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Effect of phacoemulsification on intraocular pressure in patients with primary open angle glaucoma and pseudoexfoliation glaucoma 被引量:7
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作者 Jesus Jimenez-Roman Gabriel Lazcano-Gomez +6 位作者 Karina Martínez-Baez Mauricio Turati Rosario Gulías-Canizo Luis F.Hernández-Zimbrón Lenin Ochoa-De la Paz Rubén Zamora Roberto Gonzalez-Salinas 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2017年第9期1374-1378,共5页
AIM:To compare the effect of phacoemulsification on intraocular pressure(IOP)in patients with primary open angle glaucoma(POAG)and pseudoexfoliation glaucoma(PXG).METHODS:A retrospective comparative case serie... AIM:To compare the effect of phacoemulsification on intraocular pressure(IOP)in patients with primary open angle glaucoma(POAG)and pseudoexfoliation glaucoma(PXG).METHODS:A retrospective comparative case series conducted at the Glaucoma Department at the Association to Prevent Blindness in Mexico.The study enrolled consecutive patients having phacoemulsification with intraocular lens(IOL)implantation and a diagnosis of POAG or PXG.Data about IOP values and number of glaucoma medications used was collected at baseline,1,3,6 and12mo postoperatively.RESULTS:The study enrolled 88 patients(88 eyes).After phacoemulsification,there was a statistically significant reduction in IOP values and glaucoma medications use compared to baseline in both POAG and PXG patients(P〈0.001).In the POAG group,a 20%decrease in IOP values was evidenced,and a 56.5%reduction in the number of medications used at the one-year follow-up.The PXG group showed a 20.39%,and a 34.46%decrease in IOP and number of medications used,respectively.A significant difference in the meanΔIOP(postoperative changes in IOP)was evidenced between groups(P=0.005).The reduction of the postsurgical IOP mean values in both groups,the POAG group showed a greater reduction in IOP values compared to the PXG group.CONCLUSION:In both types of glaucoma,phacoemulsification cataract surgery can result in a significant IOP reduction(20%)over a 12mo follow-up period.The number of medications used is also significantly reduced up to 12mo after surgery,especially in the PXG group. 展开更多
关键词 cataract surgery pseudoexfoliation glaucoma secondary glaucoma primary open angle glaucoma INTRAOCULARPRESSURE
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Two-year outcomes of ab interno trabeculectomy with the Trabectome for Chinese primary open angle glaucoma: a retrospective multicenter study 被引量:6
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作者 Ya-Long Dang Xiao Wang +4 位作者 Wan-Wei Dai Ping Huang Nils A Loewen Chun Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第6期945-950,共6页
AIM: To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with the Trabectome in Chinese primary open angle glaucoma (POAG) patients. METHODS: This was a multicenter, retrospective, observatio... AIM: To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with the Trabectome in Chinese primary open angle glaucoma (POAG) patients. METHODS: This was a multicenter, retrospective, observational study and included POAG patients with or without visually-significant cataracts. The Chinese patients were enrolled from three glaucoma centers and a group of comparable Japanese POAG patients was analyzed from our international Trabectome database. The patients received Trabectome or a combined surgery with phacoemulsification and intraocular lens implantation. The primary outcome was intraocular pressure (IOP) reduction. Secondary outcomes included reduction of glaucoma medications, surgical complications, and success at 2y. Success was defined as: 1) IOP≤21 mm Hg and at least 20% IOP reduction from baseline after 3mo at any two consecutive visits; 2) no additional glaucoma surgery required. RESULTS: A total of 42 Chinese POAG patients from three glaucoma centers were enrolled. Twelve patients underwent Trabectome surgery combined with phacoemulsification and intraocular lens implantation while the remainder underwent Trabectome surgery alone. Thirteen patients had a history of failed glaucoma surgery and were considered as complicated cases. In China data, the mean preoperative IOP was 21.4±1.23 mm Hg. The Trabectome lowered IOP to 17.9±1.8 mm Hg at 2y (P=0.05). The number of glaucoma medications also