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Gastric microbiota transplantation as a potential treatment for immune checkpoint inhibitor-associated gastritis
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作者 Bo-Tong Ma Li-Xuan Sang Bing Chang 《World Journal of Gastroenterology》 SCIE CAS 2024年第24期3123-3125,共3页
Immune-related adverse events(irAEs)are complications of the use of immune checkpoint inhibitors(ICIs).ICI-associated gastritis is one of the main irAEs.The gastric microbiota is often related to the occurrence and de... Immune-related adverse events(irAEs)are complications of the use of immune checkpoint inhibitors(ICIs).ICI-associated gastritis is one of the main irAEs.The gastric microbiota is often related to the occurrence and development of many gastric diseases.Gastric microbiota adjustment may be used to treat gastric disorders in the future.Faecal microbiota transplantation can alter the gut microbiota of patients and has been used for treating ICI-associated colitis.Therefore,we propose gastric microbiota transplantation as a supplementary treatment for patients with ICI-associated gastritis who do not respond well to conventional therapy. 展开更多
关键词 Immune checkpoint inhibitor Immune-related adverse events Gastritis gastric microbiota transplantation Probiotics
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Helicobacter pylori,gastric microbiota and gastric cancer relationship:Unrolling the tangle 被引量:18
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作者 Christos Liatsos Apostolis Papaefthymiou +7 位作者 Nikolaos Kyriakos Michail Galanopoulos Michael Doulberis Marios Giakoumis Evangelia Petridou Christos Mavrogiannis Theodore Rokkas Jannis Kountouras 《World Journal of Gastrointestinal Oncology》 SCIE 2022年第5期959-972,共14页
Helicobacter pylori infection(Hp-I)represents a typical microbial agent intervening in the complex mechanisms of gastric homeostasis by disturbing the balance between the host gastric microbiota and mucosa-related fac... Helicobacter pylori infection(Hp-I)represents a typical microbial agent intervening in the complex mechanisms of gastric homeostasis by disturbing the balance between the host gastric microbiota and mucosa-related factors,leading to inflammatory changes,dysbiosis and eventually gastric cancer.The normal gastric microbiota shows diversity,with Proteobacteria[Helicobacter pylori(H.pylori)belongs to this family],Firmicutes,Actinobacteria,Bacteroides and Fusobacteria being the most abundant phyla.Most studies indicate that H.pylori has inhibitory effects on the colonization of other bacteria,harboring a lower diversity of them in the stomach.When comparing the healthy with the diseased stomach,there is a change in the composition of the gastric microbiome with increasing abundance of H.pylori(where present)in the gastritis stage,while as the gastric carcinogenesis cascade progresses to gastric cancer,the oral and intestinal-type pathogenic microbial strains predominate.Hp-I creates a premalignant environment of atrophy and intestinal metaplasia and the subsequent alteration in gastric microbiota seems