Gambogic acid(GA) is a natural substance with a good antitumor effect, but it is too lipophilic to be metabolized and excreted, thus accumulating in the body. Gemcitabine(GEM), one of the first-line antitumor drugs, h...Gambogic acid(GA) is a natural substance with a good antitumor effect, but it is too lipophilic to be metabolized and excreted, thus accumulating in the body. Gemcitabine(GEM), one of the first-line antitumor drugs, has high hydrophilicity, which greatly shortens its half-life in vivo. We previously reported a compound named N-gamboyl gemcitabine(GAG), derived from the condensation of GEM and GA, whose hydrophilicity is better than GA and stability is better than GEM. Here, the antitumor performance of GAG was investigated for the first time by using several common tumor cell lines as tumor models. The results of in vitro study showed that GAG significantly inhibited the proliferation and migration of the tumor cells. The IC50 values of GAG for the tumor cells were lower than those of GEM and GA. The present study suggests that GAG has a promising potential to be developed into a broad-spectrum antitumor drug.展开更多
目的探讨提高GEM Premier 3000血气分析仪检测结果准确性的有效措施。方法按照分析前、分析中和分析后三个阶段,对1986例血气分析中检测失败或检测结果与临床不符者共141例进行总结分析,明确影响GEM Premier 3000血气分析仪检测准确性...目的探讨提高GEM Premier 3000血气分析仪检测结果准确性的有效措施。方法按照分析前、分析中和分析后三个阶段,对1986例血气分析中检测失败或检测结果与临床不符者共141例进行总结分析,明确影响GEM Premier 3000血气分析仪检测准确性的各因素构成。结果影响GEM Premier 3000血气分析仪检测准确性的分析前因素占74.5%、分析中因素占20.6%、分析后因素占2.8%,原因不明占2.1%。结论血气分析结果的准确测得需要临床医护人员和临床检验人员的密切协作。展开更多
基金Science&Technology Commission of Shanghai MunicipalityChina (No.20DZ2254900)+3 种基金Municipal Public Welfare Research Project from JiaxingZhejiang ProvinceChina (No.2022AY10001)Open Project Program of Jiaxing Key Laboratory of Virus-Related Infectious Diseases。
文摘Gambogic acid(GA) is a natural substance with a good antitumor effect, but it is too lipophilic to be metabolized and excreted, thus accumulating in the body. Gemcitabine(GEM), one of the first-line antitumor drugs, has high hydrophilicity, which greatly shortens its half-life in vivo. We previously reported a compound named N-gamboyl gemcitabine(GAG), derived from the condensation of GEM and GA, whose hydrophilicity is better than GA and stability is better than GEM. Here, the antitumor performance of GAG was investigated for the first time by using several common tumor cell lines as tumor models. The results of in vitro study showed that GAG significantly inhibited the proliferation and migration of the tumor cells. The IC50 values of GAG for the tumor cells were lower than those of GEM and GA. The present study suggests that GAG has a promising potential to be developed into a broad-spectrum antitumor drug.
文摘目的探讨提高GEM Premier 3000血气分析仪检测结果准确性的有效措施。方法按照分析前、分析中和分析后三个阶段,对1986例血气分析中检测失败或检测结果与临床不符者共141例进行总结分析,明确影响GEM Premier 3000血气分析仪检测准确性的各因素构成。结果影响GEM Premier 3000血气分析仪检测准确性的分析前因素占74.5%、分析中因素占20.6%、分析后因素占2.8%,原因不明占2.1%。结论血气分析结果的准确测得需要临床医护人员和临床检验人员的密切协作。
