期刊文献+
共找到32篇文章
< 1 2 >
每页显示 20 50 100
Endoscopic resolution and recurrence of gastric antral vascular ectasia after serial treatment with argon plasma coagulation 被引量:5
1
作者 Shashank Garg Bilal Aslam Nicholas Nickl 《World Journal of Gastrointestinal Endoscopy》 CAS 2017年第6期263-266,共4页
To evaluate long-term endoscopic resolution and recurrence rate of gastric antral vascular ectasia (GAVE) after argon plasma coagulation (APC) treatment. METHODSThis was an IRB-approved retrospective single center stu... To evaluate long-term endoscopic resolution and recurrence rate of gastric antral vascular ectasia (GAVE) after argon plasma coagulation (APC) treatment. METHODSThis was an IRB-approved retrospective single center study that included patients endoscopically treated for GAVE between 1/1/2008 to 12/31/2014. The primary and secondary end points of the study were rate of endoscopic resolution of GAVE after APC treatment and recurrence rate of GAVE after endoscopic resolution, respectively. Endoscopic resolution of GAVE was defined as no endoscopic evidence of GAVE after treatment with APC. Recurrence of GAVE was defined as endoscopic reappearance of GAVE after prior resolution. RESULTSTwenty patients met the study criteria. Median age (range) of the patients was 59.5 years (42-74 years). GAVE was associated with underlying cirrhosis in 16 (80%) patients. Indications for initial esophagogastroduodenoscopy (EGD) included hematemesis and/or melena (9/20, 45%), iron deficiency anemia (6/20, 30%), screening or surveillance of varices (4/20, 20%), and occult gastrointestinal bleeding (1/20, 5%). The patients were treated with a total of 55 APC sessions (range 1-7 sessions). Successful endoscopic resolution of GAVE was achieved in 8 out of 20 patients (40%). There was no correlation between number of treatment sessions and GAVE treatment success (P = NS). Recurrence of GAVE was noted on a subsequent EGD in 2 out of 8 patients (25%) with prior endoscopic resolution of GAVE. Median follow-up period for the study population was 627 d (range 63-1953 d). CONCLUSIONEndoscopic resolution rate of GAVE was low (40%) with a 25% recurrence rate after treatment with APC. These rates suggest that APC treatment of GAVE may not be optimal in many circumstances. 展开更多
关键词 gastric antral vascular ectasia Argon plasma coagulation
下载PDF
Successful treatment of refractory gastric antral vascular ectasia by distal gastrectomy:A case report 被引量:1
2
作者 Ting Jin Bao-Ying Fei +1 位作者 Wei-Hua Zheng Yong-Xiang Wang 《World Journal of Gastroenterology》 SCIE CAS 2014年第38期14073-14075,共3页
Gastric antral vascular ectasia (GAVE) is an uncommon and often neglected cause of gastric hemorrhage. The treatments for GAVE include surgery, endoscopy and medical therapies. Here, we report an unusual case of GAVE.... Gastric antral vascular ectasia (GAVE) is an uncommon and often neglected cause of gastric hemorrhage. The treatments for GAVE include surgery, endoscopy and medical therapies. Here, we report an unusual case of GAVE. A 72-year-old man with a three-month history of recurrent melena was diagnosed with GAVE. Endoscopy revealed the classical &#x0201c;watermelon stomach&#x0201d; appearance of GAVE and complete pyloric involvement. Melena reoccurred three days after argon plasma coagulation treatment, and the level of hemoglobin dropped to 47 g/L. The patient was then successfully treated with distal gastrectomy with Billroth II anastomosis. We propose that surgery should be considered as an effective option for GAVE patients with extensive and severe lesions upon deterioration of general conditions and hemodynamic instability. 展开更多
关键词 gastric antral vascular ectasia MELENA Distal gastrectomy Argon plasma coagulation Endoscopic band ligation
下载PDF
Influences of etiology and endoscopic appearance on the long-term outcomes of gastric antral vascular ectasia
3
作者 Hyo Jin Kwon Si Hyung Lee Joon Hyun Cho 《World Journal of Clinical Cases》 SCIE 2022年第18期6050-6059,共10页
