目的探讨入院时血清胆碱酯酶(cholinesterase,ChE)联合格拉斯哥昏迷评分(Glasgow coma scale,GCS)对重型闭合性颅脑损伤病人28d院内预后的预测价值。方法回顾性分析87例重型闭合性颅脑损伤病例资料,根据28d院内的生存情况分为存活组(n=...目的探讨入院时血清胆碱酯酶(cholinesterase,ChE)联合格拉斯哥昏迷评分(Glasgow coma scale,GCS)对重型闭合性颅脑损伤病人28d院内预后的预测价值。方法回顾性分析87例重型闭合性颅脑损伤病例资料,根据28d院内的生存情况分为存活组(n=64)与死亡组(n=23)。比较两组病人基线资料、GCS评分、ChE以及急性生理学和慢性健康评估Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分。采用多因素Logistic回归,分析重型闭合性颅脑损伤病人28d院内预后的影响因素。绘制受试者工作特征曲线(receiver operating characteristic,ROC),确定最佳临界值,分析ChE联合GCS评分评估重型闭合性颅脑损伤病人28d院内预后的价值。结果存活组ChE水平、GCS评分及血红蛋白均显著高于死亡组,而血糖、D-二聚体、凝血酶原时间及APACHEⅡ评分显著低于死亡组(均P<0.05)。多因素Logistic回归分析显示:ChE、GCS评分及APACHEⅡ评分是重型闭合性颅脑损伤病人28d院内出现死亡的影响因素(均P<0.05)。ROC曲线分析显示:ChE联合GCS评分曲线下面积大于两者单独预测时的曲线下面积。结论入院时ChE、GCS评分均对重型闭合性颅脑损伤病人预后具有预测价值,两者联合价值更高。展开更多
西方的科学研究成果大多来源于英语的语言文化环境,把西方的科学研究成果介绍到中国,必须重视英语的语言文化环境和汉语的语言文化环境的不同,这样才能使国人准确、方便地应用西方的科学研究成果,西学东渐。格拉斯哥昏迷评分(Glasgow co...西方的科学研究成果大多来源于英语的语言文化环境,把西方的科学研究成果介绍到中国,必须重视英语的语言文化环境和汉语的语言文化环境的不同,这样才能使国人准确、方便地应用西方的科学研究成果,西学东渐。格拉斯哥昏迷评分(Glasgow coma scale)被翻译、介绍到国内已有数十年,但汉语版的"Glasgow coma scale"多种多样,容易造成初学者和使用者的迷惑。本文复习有关"Glasgow coma scale"的原始英式英文文献、美式英语英文文献和以往的几个主要的汉语翻译版。结合英式英语、美式英语和汉语的语言文化特点,新译了"Glasgow coma scale",以方便医护人员使用。展开更多
BACKGROUND:The timing and selection of patients for liver transplantation in acute liver failure are great challenges.This study aimed to investigate the effect of Glasgow coma scale(GCS)and APACHE-II scores on liver ...BACKGROUND:The timing and selection of patients for liver transplantation in acute liver failure are great challenges.This study aimed to investigate the effect of Glasgow coma scale(GCS)and APACHE-II scores on liver transplantation outcomes in patients with acute liver failure.METHOD:A total of 25 patients with acute liver failure were retrospectively analyzed according to age,etiology,time to transplantation,coma scores,complications and mortality.RESULTS:Eighteen patients received transplants from live donors and 7 had cadaveric whole liver transplants.The mean duration of follow-up after liver transplantation was 39.86±40.23 months.Seven patients died within the perioperative period and the 1-,3-,5-year survival rates of the patients were72%,72%and 60%,respectively.The parameters evaluated for the perioperative deaths versus alive were as follows:the mean age of the patients was 33.71 vs 28 years,MELD score was 40 vs32.66,GCS was 5.57 vs 10.16,APACHE-II score was 23 vs 18.11,serum sodium level was 138.57 vs 138.44 mmol/L,mean waiting time before the operation was 12 vs 5.16 days.Low GCS,high APACHE-II score and longer waiting time before the operation(P【0.01)were found as statistically significant factors for perioperative mortality.CONCLUSION:Lower GCS and higher APACHE-II scores are related to poor outcomes in patients with acute liver failure after liver transplantation.展开更多