to play a crucial role in gastric tumorigenesis itself.Successful H.pylori eradication is suggested to restore gastric microbiota,at least in primary stages.It is more than clear that Hp-I,gastric microbiota and gastric cancer constitute a challenging tangle and the strong interaction between them makes it difficult to unroll.Future studies are considered of crucial importance to test the complex interaction on the modulation of the gastric microbiota by H.pylori as well as on the relationships between the gastric microbiota and gastric carcinogenesis. 展开更多
关键词 Helicobacter pylori infection gastric microbiota gastric cancer ONCOGENESIS DYSBIOSIS Helicobacter pylori eradication
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Effect of gastric microbiota on quadruple Helicobacter pylori eradication therapy containing bismuth 被引量:7
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作者 Zhan-Yue Niu Si-Zhu Li +1 位作者 Yan-Yan Shi Yan Xue 《World Journal of Gastroenterology》 SCIE CAS 2021年第25期3913-3924,共12页
BACKGROUND Helicobacter pylori(H.pylori)is an important pathogen that can cause a variety of diseases.Yet,full eradication of H.pylori remains a significant challenge in clinical practice.H.pylori and other microbial ... BACKGROUND Helicobacter pylori(H.pylori)is an important pathogen that can cause a variety of diseases.Yet,full eradication of H.pylori remains a significant challenge in clinical practice.H.pylori and other microbial communities have complex interactions in the unique gastric microecological environment.However,it is not clear whether the interactions have any effect on the therapeutic effect of H.pylori.AIM The aim was to investigate the characteristics of the gastric microbiota with H.pylori infection and the influence on the H.pylori eradication treatment.METHODS Patients with H.pylori infection underwent gastroscopy and received treatment for eradication.The prescription included esomeprazole 20 mg bid,Livzon Dele 220 mg bid,amoxicillin 1000 mg bid,and clarithromycin 500 mg bid for 14 d.Patients who did not respond to treatment and failed eradication were compared with those who achieved eradication by 1:2 propensity matching.Highthroughput sequencing of the gastric mucosal microbiota was performed,and the results were evaluated by alpha diversity analysis,beta diversity analysis,species correlation analysis,and metabolic pathway correlation analysis.RESULTS The eradication rate of all the patients was 95.5%(171/179).Twenty-four patients were enrolled in the study after propensity-matched scoring.There were eight cases in the failure group(patients who did not respond well to therapy)and 16 cases in the success group.The majority phyla in the two groups were the same,and included Proteobacteria,Bacteroides,Firmicutes,Actinomycetes,and Fusobacteria.The microbial diversity in the failure group had a decreasing trend(P=0.092)and the species abundance was significantly lower(P=0.031)compared with the success group.The high rate of H.pylori eradication was associated with Rhodococcus,Lactobacillus,and Sphingomonas,as they were significantly enriched