曹学丽 《食品与机械》 CSCD 北大核心 2014年第3期179-184,共6页
对藤黄果中羟基柠檬酸的纯化工艺进行系统的研究,通过比较D201、D315、D301、HZ-202和335 5种离子交换树脂对羟基柠檬酸的吸附和解吸能力,筛选出最佳树脂为D201,确定最佳的吸附与解吸工艺条件,吸附条件:pH=5,上样浓度3.12mg/mL,上样流速... 对藤黄果中羟基柠檬酸的纯化工艺进行系统的研究,通过比较D201、D315、D301、HZ-202和335 5种离子交换树脂对羟基柠檬酸的吸附和解吸能力,筛选出最佳树脂为D201,确定最佳的吸附与解吸工艺条件,吸附条件:pH=5,上样浓度3.12mg/mL,上样流速1mL/min;解吸条件:洗脱液为0.4mol/L NaCl水溶液,洗脱流速1mL/min,羟基柠檬酸样品溶液经D201树脂吸附与解吸后纯度由40.3%提高到91.3%。结果表明,D201树脂对羟基柠檬酸的分离纯化具有良好的选择性和应用前景。 展开更多
关键词 离子交换树脂 藤黄果 羟基柠檬酸 分离 纯化
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藤黄果提取物对雄性大鼠脂代谢的影响及降脂机理 被引量:2
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作者 刘冠星 韩宁宁 马海田 《食品科学》 EI CAS CSCD 北大核心 2015年第9期202-208,共7页
以雄性大鼠为研究对象,探讨日粮中添加不同剂量的藤黄果提取物对大鼠脂代谢常规生化指标及相关基因表达的影响。结果表明:日粮中添加不同剂量的藤黄果提取物均可显著降低大鼠血清中甘油三酯的含量(P<0.05),高剂量藤黄果提取物则可显... 以雄性大鼠为研究对象,探讨日粮中添加不同剂量的藤黄果提取物对大鼠脂代谢常规生化指标及相关基因表达的影响。结果表明:日粮中添加不同剂量的藤黄果提取物均可显著降低大鼠血清中甘油三酯的含量(P<0.05),高剂量藤黄果提取物则可显著降低肝脏组织中甘油三酯的含量(P<0.05);不同剂量藤黄果提取物处理对血清和肝脏组织中总胆固醇含量均无显著影响(P>0.05)。脂肪代谢相关基因分析结果表明:高剂量藤黄果提取物处理可显著抑制SREBP1c(P<0.01)和ACL(P<0.05)基因表达水平,同时显著提高ACO和ATGL基因表达水平(P<0.05);MCD和PPARα基因表达水平在中剂量(P<0.05)和高剂量(P<0.01)藤黄果提取物处理组显著高于对照组;高剂量藤黄果提取物处理可显著促进AMPKα1和Adipo R-1基因表达水平(P<0.05),但对脂联素基因表达水平没有影响。以上结果提示,藤黄果提取物处理可通过激活Adipo-AMPK信号通路,进而抑制脂肪酸合成途径中的关键因子、增强脂肪酸氧化途径中的关键因子基因的表达,最终降低雄性大鼠体内脂肪的沉积。 展开更多
关键词 藤黄果提取物 羟基柠檬酸 脂代谢 5’-腺苷-磷酸激活的蛋白激酶
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健美操运动结合藤黄果提取物对肥胖女大学生脂代谢及身体形态的影响 被引量:7
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作者 吕仙利 熊正英 《陕西师范大学学报(自然科学版)》 CAS CSCD 北大核心 2019年第3期31-37,共7页
以40名女大学生为实验对象,将其分成4组:服用安慰剂组(A组)、健美操运动组(B组)、服用藤黄果提取物组(C组)、健美操运动结合藤黄果提取物组(D组),测定实验(12周)前、后甘油三酯(TG)、血清总胆固醇(STC)、高密度脂蛋白胆固醇(HDL-C)、低... 以40名女大学生为实验对象,将其分成4组:服用安慰剂组(A组)、健美操运动组(B组)、服用藤黄果提取物组(C组)、健美操运动结合藤黄果提取物组(D组),测定实验(12周)前、后甘油三酯(TG)、血清总胆固醇(STC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、体脂(PBF)等生物化学指标;测定体质量(BM)、身体质量指数(BMI)、腰臀比(WHR)、肩脚下部皮褶厚度(SST)、肱三头肌皮褶厚度(TST)、腹部皮褶厚度(AST)等形态学指标,以探讨健美操运动结合藤黄果提取物对肥胖女大学生脂代谢的影响。结果表明:12周实验前、后比较,A组TG、STC、HDL-C、LDL-C含量和PBF变化无显著性差异(P>0.05),B组、C组和D组TG、STC、LDL-C和PBF含量下降(P<0.01或P<0.05),HDL-C含量上升(P<0.05)。A组BM、BMI、WHR变化无显著性差异(P>0.05),B组、C组和D组BM、BMI、WHR下降(P<0.05或P<0.01)。A组SST、TST、AST变化无显著性差异(P>0.05),B组、C组和D组SST、TST、AST下降(P<0.05或P<0.01)。结果提示,藤黄果提取物的作用是限制脂肪合成(限肥),而非促进脂肪的分解(减肥),其主要机理是藤黄果提取物中的HCA是ECC的竞争性抑制剂,可降低ECC活性,使合成脂类物质的原料乙酰CoA减少,脂肪和胆固醇合成量下降,从而改善体脂和血脂的含量及机体形态。健美操运动结合藤黄果提取物双重干预对肥胖女大学生脂代谢控制的效果更为显著,既可降低脂肪合成,亦可促进脂肪消耗,减少体脂(与血脂),塑造良好体形,维护身体健康。 展开更多
关键词 藤黄果提取物 柠檬酸裂解酶 羟基柠檬酸 限制肥胖 身体形态 女大学生 健美操
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藤黄果果实羟基柠檬钾盐的提取工艺优化与鉴定