BACKGROUND Gastric antral vascular ectasia(GAVE)has diverse associations and presumed causes,which include liver cirrhosis,chronic kidney disease,and autoimmune disease.This heterogeneity of underlying disorders sugge... BACKGROUND Gastric antral vascular ectasia(GAVE)has diverse associations and presumed causes,which include liver cirrhosis,chronic kidney disease,and autoimmune disease.This heterogeneity of underlying disorders suggests that the pathogenesis of GAVE may be variable.AIM To compare the clinical features and long-term outcomes of GAVE according to endoscopic patterns and etiologies.METHODS The medical records and endoscopic images of 23 consecutive patients diagnosed with GAVE by endoscopy at Yeungnam University Hospital from January 2006 to December 2020 were retrospectively reviewed.Patients were allocated to cirrhosis(16 patients)and non-cirrhosis groups(7 patients).GAVE subtypes,as determined by endoscopy,were categorized as punctate(a diffuse,honeycomb-like appearance,17 patients)or striped(a linear,watermelon-like appearance,6 patients).RESULTS All GAVE patients with cirrhosis(16/16,100%)had a punctate pattern by endoscopy,whereas the majority of patients(6/7,85.7%)without cirrhosis had a striped pattern(P<0.001).Overt GAVE bleeding(10/23,43%)was significantly more common in the non-cirrhosis group than in the cirrhosis group(6/7,85.7%vs 4/16,25.0%;P=0.019),and more common in the striped group than in the punctate group(5/6,83.3%vs 5/17,29.4%;P=0.052).However,mean numbers of admissions due to GAVE bleeding and argon plasma coagulation(APC)sessions to address overt bleeding were similar in the cirrhosis and non-cirrhosis groups and in the punctate and striped groups.All patients with GAVE bleeding were successfully treated by APC,and no patient died from GAVE-related blood loss during a median follow-up of 24 mo.CONCLUSION Punctate-type GAVE is strongly associated with liver cirrhosis,and GAVE patients without cirrhosis tend to be more prone to overt bleeding.However,the presence of cirrhosis and endoscopic patterns did not influence long-term clinical courses or outcomes in cases of overt bleeding. 展开更多
关键词 gastric antral vascular ectasia CIRRHOSIS ENDOSCOPY Gastrointestinal bleeding Argon plasma coagulation
下载PDF
Accuracy of virtual chromoendoscopy in differentiating gastric antral vascular ectasia from portal hypertensive gastropathy:A proof of concept study
4
作者 Ahmad M Al-Taee Mark P Cubillan +4 位作者 Alice Hinton Lindsay A Sobotka Alex S Befeler Christine Y Hachem Hisham Hussan 《World Journal of Hepatology》 2021年第12期2168-2178,共11页
BACKGROUND Accurate detection of gastric antral vascular ectasia(GAVE)is critical for proper management of cirrhosis-related gastrointestinal bleeding.However,endoscopic diagnosis of GAVE can be challenging when GAVE ... BACKGROUND Accurate detection of gastric antral vascular ectasia(GAVE)is critical for proper management of cirrhosis-related gastrointestinal bleeding.However,endoscopic diagnosis of GAVE can be challenging when GAVE overlaps with severe portal hypertensive gastropathy(PHG).AIM To determine the added diagnostic value of virtual chromoendoscopy to high definition white light for real-time endoscopic diagnosis of GAVE and PHG.METHODS We developed an I-scan virtual chromoendoscopy criteria for diagnosis of GAVE and PHG.We tested our criteria in a cross-sectional cohort of cirrhotic adults with GAVE and PHG when high-definition white light endoscopy(HDWLE)diagnosis was in doubt.We then compared the accuracy of I-scan vs HDWLE alone to histology.RESULTS Twenty-three patients were included in this study(65.2%Caucasians and 60.9%males).Chronic hepatitis C was the predominant cause of cirrhosis(43.5%)and seven adults(30.4%)had confirmed GAVE on histology.I-scan had higher sensitivity(100%vs 85.7%)and specificity(75%vs 62.5%)in diagnosing GAVE compared to HDWLE.This translates into a higher,albeit not statistically significant,accuracy of I-scan in detecting GAVE compared to HDWLE alone(82%vs 70%).I-scan was less likely to lead to an accurate diagnosis of GAVE in patients on dialysis(P<0.05)and in patients with elevated creatinine(P<0.05).Iscan had similar accuracy to HDWLE in detecting PHG.CONCLUSION This pilot work supports that virtual chromoendoscopy may obviate the need for biopsies when the presence of GAVE is in doubt.Larger studies are needed to assess the impact of virtual chromoendoscopy on success of endoscopic therapy for GAVE. 展开更多
关键词 Portal hypertensive gastropathy gastric antral vascular ectasia Virtual chromoendoscopy ENDOSCOPY