in the successful group(P<0.05).Veronococcus and Cilium were enriched in the mucosa of chronic atrophic gastritis patients compared with chronic superficial gastritis patients(P=0.0466 and 0.0122,respectively).In both study groups,H.pylori was negatively correlated with other bacterial genera.More bacterial genera were directly related to H.pylori in the successful group compared with the failure group.CONCLUSION The effectiveness of quadruple H.pylori eradication therapy containing bismuth depended on gastric microbiota,and the high rate of H.pylori eradication was associated with the presence of Rhodococcus,Lactobacillus,and Sphingomonas. 展开更多
关键词 Helicobacter pylori ERADICATION Quadruple therapy Influence factors propensity matching gastric microbiota
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Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health
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作者 Christina Larsen Simone Margaard Offersen +4 位作者 Anders Brunse Mattia Pirolo Soumya Kanti Kar Luca Guadabassi Thomas Thymann 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第2期645-658,共14页
Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig industry.Diarrhea and gut dysbiosis may in part be pre... Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig industry.Diarrhea and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the gut.To secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning period.Our objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and diversity.Results Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single housing.However,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all P<0.05).CcFT also showed a lower ETEC prevalence on d 27(P<0.05).CMT showed a higher alpha diversity and a difference in beta diversity compared to CON(P<0.05).Growth and other paraclinical endpoints were similar across groups.Conclusion In conclusion,only CcFT reduced ETEC-related post-weaning diarrhea.However,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration,longer treatment periods,and better donor quality should be explored by future research to optimize the protective effects of transplantation. 展开更多
关键词 Colonic content filtrate transplantation Colonic microbiota transplantation gastric microbiota transplantation Gut microbiota MUCOSA Neonatal Post-weaning diarrhea
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Fusobacterium nucleatum:Unraveling its potential role in gastric carcinogenesis
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作者 Vytenis Petkevicius Konrad Lehr +1 位作者 Juozas Kupcinskas Alexander Link 《World Journal of Gastroenterology》 SCIE CAS 2024年第35期3972-3984,共13页