decreased significantly from a baseline of 2.0±0.9 to 1.1±0.8 at 2y post-surgery (P=0.04). The overall 2-year success rate was 78%, with patients undergoing combined surgery having a higher success rate compared with those undergoing Trabectome surgery alone (100% vs 76%). In Japan data, the mean preoperative IOP was 20.8±7.7 mm Hg. The Trabectome lowered IOP to 12.20±2.0 mm Hg at 2y. The number of glaucoma medications also decreased significantly from a baseline of 2.1±0.9 to 3.4±0.6 at 2y post-surgery. In all patients, no major complications were seen. CONCLUSION: Surgery with the Trabectome appears to be an efficient and safe procedure in Chinese POAG patients in the long-term. 展开更多
关键词 primary open angle glaucoma minimallyinvasive glaucoma surgeries intraocular pressure surgical complications
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Effect of subconjunctival injection with conbercept as an adjuvant to filtration surgery for open angle glaucoma: a prospective randomized interventional 6-month follow-up study 被引量:3
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作者 Jing Zhang Vikash Vikash +4 位作者 Ping Wang Tian Zheng Dong-Lai Chen Qing Wang Min Ke 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第2期235-240,共6页
AIM: To compare the safety and efficacy of subconjunctival injection with conbercept and 5-fluorouracil(5-FU) for open angle glaucoma(OAG) patients after filtration surgery. METHODS: As a prospective randomized interv... AIM: To compare the safety and efficacy of subconjunctival injection with conbercept and 5-fluorouracil(5-FU) for open angle glaucoma(OAG) patients after filtration surgery. METHODS: As a prospective randomized interventional trial, 36 eyes from 36 patients after OAG surgery were collected and divided randomly into conbercept and 5-FU groups. All patients were subconjunctivally injected with either conbercept(0.2 mL) or 5-FU(0.2 mL) on the 5th day post-operatively. The intraocular pressure(IOP), number of medications used, type of conjunctival bleb, and complications were recorded and analyzed pre-operatively and 1d, 1wk, 1, 3 and 6mo post-injection. RESULTS: There were significant differences in IOP between the conbercept and 5-FU groups 1mo(conbercept group: 12.17±1.04 mm Hg; 5-FU group: 13.50±2.33 mm Hg, t=2.214, P=0.037), 3mo(conbercept group: 13.00±1.88 mm Hg; 5-FU group: 14.50±2.28 mm Hg, t=2.153, P=0.039), and 6mo post-injection(conbercept group: 13.28±2.95 mm Hg; 5-FU group: 15.22±2.49 mm Hg, t=2.140, P=0.040); however, in the number of medications, a prominent difference was not shown between groups on post-injection 6mo(t=1.312, P=0.200). Moreover, there was mild vascularity observed in the conbecept group than the 5-FU group 1d(3a, 3b, 3c: t=8.497, 6.693, 4.515, P=0.000), 1wk(3a, 3b, 3c: t=3.431, 6.408, 3.984, P=0.002, 0.000, 0.000), and 1mo post-injection(3a, 3b, 3c: t=2.466, 2.466, 2.503, P=0.019, 0.019, 0.017). Simultaneously, differences from other indicators between the two groups were not demonstrated. Also, there was a lower probability of corneal epithelial stripping in the conbercept group than the 5-FU group(χ2=4.500, P=0.034). CONCLUSION: Subconjunctival injection of conbercept has a safe, effective, and tolerable profile for open angle glaucoma patients with distinct conjunctival congestion after filtration surgery. 展开更多
关键词 filtration surgery conbercept 5-FLUOROURACIL open angle glaucoma
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Meta Analysis of Non-penetrating Trabecular Surgery versus Trabeculectomy for the Treatment of Open Angle Glaucoma 被引量:3
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作者 柯敏 郭敬 钱志刚 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2011年第2期264-270,共7页
This study compared the efficacy of non-penetrating trabecular surgery and trabeculectomy for the treatment of open angle glaucoma. We searched the Cochrane Library, PUBMED (1966 to 2009), Embase (1980 to 2009) an... This study compared the efficacy of non-penetrating trabecular surgery and trabeculectomy for the treatment of open angle glaucoma. We searched the Cochrane Library, PUBMED (1966 to 2009), Embase (1980 to 2009) and CMB-disk (1979 to 2009) for the randomized clinical trials (RCT) concerning the two treatment strategies. The reports, including the papers listed in bibliographies, were evaluated against a set of quality criteria and the RCTs that satisfied