下载PDF
Diagnosis and management of gastric antral vascular ectasia 被引量:11
5
作者 Lorenzo Fuccio Alessandro Mussetto +2 位作者 Liboria Laterza Leonardo Henry Eusebi Franco Bazzoli 《World Journal of Gastrointestinal Endoscopy》 CAS 2013年第1期6-13,共8页
Gastric antral vascular ectasia (GAVE) is an uncommon but often severe cause of upper gastrointestinal (GI) bleeding, responsible of about 4% of non-variceal upper GI haemorrhage. The diagnosis is mainly based on endo... Gastric antral vascular ectasia (GAVE) is an uncommon but often severe cause of upper gastrointestinal (GI) bleeding, responsible of about 4% of non-variceal upper GI haemorrhage. The diagnosis is mainly based on endoscopic pattern and, for uncertain cases, on histology. GAVE is characterized by a pathognomonic endoscopic pattern, mainly represented by red spots either organized in stripes radially departing from pylorus, defined as watermelon stomach, or arranged in a diffused-way, the so called honeycomb stomach. The histological pattern, although not pathognomonic, is characterized by four alterations:vascular ectasia of mucosal capillaries, focal thrombosis, spindle cell proliferation and fibrohyalinosis, which consist of homogeneous substance around the ectatic capillaries of the lamina propria. The main differential diagnosis is with Portal Hypertensive Gastropathy, that can frequently co-exists, since about 30% of patients with GAVE co-present a liver cirrhosis. Autoimmune disorders, mainly represented by Reynaud's phenomenon and sclerodactyly, are co-present in about 60% of patients with GAVE; other autoimmune and connective tissue disorders are occasionally reported such as Sjogren's syndrome, systemic lupus erythematosus, primary biliary cirrhosis and systemic sclerosis. In the remaining cases, GAVE syndrome has been described in patients with chronic renal failure, bone marrow transplantation and cardiac diseases. The pathogenesis of GAVE is still obscure and many hypotheses have been proposed such as mechanical stress, humoural and autoimmune factors and hemodynamic alterations. In the last two decades, many therapeutic options have been proposed including surgical, endoscopic and medical choices. Medical therapy has not clearly shown satisfactory results and surgery should only be considered for refractory severe cases, since this approach has significant mortality and morbidity risks, especially in the setting of portal hypertension and liver cirrhosis. Endoscopic therapy, particularly treatment with Argon Plasma Coagulation, has shown to be as effective and also safer than surgery, and should be considered the first-line treatment for patients with GAVE-related bleeding. 展开更多
关键词 gastric antral vascular ectasia BLEEDING WATERMELON STOMACH ARGON plasma COAGULATION
下载PDF
Massive gastric antral vascular ectasia successfully treated by endoscopic band ligation as the initial therapy 被引量:5
6
作者 Varayu Prachayakul Pitulak Aswakul Somchai Leelakusolvong 《World Journal of Gastrointestinal Endoscopy》 CAS 2013年第3期135-137,共3页
Gastric antral vascular ectasia(GAVE) accounted for 4% of non-variceal gastrointestinal hemorrhage.Even though unclear pathogenesis,GAVE often associated with chronic renal failure,autoimmune diseases and cirrhosis.As... Gastric antral vascular ectasia(GAVE) accounted for 4% of non-variceal gastrointestinal hemorrhage.Even though unclear pathogenesis,GAVE often associated with chronic renal failure,autoimmune diseases and cirrhosis.Asymptomatic lesions were reasonably not to treated.The treatment options for GAVE are nonendoscopic and endoscopic treatments.For the pharmacological treatment,some success were reported for the use of octreotide,thalidomide and tranexamic acid.While the endoscopic treatment is the mainstay for treatment of symptomatic lesions.The endoscopic ablative therapies such as argon plasma coagulation was reported with good clinical outcomes.However,these treatment options had some limitation due to the need of special equipment and multiple sessions needed to control the bleeding.We reported another treatment option using the routine-achievable instrument such as endoscopic band ligation as an initial treatment which also provided a good treatment outcome and less sessions. 展开更多