Fusobacterium nucleatum(F.nucleatum)is a Gram-negative anaerobic bacterium that plays a key role in the development of oral inflammation,such as periodontitis and gingivitis.In the last 10 years,F.nucleatum has been i... Fusobacterium nucleatum(F.nucleatum)is a Gram-negative anaerobic bacterium that plays a key role in the development of oral inflammation,such as periodontitis and gingivitis.In the last 10 years,F.nucleatum has been identified as a prevalent bacterium associated with colorectal adenocarcinoma and has also been linked to cancer progression,metastasis and poor disease outcome.While the role of F.nucleatum in colon carcinogenesis has been intensively studied,its role in gastric carcinogenesis is still poorly understood.Although Helicobacter pylori infection has histo-rically been recognized as the strongest risk factor for the development of gastric cancer(GC),with recent advances in DNA sequencing technology,other members of the gastric microbial community,and F.nucleatum in particular,have received increasing attention.In this review,we summarize the existing knowledge on the involvement of F.nucleatum in gastric carcinogenesis and address the potential translational and clinical significance of F.nucleatum in GC. 展开更多
关键词 Fusobacterium nucleatum gastric microbiota gastric cancer Preneoplastic changes PROGNOSIS
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Participation of microbiota in the development of gastric cancer 被引量:4
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作者 Li-Li Wang Xin-Juan Yu +3 位作者 Shu-Hui Zhan Sheng-Jiao Jia Zi-Bin Tian Quan-Jiang Dong 《World Journal of Gastroenterology》 SCIE CAS 2014年第17期4948-4952,共5页
There are a large number of bacteria inhabiting the human body,which provide benefits for the health.Alterations of microbiota participate in the pathogenesis of diseases.The gastric microbiota consists of bacteria fr... There are a large number of bacteria inhabiting the human body,which provide benefits for the health.Alterations of microbiota participate in the pathogenesis of diseases.The gastric microbiota consists of bacteria from seven to eleven phyla,predominantly Proteobacteria,Firmicutes,Bacteroidetes,Actinobacteria and Fusobacteria.Intrusion by Helicobacter pylori(H.pylori)does not remarkably interrupt the composition and structure of the gastric microbiota.Absence of bacterial commensal from the stomach delays the onset of H.pylori-induced gastric cancer,while presence of artificial microbiota accelerates the carcinogenesis.Altered gastric microbiota may increase the production of N-nitroso compounds,promoting the development of gastric cancer.Further investigation of the carcinogenic mechanisms of microbiota would benefit for the prevention and management of gastric cancer. 展开更多
关键词 microbiota Helicobacter pylori gastric cancer NITRITE METAGENOMICS
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胃复春对胃黏膜肠化生患者胃黏膜菌群的影响 被引量:1
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作者 沈睿 肖灵 +4 位作者 华召来 陆斌 李美凤 周平 张军峰 《中国中医基础医学杂志》 CAS CSCD 2024年第3期489-494,共6页
目的基于胃黏膜菌群探讨胃复春治疗胃癌前病变的功效机制。方法临床招募37例胃黏膜肠化生(gastric intestinal metaplasia,GIM)患者作为治疗组,胃复春治疗4周,31例健康志愿者为对照组。基于16S rRNA基因高通量测序检测胃黏膜菌群。结果3... 目的基于胃黏膜菌群探讨胃复春治疗胃癌前病变的功效机制。方法临床招募37例胃黏膜肠化生(gastric intestinal metaplasia,GIM)患者作为治疗组,胃复春治疗4周,31例健康志愿者为对照组。基于16S rRNA基因高通量测序检测胃黏膜菌群。结果37例GIM患者经胃复春治疗后,23例患者肠化生未检出,5例患者GIM等级下降,肠化生等级改善有效率75.7%。与治疗前相比,GIM患者治疗后胃黏膜菌群丰富度指数(Ace,Chao,Observed OTUs)显著升高(P<0.01),但菌群多样性指数(Shannon)无显著变化(P>0.05)。线性判别分析发现,16个胃黏膜菌属(Acinetobacter、Fusobacterium、Leptotrichia等)富集在胃复春治疗组,胃复春治疗增强4个KEGG菌群预测功能(膜转运、ABC转运蛋白、脂类代谢、脂肪酸代谢)。结论胃复春治疗促进GIM患者胃菌群丰富度和脂质代谢功能,可能体现了胃复春活血化瘀功效机制。 展开更多