the criteria were selected and subjected to Meta analysis by employing the Cochrane Collaboration's RevMan 4.5 software package. A total of nine RCTs were included in the study. The analyses of the reports showed that, 12 months after surgery, there was significant difference in the reduction of interocular pressure (IOP) between non-penetrating trabecular surgery and trabeculectomy (Z=6.05 P0.00001). There also existed statistically significant difference in the reduction of IOP at the censored time between the two procedures (Z=4.92, P0.00001). Difference in the success rate was also found between the two surgeries (Z=3.82, P=0.0001). It is concluded that, compared with the non-penetrating trabeculectomy, the traditional trabeculectomy could reduce IOP more and had higher success rate while the non-penetrating trabecular surgery is associated with lower postoperative complications. 展开更多
关键词 open angle glaucoma non-penetrating trabecular surgery sclerectomy VISCOCANALOSTOMY TRABECULECTOMY
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Meta-analysis of the efficacy and safety of combined surgery in the management of eyes with coexisting cataract and open angle glaucoma
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作者 Nan Jiang Gui-Qiu Zhao +6 位作者 Jing Lin Li-Ting Hu Cheng-Ye Che Qian Wang Qiang Xu Cui Li Jie Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第2期279-286,共8页
AIM: To conduct a systematic review and quantitative Meta-analysis of the efficacy and safety of combined surgery for the eyes with coexisting cataract and open angle glaucoma.METHODS: We performed a systematic sear... AIM: To conduct a systematic review and quantitative Meta-analysis of the efficacy and safety of combined surgery for the eyes with coexisting cataract and open angle glaucoma.METHODS: We performed a systematic search of the related literature in the Cochrane Library, PubM ed, EMBASE, Web of Science databases, CNKI, CBM and Wan Fang databases, with no limitations on language or publication date. The primary efficacy estimate was identified by weighted mean difference of the percentage of intraocular pressure reduction(IOPR%) from baseline to end-point, the percentage of number of glaucoma medications reduction from pre-to post-operation, and the secondary efficacy evaluations were performed by odds ratio(OR) and 95% confidence interval(CI) for complete and qualified success rate. Besides, ORs were applied to assess the tolerability of adverse incidents. Meta-analyses of fixed or random effect models were performed using Rev Man software 5.2 to gather the consequences. Heterogeneity was evaluated by Chi^2 test and the I^2 measure.RESULTS: Ten studies enrolling 3108 patients were included. The combined consequences indicated that both glaucoma and combined cataract and glaucoma surgery significantly decreased IOP. For deep sclerectomy vs deep sclerectomy plus phacoemulsification and canaloplasty vs phaco-canaloplasty, the differences in IOPR% were not all statistically significant while trabeculotomy was detected to gain a quantitatively greater IOPR% compared with trabeculotomy plus phacoemulsification. Furthermore, there was no statistical significance in the complete and qualified success rate, and the rates of adverse incidents for trabeculotomy vs trabeculotomy plus phacoemulsification.CONCLUSION: Compared with trabeculotomy plus phacoemulsification, trabeculectomy alone is more effective in lowering IOP and the number of glaucoma medications, while the two surgeries can not demonstrate statistical differences in the complete success rate, qualified success rate, or incidence of adverse incidents. 展开更多
关键词 open angle glaucoma cataract glaucoma surgery phacoemulsification combined surgery Meta-analysis
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Efficacy and safety of XEN 45 gel stent alone or in combination with phacoemulsification in advanced open angle glaucoma patients: 1-year retrospective study 被引量:1
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作者 Teresa Laborda-Guirao Juan M Cubero-Parra Antonio Hidalgo-Torres 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第8期1250-1256,共7页