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作者 曾媛 宋雅慧 +5 位作者 俞泉 韩晏麒 金晨钟 王艳 张雪娇 胡一鸿 《食品工业科技》 CAS 北大核心 2020年第21期208-212,共5页
为了从藤黄果果实中制备游离羟基柠檬酸钾盐,采用水提取法对藤黄果果实粉末进行提取,通过单因素实验和正交试验对提取工艺进行优化,并对提取物进行了偏矾酸铵显色、薄层层析和HPLC鉴定,得到最佳条件为:料液比为1∶18、浓缩倍数为5倍、... 为了从藤黄果果实中制备游离羟基柠檬酸钾盐,采用水提取法对藤黄果果实粉末进行提取,通过单因素实验和正交试验对提取工艺进行优化,并对提取物进行了偏矾酸铵显色、薄层层析和HPLC鉴定,得到最佳条件为:料液比为1∶18、浓缩倍数为5倍、酒精度数为60%vol、pH为12。各因素对游离羟基柠檬酸回收率效果影响大小依次为料液比>浓缩倍数>pH>酒精度数。在该最佳条件下,藤黄果羟基柠檬酸钾的得率为3.24%±0.32%。该方法在提取过程中采用KOH在偏碱性条件下保护游离羟基柠檬酸,形成羟基柠檬酸盐,经HPLC鉴定为与羟基柠檬酸标品保留时间相同的单峰,纯度为52.10%±0.53%,优于现有工艺水平。 展开更多
关键词 藤黄果 羟基柠檬酸 提取 碱性条件 纯度
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RP-HPLC法测定藤黄果原料中羟基柠檬酸的含量 被引量:5
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作者 惠战锋 肖红 +2 位作者 惠玉虎 王新萍 杨军仁 《西北药学杂志》 CAS 2015年第4期371-372,共2页
目的建立藤黄果原料中羟基柠檬酸的HPLC测定方法。方法色谱柱Agilent TC-C18(250mm×4.6mm,5μm);流动相为0.05mol·L^-1的无水硫酸钠水溶液(用硫酸调节pH为2.3);检测波长210nm;进样量10μL;体积流量1.0mL·min^-1;柱... 目的建立藤黄果原料中羟基柠檬酸的HPLC测定方法。方法色谱柱Agilent TC-C18(250mm×4.6mm,5μm);流动相为0.05mol·L^-1的无水硫酸钠水溶液(用硫酸调节pH为2.3);检测波长210nm;进样量10μL;体积流量1.0mL·min^-1;柱温30℃。结果羟基柠檬酸的线性范围为0.209 9-2.099 0μg,r=0.999 9(n=6),平均回收率99.2%,RSD为0.5%。结论该方法简单、准确、重复性好,可用于藤黄果原料中羟基柠檬酸的定量测定。 展开更多
关键词 藤黄果 羟基柠檬酸 HPLC
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“双盲、安慰剂对照交叉设计研究植物药对于进食量、饱腹感、体重减轻及氧化应激的影响”的研究方案(英文) 被引量:2
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作者 Stephen D.Anton Jonathan Shuster Christiaan Leeuwenburgh 《中西医结合学报》 CAS 2011年第11期1190-1198,共9页
背景:植物性治疗药物作为一种重要且尚未被完全开发的药用资源,可能有助于热量控制从而产生长期的减重功效。从藤黄果(Garcinia combogia Desr.)中提取的羟基柠檬酸可能通过影响与饱腹有关的神经通路而减少摄食量和减轻体重。方法与设计... 背景:植物性治疗药物作为一种重要且尚未被完全开发的药用资源,可能有助于热量控制从而产生长期的减重功效。从藤黄果(Garcinia combogia Desr.)中提取的羟基柠檬酸可能通过影响与饱腹有关的神经通路而减少摄食量和减轻体重。方法与设计:本研究为双盲、安慰剂对照、交叉设计试验,共计划纳入48名超重或肥胖的健康受试者(体重指数25.0~39.9 kg/m^2,年龄50~70岁),研究两种剂量藤黄果来源的羟基柠檬酸对摄食量、饱腹感、体重减轻及氧化应激水平的影响。摄食量作为主要结局指标,根据受试者在测量日的早餐、午餐和晚餐的摄食量计算。与平行设计的研究相比,本研究所使用的受试者数量将大大减少。讨论:本研究选择藤黄果来源的羟基柠檬酸为研究对象是因为该药物能够安全地减少摄食量、减轻体重和降低氧化应激水平。我们将会在研究过程中探讨其可能的作用机制和安全指标。 展开更多
关键词 藤黄果 植物提取物 羟基柠檬酸 减肥药 营养保健品 交叉研究 临床方案
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Liver injury and dietary supplements:Does hydroxycitric acid trigger hepatotoxicity? 被引量:1
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作者 Andrea Zovi Roberto Langella +2 位作者 Andrea Nisic Antonio Vitiello Umberto M.Musazzi a 《Journal of Integrative Medicine》 SCIE CAS CSCD 2022年第5期473-475,共3页