关键词 胃复春 胃黏膜 菌群 肠化生等级
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幽门螺杆菌与胃肠微生物群相互作用及关系的研究进展
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作者 王腾腾 孟存英 时永全 《空军军医大学学报》 CAS 2024年第3期356-360,共5页
幽门螺杆菌(Hp)是慢性萎缩性胃炎、消化性溃疡、胃癌等消化道疾病的重要病因之一。Hp感染可以通过影响胃微环境及宿主免疫进而改变胃肠微生态的多样性及结构,而根除Hp的治疗可造成胃肠微生态短期紊乱,且不同的Hp根除治疗方案对肠道微生... 幽门螺杆菌(Hp)是慢性萎缩性胃炎、消化性溃疡、胃癌等消化道疾病的重要病因之一。Hp感染可以通过影响胃微环境及宿主免疫进而改变胃肠微生态的多样性及结构,而根除Hp的治疗可造成胃肠微生态短期紊乱,且不同的Hp根除治疗方案对肠道微生态的影响各不相同。本文仅就Hp与胃肠微生态的相互作用进行综述,以便为防治Hp感染提供参考。 展开更多
关键词 幽门螺杆菌 胃微生物群 肠道微生物群 根除治疗 益生菌 耐药性
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基于“胃喜润恶燥”理论探讨胃酸分泌减少对胃内微生态系统的影响
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作者 杜鹏飞 赵鲲鹏 +2 位作者 张秋菊 张铭 何霞 《中医药信息》 2024年第3期67-70,共4页
中医学认为,胃是阳明燥土之腑,易阳亢而生燥热,需胃中津液的不断滋养濡润,才能维持其正常生理功能,若胃中津液不足,失于润养就易引发胃的病变,故言胃有“喜润恶燥”的生理特性。笔者基于该理论,通过深入探讨人体胃酸分泌对胃内微生态系... 中医学认为,胃是阳明燥土之腑,易阳亢而生燥热,需胃中津液的不断滋养濡润,才能维持其正常生理功能,若胃中津液不足,失于润养就易引发胃的病变,故言胃有“喜润恶燥”的生理特性。笔者基于该理论,通过深入探讨人体胃酸分泌对胃内微生态系统的影响后发现,胃酸分泌减少不仅能引起胃内大量致病菌的滋生,破坏胃内微生态环境,造成胃部感染,还可抑制胃蛋白酶的产生,导致消化不良。进而从现代医学角度揭示了“胃喜润恶燥”理论的科学内涵,使中医辨证更趋微观化,临床论治更加精准化,选方用药更为高效化。 展开更多
关键词 胃喜润恶燥 胃酸分泌减少 胃内微生态
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全血NPM1、MCP-1和肠道菌群与胃癌进展及预后相关
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作者 侯楠 刘源 +2 位作者 高俊 王晶 袁萌 《基础医学与临床》 CAS 2024年第8期1137-1142,共6页
目的探讨全血核仁磷酸蛋白1(NPM1)、单核细胞趋化蛋白-1(MCP-1)、肠道菌群与胃癌进展及预后的相关性。方法选取2018年5月至2020年5月在南阳市第二人民医院收治的胃癌患者120例作为胃癌组,另选取同期胃镜检查胃良性病变患者120例作为胃... 目的探讨全血核仁磷酸蛋白1(NPM1)、单核细胞趋化蛋白-1(MCP-1)、肠道菌群与胃癌进展及预后的相关性。方法选取2018年5月至2020年5月在南阳市第二人民医院收治的胃癌患者120例作为胃癌组,另选取同期胃镜检查胃良性病变患者120例作为胃良性病变组,再选取同期健康体检者120例作为对照组。RT-qPCR检测NPM1 mRNA、MCP-1 mRNA转录水平;用MicroScan微生物鉴定分析系统检测肠道菌群;用Pearson法分析血清NPM1、MCP-1和肠道菌群的相关性;用多因素COX回归分析胃癌患者预后的影响因素。结果对照组、胃良性病变组和胃癌组NPM1 mRNA、双歧杆菌和乳酸杆菌水平依次降低(P<0.05),而MCP-1 mRNA、肠球菌和大肠埃希菌水平依次升高(P<0.05)。胃癌Ⅲ~Ⅳ期的NPM1 mRNA、双歧杆菌和乳酸杆菌水平显著低于Ⅰ~Ⅱ期(P<0.05),MCP-1 mRNA、肠球菌和大肠埃希菌水平显著高于Ⅰ~Ⅱ期(P<0.05)。Pearson相关性分析表明,胃癌患者NPM1 mRNA与MCP-1 mRNA水平呈负相关(P<0.05),NPM1 mRNA与双歧杆菌和乳酸杆菌呈正相关(P<0.05),与肠球菌和大肠埃希菌呈负相关(P<0.05),MCP-1 mRNA与与双歧杆菌和乳酸杆菌呈负相关(P<0.05),与肠球菌和大肠埃希菌呈正相关(P<0.05)。预后不良组NPM1 mRNA、双歧杆菌和乳酸杆菌水平显著低于预后良好组(P<0.05),MCP-1 mRNA、肠球菌和大肠埃希菌水平显著高于预后良好组(P<0.05)。COX回归分析表明,MCP-1 mRNA、肠球菌和大肠埃希菌是影响胃癌患者预后的危险因素(P<0.05),NPM1 mRNA、双歧杆菌、乳酸杆菌是保护因素(P<0.05)。结论胃癌患者中NPM1、肠道双歧杆菌和乳酸杆菌水平降低,MCP-1、肠球菌和大肠埃希菌水平升高,其均与胃癌进展和预后密切相关。 展开更多
关键词 核仁磷酸蛋白1 单核细胞趋化蛋白-1 肠道菌群 胃癌 预后
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幽门螺杆菌阴性的慢性萎缩性胃炎患者胃液微生物群特征分析
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作者 郗家慧 房广娟 +3 位作者 马瑞霞 周瑞丽 聂蓬 白仲添 《兰州大学学报(医学版)》 2024年第1期28-34,共7页
目的探究幽门螺杆菌阴性慢性萎缩性胃炎(CAGn)患者的胃液微生物群组成,寻找可能与CAGn发生相关的胃液微生物群。方法选取2020—2021年到兰州大学第一医院外科内镜中心接受胃镜检查的48例患者作为研究对象,其中幽门螺杆菌阴性慢性非萎缩... 目的探究幽门螺杆菌阴性慢性萎缩性胃炎(CAGn)患者的胃液微生物群组成,寻找可能与CAGn发生相关的胃液微生物群。方法选取2020—2021年到兰州大学第一医院外科内镜中心接受胃镜检查的48例患者作为研究对象,其中幽门螺杆菌阴性慢性非萎缩性胃炎(CNAGn)患者21例,CAGn患者27例。收集胃液标本,使用16S rRNA三代全长测序技术测定分析两组患者的胃液微生物群组成。结果CAGn组的平均年龄高于CNAGn组[(52.33±12.20)岁vs.(40.67±7.95)岁,P=0.0004]。两组患者微生物α多样性及β多样性无明显差异,微生物群整体组成较为相似。组间差异显著性分析发现了CNAGn组显著富集的11个属和CAGn组显著富集的2个属。结论本研究筛选出CAGn患者的差异性非幽门螺杆菌微生物,这些差异微生物可能为CAGn患者的诊断和治疗提供参考。 展开更多
关键词 慢性萎缩性胃炎 幽门螺杆菌 胃液微生物群 16S rRNA三代全长测序