关键词 gastric antral vascular ectasia Non variceal HEMORRHAGE Endoscopic band LIGATION Water MELON STOMACH Treatment
下载PDF
Transjugular intrahepatic portosystemic shunt as bridge-to-surgery in refractory gastric antral vascular ectasia 被引量:3
7
作者 Aymeric Becq Violaine Ozenne +2 位作者 Aurélie Plessier Patrice Valleur Xavier Dray 《World Journal of Gastroenterology》 SCIE CAS 2015年第18期5749-5750,共2页
Gastric antral vascular ectasia(GAVE) may cause gastrointestinal bleeding(GIB). The treatment of GAVE relies on endoscopic approaches such as electrocoagulation(argon plasma coagulation, laser therapy, heater probe th... Gastric antral vascular ectasia(GAVE) may cause gastrointestinal bleeding(GIB). The treatment of GAVE relies on endoscopic approaches such as electrocoagulation(argon plasma coagulation, laser therapy, heater probe therapy, radiofrequency ablation), cryotherapy, and band ligation. In refractory cases, antrectomy may be considered. In the event of an associated cirrhosis and portal hypertension, it has been suggested that antrectomy could be an option, provided the mortality risk isn't considered too great. We report the case of a 67-year-old cirrhotic patient who presented with GAVE related GIB, unresponsive to multiple endoscopic treatments. The patient had a good liver function(model for end-stage disease 10). After a multidisciplinary meeting, a transjugular intrahepatic portosystemic shunt(TIPS) procedure was performed, in order to treat the cirrhosis associated ascites. The outcome was successful. An antrectomy was then performed, with no recurrence of GIB and no transfusion need during three months of follow up. In this case, the TIPS procedure achieved a complete ascites regression, allowing a safer surgical treatment of the GAVE-related GIB. 展开更多
关键词 gastric antral vascular ectasia Gastro-intestinal BLEEDING CIRRHOSIS ASCITES Transjugular INTRAHEPATIC portosystemic SHUNT Antrectomy
下载PDF
Detection of active bleeding from gastric antral vascular ectasia by capsule endoscopy 被引量:2
8
作者 Tetsuya Ohira Akira Hokama +7 位作者 Nagisa Kinjo Manabu Nakamoto Chiharu Kobashigawa Yuya Kise Satoshi Yamashiro Fukunori Kinjo Yukio Kuniyoshi Jiro Fujita 《World Journal of Gastrointestinal Endoscopy》 CAS 2013年第3期138-140,共3页
Gastric antral vascular ectasia(GAVE) has been recognized as one of the important causes of occult and obscure gastrointestinal bleeding.The diagnosis is typically made based on the characteristic endoscopic features,... Gastric antral vascular ectasia(GAVE) has been recognized as one of the important causes of occult and obscure gastrointestinal bleeding.The diagnosis is typically made based on the characteristic endoscopic features,including longitudinal row of flat,reddish stripes radiating from the pylorus into the antrum that resemble the stripes on a watermelon.These appearances,however,can easily be misinterpreted as moderate to severe gastritis.Although it is believed that capsule endoscopy(CE) is not helpful for the study of the stomach with its large lumen,GAVE can be more likely to be detected at CE rather than conventional endoscopy.CE can be regarded as "physiologic" endoscopy,without the need for gastric inflation and subsequent compression of the vasculature.The blood flow of the ecstatic vessels may be diminished in an inflated stomach.Therefore,GAVE may be prominent in CE.We herein describe a case of active bleeding from GAVE detected by CE and would like to emphasize a possibility that CE can improve diagnostic yields for GAVE. 展开更多
关键词 GASTROINTESTINAL BLEEDING GASTROINTESTINAL ENDOSCOPY Capsule ENDOSCOPY gastric antral vascular ectasia Argon plasma COAGULATION
下载PDF
A novel endoscopic ablation of gastric antral vascular ectasia
9
作者 Masae Komiyama Kuangi Fu +5 位作者 Takashi Morimoto Hironori Konuma Toshifumi Yamagata Yuko Izumi Akihisa Miyazaki Sumio Watanabe 《World Journal of Gastrointestinal Endoscopy》 CAS 2010年第8期298-300,共3页