This study was a retrospective analysis of outcome of surgically treated acute traumatic epidural hematomas based on the Glasgow coma scale. The series enrolled forty-six consecutive cases of acute traumatic epidural ...This study was a retrospective analysis of outcome of surgically treated acute traumatic epidural hematomas based on the Glasgow coma scale. The series enrolled forty-six consecutive cases of acute traumatic epidural hematomas. The mean age of patients was 29.56 years and 63.04% of the patients were between 21 and 30 years of age. Forty-tree out of 46 (93.47%) of the patients were males. Road traffic crash was the main mode of injury. The severity of the traumatic brain injury was classified according to the Glasgow coma scale score at admission. The injury was mild or moderate in 35 (76.08%) cases and severe in 11. Eight patients (17.39%) presented with pupillary abnormalities. The computed tomography scanning of the head has objectivized the epidural hematoma in all patients and has shown a mass effect with midline shift in all but one case (45/46). The most frequent surgical procedure done was craniotomy. Six (13.04%) patients died (GOS 1), but 38 (82.60%) recovered fully (GOS 5) and two (04.34%) were disabled but independent (GOS 4). The Glasgow coma score at admission was very predictive for good or poor outcome, since all patients but one who died and all survivors who were disabled were comatose at admission (GCS ≤ 8).展开更多
Glasgow coma scale is the most cited paper in neurosurgery. It has vast implications in the fields of neurology and neurosurgery. But lack of proper understanding in the neuro-anatomical basis of the score is the Achi...Glasgow coma scale is the most cited paper in neurosurgery. It has vast implications in the fields of neurology and neurosurgery. But lack of proper understanding in the neuro-anatomical basis of the score is the Achilles heel in proper utilization of the same. Herein we review the anatomical aspects behind each variable in the score. We also discuss common limitations of the score and highlight future directives to limit the same.展开更多
目的探讨格拉斯哥昏迷评分(glasgow coma scale,GCS)、因斯布鲁克昏迷评分(innsbruck comascale,ICS)和急性生理和慢性健康评分Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)对昏迷患者脑功能及预后判断的评价价值。...目的探讨格拉斯哥昏迷评分(glasgow coma scale,GCS)、因斯布鲁克昏迷评分(innsbruck comascale,ICS)和急性生理和慢性健康评分Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)对昏迷患者脑功能及预后判断的评价价值。方法按3种临床评分标准对GCS3~8分、入院3 d的68例昏迷患者进行评分,并对所得评分结果进行分级、对比,分析其与患者预后的相关性。结果各临床分级标准与预后均有较好的相关性,3种临床评分标准比较,其预测预后的准确性差异无统计学意义(P<0.05)。结论GCS、ICS和APACHEⅡ3种临床评分量表均能对昏迷患者的预后提供良好的诊断价值,3种标准间预测价值差异不明显。展开更多