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丹参酮ⅡA调控肠道微生物群抑制胃癌生长的实验研究
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作者 庄辛福 於敏 +1 位作者 范艳 朱长红 《现代肿瘤医学》 CAS 2024年第3期420-423,共4页
目的:探讨丹参酮ⅡA对胃癌异种移植小鼠肠道菌群失调的调控作用。方法:建立小鼠胃癌移植瘤模型,分对照组、TanⅡA高剂量组和TanⅡA+菌群失调组,比较各组肿瘤生长情况。Western blot法检测NF-κB的磷酸化及下游细胞因子IL-6和IL-1β的表... 目的:探讨丹参酮ⅡA对胃癌异种移植小鼠肠道菌群失调的调控作用。方法:建立小鼠胃癌移植瘤模型,分对照组、TanⅡA高剂量组和TanⅡA+菌群失调组,比较各组肿瘤生长情况。Western blot法检测NF-κB的磷酸化及下游细胞因子IL-6和IL-1β的表达。结果:与对照组相比,丹参酮ⅡA抑制移植瘤生长,但肠道菌群失调状态部分阻断了丹参酮ⅡA的抗肿瘤作用。此外,肠道菌群失调消除了丹参酮ⅡA刺激的移植瘤小鼠中NF-κB信号的减少。结论:丹参酮ⅡA可能通过调节NF-κB信号影响肠道微生物群而抑制胃癌生长。 展开更多
关键词 丹参酮ⅡA 肠道微生物 胃癌
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基于脑肠轴学说探讨中医调节肠道菌群治疗胃癌伴抑郁研究进展
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作者 胡鑫 刘杰 +1 位作者 梁凤萍 刘礼剑 《河南中医》 2024年第6期948-955,共8页
生理状态下,脑与肠道上下相通、互为滋养;病理状态下,脑与肠道相互影响,促使疾病发生、发展。中医药可通过调控肠道菌群治疗胃癌伴抑郁,其作用机制可能为通过调控脑肠肽水平、调节肠道菌群从而发挥作用。胃癌伴抑郁的常用治疗方法有单... 生理状态下,脑与肠道上下相通、互为滋养;病理状态下,脑与肠道相互影响,促使疾病发生、发展。中医药可通过调控肠道菌群治疗胃癌伴抑郁,其作用机制可能为通过调控脑肠肽水平、调节肠道菌群从而发挥作用。胃癌伴抑郁的常用治疗方法有单药及其高纯度提取物、中药复方、针灸、穴位贴敷、腧穴艾灸、针药结合等,均取得较好疗效,但目前的研究还存在以下不足:(1)当前用于探索中医治疗胃癌疗效的动物模型多基于单一疾病模型,未能充分融合中医辨证论治的独特理念,这可能限制了对胃癌相关生物学变化的全面理解;(2)对中药复方和单体成分的物质基础研究缺乏深入研究,各种药效之间的内在联系以及单体成分在机制中的具体贡献与协调机制不明确。今后,需开发结合病证特点的现代化动物模型,更能准确反映临床实际,满足现代中医药研究的科技需求。此外,还需要制定更为严格的中药质量把控标准,加深对中药复方和单体成分的物质基础研究,明确各种药效关系。 展开更多
关键词 胃癌伴抑郁 脑肠轴学说 肠道菌群
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Probiotics against neoplastic transformation of gastric mucosa:Effects on cell proliferation and polyamine metabolism 被引量:4
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作者 Francesco Russo Michele Linsalata Antonella Orlando 《World Journal of Gastroenterology》 SCIE CAS 2014年第37期13258-13272,共15页
Gastric cancer is still the second leading cause of cancer death worldwide, accounting for about 10% of newly diagnosed neoplasms. In the last decades, an emerging role has been attributed to the relations between the... Gastric cancer is still the second leading cause of cancer death worldwide, accounting for about 10% of newly diagnosed neoplasms. In the last decades, an emerging role has been attributed to the relations between the intestinal microbiota and the onset of both gastrointestinal and non-gastrointestinal neoplasms. Thus, exogenous microbial administration of peculiar bacterial strains(probiotics) has been suggested as having a profound influence on multiple processes associated with a change in cancer risk. The internationally accepted definition of probiotics is live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. The possible effects on the gastrointestinal tract following probiotic administration have been investigated in vitro and in animal models, as well as in healthy volunteers and in patients suffering from different human gastrointestinal diseases. Although several evidences are available on the use of probiotics against the carcinogen Helicobacter pylori,little is still known about the potential cross-interactions among probiotics, the composition and quality of intestinal flora and the neoplastic transformation of gastric mucosa. In this connection, a significant role in cell