An 80-year-old woman was admitted to our hospital because of tarry stool with iron deficiency anemia. Her past history included autoimmune hepatitis. Esophagogastroduodenal endoscopy was performed to investigate the b... An 80-year-old woman was admitted to our hospital because of tarry stool with iron deficiency anemia. Her past history included autoimmune hepatitis. Esophagogastroduodenal endoscopy was performed to investigate the bleeding source and revealed multiple linear gastric vascular malformations in the antrum and cardia, compatible with Gastric antral vascular ectasia (GAVE). Endoscopic ablation was carried out with the tip of the hot biopsy forceps without opening at soft coagulation mode of 80W. The patient tolerated the procedure well and there were no complications associated with endoscopic therapies. After two sessions of endoscopic ablation her anemia improved to around 10 g/dL, an increase of 3.6 g/dL. Various endoscopic treatments have been described to manage GAVE. The most popular is argon plasma coagulation (APC), although APC is associated with over-distension induced by the argon plasma gas. To avoid over-distension and to reduce the abdominal discomfort/pain of this patient,we have used hot biopsy forceps instead of APC. Our case suggests that this procedure is effective, easy and convenient,as no special equipment or skill is necessary. 展开更多
关键词 Hot BIOPSY FORCEPS ENDOSCOPIC ablation gastric antral vascular ectasia
下载PDF
Case series on multimodal endoscopic therapy for gastric antral vascular ectasia, a tertiary center experience
10
作者 Tasnia Matin Mohammed Naseemuddin +4 位作者 Mohamed Shoreibah Peng Li Kondal Kyanam Kabir Baig Charles Mel Wilcox Shajan Peter 《World Journal of Gastrointestinal Endoscopy》 CAS 2018年第1期30-36,共7页
AIM To study and describe patients who underwent treatment for gastric antral vascular ectasia(GAVE) with different endoscopic treatment modalities.METHODS We reviewed patients with GAVE who underwent treatment at Uni... AIM To study and describe patients who underwent treatment for gastric antral vascular ectasia(GAVE) with different endoscopic treatment modalities.METHODS We reviewed patients with GAVE who underwent treatment at University of Alabama at Birmingham between March 1, 2012 and December 31, 2016. Included patients had an endoscopic diagnosis of GAVE with associated upper gastrointestinal bleeding or iron deficiency anemia.RESULTS Seven out of 15 patients had classic watermelon description for GAVE, 1/15 with diffuse/honeycomb pattern and 6/15 with nodular GAVE per EGD description. Seven out of 15 patients required multimodal treatment. Four out of six of patients with endoscopically nodular GAVE required multimodal therapy. Overall, mean pre-and post-treatment hemoglobin(Hb) values were 8.2 ± 0.8 g/dL and 9.7 ± 1.6 g/dL, respectively(P ≤ 0.05). Mean number of packed red blood cells transfusions before and after treatment was 3.8 ± 4.3 and 1.2 ± 1.7(P ≤ 0.05), respectively.CONCLUSION Patients with nodular variant GAVE required multimodal approach more frequently than non-nodular variants. Patients responded well to multimodal therapy and saw decrease in transfusion rates and increase in Hb concentrations. Our findings suggest a multimodal approach may be beneficial in nodular variant GAVE. 展开更多
关键词 gastric antral vascular ectasia Upper GI bleed RADIOFREQUENCY ablation Endoscopic band LIGATION ARGON plasma COAGULATION
下载PDF
Case report of gastric antral vascular ectasia (GAVE)
11
作者 Fengli Liu Feng Ji +1 位作者 Xi Jin Yechun Du 《Open Journal of Internal Medicine》 2013年第2期76-80,共5页
Gastric antral vascular ectasia (GAVE) is a rare clinical disease which can cause recurrent upper gastrointestinal (GI) tract bleeding. It is responsible for about 4% of non-variceal upper GI haemorrhages. As one of t... Gastric antral vascular ectasia (GAVE) is a rare clinical disease which can cause recurrent upper gastrointestinal (GI) tract bleeding. It is responsible for about 4% of non-variceal upper GI haemorrhages. As one of the vascular diseases that happened in stomach, GAVE was also named as watermelon stomach (WS) for its characteristic endoscopic performance. Compared with portal hypertensive gastropathy (PHG) which with similar performances under endoscopy but often appeared as the result of portal hypertension, the etiology of GAVE is unknown. Recent years with further research it received several presumptions according to its histopathological features. Here we will introduce the disease systematically through two cases. 展开更多