AIM:To assess the effectiveness of the XEN 45 gel stent,either alone or combined with cataract surgery,in advanced stage open angle glaucoma(OAG)patients.METHODS:Retrospective and single-center study conducted on cons... AIM:To assess the effectiveness of the XEN 45 gel stent,either alone or combined with cataract surgery,in advanced stage open angle glaucoma(OAG)patients.METHODS:Retrospective and single-center study conducted on consecutive OAG patients who underwent a XEN 45 gel stent implantation surgery,between July 2017 and September 2018.The primary efficacy end-point was the mean intraocular pressure(IOP)reduction at the end of the follow-up period.Success was defined as an IOP reduction of at least 20%and an IOP value≤18 mm Hg without(complete)or with(qualified)hypotensive medication.RESULTS:Seventy-four patients(80 eyes)were included in the study.In the overall study sample,XEN implant significantly reduced IOP from 21.0(19.8 to 22.1)mm Hg at baseline to 9.3(8.2 to 10.4),10.7(9.6 to 11.9),13.4(12.2 to 14.7),14.5(13.6 to 15.4),14.7(13.8 to 15.6),and 14.7(13.9 to 15.4)mm Hg at 1 d,1 wk,1,3,6,and 12 mo of follow-up,respectively(P<0.0001 each).In the overall study population,at the end of the study the mean IOP reduction was 27.4%(23.3%to 31.5%).Adjusted IOP reduction was similar in XEN and XEN+phacoemulsification groups[30.0(23.4 to 36.4)mm Hg vs 24.8(18.4 to 31.2)mm Hg,respectively,P=0.2939].At the last follow-up visit,52(65.0%)eyes were considered success,29(36.3%)eyes as complete success and 23(28.7%)as qualified success.Mean number of hypotensive medications was significantly reduced from 2.8(2.7 to 3.0)at baseline to 1.1(0.8 to 1.3),P<0.0001.Kaplan-Meier survival analysis did not find any difference in the success rate between XEN and XEN+PHACO,mean hazard ratio 0.56,95%CI 0.26 to 1.23;P=0.1469.Needling was performed in 7(8.8%)eyes at months 1(n=3);3(n=2);4(n=1)and 11(n=1).Eleven(13.8%)eyes presented adverse events.CONCLUSION:XEN implant,either alone or in combination with phacoemulsification,significantly reduced the IOP and the number of hypotensive medications in patients with OAG in advanced stage. 展开更多
关键词 open angle glaucoma advanced stage XEN implant intraocular pressure minimally-invasive glaucoma surgery
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Modified viscocanalostomy in the Chinese population with open angle glaucoma: a 10-year follow-up results 被引量:3
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作者 Ya Liang Hong Sun +4 位作者 Jie Shuai Kai Xu Fang-Fang Ji Sucijanti Zhi-Lan Yuan 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第3期429-435,共7页
AIM: To study the long-term efficacy and safety of modified viscocanalostomy in Chinese people with open angle glaucoma(OAG).METHODS: This retrospective study included a total of 100 eyes from 100 Chinese patients wit... AIM: To study the long-term efficacy and safety of modified viscocanalostomy in Chinese people with open angle glaucoma(OAG).METHODS: This retrospective study included a total of 100 eyes from 100 Chinese patients with medically uncontrolled OAG. All the patients underwent modified viscocanalostomy with injection of viscoelastic material in the surgically created ostia of Schlemm's canal(SC). The modifications included peeling of the inner wall of SC and the juxtacanalicular meshwork, use of mitomycin C, and loosely suturing the superficial scleral flap. Intraocular pressure(IOP), visual acuity, number of medications, laser goniopuncture data and complications were recorded. The definition of complete(qualified) success was an IOP equal to or lower than 21, 18, 16 mm Hg without(with or without) anti-glaucoma medications. RESULTS: The mean IOP was 33.5±9.9 mm Hg before surgery, 15.2±3.6 mm Hg(mean IOP reduction of 51%) at 5 y after surgery, and 15.6±2.8 mm Hg(mean IOP reduction of 49.9%) at 10 y after surgery(P<0.001). The number of anti-glaucoma medications dropped from 2.39±0.5 preoperatively to 0.47±0.8 at 5 y and 0.67±0.8 at 10 y postoperatively(P<0.001). The follow-up period was 104.5±37.0 mo. The qualified success rate for an IOP of 21, 18 or 16 mm Hg or less was 84% [95% confidence interval(CI): 0.80-0.88], 73%(95%CI: 0.68-0.78), and 59%(95%CI: 0.52-0.66) after 5 y, and 80%(95%CI: 0.76-0.84), 69%(95%CI: 0.64-0.74), 51%(95%CI: 0.44-0.58) after 10 y, respectively. There was a relationship between age, preoperative IOP and success rate(P<0.01, P<0.05). A total of 31 eyes(31.3%)in 31 patients underwent laser goniopuncture, decreasing the IOP from 22.9±4.3 mm Hg to 16.3±2.5 mm Hg(P<0.01). Neither blebitis nor endophthalmitis occurred.CONCLUSION: Modified viscocanalostomy could be performed to lower IOP, decrease multiple anti-glaucoma drops use as well. It's a safe procedure with less complications over 10 y in Chinese individuals with OAG. 展开更多