proliferation is played by polyamines(putrescine, spermidine, and spermine). These small amines are required in both pre-neoplastic and neoplastic tissue to sustain the cell growth and the evidences here provided suggest that probiotics may act as antineoplastic agents in the stomach by affecting also the polyamine content and functions. This review will summarize data on the most widely recognized effects of probiotics against neoplastic transformation of gastric mucosa and in particular on their ability in modulating cell proliferation, paying attention to the polyamine metabolism. 展开更多
关键词 Cell proliferation gastric cancer microbiota Polyamines PROBIOTICS
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长测序技术揭示胃黏膜肠化生患者舌苔-胃黏膜菌群共生关系变化特征
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作者 吴剑平 李美凤 +4 位作者 华召来 陆斌 向娇 吴震峰 张军峰 《Digital Chinese Medicine》 CAS CSCD 2023年第4期438-450,共13页
目的 探索胃黏膜肠化生(GIM)患者舌苔与胃黏膜菌群相关性。方法 本研究招募了1 360例志愿者参与上消化道癌筛查。收集舌苔和胃黏膜样本,基于16S r RNA基因长测序技术分析舌苔和胃黏膜菌群。利用Visual Genomics软件进行菌群分析,包括多... 目的 探索胃黏膜肠化生(GIM)患者舌苔与胃黏膜菌群相关性。方法 本研究招募了1 360例志愿者参与上消化道癌筛查。收集舌苔和胃黏膜样本,基于16S r RNA基因长测序技术分析舌苔和胃黏膜菌群。利用Visual Genomics软件进行菌群分析,包括多样性、群落结构和线性判别分析(LEf Se)。Spar CC相关性分析用于构建共生网络,R软件图形化展示。结果 本研究人群包括44例癌前病变的GIM组和28例匹配的对照组(快速尿素酶试验阴性、无任何消化道症状的慢性浅表性胃炎患者)。GIM患者舌苔和胃黏膜菌群多样性无显著变化(P> 0.05),GIM患者舌苔-胃黏膜共现41–60个OTUs的个体比例(34.1%)显著高于对照组(25.0%)(P<0.05)。LEf Se分析显示,舌苔Prevotella melaninogenica和胃黏膜螺旋杆菌属的3个种(Helicobacter pylori、Helicobacter pylori XZ274和Helicobacter pylori 83)富集在GIM组。而且,在GIM组中,RUT阳性者舌苔-胃黏膜共享OTUs大于20的个体比例显著低于RUT阴性者(P<0.05),RUT阳性者胃黏膜Veillonella、 Pseudonocardia和Mesorhizobium的丰度显著低于RUT阴性者(P<0.05)。GIM组舌苔-胃黏膜菌群共生网络比对照组更复杂。在GIM组中,RUT阳性者舌苔-胃黏膜间的显著相关细菌对高于RUT阴性者。最后,RUT阴性者胃内3种螺旋杆菌属细菌(Helicobacter pylori、Helicobacter pylori XZ274和Helicobacter pylori 83)与PG-I/II比值呈显著负相关(P<0.05),RUT阳性者舌苔上两种菌株(Fusobacterium nucleatum subsp. nucleatum和Campylobacter showae)与PG-I/II比值呈显著负相关(P<0.05)。结论 GIM增强了舌苔和胃黏膜菌群的共生网络,为舌苔与胃之间的相关性提供了微生态学依据。 展开更多
关键词 肠黏膜化生 舌苔 胃黏膜 菌群 共生关系
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自身免疫性胃炎的研究进展 被引量:1
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作者 马欣跃 房静远 《胃肠病学》 北大核心 2023年第12期746-750,共5页
自身免疫性胃炎是发生在自身免疫基础上的慢性进展性胃黏膜炎症,合并症多,并发症复杂,早期诊断并有效干预有较大难度。本文简要综述自身免疫性胃炎的流行病学、发病机制、临床特征、诊治重点等方面的研究进展,以期探讨基于此而拓展的管... 自身免疫性胃炎是发生在自身免疫基础上的慢性进展性胃黏膜炎症,合并症多,并发症复杂,早期诊断并有效干预有较大难度。本文简要综述自身免疫性胃炎的流行病学、发病机制、临床特征、诊治重点等方面的研究进展,以期探讨基于此而拓展的管理策略。 展开更多
关键词 自身免疫性胃炎 发病机制 诊断 胃内微生态 胃肿瘤
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NF-κB信号通路、微生物群在胃癌发生机制中的最新研究进展 被引量:1
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作者 高春 江晶晶 +3 位作者 冯富娟 于晓辉 郑晓凤 张久聪 《胃肠病学和肝病学杂志》 CAS 2023年第6期683-686,共4页
胃癌是威胁全球健康的主要问题,其发病机制复杂,尚无明确的相关报道。研究发现胃肠道中的大量微生物可调节人体的生理过程,如免疫反应、代谢平衡和体内平衡。越来越多的证据表明,微生物群的改变与胃癌的发生密切相关。细胞和动物模型的... 胃癌是威胁全球健康的主要问题,其发病机制复杂,尚无明确的相关报道。研究发现胃肠道中的大量微生物可调节人体的生理过程,如免疫反应、代谢平衡和体内平衡。越来越多的证据表明,微生物群的改变与胃癌的发生密切相关。细胞和动物模型的实验研究显示了几种细菌在胃癌中的功能作用和分子机制,包括幽门螺杆菌、梭杆菌、大肠杆菌、脆弱类杆菌等。转录因子NF-κB通过协调先天性免疫功能和适应性免疫功能在宿主对微生物感染的反应中起至关重要的作用。此外,NF-κB活性通过诱导慢性炎症、细胞转化和增殖与胃癌的发生和发展有关。因此,本文就以感染性细菌为主的胃肠道微生物群对NF-κB信号通路的调节作一简要综述。 展开更多
关键词 NF-ΚB信号通路 幽门螺杆菌 微生物群 胃癌 进展
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肠道菌群与胃癌:致癌还是治癌?