目的探讨创伤性脑损伤(traumatic brain injury,TBI)患者血清降钙素原(procalcitonin,PCT)、可溶性髓样细胞触发受体-1(soluble triggering re ceptor-1,sTREM-1)水平检测联合格拉斯哥昏迷评分(Glasgow comd scale,GCS)对临床预后评估...目的探讨创伤性脑损伤(traumatic brain injury,TBI)患者血清降钙素原(procalcitonin,PCT)、可溶性髓样细胞触发受体-1(soluble triggering re ceptor-1,sTREM-1)水平检测联合格拉斯哥昏迷评分(Glasgow comd scale,GCS)对临床预后评估的价值。方法选取2018年1月~2020年5月涿州市医院收治的TBI患者142例,根据28天预后情况分成存活组(n=110)和死亡组(n=32)。采用格拉斯哥昏迷评分(GCS)分为轻度组(n=10,13~15分)、中度组(n=79,9~12分)和重度组(n=53,3~8分)。比较各组血清PCT及sTREM-1水平,绘制受试者工作特征(ROC)曲线分析PCT,sTREM-1及GCS评分预测TBI患者死亡的价值。结果死亡组血清PCT(1.91±1.06ng/ml vs 0.48±0.30ng/ml)及sTREM-1(60.28±9.74pg/ml vs 36.50±6.83pg/ml)水平均明显高于存活组,差异均有统计学意义(t=8.284,8.117,均P<0.01)。重度组血清PCT(1.74±0.95ng/ml vs 0.63±0.38ng/ml)及sTREM-1(53.90±8.32pg/ml vs 42.70±7.26pg/ml)水平均明显高于轻中度组,差异具有统计学意义(t=7.506,6.974,均P<0.01)。ROC曲线分析显示,PCT,sTREM-1及GCS评分三项联合预测TBI患者死亡的曲线下面积(0.928,95%CI:0.870~0.991)最大,其敏感度和特异度分别为94.8%和87.0%。结论血清PCT及sTREM-1水平升高与TBI患者的病情严重程度相关,联合GCS评分对TBI患者预后评估有较好的价值。展开更多
文摘目的探讨入院时血清胆碱酯酶(cholinesterase,ChE)联合格拉斯哥昏迷评分(Glasgow coma scale,GCS)对重型闭合性颅脑损伤病人28d院内预后的预测价值。方法回顾性分析87例重型闭合性颅脑损伤病例资料,根据28d院内的生存情况分为存活组(n=64)与死亡组(n=23)。比较两组病人基线资料、GCS评分、ChE以及急性生理学和慢性健康评估Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分。采用多因素Logistic回归,分析重型闭合性颅脑损伤病人28d院内预后的影响因素。绘制受试者工作特征曲线(receiver operating characteristic,ROC),确定最佳临界值,分析ChE联合GCS评分评估重型闭合性颅脑损伤病人28d院内预后的价值。结果存活组ChE水平、GCS评分及血红蛋白均显著高于死亡组,而血糖、D-二聚体、凝血酶原时间及APACHEⅡ评分显著低于死亡组(均P<0.05)。多因素Logistic回归分析显示:ChE、GCS评分及APACHEⅡ评分是重型闭合性颅脑损伤病人28d院内出现死亡的影响因素(均P<0.05)。ROC曲线分析显示:ChE联合GCS评分曲线下面积大于两者单独预测时的曲线下面积。结论入院时ChE、GCS评分均对重型闭合性颅脑损伤病人预后具有预测价值,两者联合价值更高。
文摘西方的科学研究成果大多来源于英语的语言文化环境,把西方的科学研究成果介绍到中国,必须重视英语的语言文化环境和汉语的语言文化环境的不同,这样才能使国人准确、方便地应用西方的科学研究成果,西学东渐。格拉斯哥昏迷评分(Glasgow coma scale)被翻译、介绍到国内已有数十年,但汉语版的"Glasgow coma scale"多种多样,容易造成初学者和使用者的迷惑。本文复习有关"Glasgow coma scale"的原始英式英文文献、美式英语英文文献和以往的几个主要的汉语翻译版。结合英式英语、美式英语和汉语的语言文化特点,新译了"Glasgow coma scale",以方便医护人员使用。
文摘BACKGROUND:The timing and selection of patients for liver transplantation in acute liver failure are great challenges.This study aimed to investigate the effect of Glasgow coma scale(GCS)and APACHE-II scores on liver transplantation outcomes in patients with acute liver failure.METHOD:A total of 25 patients with acute liver failure were retrospectively analyzed according to age,etiology,time to transplantation,coma scores,complications and mortality.RESULTS:Eighteen patients received transplants from live donors and 7 had cadaveric whole liver transplants.The mean duration of follow-up after liver transplantation was 39.86±40.23 months.Seven patients died within the perioperative period and the 1-,3-,5-year survival rates of the patients were72%,72%and 60%,respectively.The parameters evaluated for the perioperative deaths versus alive were as follows:the mean age of the patients was 33.71 vs 28 years,MELD score was 40 vs32.66,GCS was 5.57 vs 10.16,APACHE-II score was 23 vs 18.11,serum sodium level was 138.57 vs 138.44 mmol/L,mean waiting time before the operation was 12 vs 5.16 days.Low GCS,high APACHE-II score and longer waiting time before the operation(P【0.01)were found as statistically significant factors for perioperative mortality.CONCLUSION:Lower GCS and higher APACHE-II scores are related to poor outcomes in patients with acute liver failure after liver transplantation.