关键词 gastric antral vascular ectasia (GAVE) ENDOSCOPIC Performance ETIOLOGY TREATMENTS
下载PDF
Thalidomide for refractory gastrointestinal bleeding from vascular malformations in patients with significant comorbidities 被引量:5
12
作者 Alexis Mae Bayudan Chien-Huan Chen 《World Journal of Clinical Cases》 SCIE 2020年第15期3218-3229,共12页
BACKGROUND Refractory gastrointestinal bleeding(GIB)secondary to gastrointestinal vascular malformations(GIVM)such as gastrointestinal angiodysplasia(GIAD)and gastric antral vascular ectasia(GAVE)remains challenging t... BACKGROUND Refractory gastrointestinal bleeding(GIB)secondary to gastrointestinal vascular malformations(GIVM)such as gastrointestinal angiodysplasia(GIAD)and gastric antral vascular ectasia(GAVE)remains challenging to treat when endoscopic therapy fails.Recently thalidomide has been suggested as a treatment option for refractory GIB.AIM To determine the outcome of patients treated with thalidomide for refractory GIB due to GIVM.METHODS IRB approved,single center,retrospective review of electronic medical records from January 2012 to November 2018.Patients age>18 years old,who had>3 episodes of GIB refractory to medical or endoscopic therapy,and who had been treated with thalidomide for at least 3 mo were included.The primary endpoint was recurrence of GIB 6 mo after initiation of thalidomide.RESULTS Fifteen patients were included in the study,all with significant cardiac,hepatic,or renal comorbidities.The cause of GIB was GIAD in 10 patients and GAVE in 5 patients.Two patients were lost to follow up.Of the 13 patients followed,38.5%(n=5)had no recurrent GIB or transfusion requirement after treatment with thalidomide.Furthermore,84.6%(n=11)of patients had a reduction in transfusion requirements and hospitalizations for GIB.Thalidomide was discontinued in 2 patients due to cost(n=1)and medication interaction(n=1).Reported adverse reactions included fatigue(n=3),neuropathy(n=2),dizziness(n=1),and constipation(n=1).Six patients died during follow up due to unknown cause(n=4)and sepsis(n=2).CONCLUSION Thalidomide appears to be an effective treatment for refractory GIB due to GIAD or GAVE in a Western population with significant comorbidities. 展开更多
关键词 vascular malformation THALIDOMIDE Refractory gastrointestinal bleeding gastric antral vascular ectasia ANGIODYSPLASIA
下载PDF
Shared changes in angiogenic factors across gastrointestinal vascular conditions:A pilot study
13
作者 Atiyekeogbebe R Douglas Grainne Holleran +1 位作者 Sinead M Smith Deirdre McNamara 《World Journal of Gastrointestinal Pharmacology and Therapeutics》 CAS 2020年第3期40-47,共8页
BACKGROUND Neovascularisation is common to a variety of gastrointestinal(GI)disorders with differing aetiologies and presentations;usually affecting adults above 60 years.Shared angiogenic factors modulated by disease... BACKGROUND Neovascularisation is common to a variety of gastrointestinal(GI)disorders with differing aetiologies and presentations;usually affecting adults above 60 years.Shared angiogenic factors modulated by disease specific elements could be a common denominator and represent novel diagnostic and therapeutic targets.As yet,assessment of angiogenic factors across several GI vascular disorders associated with recurrent bleeding and anaemia has not been reported.AIM To assess serum levels of angiogenic factors in several intestinal vascular disorders.METHODS A case control study was performed in Tallaght University Hospital in patients with endoscopically proven small bowel angiodysplasia(SBA),portal hypertensive gastropathy(PHG),gastric antral vascular ectasia(GAVE)and nonbleeding,non-anaemic controls.Using enzyme-linked immunosorbent assay,concentrations of Angiopoietin 1(Ang-1),Ang-2 and vascular endothelial growth factor(VEGF)were measured from 2 serum tubes of blood following informed consent.The relative expression of Ang-1 and Ang-2 and Ang-1/2 ratio was calculated and compared between groups.Statistical analysis was applied using a t-test,and a P value of<0.05 was considered significant.RESULTS To date 44 samples were tested:10 SBA,11 PHG,8 GAVE and 15 controls.Mean age 60(range 20-85)years and 20(45%)were males.Controls were significantly younger(49 years vs 66 years,P=0.0005).There was no difference in VEGF levels between