关键词 non-penetrating glaucoma surgery VISCOCANALOSTOMY Schlemm’s CANAL open angle glaucoma laser goniopuncture
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Comparison of phacotrabeculectomy and sequential surgery in the treatment of chronic angle-closure glaucoma coexisted with cataract 被引量:4
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作者 Hai-Jun Li Jie Xuan +1 位作者 Xiao-Min Zhu Lin Xie 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第5期687-692,共6页
AIM: To compare the safety and effectiveness of phacotrabeculectomy versus sequential surgery in chronic angle-closure glaucoma(CACG) with coexisting cataract.·METHODS: One hundred and sixty-two CACG patients... AIM: To compare the safety and effectiveness of phacotrabeculectomy versus sequential surgery in chronic angle-closure glaucoma(CACG) with coexisting cataract.·METHODS: One hundred and sixty-two CACG patients(162 eyes) were retrospectively analyzed. Of them, 87patients(87 eyes) in group A had underwent phacotrabeculectomy with intraocular lens(IOL)implantation, and 75 patients(75 eyes) in group B had underwent sequential surgery with IOL implanted. Best-corrected visual acuity(BCVA), intraocular pressure(IOP), complications and anterior chamber angle(ACA)were measured.· RESULTS: Demographic characteristics of the two groups were similar. A mean follow-up period was 15±6mo(range 13 to 24mo), a mean IOP of 12.14 ±5.32 mm Hg in group A and 11.38 ±4.06 mm Hg in group B(P =0.84) at the last follow up. The Kaplan-Meier analysis revealed that the cumulative probability of success in both groups was similar(P =0.61). Anterior uveitis and hypotony were the most common complications in group A, whereas group B experienced shallow anterior chamber with trabeculectomy. With the exception of anterior uveitis, no complications occurred to 11 trabeculectomized eyes. All postoperative measurements of anterior chamber showed statistically significant differences in each group according to the preoperative data(P〈 0.05). However,fewer changes occurred in group B than in group A.· CONCLUSION: Phacotrabeculectomy and sequential surgery exhibit similar IOP reduction, visual recovery,and complications when treating CACG patients with cataract. However, for a wider ACA, phacotrabeculectomy has demonstrated higher effectiveness than sequential surgery. 展开更多
关键词 CHRONIC angle-closure glaucoma PHACOTRABECULECTOMY sequential surgery anterior chamber angle
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Efficacy of non-penetrating trabecular surgery for open angle glaucoma: a meta-analysis 被引量:6
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作者 程金伟 马晓晔 魏锐利 《Chinese Medical Journal》 SCIE CAS CSCD 2004年第7期1006-1010,共5页
Background Non-penetrating trabecular surgery is a new filtrating surgery without opening in ternal trabecular structures. This study was to estimate the overall efficacy of non-penetrating trabecular surgery for ope... Background Non-penetrating trabecular surgery is a new filtrating surgery without opening in ternal trabecular structures. This study was to estimate the overall efficacy of non-penetrating trabecular surgery for open angle glaucoma.Methods The published articles selected for this study were obtained by a computerised Medline and China Biological Medicine Disk search of the literature and a manual search of the bibliographies of relevant articles. Articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using the statistical techniques of meta-analysis.Results A total of 37 articles were included in the meta-analysis. The pooled complete success rates of non-penetrating trabecular surgery with different techniques were: deep sclerectomy single, 69.7% (95% CI: 58.5%-81.0%); deep sclerectomy with collagen implant, 59.4% (95% CI: 47.0%-71.8%); deep sclerectomy with reticulated hyaluronic acid implant, 71.1% (95% CI: 56.8%-85.3%); and viscocanalostomy, 72.0% (95% CI: 57.6%-86.4%). The overall weighted complete success rate of non-penetrating trabecular surgery was 67.8% (95% CI: 61.4%-74.3%).Conclusions Non-penetrating trabecular surgery is the best available therapy method for medically uncontrolled open angle glaucoma with a complete success rate of over 60%. But the different techniques cannot belie the complete success rate of non-penetrating trabecular surgery. 展开更多