文摘This study was a retrospective analysis of outcome of surgically treated acute traumatic epidural hematomas based on the Glasgow coma scale. The series enrolled forty-six consecutive cases of acute traumatic epidural hematomas. The mean age of patients was 29.56 years and 63.04% of the patients were between 21 and 30 years of age. Forty-tree out of 46 (93.47%) of the patients were males. Road traffic crash was the main mode of injury. The severity of the traumatic brain injury was classified according to the Glasgow coma scale score at admission. The injury was mild or moderate in 35 (76.08%) cases and severe in 11. Eight patients (17.39%) presented with pupillary abnormalities. The computed tomography scanning of the head has objectivized the epidural hematoma in all patients and has shown a mass effect with midline shift in all but one case (45/46). The most frequent surgical procedure done was craniotomy. Six (13.04%) patients died (GOS 1), but 38 (82.60%) recovered fully (GOS 5) and two (04.34%) were disabled but independent (GOS 4). The Glasgow coma score at admission was very predictive for good or poor outcome, since all patients but one who died and all survivors who were disabled were comatose at admission (GCS ≤ 8).
文摘Glasgow coma scale is the most cited paper in neurosurgery. It has vast implications in the fields of neurology and neurosurgery. But lack of proper understanding in the neuro-anatomical basis of the score is the Achilles heel in proper utilization of the same. Herein we review the anatomical aspects behind each variable in the score. We also discuss common limitations of the score and highlight future directives to limit the same.
文摘目的探讨格拉斯哥昏迷评分(glasgow coma scale,GCS)、因斯布鲁克昏迷评分(innsbruck comascale,ICS)和急性生理和慢性健康评分Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)对昏迷患者脑功能及预后判断的评价价值。方法按3种临床评分标准对GCS3~8分、入院3 d的68例昏迷患者进行评分,并对所得评分结果进行分级、对比,分析其与患者预后的相关性。结果各临床分级标准与预后均有较好的相关性,3种临床评分标准比较,其预测预后的准确性差异无统计学意义(P<0.05)。结论GCS、ICS和APACHEⅡ3种临床评分量表均能对昏迷患者的预后提供良好的诊断价值,3种标准间预测价值差异不明显。
文摘目的探讨创伤性脑损伤(traumatic brain injury,TBI)患者血清降钙素原(procalcitonin,PCT)、可溶性髓样细胞触发受体-1(soluble triggering re ceptor-1,sTREM-1)水平检测联合格拉斯哥昏迷评分(Glasgow comd scale,GCS)对临床预后评估的价值。方法选取2018年1月~2020年5月涿州市医院收治的TBI患者142例,根据28天预后情况分成存活组(n=110)和死亡组(n=32)。采用格拉斯哥昏迷评分(GCS)分为轻度组(n=10,13~15分)、中度组(n=79,9~12分)和重度组(n=53,3~8分)。比较各组血清PCT及sTREM-1水平,绘制受试者工作特征(ROC)曲线分析PCT,sTREM-1及GCS评分预测TBI患者死亡的价值。结果死亡组血清PCT(1.91±1.06ng/ml vs 0.48±0.30ng/ml)及sTREM-1(60.28±9.74pg/ml vs 36.50±6.83pg/ml)水平均明显高于存活组,差异均有统计学意义(t=8.284,8.117,均P<0.01)。重度组血清PCT(1.74±0.95ng/ml vs 0.63±0.38ng/ml)及sTREM-1(53.90±8.32pg/ml vs 42.70±7.26pg/ml)水平均明显高于轻中度组,差异具有统计学意义(t=7.506,6.974,均P<0.01)。ROC曲线分析显示,PCT,sTREM-1及GCS评分三项联合预测TBI患者死亡的曲线下面积(0.928,95%CI:0.870~0.991)最大,其敏感度和特异度分别为94.8%和87.0%。结论血清PCT及sTREM-1水平升高与TBI患者的病情严重程度相关,联合GCS评分对TBI患者预后评估有较好的价值。