the groups(P=0.6).SBA,PHG and GAVE Ang-1 levels were similar and were significantly lower than controls,(P=0.0002,95%CI:241 to 701).Ang-2 levels were statistically higher in PHG and GAVE groups compared to controls(P= 0.01, 95%CI: 77.8 to 668) and as a result, also had a lower Ang-1/2 ratioscompared to controls. While SBA Ang-2 levels were higher than controls, this didnot reach statistical significance. Neither age nor haemoglobin level, which wassimilar between disease groups, could explain the difference. In addition, themedian Ang-1/Ang-2 ratio for all patients was found to be significantly lowercompared to controls, 8 vs 28 respectively, P = 0.001, 95%CI: -27.55 to -7.12.CONCLUSIONOur novel pilot study suggests common alterations in Ang-1 and Ang-2 levelsacross several GI vascular disorders. Differences in Ang-1/Ang-2 ratios amongvascular disorders compared to controls suggest disease-specific modulation. 展开更多
关键词 gastric antral vascular ectasia Portal hypertensive gastropathy ANGIODYSPLASIA ANGIOPOIETINS Angiogenic factors Recurrent bleeding
下载PDF
血管靶向光动力疗法治疗胃窦血管扩张症 被引量:4
14
作者 毛永平 邱海霞 +5 位作者 顾瑛 王颖 朱建国 曾晶 刘庆森 杨云生 《中国激光医学杂志》 CAS CSCD 2010年第4期220-222,271,共4页
目的探索血管靶向光动力疗法治疗胃窦血管扩张症的可行性。方法胃窦血管扩张症合并出血患者1例,静脉注射光敏剂PSD-007 5 mg/kg后即刻,以波长630 nm的半导体激光先用柱状光纤照射胃窦病变20 min,再以点状光纤照射10 min,功率密度均为80... 目的探索血管靶向光动力疗法治疗胃窦血管扩张症的可行性。方法胃窦血管扩张症合并出血患者1例,静脉注射光敏剂PSD-007 5 mg/kg后即刻,以波长630 nm的半导体激光先用柱状光纤照射胃窦病变20 min,再以点状光纤照射10 min,功率密度均为80~100 mW/cm^2,总能量密度144~180 J/cm^2。术后第1周及第5周复查胃镜,第5周进行近期疗效评价。并观察和记录术中和术后不良反应。结果治疗后病变处渗血停止,扩张毛细血管颜色明显变暗,黏膜明显水肿。术后第4天患者黑便消失,大便潜血阴性。术后1周胃镜检查见胃窦近端异常扩张毛细血管基本消失,远端黏膜见表浅溃疡。术后5周患者贫血情况明显改善,胃镜检查见胃窦近端异常扩张毛细血管基本消失,黏膜光滑、完整,患者大便潜血持续阴性。术后及术后均无不良反应发生。结论血管靶向光动力疗法治疗胃窦血管扩张症具有靶向选择性高,止血作用确切,起效快,疗效持久,安全无创等优点,但尚需大样本、前瞻性研究来进一步验证其安全性及有效性。 展开更多
关键词 胃窦血管扩张症 激光 光动力疗法 血管靶向
下载PDF
Felty综合征合并胃窦血管扩张症1例 被引量:2
15
作者 韦新焕 孟凡冬 +1 位作者 吴咏冬 陈乐天 《胃肠病学》 2013年第2期127-128,共2页
病例:患者男,59岁,因“乏力气促,伴食欲减退3年”于2012年7月入院。患者3年前曾因“乏力气促,大便发黑,食欲减退2个月”,于当地医院住院治疗,当时无发热、恶心、呕吐、腹痛、腹泻等不适。实验室检查:多次大便潜血试验阳性,
关键词 FELTY综合征 胃窦血管扩张 贫血 诊断
下载PDF
胃窦血管扩张症的发病与诊治 被引量:5
16
作者 罗海峰 吴志勇 《上海第二医科大学学报》 CSCD 2004年第6期487-489,共3页
胃窦血管扩张症是引起严重的上消化道出血的一种少见疾病。文章介绍其发病原因,病理机制,诊断治疗等,重点阐述其与门静脉高压性胃病的区别。
关键词 胃窦血管扩张症 上消化道出血 门静脉高压性胃病 GAVE 病理学
下载PDF
血管病变所致消化道出血的内镜诊治进展 被引量:2
17
作者 谭红红 戈之铮 《胃肠病学》 2010年第6期361-363,共3页
胃肠道血管病变如血管发育不良、血管扩张、血管畸形、遗传性卅血性毛细血管扩张症等是引起反复、隐性或难治性消化道出血的主要原因。病变可孤立或多发,甚至累及整个消化道,尤以小肠多见。胃肠道血管病变的发病机制和治疗仍处于不断... 胃肠道血管病变如血管发育不良、血管扩张、血管畸形、遗传性卅血性毛细血管扩张症等是引起反复、隐性或难治性消化道出血的主要原因。病变可孤立或多发,甚至累及整个消化道,尤以小肠多见。胃肠道血管病变的发病机制和治疗仍处于不断研究和探索中,内镜在其早期诊断和治疗中发挥重要作用。本文就各种内镜技术在胃肠道血管病变,尤其是血管发育不良和胃窦血管扩张中的临床诊断和治疗价值作一综述。 展开更多
关键词 内镜 胃肠出血 血管发育不良 胃窦血管扩张 毛细血管扩张 遗传性出血性
下载PDF
Endoscopic management and outcome of non-variceal bleeding in patients with liver cirrhosis:A systematic review 被引量:2
18
作者 Georgios Demetiou Aikaterini Augoustaki Evangelos Kalaitzakis 《World Journal of Gastrointestinal Endoscopy》 2022年第3期163-175,共13页
BACKGROUND Acute non-variceal bleeding accounts for approximately 20%of all-cause bleeding episodes in patients with liver cirrhosis.It is associated with high morbidity and mortality therefore prompt diagnosis and en... BACKGROUND Acute non-variceal bleeding accounts for approximately 20%of all-cause bleeding episodes in patients with liver cirrhosis.It is associated with high morbidity and mortality therefore prompt diagnosis and endoscopic management are crucial.AIM To evaluate available data on the efficacy of endoscopic treatment modalities used to control acute non-variceal gastrointestinal bleeding(GIB)in cirrhotic patients as well as to assess treatment outcomes.METHODS Employing PRISMA methodology,the MEDLINE was searched through PubMed using appropriate MeSH terms.Data are reported in a summative manner and separately for each major non-variceal cause of bleeding.RESULTS Overall,23 studies were identified with a total of 1288 cirrhotic patients of whom 958/1288 underwent endoscopic therapy for acute non-variceal GIB.Peptic ulcer bleeding was the most common cause of acute non-variceal bleeding,followed by portal hypertensive gastropathy,gastric antral vascular ectasia,Mallory-Weiss syndrome,Dieaulafoy lesions,portal hypertensive colopathy,and hemorrhoids.Failure to control bleeding from all-causes of non-variceal GIB accounted for less than 3.5%of cirrhotic