HIV/AIDS has brought to light the challenge of incorporating the many influences between living conditions, social characteristics and health services performance to an adequate care for PLWHA （people living with AID...HIV/AIDS has brought to light the challenge of incorporating the many influences between living conditions, social characteristics and health services performance to an adequate care for PLWHA （people living with AIDS）. Vulnerability of these populations is under the responsibility of specialized care units whose assistance does not always occur according to their real needs and demands. Therefore, this study aimed to analyze demographic, social and clinical profiles of PLWHA, as well as their follow-up in SS （Specialized Health Services） in Ribeir^o Preto, Brazil. It is a descriptive study conducted by the application of structured questionnaires to 253 patients with HIV/AIDS in follow-up during the years of 2012-2013. Variables were analyzed by descriptive statistics procedures. The findings pointed out gender parity, aging population, low education and economic predominance of class C. Regarding clinical characteristics, there was a predominance of asymptomatic individuals, with no clinical manifestations of AIDS or major comorbidities. The main mode of transmission was through sexual contact. The results led to the need of adequating the assistance provided to the specificities inherent to PLWHA. The care provision should cross an interdisciplinary perspective, targeting recognition of problems and ensuring comprehensive health care adequate to users＇ needs and demands.展开更多
By analyzing GPS, leveling and gravity observation data from the Minle, Huazangsi and Shagouhe profiles across the Qilian Mountain-Haiyuan fault during 2005 - 2009, the changes of these data and activity characteristi...By analyzing GPS, leveling and gravity observation data from the Minle, Huazangsi and Shagouhe profiles across the Qilian Mountain-Haiyuan fault during 2005 - 2009, the changes of these data and activity characteristics of the main faults in different time are obtained. The results show that the Changma-Erbo, Maomaoshan, Zhunglanghe and Haiyuan faults have been active in recent years. The relationship between the vertical displacement and mobile gravity data is analyzed, and the results reveal the gravity changes are mainly due to mass transfer. The results of GPS observation show that the direction of the horizontal movement velocity was almost along the fault strike in 2006 - 2007, while the horizontal velocity deviated from the fault direction in 2007 - 2008, characterized by increased eastward displacement. Further analysis upon removal of the linear trend on the time series of the N and E coordinate values of the continuous observation stations of the Crustal Movement Observation Network of China near the three profiles reveals that the Wenchuan earthquake had an effect on the observations in 2007 - 2008. Comparing the gravitational changes in 2008 - 2009 with the Bouguer gravity anomaly background, we find that the area near Minle profile is in the stage of adjustment and recovery, while the anomaly is not completely recovered around Huazangsi and Shagouhe profiles.展开更多
Aiming to ensure the consistency of quality control of Traditional Chinese Medicines(TCMs),a combination method of high-performance liquid chromatography(HPLC),ultraviolet(UV),electrochemical(EC)was developed in this ...Aiming to ensure the consistency of quality control of Traditional Chinese Medicines(TCMs),a combination method of high-performance liquid chromatography(HPLC),ultraviolet(UV),electrochemical(EC)was developed in this study to comprehensively evaluate the quality of Antiviral Mixture(AM),and Comprehensive Linear Quantification Fingerprint Method(CLQFM)was used to process the data.Quantitative analysis of three active substances in TCM was conducted.A fivewavelength fusion fingerprint(FWFF)was developed,using second-order derivatives of UV spectral data to differentiate sample levels effectively.The combination of HPLC and UV spectrophotometry,along with electrochemical fingerprinting(ECFP),successfully evaluated total active substances.Ultimately,a multidimensional profiling analytical system for TCM was developed.展开更多
A comprehensive study in this paper for the lithosphere velocity structure, conductivity structure, density and magnetism structure at the Qinghai-Xizang(Tibetan) Plateau has been completed based on the data of gravit...A comprehensive study in this paper for the lithosphere velocity structure, conductivity structure, density and magnetism structure at the Qinghai-Xizang(Tibetan) Plateau has been completed based on the data of gravity, geomagnetism, and magneto-telluric sounding (MTS), explosion seismology acquired on the comprehensive geophysical profile along Gyirong-Sange-展开更多
Background:Cholangiocarcinoma(CCA)is a diverse group of malignancies arising from the intra-or extrahepatic biliary epithelium and characterized by its late diagnosis and fatal outcome.Extrahepatic cholangiocarcinoma(...Background:Cholangiocarcinoma(CCA)is a diverse group of malignancies arising from the intra-or extrahepatic biliary epithelium and characterized by its late diagnosis and fatal outcome.Extrahepatic cholangiocarcinoma(ECC)accounts for 90%of CCA.However,little is known about the comprehensive genomic alterations of ECC in Chinese population for providing clinical managements especially targeted therapy.Methods:Comprehensive genomic profiling(CGP)was performed with next generation sequencing panel on paraffin-embedded tumor from a cohort of 80 Chinese ECC patients.Results:The most frequently altered genes were TP53(68%),KRAS(46%),SMAD4(22%),ARID1A(20%)and CDKN2A(19%).Mutual exclusivity was observed between multiple genes including ARID1A:TP53,KRAS:LRP1B and NF2:TP53.Genetic alterations with potential therapeutic implications were identified in 43%of patients.The top three actionable alterations include CDKN2A(n=11),BRAF(n=5)and ERBB2(n=4).Potentially actionable alterations were mainly enriched in the G1-S transition,homologous recombination repair,MAPK/ERK pathway.Conclusions:This is the largest data set of ECC cases providing a comprehensive view on genetic alterations in Chinese population which differs significantly from a US cohort,and indicates the potential clinical implications for targeted therapies.展开更多
文摘HIV/AIDS has brought to light the challenge of incorporating the many influences between living conditions, social characteristics and health services performance to an adequate care for PLWHA （people living with AIDS）. Vulnerability of these populations is under the responsibility of specialized care units whose assistance does not always occur according to their real needs and demands. Therefore, this study aimed to analyze demographic, social and clinical profiles of PLWHA, as well as their follow-up in SS （Specialized Health Services） in Ribeir^o Preto, Brazil. It is a descriptive study conducted by the application of structured questionnaires to 253 patients with HIV/AIDS in follow-up during the years of 2012-2013. Variables were analyzed by descriptive statistics procedures. The findings pointed out gender parity, aging population, low education and economic predominance of class C. Regarding clinical characteristics, there was a predominance of asymptomatic individuals, with no clinical manifestations of AIDS or major comorbidities. The main mode of transmission was through sexual contact. The results led to the need of adequating the assistance provided to the specificities inherent to PLWHA. The care provision should cross an interdisciplinary perspective, targeting recognition of problems and ensuring comprehensive health care adequate to users＇ needs and demands.
