AIM: To study the evolution of gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia (FD).METHODS: From June 2008 to November 2009, a total of 1049 patients with FD (65.3% fema...AIM: To study the evolution of gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia (FD).METHODS: From June 2008 to November 2009, a total of 1049 patients with FD (65.3% female, mean age 42.80 ± 11.64 years) who visited the departments of gastroenterology in Wuhan, Beijing, Shanghai, Guangzhou, and Xi’an, China were referred for this study. All of the patients fulfilled the Rome III criteria for FD. Baseline demographic data, dyspepsia symptoms, anxiety, depression, sleep disorder, and drug treatment were assessed using self-report questionnaires. Patients completed questionnaires at baseline and after 1, 3, 6 and 12 mo follow-up. Comparison of dyspepsia symptoms between baseline and after follow-up was explored using multivariate analysis of variance of repeated measuring. Multiple linear regression was done to examine factors associated with outcome, both longitudinally and horizontally.RESULTS: Nine hundred and forty-three patients (89.9% of the original population) completed all four follow-ups. The average duration of follow-up was 12.24 ± 0.59 mo. During 1-year follow-up, the mean dyspeptic symptom score (DSS) in FD patients showed a significant gradually reduced trend (P < 0.001), and similar differences were found for all individual symptoms (P < 0.001). Multiple linear regression analysis showed that sex (P < 0.001), anxiety (P = 0.018), sleep disorder at 1-year follow-up (P = 0.019), weight loss (P < 0.001), consulting a physician (P < 0.001), and prokinetic use during 1-year follow-up (P = 0.035) were horizontally associated with DSS at 1-year follow-up. No relationship was found longitudinally between DSS at 1-year follow-up and patient characteristics at baseline.CONCLUSION: Female sex, anxiety, and sleep disorder, weight loss, consulting a physician and prokinetic use during 1-year follow-up were associated with outcome of FD.展开更多
目的：探讨以胃肠道表现为首发症状的婴儿牛奶蛋白过敏的临床特点,以减少误诊。方法：选取2014年3月至2015年3月南京医科大学附属儿童医院消化门诊就诊的224例诊断为婴儿牛奶蛋白过敏的患儿,采用问卷调查法收集临床资料,应用Co Mi SS表...目的：探讨以胃肠道表现为首发症状的婴儿牛奶蛋白过敏的临床特点,以减少误诊。方法：选取2014年3月至2015年3月南京医科大学附属儿童医院消化门诊就诊的224例诊断为婴儿牛奶蛋白过敏的患儿,采用问卷调查法收集临床资料,应用Co Mi SS表进行症状量化评估。结果：224例患儿中,男108例,女116例,发病年龄以0~6个月为主。胃肠道首发症状就诊中腹泻50.0%,便血28.6%,反流或呕吐8.9%,阵发性哭闹7.1%,便秘5.3%。患儿治疗前Co Mi SS评分为（10.25±2.61）分,饮食回避2~4周后评分为（3.69±1.18）分,下降〉50%以上。224例患儿中误诊病例148例,不同胃肠道首发症状患儿的误诊率为腹泻54.1%,便血29.7%,阵发性哭闹5.4%,反流或呕吐5.4%,便秘5.4%。既往误诊病例中抗生素使用率达60.8%。误诊病例中发生营养不良56例,非误诊病例中发生营养不良2例,差异有统计学意义（P〈0.05）。结论：胃肠型婴儿牛奶蛋白过敏主要症状为腹泻及便血。因症状缺乏特异性,临床实践中误诊发生率较高。Co Mi SS症状评分法有助于临床医师对该病轻中度患儿的诊断和疗效观察。展开更多
基金Supported by Project of the National Key Technologies R and D Program in the 11th Five-Year PlanNo.2007BAI04B01partially supported by Xi’an-Janssen Pharmaceutical Ltd
文摘AIM: To study the evolution of gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia (FD).METHODS: From June 2008 to November 2009, a total of 1049 patients with FD (65.3% female, mean age 42.80 ± 11.64 years) who visited the departments of gastroenterology in Wuhan, Beijing, Shanghai, Guangzhou, and Xi’an, China were referred for this study. All of the patients fulfilled the Rome III criteria for FD. Baseline demographic data, dyspepsia symptoms, anxiety, depression, sleep disorder, and drug treatment were assessed using self-report questionnaires. Patients completed questionnaires at baseline and after 1, 3, 6 and 12 mo follow-up. Comparison of dyspepsia symptoms between baseline and after follow-up was explored using multivariate analysis of variance of repeated measuring. Multiple linear regression was done to examine factors associated with outcome, both longitudinally and horizontally.RESULTS: Nine hundred and forty-three patients (89.9% of the original population) completed all four follow-ups. The average duration of follow-up was 12.24 ± 0.59 mo. During 1-year follow-up, the mean dyspeptic symptom score (DSS) in FD patients showed a significant gradually reduced trend (P < 0.001), and similar differences were found for all individual symptoms (P < 0.001). Multiple linear regression analysis showed that sex (P < 0.001), anxiety (P = 0.018), sleep disorder at 1-year follow-up (P = 0.019), weight loss (P < 0.001), consulting a physician (P < 0.001), and prokinetic use during 1-year follow-up (P = 0.035) were horizontally associated with DSS at 1-year follow-up. No relationship was found longitudinally between DSS at 1-year follow-up and patient characteristics at baseline.CONCLUSION: Female sex, anxiety, and sleep disorder, weight loss, consulting a physician and prokinetic use during 1-year follow-up were associated with outcome of FD.
文摘目的：探讨以胃肠道表现为首发症状的婴儿牛奶蛋白过敏的临床特点,以减少误诊。方法：选取2014年3月至2015年3月南京医科大学附属儿童医院消化门诊就诊的224例诊断为婴儿牛奶蛋白过敏的患儿,采用问卷调查法收集临床资料,应用Co Mi SS表进行症状量化评估。结果：224例患儿中,男108例,女116例,发病年龄以0~6个月为主。胃肠道首发症状就诊中腹泻50.0%,便血28.6%,反流或呕吐8.9%,阵发性哭闹7.1%,便秘5.3%。患儿治疗前Co Mi SS评分为（10.25±2.61）分,饮食回避2~4周后评分为（3.69±1.18）分,下降〉50%以上。224例患儿中误诊病例148例,不同胃肠道首发症状患儿的误诊率为腹泻54.1%,便血29.7%,阵发性哭闹5.4%,反流或呕吐5.4%,便秘5.4%。既往误诊病例中抗生素使用率达60.8%。误诊病例中发生营养不良56例,非误诊病例中发生营养不良2例,差异有统计学意义（P〈0.05）。结论：胃肠型婴儿牛奶蛋白过敏主要症状为腹泻及便血。因症状缺乏特异性,临床实践中误诊发生率较高。Co Mi SS症状评分法有助于临床医师对该病轻中度患儿的诊断和疗效观察。