patients.Rebleeding(range 2%-25%)and mortality(range 3%-40%)rates varied,presumably due to study heterogeneity.Rebleeding was usually managed endoscopically and salvage therapy using arterial embolisation or surgery was undertaken in very few cases.Mortality was usually associated with liver function deterioration and other organ failure or infections rather than uncontrolled bleeding.Endoscopic treatment-related complications were extremely rare.Lower acute non-variceal bleeding was examined in two studies(197/1288 patients)achieving initial hemostasis in all patients using argon plasma coagulation for portal hypertensive colopathy and endoscopic band ligation or sclerotherapy for bleeding hemorrhoids(rebleeding range 10%-13%).Data on the efficacy of endoscopic therapy of cirrhotic patients vs non-cirrhotic controls with acute GIB are very scarce.CONCLUSION Endotherapy seems to be efficient as a means to control non-variceal hemorrhage in cirrhosis,although published data are very limited,particularly those comparing cirrhotics with noncirrhotics and those regarding acute bleeding from the lower gastrointestinal tract.Rebleeding and mortality rates appear to be relatively high,although firm conclusions may not be drawn due to study heterogeneity.Hopefully this review may stimulate further research on this subject and help clinicians administer optimal endoscopic therapy for cirrhotic patients. 展开更多
关键词 Liver cirrhosis Non-variceal gastrointestinal hemorrhage Gastrointestinal endoscopy Endoscopic therapy Patient outcomes Peptic ulcer Mallory Weiss syndrome gastric antral vascular ectasia
下载PDF
慢性肾衰竭合并胃窦血管扩张症1例并文献复习
19
作者 刘爱玲 李晓青 +1 位作者 伍东升 钱家鸣 《胃肠病学》 2018年第1期62-64,共3页
病例:患者女,71岁,因"黑便2年,加重7个月"于2017年3月21日收治入院。两年前无明显诱因下排成形黑便,50-100 m L/d,无腹痛、腹胀、恶心、呕吐、反酸、烧心等,血红蛋白(Hb)80-100 g/L(接受血液透析以来Hb 100-110 g/L)。7个月前症... 病例:患者女,71岁,因"黑便2年,加重7个月"于2017年3月21日收治入院。两年前无明显诱因下排成形黑便,50-100 m L/d,无腹痛、腹胀、恶心、呕吐、反酸、烧心等,血红蛋白(Hb)80-100 g/L(接受血液透析以来Hb 100-110 g/L)。7个月前症状加重,排成形柏油便150-200 m L/d,伴乏力、头晕,就诊于当地医院。Hb 60 g/L,胃镜检查示糜烂性胃炎;结肠镜检查进镜约25 cm, 展开更多
关键词 胃窦血管扩张 肾功能衰竭 慢性 诊断 治疗
下载PDF
Endoscopic cryotherapy:Indications,techniques,and outcomes involving the gastrointestinal tract
20
作者 Amaninder Dhaliwal Syed M Saghir +8 位作者 Harmeet S Mashiana Annie Braseth Banreet S Dhindsa Daryl Ramai Pushpak Taunk Rene Gomez-Esquivel Aamir Dam Jason Klapman Douglas G Adler 《World Journal of Gastrointestinal Endoscopy》 2022年第1期17-28,共12页
Endoscopic cryotherapy is a technique utilized for the ablation of target tissue within the gastrointestinal tract.A cryotherapy system utilizes the endoscopic application of cryogen such as liquid nitrogen,carbon dio... Endoscopic cryotherapy is a technique utilized for the ablation of target tissue within the gastrointestinal tract.A cryotherapy system utilizes the endoscopic application of cryogen such as liquid nitrogen,carbon dioxide or liquid nitrous oxide.This leads to disruption of cell membranes,apoptosis,and thrombosis of local blood vessels within the target tissue.Several trials utilizing cryotherapy for Barrett’s esophagus(BE)with variable dysplasia,gastric antral vascular ectasia(GAVE),esophageal carcinoma,radiation proctitis,and metastatic esophageal carcinomas have shown safety and efficacy.More recently,liquid nitrogen cryotherapy(cryodilation)was shown to be safe and effective for the treatment of a benign esophageal stricture which was refractory to dilations,steroid injections,and stenting.Moreover,liquid nitrogen cryotherapy is associated with less post procedure pain as compared to radiofrequency ablation in BE with comparable ablation rates.In patients with GAVE,cryotherapy was found to be less tedious as compared to argon plasma coagulation.Adverse events from cryotherapy most commonly include chest pain,esophageal strictures,and bleeding.Gastric perforations did occur as well,but less often.In summary,endoscopic cryotherapy is a promising and growing field,which was first demonstrated in BE,but the use now spans for several other disease processes.Larger randomized controlled trials are needed before its role can be established for these different diseases. 展开更多
关键词 CRYOTHERAPY gastric antral vascular ectasia Barrett’s esophagus Esophageal cancer Palliative therapy
下载PDF
上一页 1 2 下一页 到第
使用帮助 返回顶部