As a solid reservoir, a glacier can regulate regional water resources. The annual net mass balance directly reflects the fluctuation of the glacier and climate variability. Based on 51 years of mass balance observatio...As a solid reservoir, a glacier can regulate regional water resources. The annual net mass balance directly reflects the fluctuation of the glacier and climate variability. Based on 51 years of mass balance observation data, the mass balance of Tianshan Mountains Urumqi Glacier No. 1 experienced a nine times positive balance fluctuation and nine times negative balance fluctuation. There were 35 and 16 negative and positive balance years, respectively. From 1996/97 to 2008/09, 12 consecutive negative balance years were observed at Tianshan Mountains Urumqi Glacier No. 1. These results demon- strate that the Urumqi Glacier No. 1 is experiencing a strong negative balance, and the strongest negative balance, -931 mm w.e. （mm water equivalent）, during the observation period occurred in 2008. In addition, the cumulative mass balance reached 13,709 mm w.e. in 2008. However, in 2009, the mass balance was positive at 63 mm w.e. The equilibrium-line al- titude changes with the fluctuation in the mass balance, and the effective mass balance gradient is 7.4 mrn/m. In this paper, the headwaters of the Urumqi River were analyzed using meteorological data from 1958 to 2009, including the average seasonal temperature and precipitation. The results showed that the main factor associated with the mass balance variation of Glacier No. 1 is the fluctuation in the summer air temperature, followed by changes in the precipitation.展开更多
This paper is based on observed mass balance between East and West Branch of Urumqi Glacier No. l, meteorological data dur- ing 1988-2010, comparative studies the mass balance variations, and analyses the mass balance...This paper is based on observed mass balance between East and West Branch of Urumqi Glacier No. l, meteorological data dur- ing 1988-2010, comparative studies the mass balance variations, and analyses the mass balance sensitivity to climate change. Re- sults show that average mass balance of East and West Branch was -532 mm/a and 435 mm/a, cumulative mass balance was 12,227 mm （ice thinned by 13.6 m） and -10,001 mm （ice thinned by 11.1 m）, respectively, and mass loss of East Branch was 97 mm/a larger than West Branch. The East and West Branch ELA （equilibrium line altitude） ascended about 176 m and 154 m, analysis shows the steady-state ELA0 was 3,942 m a.s.1, and 4,011 m a.s.1., and when East and West Branch mass balance de- creased by 100 ram, ELA ascended 20 m and 23 m, respectively. The AAR （accumulation area ratio） of East and West Branch presented an obviously decreasing trend of 34.5% and 23%, equilibrium-state AAR0 was 65% and 66%, when East and West Branch mass balance increased by 100 mm, AAR ascended 4.6% and 4.2%, respectively. Glacier mass balance was sensitive to change of net ablation, net ablation of East and West Branch increased 10x 104 m3, and mass balance decreased 110 mm and 214 mm, respectively. By analyzing mass balance sensitivity to climate change, results suggest that East and West Branch mass bal- ance decreased （increased） 463 mm and 388 mm when ablation period temperature increased （decreased） by 1 ~C, East and West Branch mass balance increased （decreased） 140 mm and 158 mm when annual precipitation increased （decreased） by 100 mm, and sensitivity of East Branch mass balance to climate change was more intense than that of West Branch.展开更多