关键词 non-penetrating trabecular surgery open angle glaucoma intraocular pressure META-ANALYSIS
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XEN® Gel Implant for Glaucoma;Prospective Cohort Study in a High-Volume Department
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作者 Hans Wilhelm Meyer Tiril Sandell 《Open Journal of Ophthalmology》 2023年第2期208-220,共13页
Purpose: To evaluate the 3-year efficiency and safety of XEN<sup>®</sup> 45 gel stent implantation in a heterogenous group of open angle glaucoma patients. Methods: In this prospective, non-randomized... Purpose: To evaluate the 3-year efficiency and safety of XEN<sup>®</sup> 45 gel stent implantation in a heterogenous group of open angle glaucoma patients. Methods: In this prospective, non-randomized observational study we identified patients who had undergone either stand-alone XEN<sup>®</sup> implantation (XEN solo) or XEN<sup>®</sup> implantation in combination with phacoemulsification (XEN combi). All patients who had undergone an implantation during the period 01.04.17-31.10.19 at the Department of Ophthalmology, Drammen Hospital, Norway, were asked to participate. Success was defined as IOP between 5 - 18 mmHg and 20% pressure reduction without medications. Qualified success required the same pressure interval and reduction but allowed medications. The procedure was deemed as failure if pressure requirements were not met, vision was reduced to light perception or worse, or if there was a converion to secondary glaucoma surgery. Results: Out of 115 patients and 133 eyes identified, 87 patients and 99 eyes consented to participate. All patients were Caucasians with a mean age of 73.6 years. The study had a mean (range) follow-up of 38.9 (28 - 54) months. The mean medicated baseline (SD) was reduced from 22.6 (7.9) mmHg on 3.2 (1.1) medications to 14.2 (5.6) mmHg on 1.4 (1.6) medications. Success and qualified success were achieved in 22.2% and 21.2%, respectively. Needling was performed in 34 eyes. Conclusion: XEN<sup>®</sup> 45 gel stent implantation is a safe procedure, offering a significantly lower IOP and number of medications in a subset of patients with open angle glaucoma. 展开更多
关键词 Long Term Outcome after XEN® Gel Stent open angle glaucoma OAG Pseudoexfoliative glaucoma Minimally Invasive glaucoma Surgeries MIGS
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Ethylenediaminetetraacetic Acid Chelation for Band Keratopathy before Ab Interno Glaucoma Surgery
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作者 Tomoki Shirakami Yasuyuki Takai +1 位作者 Mihoko Mochiji Masaki Tanito 《Open Journal of Ophthalmology》 2019年第4期165-167,共3页
An 87-year-old woman with primary open-angle glaucoma presented to our hospital. Although the combined cataract and minimally invasive glaucoma surgeries (MIGS) were an appropriate surgical option, the presence of ban... An 87-year-old woman with primary open-angle glaucoma presented to our hospital. Although the combined cataract and minimally invasive glaucoma surgeries (MIGS) were an appropriate surgical option, the presence of band keratopathy made it difficult to perform ab interno glaucoma surgery in her right eye (OD);therefore, the corneal opacity was removed using ethylenediaminetetraacetic acid (EDTA) chelation procedure. One month after chelation, microhook ab interno trabeculotomy and cataract surgery were performed successfully. Clear intraoperative visualization of the angle structures is critical for the success of these MIGS procedures. In glaucomatous eyes that require MIGS, EDTA chelation is a good neoadjuvant therapy for coexisting band keratopathy. 展开更多
关键词 Microhook Ab Interno TRABECULOTOMY Minimally Invasive glaucoma surgery (MIGS) BAND KERATOPATHY Primary open-angle glaucoma Ethylene-Diamine-Tetra-Acetic Acid (EDTA) CHELATION
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XEN引流管植入联合丝裂霉素C治疗开角型青光眼
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作者 赵茹梦 崔慧玲 +2 位作者 任静 王迪 李海军 《国际眼科杂志》 CAS 2024年第6期965-969,共5页