Rising rates of obesity has increased the global use of herbal supplements intended to control weight.However,taking these preparations without appropriate medical supervision could increase the risk of manifestation ... Rising rates of obesity has increased the global use of herbal supplements intended to control weight.However,taking these preparations without appropriate medical supervision could increase the risk of manifestation of side effects,especially at the hepatic level.In literature,different cases of acute liver injury consequent to the use of food supplements containing Garcinia cambogia and hydroxycitric acid are reported.This letter aims to review the most recent literature that analysed the herb-induced liver disease due to the use of hydroxycitric acid,from the first alert coming from the European Food and Drug Administration in 2009,to the last recent European food alerts from 2020 to 2021.It is noteworthy that in some cases it demonstrated the relationship between hydroxycitric acid and hepatotoxicity.Therefore,there is a need to draw more attention to the relationship between a safe use and a more awareness in the intake of these supplements,to preserve the safety of the consumers who increasingly purchase food supplements,products that have only nutritive properties and are never curative. 展开更多
关键词 Weight loss garcinia cambogia Hydroxycitric acid HEPATOTOXICITY Adverse event
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藤黄果提取物对高脂日粮诱导的大鼠部分组织中氨基酸谱的影响
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作者 韩宁宁 刘冠星 +1 位作者 李龙龙 马海田 《畜牧与兽医》 北大核心 2016年第4期1-9,共9页
为探讨藤黄果提取(-)-羟基柠檬酸(HCA)对高脂日粮诱导的大鼠部分组织器官中氨基酸谱的影响,选用100只雄性SD大鼠随机分成5组:普通日粮对照组,高脂日粮对照组,高脂日粮添加藤黄果提取物低剂量组、中剂量组和高剂量组,每组20只。高脂日粮... 为探讨藤黄果提取(-)-羟基柠檬酸(HCA)对高脂日粮诱导的大鼠部分组织器官中氨基酸谱的影响,选用100只雄性SD大鼠随机分成5组:普通日粮对照组,高脂日粮对照组,高脂日粮添加藤黄果提取物低剂量组、中剂量组和高剂量组,每组20只。高脂日粮组分别于日粮中添加相当于(-)-HCA的剂量为0,1 000,2 000和3 000 mg/kg的藤黄果提取物,饲养8周后采集静脉血,分离血清,取肝脏、腿肌等样品。试验结果表明:与普通日粮对照组比较,高脂日粮对照组中,大鼠体增重和BMI均极显著升高(P<0.01)。与高脂日粮对照组比较,3个剂量的藤黄果提取物处理均可极显著降低大鼠的体增重(P<0.01);低剂量组中肝糖原含量显著升高(P<0.05),高剂量组肌糖原含量显著升高(P<0.05),但对血糖浓度无显著性影响(P>0.05);血清中T3和T4含量在高剂量处理组均显著升高(P<0.05),血清瘦素含量在低剂量组显著升高(P<0.05),而血清中胰岛素的含量则无显著变化(P>0.05)。氨基酸组成分析结果表明:在血清中,藤黄果提取物处可以显著升高血清中部分生糖氨基酸的含量,支链氨基酸中异亮氨酸(Ile)及芳香族氨基酸色氨酸(Trp)的含量(P<0.05);在肝脏中,藤黄果提取物可以显著降低肝脏组织中大部分生糖氨基酸和芳香族氨基酸的含量(P<0.05),而对肝脏中支链氨基酸的影响不显著(P>0.05);在腿肌中,(-)-HCA处理可显著降低生糖氨基酸的含量(P<0.05),可以极显著降低支链氨基酸的含量(P<0.01),同时(-)-HCA可以极显著降低芳香族氨基酸的含量(P<0.01)。以上结果表明,藤黄果提取物通过改变大鼠血清中激素的含量、降低肝脏和肌肉中生糖氨基酸的含量,提高机体糖代谢的水平,达到抑制大鼠体重增加的效果。 展开更多
关键词 藤黄果提取物 糖代谢 氨基酸谱 大鼠
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