Retrieval of oxalate from snow and ice provides information on past environmental changes. In recent years, records of organic acids in middle-and low-latitude glaciers have attracted the attention of researchers glob...Retrieval of oxalate from snow and ice provides information on past environmental changes. In recent years, records of organic acids in middle-and low-latitude glaciers have attracted the attention of researchers globally. In this study, we analyzed oxalates in an ice core from Laohugou Glacier No. 12 on the Qilian Mountains at an elevation of 5,040 m a.s.l. in2006. Average oxalate concentration was 18.5±2.4 ng/g over the prior 46 years. Oxalate values showed a significantly increasing trend since 1985. From 1985 to 1995, oxalate concentrations had large fluctuations, peaking in about 1987 and exhibiting a slightly decreasing trend since 1995. The result shows that the abrupt increase of oxalate concentration in the ice core since the mid-1980 s reflects atmospheric environmental pollution by human and industrial activities.展开更多
目的:探讨富含丝氨酸结构域1的RNA结合蛋白(RNA-binding protein with serine-rich domain 1,RNPS1)在胰腺癌进展中的作用及可能分子机制。方法:免疫组织化学与免疫荧光检测RNPS1与Notch3在胰腺癌组织及癌旁组织的表达;RTq PCR、免疫荧...目的:探讨富含丝氨酸结构域1的RNA结合蛋白(RNA-binding protein with serine-rich domain 1,RNPS1)在胰腺癌进展中的作用及可能分子机制。方法:免疫组织化学与免疫荧光检测RNPS1与Notch3在胰腺癌组织及癌旁组织的表达;RTq PCR、免疫荧光检测RNPS1与Notch3在胰腺癌细胞中的表达情况;Hoechst与CCK-8实验检测胰腺癌细胞凋亡与增殖;划痕实验与transwell实验检测胰腺癌细胞迁移与侵袭能力;Western blot实验检测胰腺癌细胞中N-Cadherin和E-Cadherin的表达;Western blot与RT-q PCR实验检测胰腺癌细胞中Notch3与HEY1的表达。结果:与癌旁组织与正常细胞系相比较,RNPS1与Notch3在胰腺癌组织中及胰腺癌细胞的表达均增高(F=121.612、34.649,均P<0.05);与对照组相比较,敲低RNPS1抑制生物标志物N-Cadherin的表达(t=39.922,P<0.05),促进E-Cadherin的表达(t=8.281,P<0.05),敲低RNPS1可减弱癌细胞的生存、迁移侵袭的能力(t=2.017、4.874、19.747,均P<0.05,),促进了细胞凋亡(t=33.673,P<0.05);敲低RNPS1降低了癌细胞中Notch3与HEY1的表达(t=17.546、6.258,均P<0.05)。结论:RNPS1的表达与胰腺癌细胞生存、恶性表型有关,RNPS1可能通过调控Notch3/HEY1信号通路促进胰腺癌细胞的生存及肿瘤进展。展开更多
目的探讨骨外膜素(Periostin)、Notch跨膜受体-1(Notch1)m RNA、维生素D(VitD)与自身免疫性甲状腺炎(AIT)淋巴细胞浸润程度、调节性T细胞/辅助性T细胞17(Treg/Th17)的相关性。方法选取2021年7月至2023年12月郑州大学第一附属医院收治的9...目的探讨骨外膜素(Periostin)、Notch跨膜受体-1(Notch1)m RNA、维生素D(VitD)与自身免疫性甲状腺炎(AIT)淋巴细胞浸润程度、调节性T细胞/辅助性T细胞17(Treg/Th17)的相关性。方法选取2021年7月至2023年12月郑州大学第一附属医院收治的92例AIT患者纳入AIT组,另选取同期50例无甲状腺疾病的健康人群纳入对照组。比较两组受检者的淋巴细胞浸润程度及抗体水平,采用Spearman、Pearson相关系数分析淋巴细胞浸润程度、Treg/Th17与甲状腺功能、抗体水平的相关性,比较两组受检者的Periostin、Notch1 m RNA、VitD及Treg/Th17,采用Pearson相关系数分析Periostin、Notch1 mRNA、VitD与淋巴细胞浸润程度及Treg/Th17的相关性。结果AIT组患者的CD3^(+)、CD3^(+)CD4^(+)、CD4^(+)CD25^(+)CD127^(-)、TgAb、TPOAb、TRAb水平及甲亢/亚临床甲亢、甲减/亚临床甲减患者占比明显高于对照组,差异均有统计学意义(P<0.05);Pearson相关系数分析结果显示,CD3^(+)(r=0.579、0.602、0.563)、CD3^(+)CD4^(+)(r=0.612、0.637、0.606)、CD~4+CD25^(+)CD127^(-)(r=0.655、0.643、0.687)与TgAb、TPOAb、TRAb呈正相关(P<0.05);AIT组患者的Periostin、Notch1 m RNA分别为(4.27±1.40)μg/L、1.73±0.56,明显高于对照组的(2.86±0.49)μg/L、1.02±0.14,VitD、Treg/Th17分别为(17.82±5.09)ng/mL、2.82±0.97,明显低于对照组的(22.30±3.76)ng/mL、12.36±2.03,差异均有统计学意义(P<0.05);Pearson相关系数分析结果显示,Periostin(r=0.792、0.811、0.737)、Notch1 mRNA(r=0.812、0.775、0.792)与CD3^(+)、CD3^(+)CD4^(+)、CD4^(+)CD25+CD127-呈正相关(P<0.05),VitD(r=-0.687、-0.753、-0.799)与之呈负相关(P<0.05),且Periostin(r=-0.823)、Notch1 m RNA(r=-0.772)与Treg/Th17呈负相关(P<0.05),VitD(r=0.745)与之呈正相关(P<0.05)。结论Periostin、Notch1 mRNA在AIT患者血清中表达上调,VitD表达下调,各指标与AIT淋巴细胞浸润程度及Treg/Th17均具有一定相关性,可为临床判断病情提供参考,并对后续临床治疗具有一定指导价值。展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 41001040 and J0630966)the Foundation for Excellent Youth Scholars of CAREERI (No. 51Y084911)+1 种基金the Knowledge Innovation Project of the Chinese Academy of Sciences (KZCX2-EW-311)the National Basic Research Program of China (2010CB951003)
文摘As a solid reservoir, a glacier can regulate regional water resources. The annual net mass balance directly reflects the fluctuation of the glacier and climate variability. Based on 51 years of mass balance observation data, the mass balance of Tianshan Mountains Urumqi Glacier No. 1 experienced a nine times positive balance fluctuation and nine times negative balance fluctuation. There were 35 and 16 negative and positive balance years, respectively. From 1996/97 to 2008/09, 12 consecutive negative balance years were observed at Tianshan Mountains Urumqi Glacier No. 1. These results demon- strate