目的:探讨XEN引流管植入联合丝裂霉素C(MMC)治疗开角型青光眼(OAG)的临床疗效和安全性。方法:回顾性纳入OAG患者37例37眼,按初始接受抗青光眼手术治疗与否分为初次青光眼手术组17例17眼,多次青光眼手术组20例20眼,记录各随访时间点眼压... 目的:探讨XEN引流管植入联合丝裂霉素C(MMC)治疗开角型青光眼(OAG)的临床疗效和安全性。方法:回顾性纳入OAG患者37例37眼,按初始接受抗青光眼手术治疗与否分为初次青光眼手术组17例17眼,多次青光眼手术组20例20眼,记录各随访时间点眼压、降眼压药物种类及并发症,术后随访时间大于1 a。结果:术后1 a,初次与多次青光眼手术组眼压分别从术前27.56±9.94、28.43±14.18 mmHg降至15.16±3.65、17.18±5.83 mmHg,分别下降55.01%和60.43%(t=4.863,P<0.001;t=3.255,P=0.004)。术后不同时间点两组眼压均较术前降低,时间有差异(F_(时间)=6.876,P_(时间)<0.001),组间及交互均无差异(F_(组间)=0.242,P_(组间)=0.626;F_(时间×组间)=0.959,P_(时间×组间)=0.458)。两组手术完全成功率分别为47%、45%,条件成功率为76%、75%(Z=-0.115,P=0.909),完全成功与条件成功累积生存率分析均无差异(χ^(2)=0.042,P=0.838;χ^(2)=0.004,P=0.949)。术后1 a随访时两组降眼压药物均由术前的3(2,3)种减少为1(0,2)种(Z=-3.289、-3.796,均P<0.001),组间无差异(Z=-0.581,P=0.561)。术后短期并发症以低眼压为主,前房出血次之,远期并发症以滤过泡包裹为主,除外引流管暴露及脱落各1眼,无其他严重并发症发生。结论:XEN引流管植入联合MMC治疗初次与多次青光眼手术OAG患眼均安全有效,但多次青光眼手术组滤过泡包裹发生率高。 展开更多
关键词 XEN引流管植入术 开角型青光眼 微创青光眼手术 丝裂霉素C
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XEN凝胶引流管植入治疗原发性开角型青光眼的初步疗效观察 被引量:1
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作者 胡甜 张虹 +2 位作者 王军明 王琳颢 成前悦 《华中科技大学学报(医学版)》 CAS CSCD 北大核心 2023年第3期351-355,共5页
目的初步评估XEN凝胶引流管植入术在原发性开角型青光眼(POAG)治疗中的有效性及安全性。方法回顾性分析2020年1月至2022年3月就诊于华中科技大学同济医学院附属同济医院的8例(10眼)进行了XEN凝胶引流管植入术的患者,其中男性6例(8眼),女... 目的初步评估XEN凝胶引流管植入术在原发性开角型青光眼(POAG)治疗中的有效性及安全性。方法回顾性分析2020年1月至2022年3月就诊于华中科技大学同济医学院附属同济医院的8例(10眼)进行了XEN凝胶引流管植入术的患者,其中男性6例(8眼),女性2例(2眼)。年龄分布24~41岁,平均(33.9±5.9)岁。比较手术前后各项指标的变化,包括视力、眼压、青光眼用药数量及术后并发症。结果8例患者均诊断为原发性开角型青光眼,平均随访时间为(13.0±3.9)个月。术前平均眼压为(24.7±6.2)mmHg,末次随访时平均眼压为(13.9±1.7)mmHg,较术前下降了43.7%。术前平均用药数量为3.1种,末次随访时为0.2种。4眼(40%)进行了滤过泡分离手术,其中1眼发生色素颗粒阻塞引流管出口,行滤过泡分离时清除阻塞物,房水顺利流出。截至末次随访,3眼获得手术完全成功,5眼获得部分成功,总成功率为80%。2眼术后发生前房积血,均在术后1个月内自行消退。其余患者未发生其他严重并发症。结论XEN凝胶引流管植入术是POAG的一种有效的外科治疗方法,在1年的随访中,患者眼压和青光眼用药数量显著降低。 展开更多
关键词 原发性开角型青光眼 XEN凝胶引流管 微创青光眼手术
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Intraocular pressure modifications in patients with acute central/hemicentral retinal vein occlusions 被引量:1
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作者 Dan Calugaru Mihai Calugaru 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2021年第6期931-935,共5页
Intraocular pressure(IOP)modifications in patients with acute central/hemicentral retinal vein occlusions(RVOs)consist in IOP reductions and increases.The IOP reduction is due to a transitional hyposecretory phase of ... Intraocular pressure(IOP)modifications in patients with acute central/hemicentral retinal vein occlusions(RVOs)consist in IOP reductions and increases.The IOP reduction is due to a transitional hyposecretory phase of the aqueous humor,that increases gradually until 3 mo after the venous occlusion onset,and then finally disappears after month 4 th.The IOP increases lead to the ocular hypertension and glaucoma.The possible pathogenetic correlations between ocular hypertension/glaucoma and acute central/hemicentral RVOs have been classified into three groups:1)the venous occlusion precedes the ocular hypertension/glaucoma causing neovascular glaucoma and secondary angle-closure glaucoma without rubeosis;2)the ocular hypertension and the glaucoma precede the venous occlusion and favor its appearance(ocular hypertension,primary angle-closure,primary angle-closure glaucoma,and open angle glaucomas);and 3)the venous occlusion and the ocular hypertension/glaucoma are mostly age dependent appearances due to common vascular and collagen alterations,lacking a causal connection between the 2 conditions. 展开更多
关键词 intraocular pressure acute central/hemicentral retinal vein occlusion neovascular glaucoma ocular hypertension primary angle-closure open angle glaucoma secondary nonrubeotic angle-closure glaucoma
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EX-PRESS青光眼引流器植入术治疗开角型青光眼 被引量:16
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作者 黄志坚 张文强 +1 位作者 周和政 曾波 《国际眼科杂志》 CAS 2014年第6期1148-1150,共3页
目的:EX-PRESS青光眼引流器植入术治疗开角型青光眼的临床疗效和安全性。方法:回顾经视力、眼压、房角镜、眼底、视野等检查确诊为开角型青光眼患者40例47眼。患者年龄6~73(平均39.9±16.5)岁,最佳矫正视力0.01~0.60,眼压18... 目的:EX-PRESS青光眼引流器植入术治疗开角型青光眼的临床疗效和安全性。方法:回顾经视力、眼压、房角镜、眼底、视野等检查确诊为开角型青光眼患者40例47眼。患者年龄6~73(平均39.9±16.5)岁,最佳矫正视力0.01~0.60,眼压18~65mmHg。给予3种以上降眼压药物控制不理想,行EX-PRESS青光眼引流器植入术。术后1,3d; 1wk进行眼压、裂隙灯检查。比较治疗前后最佳矫正视力、眼压的临床资料,观察其疗效及安全性。结果:术前平均视力0.26±0.29,术后1wk平均视力0.24±0.22,平均视力稍有下降,但无统计学意义(t=1.56,P=0.13)。术前平均眼压36.62±14.01mmHg,术后1,3d; 1wk平均眼压分别为10.04±5.77,9.59±4.93,9.47±3.06mmHg。EX-PRESS青光眼引流器植入术后1,3d; 1wk的眼压均较治疗前明显降低(F=157.20,P〈0.05)。除5眼术后1d眼压〈5mmHg,所有患者在治疗过程中及术后1wk均未见明显眼部或全身不良反应。结论:EX-PRESS青光眼引流器植入术治疗开角型青光眼是安全有效的,术中及术后风险低、并发症少。 展开更多
关键词 EX-PRESS青光眼引流器 手术 开角型青光眼 眼压
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P50型与P200型Ex-PRESS引流器植入术对开角型青光眼疗效及安全性的随机对照研究 被引量:13