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作者 张雅楠 崔曼莉 +5 位作者 张灵敏 路宁 权昕 殷坤 李安娜 张明鑫 《世界华人消化杂志》 CAS 2023年第22期933-939,共7页
肠道菌群对宿主健康和疾病的影响越来越引起人们的关注.近年来,肠道菌群与癌症之间的机制联系具有可能相关性,包括肠道菌群在胃癌发生、发展和治疗中的作用.肠道菌群失调是胃癌的促成因素之一,目前已有初步共识,但其确切的作用机制尚不... 肠道菌群对宿主健康和疾病的影响越来越引起人们的关注.近年来,肠道菌群与癌症之间的机制联系具有可能相关性,包括肠道菌群在胃癌发生、发展和治疗中的作用.肠道菌群失调是胃癌的促成因素之一,目前已有初步共识,但其确切的作用机制尚不完全清楚.并且随着研究的深入,肠道菌群在胃癌治疗中也发挥着重要作用.本文综述了肠道菌群对胃癌的影响,阐述了肠道菌群对胃癌发生发展中的作用,讨论了肠道菌群在致癌或胃癌治疗中的可能作用.旨在为今后的进一步研究提供参考和思路. 展开更多
关键词 肠道菌群 胃癌 放疗 化疗 益生菌 粪便移植
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消化性溃疡患者幽门螺杆菌感染及与胃内菌群与炎症反应程度的相关性研究
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作者 张秋霞 王燕燕 詹晓文 《当代医学》 2023年第27期152-155,共4页
目的分析消化性溃疡患者幽门螺杆菌(Hp)感染及与胃内菌群、炎症反应程度的相关性。方法回顾性分析2019年10月至2021年10月南昌市第三医院收治的106例消化性溃疡患者的临床资料,所有患者均行胃镜、Hp感染、胃内菌群检查,比较Hp感染阳性... 目的分析消化性溃疡患者幽门螺杆菌(Hp)感染及与胃内菌群、炎症反应程度的相关性。方法回顾性分析2019年10月至2021年10月南昌市第三医院收治的106例消化性溃疡患者的临床资料,所有患者均行胃镜、Hp感染、胃内菌群检查,比较Hp感染阳性与Hp感染阴性患者胃内菌群分布情况、炎症反应程度,分析Hp感染与胃内菌群、炎症反应程度的相关性。结果106例消化性溃疡患者中,53例患者HP感染阳性;Hp感染阳性患者厌氧菌检出率高于Hp感染阴性患者,乳酸菌检出率低于Hp感染阴性患者,差异有统计学意义(P<0.05);Hp感染阳性与Hp感染阴性患者酵母菌、肠杆菌、链球菌检出率比较差异无统计学意义。Hp感染阳性患者重度炎症反应发生率高于Hp感染阴性患者,差异有统计学意义(P<0.05),但Hp感染阳性患者与Hp感染阴性患者无炎症反应发生率、轻微炎症反应发生率及中度炎症反应发生率比较差异均无统计学意义。Kendall相关性检验结果显示,Hp感染与厌氧菌呈负相关(r<0,P<0.05),与乳酸菌、炎症反应程度呈正相关(r>0,P<0.05),与酵母菌、链球菌、肠杆菌无显著相关性。结论消化性溃疡患者中Hp感染率较高,Hp感染会影响患者胃内菌群分布情况,加重患者炎症反应程度。 展开更多
关键词 消化性溃疡 幽门螺杆菌 感染发生率 胃内菌群 炎症反应程度
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幽门螺杆菌感染影响胃癌免疫治疗的研究进展
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作者 王丹 鄢晓丽 张渊 《中国临床药理学与治疗学》 CAS CSCD 2023年第2期228-234,共7页
胃癌是一种常见的消化道恶性肿瘤,在我国,其发病率和死亡率均非常高。近年来,以免疫检查点抑制剂为代表的免疫疗法为不可手术的晚期胃癌患者带来了新的治疗希望。幽门螺杆菌感染与胃癌的发生和发展密切相关,在这篇综述中,我们总结了目... 胃癌是一种常见的消化道恶性肿瘤,在我国,其发病率和死亡率均非常高。近年来,以免疫检查点抑制剂为代表的免疫疗法为不可手术的晚期胃癌患者带来了新的治疗希望。幽门螺杆菌感染与胃癌的发生和发展密切相关,在这篇综述中,我们总结了目前关于胃癌免疫治疗的现状、幽门螺杆菌感染对胃黏膜免疫及肿瘤免疫治疗影响的最新研究进展,并概述了当前面临的挑战和未来研究的方向,以期为临床工作和科研工作提供新的思路。 展开更多
关键词 幽门螺杆菌 胃癌 免疫治疗 肿瘤免疫逃逸 肠道菌群
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