that the Urumqi Glacier No. 1 is experiencing a strong negative balance, and the strongest negative balance, -931 mm w.e. （mm water equivalent）, during the observation period occurred in 2008. In addition, the cumulative mass balance reached 13,709 mm w.e. in 2008. However, in 2009, the mass balance was positive at 63 mm w.e. The equilibrium-line al- titude changes with the fluctuation in the mass balance, and the effective mass balance gradient is 7.4 mrn/m. In this paper, the headwaters of the Urumqi River were analyzed using meteorological data from 1958 to 2009, including the average seasonal temperature and precipitation. The results showed that the main factor associated with the mass balance variation of Glacier No. 1 is the fluctuation in the summer air temperature, followed by changes in the precipitation.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41001040 and J0630966)the Foundation for Excellent Youth Scholars of CAREERI (No. 51Y084911)the National Basic Research Program of China (2010CB951003)
文摘This paper is based on observed mass balance between East and West Branch of Urumqi Glacier No. l, meteorological data dur- ing 1988-2010, comparative studies the mass balance variations, and analyses the mass balance sensitivity to climate change. Re- sults show that average mass balance of East and West Branch was -532 mm/a and 435 mm/a, cumulative mass balance was 12,227 mm （ice thinned by 13.6 m） and -10,001 mm （ice thinned by 11.1 m）, respectively, and mass loss of East Branch was 97 mm/a larger than West Branch. The East and West Branch ELA （equilibrium line altitude） ascended about 176 m and 154 m, analysis shows the steady-state ELA0 was 3,942 m a.s.1, and 4,011 m a.s.1., and when East and West Branch mass balance de- creased by 100 ram, ELA ascended 20 m and 23 m, respectively. The AAR （accumulation area ratio） of East and West Branch presented an obviously decreasing trend of 34.5% and 23%, equilibrium-state AAR0 was 65% and 66%, when East and West Branch mass balance increased by 100 mm, AAR ascended 4.6% and 4.2%, respectively. Glacier mass balance was sensitive to change of net ablation, net ablation of East and West Branch increased 10x 104 m3, and mass balance decreased 110 mm and 214 mm, respectively. By analyzing mass balance sensitivity to climate change, results suggest that East and West Branch mass bal- ance decreased （increased） 463 mm and 388 mm when ablation period temperature increased （decreased） by 1 ~C, East and West Branch mass balance increased （decreased） 140 mm and 158 mm when annual precipitation increased （decreased） by 100 mm, and sensitivity of East Branch mass balance to climate change was more intense than that of West Branch.
基金supported by Equipment Function Development Technology Innovation Project of Chinese Academy of Science(Y429C51005)the National Natural Science Foundation of China(41301064)+1 种基金Gansu Provincial Natural Science Foundation of China(1506RJZA286)National Found for Fostering Talents of Basic Science(Y311801001)
文摘Retrieval of oxalate from snow and ice provides information on past environmental changes. In recent years, records of organic acids in middle-and low-latitude glaciers have attracted the attention of researchers globally. In this study, we analyzed oxalates in an ice core from Laohugou Glacier No. 12 on the Qilian Mountains at an elevation of 5,040 m a.s.l. in2006. Average oxalate concentration was 18.5±2.4 ng/g over the prior 46 years. Oxalate values showed a significantly increasing trend since 1985. From 1985 to 1995, oxalate concentrations had large fluctuations, peaking in about 1987 and exhibiting a slightly decreasing trend since 1995. The result shows that the abrupt increase of oxalate concentration in the ice core since the mid-1980 s reflects atmospheric environmental pollution by human and industrial activities.