基金sponsored by Special Scientific Research Project,China Earthquake Administration(200908029)National Natural Science Foundation of China(40674057)
文摘By analyzing GPS, leveling and gravity observation data from the Minle, Huazangsi and Shagouhe profiles across the Qilian Mountain-Haiyuan fault during 2005 - 2009, the changes of these data and activity characteristics of the main faults in different time are obtained. The results show that the Changma-Erbo, Maomaoshan, Zhunglanghe and Haiyuan faults have been active in recent years. The relationship between the vertical displacement and mobile gravity data is analyzed, and the results reveal the gravity changes are mainly due to mass transfer. The results of GPS observation show that the direction of the horizontal movement velocity was almost along the fault strike in 2006 - 2007, while the horizontal velocity deviated from the fault direction in 2007 - 2008, characterized by increased eastward displacement. Further analysis upon removal of the linear trend on the time series of the N and E coordinate values of the continuous observation stations of the Crustal Movement Observation Network of China near the three profiles reveals that the Wenchuan earthquake had an effect on the observations in 2007 - 2008. Comparing the gravitational changes in 2008 - 2009 with the Bouguer gravity anomaly background, we find that the area near Minle profile is in the stage of adjustment and recovery, while the anomaly is not completely recovered around Huazangsi and Shagouhe profiles.
基金This study was supported by the National Natural Science Foundation of China(No.81573586).
文摘Aiming to ensure the consistency of quality control of Traditional Chinese Medicines(TCMs),a combination method of high-performance liquid chromatography(HPLC),ultraviolet(UV),electrochemical(EC)was developed in this study to comprehensively evaluate the quality of Antiviral Mixture(AM),and Comprehensive Linear Quantification Fingerprint Method(CLQFM)was used to process the data.Quantitative analysis of three active substances in TCM was conducted.A fivewavelength fusion fingerprint(FWFF)was developed,using second-order derivatives of UV spectral data to differentiate sample levels effectively.The combination of HPLC and UV spectrophotometry,along with electrochemical fingerprinting(ECFP),successfully evaluated total active substances.Ultimately,a multidimensional profiling analytical system for TCM was developed.
文摘A comprehensive study in this paper for the lithosphere velocity structure, conductivity structure, density and magnetism structure at the Qinghai-Xizang(Tibetan) Plateau has been completed based on the data of gravity, geomagnetism, and magneto-telluric sounding (MTS), explosion seismology acquired on the comprehensive geophysical profile along Gyirong-Sange-
文摘Background:Cholangiocarcinoma(CCA)is a diverse group of malignancies arising from the intra-or extrahepatic biliary epithelium and characterized by its late diagnosis and fatal outcome.Extrahepatic cholangiocarcinoma(ECC)accounts for 90%of CCA.However,little is known about the comprehensive genomic alterations of ECC in Chinese population for providing clinical managements especially targeted therapy.Methods:Comprehensive genomic profiling(CGP)was performed with next generation sequencing panel on paraffin-embedded tumor from a cohort of 80 Chinese ECC patients.Results:The most frequently altered genes were TP53(68%),KRAS(46%),SMAD4(22%),ARID1A(20%)and CDKN2A(19%).Mutual exclusivity was observed between multiple genes including ARID1A:TP53,KRAS:LRP1B and NF2:TP53.Genetic alterations with potential therapeutic implications were identified in 43%of patients.The top three actionable alterations include CDKN2A(n=11),BRAF(n=5)and ERBB2(n=4).Potentially actionable alterations were mainly enriched in the G1-S transition,homologous recombination repair,MAPK/ERK pathway.Conclusions:This is the largest data set of ECC cases providing a comprehensive view on genetic alterations in Chinese population which differs significantly from a US cohort,and indicates the potential clinical implications for targeted therapies.