文摘目的:探讨富含丝氨酸结构域1的RNA结合蛋白(RNA-binding protein with serine-rich domain 1,RNPS1)在胰腺癌进展中的作用及可能分子机制。方法:免疫组织化学与免疫荧光检测RNPS1与Notch3在胰腺癌组织及癌旁组织的表达;RTq PCR、免疫荧光检测RNPS1与Notch3在胰腺癌细胞中的表达情况;Hoechst与CCK-8实验检测胰腺癌细胞凋亡与增殖;划痕实验与transwell实验检测胰腺癌细胞迁移与侵袭能力;Western blot实验检测胰腺癌细胞中N-Cadherin和E-Cadherin的表达;Western blot与RT-q PCR实验检测胰腺癌细胞中Notch3与HEY1的表达。结果:与癌旁组织与正常细胞系相比较,RNPS1与Notch3在胰腺癌组织中及胰腺癌细胞的表达均增高(F=121.612、34.649,均P<0.05);与对照组相比较,敲低RNPS1抑制生物标志物N-Cadherin的表达(t=39.922,P<0.05),促进E-Cadherin的表达(t=8.281,P<0.05),敲低RNPS1可减弱癌细胞的生存、迁移侵袭的能力(t=2.017、4.874、19.747,均P<0.05,),促进了细胞凋亡(t=33.673,P<0.05);敲低RNPS1降低了癌细胞中Notch3与HEY1的表达(t=17.546、6.258,均P<0.05)。结论:RNPS1的表达与胰腺癌细胞生存、恶性表型有关,RNPS1可能通过调控Notch3/HEY1信号通路促进胰腺癌细胞的生存及肿瘤进展。
文摘目的探讨骨外膜素(Periostin)、Notch跨膜受体-1(Notch1)m RNA、维生素D(VitD)与自身免疫性甲状腺炎(AIT)淋巴细胞浸润程度、调节性T细胞/辅助性T细胞17(Treg/Th17)的相关性。方法选取2021年7月至2023年12月郑州大学第一附属医院收治的92例AIT患者纳入AIT组,另选取同期50例无甲状腺疾病的健康人群纳入对照组。比较两组受检者的淋巴细胞浸润程度及抗体水平,采用Spearman、Pearson相关系数分析淋巴细胞浸润程度、Treg/Th17与甲状腺功能、抗体水平的相关性,比较两组受检者的Periostin、Notch1 m RNA、VitD及Treg/Th17,采用Pearson相关系数分析Periostin、Notch1 mRNA、VitD与淋巴细胞浸润程度及Treg/Th17的相关性。结果AIT组患者的CD3^(+)、CD3^(+)CD4^(+)、CD4^(+)CD25^(+)CD127^(-)、TgAb、TPOAb、TRAb水平及甲亢/亚临床甲亢、甲减/亚临床甲减患者占比明显高于对照组,差异均有统计学意义(P<0.05);Pearson相关系数分析结果显示,CD3^(+)(r=0.579、0.602、0.563)、CD3^(+)CD4^(+)(r=0.612、0.637、0.606)、CD~4+CD25^(+)CD127^(-)(r=0.655、0.643、0.687)与TgAb、TPOAb、TRAb呈正相关(P<0.05);AIT组患者的Periostin、Notch1 m RNA分别为(4.27±1.40)μg/L、1.73±0.56,明显高于对照组的(2.86±0.49)μg/L、1.02±0.14,VitD、Treg/Th17分别为(17.82±5.09)ng/mL、2.82±0.97,明显低于对照组的(22.30±3.76)ng/mL、12.36±2.03,差异均有统计学意义(P<0.05);Pearson相关系数分析结果显示,Periostin(r=0.792、0.811、0.737)、Notch1 mRNA(r=0.812、0.775、0.792)与CD3^(+)、CD3^(+)CD4^(+)、CD4^(+)CD25+CD127-呈正相关(P<0.05),VitD(r=-0.687、-0.753、-0.799)与之呈负相关(P<0.05),且Periostin(r=-0.823)、Notch1 m RNA(r=-0.772)与Treg/Th17呈负相关(P<0.05),VitD(r=0.745)与之呈正相关(P<0.05)。结论Periostin、Notch1 mRNA在AIT患者血清中表达上调,VitD表达下调,各指标与AIT淋巴细胞浸润程度及Treg/Th17均具有一定相关性,可为临床判断病情提供参考,并对后续临床治疗具有一定指导价值。