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作者 韩光杰 周和政 +2 位作者 张文强 江文珊 刘川 《中华实验眼科杂志》 CAS CSCD 北大核心 2015年第3期246-249,共4页
背景 目前国外对Ex-PRESS引流器植入术治疗开角性青光眼的临床应用效果已有报道,在中国临床上使用的Ex-PRESS引流器有内径分别为50μm和200μm的P50型和P200型,但2种类型引流器的临床效果是否有所不同,目前国内外报道较少. 目的 对比观... 背景 目前国外对Ex-PRESS引流器植入术治疗开角性青光眼的临床应用效果已有报道,在中国临床上使用的Ex-PRESS引流器有内径分别为50μm和200μm的P50型和P200型,但2种类型引流器的临床效果是否有所不同,目前国内外报道较少. 目的 对比观察P50型与P200型Ex-PRESS引流器植入术治疗开角型青光眼的早期临床疗效和安全性. 方法 采用随机对照临床研究设计,纳入2012年3月至2013年4月在广州军区武汉总医院行Ex-PRESS引流器植入术的开角型青光眼患者69例80眼,采用随机数字表法将患者分为基线特征匹配的2个组,分别实施P50型Ex-PRESS引流器植入术(35例40眼)和Ex-PRESS引流器植入术(34例40眼),比较2个组患者的病种构成比、最佳矫正视力恢复时间、理论住院天数、手术前后的眼压变化及并发症的发生情况.结果 P50组和P200组术眼手术前后眼压平均下降幅度分别为(21.19±11.22)和(24.35±12.27)mmHg(1 mmHg=0.133 kPa),差异无统计学意义(t=-1.201,P>0.05).P50组患者的理论住院天数和最佳矫正视力恢复时间分别为(3.65±0.92)d和(2.85±0.95)d,明显少于P200组的(4.90±0.81)d和(3.40±0.96)d,差异均有统计学意义(t=-6.444,P<0.01;t=-2.584,P<0.05).P50组和P200组术眼术后并发症发生率分别为6.06%和25.00%,差异有统计学意义(x2=9.800,P<0.05),P50组术眼发生低眼压和浅前房的跟数少于P200组.结论 P50型和P200型Ex-PRESS引流器植入术对开角性青光眼的降眼压作用接近,与P200型Ex-PRESS引流器植入术比较,P50型Ex-PRESS引流器植入后早期患者的视力恢复快,并发症的发生率低. 展开更多
关键词 开角型青光眼/手术 青光眼引流植入物 微型化 眼压 治疗效果 术后并发症 Ex-PRESS引流器 随机对照研究
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非穿透性青光眼手术治疗开角型青光眼有效性的系统评价 被引量:5
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作者 高连娣 葛轶睿 +3 位作者 程金伟 沈亚 王浩 魏锐利 《第二军医大学学报》 CAS CSCD 北大核心 2014年第2期129-135,共7页
目的评估非穿透性青光眼手术(NPGS)治疗开角型青光眼患者的降眼压(IOP)效果。方法全面收集评价NPGS治疗原发性/继发性开角型青光眼的随机对照试验,进行系统评价。主要疗效指标包括IOP下降百分比和IOP达标率。应用多功能meta分析软件2.0... 目的评估非穿透性青光眼手术(NPGS)治疗开角型青光眼患者的降眼压(IOP)效果。方法全面收集评价NPGS治疗原发性/继发性开角型青光眼的随机对照试验,进行系统评价。主要疗效指标包括IOP下降百分比和IOP达标率。应用多功能meta分析软件2.0版的随机效应模型进行汇总分析,计算合并评价量。结果术后2年,与小梁切除术(TE)相比,深层巩膜切开术(DS)、黏小管切开术(VCO)的降眼压作用均相对较低,IOP下降百分比分别为35.2%(DS)、30.2%(VCO)、45.6%(TE)。术中加用植入物及丝裂霉素C(MMC)均可提高DS的降眼压作用,术后2年的IOP下降百分比分别为41.1%和41.7%。术后4年,DS、VCO、TE的IOP达标率分别为35.4%、22.7%、47.6%;DS加用植入物和MMC的IOP达标率分别为64.6%、52.1%,高于单纯DS。NPGS并发症的发生率较TE低。结论常用的NPGS(DS和VCO)能有效降低眼压,并发症也比TE少,但是NPGS的降眼压作用要比TE为低。术中加用植入物、MMC可提高DS的降眼压作用。 展开更多
关键词 开角型青光眼 非穿透性青光眼手术 眼压 META分析
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非穿透性小梁手术联合透明质酸钠生物胶植入术治疗开角型青光眼 被引量:13
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作者 郭燕 夏晓波 +4 位作者 江海波 王平宝 黄佩刚 刘双珍 许雪亮 《国际眼科杂志》 CAS 2006年第1期92-96,共5页
目的:探讨非穿透性小梁手术(nonperforatingtra-becularsurgery,NPTS)联合透明质酸钠生物胶植入术的临床疗效。方法:对34例(48眼)开角型青光眼的患者实施NPTS联合透明质酸钠生物胶植入术。术后观察视力、眼压、滤过泡、前房反应、前房... 目的:探讨非穿透性小梁手术(nonperforatingtra-becularsurgery,NPTS)联合透明质酸钠生物胶植入术的临床疗效。方法:对34例(48眼)开角型青光眼的患者实施NPTS联合透明质酸钠生物胶植入术。术后观察视力、眼压、滤过泡、前房反应、前房形成情况及并发症。结果:术后随访3~22(平均8.2±4.1)mo。术前平均眼压(34.18±13.30)mmHg(1mmHg=0.133kPa),术后(7.71±2.69)mmHg;差异有显著性t=14.710,P<0.001。术前平均用药(2.77±0.77)种,术后(0.71±1.05)种,差异有显著性t=4.616,P<0.001。随访期间眼压≤21mmHg者46眼(96%),其中27眼(59%)不用抗青光眼药物,19眼(41%)加用抗青光眼药物。术后24眼无任何反应;10眼前房有轻度闪辉,术后2~5d消失;8眼有少量前房积血,积血均于2~4d消失。6眼出现低眼压性黄斑水肿(22%),均于术后随着眼压的回升而消失。术后均无浅前房、睫状体或脉络膜脱离等并发症发生。所有患者术后均形成显著弥散滤过泡。其中42眼I型滤过泡,6眼II型滤过泡。术后6mo复查32眼I型滤过泡,11眼II型滤过泡,1眼III型滤过泡。结论:NPTS联合透明质酸钠生物胶植入术,可有效降低眼压,并减少抗青光眼药物的应用,术后并发症少,术后远期疗效尚可,为一种治疗开角型青光眼的有效方法。 展开更多
关键词 青光眼 开角型 非穿透性小梁手术 透明质酸钠生物胶
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非穿透小梁手术和小梁切除手术治疗开角型青光眼临床效果比较 被引量:8
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作者 艾华 杨新光 +3 位作者 王润生 田冰玉 薛晓辉 郭斌 《国际眼科杂志》 CAS 2006年第5期1072-1074,共3页
目的:对比分析非穿透小梁手术和小梁切除手术治疗开角型青光眼的临床疗效。方法:原发性开角型青光眼196例222眼,其中小梁切除术197眼,非穿透小梁手术25眼,术后观察视力、眼压、滤过泡、前房深度、前房出血、前房反应以及视野等情况,随... 目的:对比分析非穿透小梁手术和小梁切除手术治疗开角型青光眼的临床疗效。方法:原发性开角型青光眼196例222眼,其中小梁切除术197眼,非穿透小梁手术25眼,术后观察视力、眼压、滤过泡、前房深度、前房出血、前房反应以及视野等情况,随访时间1d~24(平均10.6)mo。结果:小梁切除术患者术前、术后3,7d;1,6,12和24mo眼压分别为27.61±6.59,10.49±6.22,12.37±7.51,14.37±4.22,13.66±5.78,18.91±7.32和17.53±4.11mmHg,非穿透小梁手术术前、术后3,7d;1,6,12和24mo眼压分别为25.17±8.31,13.66±5.92,15.22±3.60,16.08±6.39,16.16±4.57,17.63±5.91和16.87±6.27mmHg。两种手术后眼压均明显降低,在术后3d~6mo小梁切除手术后眼压低于非穿透小梁手术后眼压(P<0.05),术后12mo以上,二者眼压比较无明显差异(P>0.05)。患者小梁切除术后随访7d;1,6,12和24mo滤过泡维持比例为195/197,113/152,60/137,47/62和33/46,而非穿透小梁手术的比例分别为25/25,17/23,12/19,5/9和5/9。术后常见并发症包括浅前房、脉络膜脱离、低眼压、前房出血、葡萄膜炎和恶性青光眼,小梁切除术后发生率为18%,2%、40%,24%和1%,非穿透小梁手术后发生率分别为4%,0%,28%,4%和0%。结论:非穿透小梁手术和小梁切除手术均是治疗开角型青光眼有效方法,前者术后并发症较少,后者术后短期眼压控制较理想。 展开更多
关键词 非穿透小梁手术 小梁切除手术 开角型青光眼 并发症
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选择性激光小梁成形术治疗原发性开角型青光眼有效性和安全性的多中心临床研究 被引量:20
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作者 葛坚 孙兴怀 +2 位作者 林丁 赵平 吴作红 《中华实验眼科杂志》 CAS CSCD 北大核心 2014年第2期159-162,共4页
背景选择性激光小梁成形术(SLT)已被美国FDA批准应用于临床并已成为原发性开角型青光眼(POAG)治疗的一线选择,中国目前已有关于其疗效的评价,但国内的研究结果均为单中心临床研究,所用的治疗参数不统一,治疗效果也存在争议,尚... 背景选择性激光小梁成形术(SLT)已被美国FDA批准应用于临床并已成为原发性开角型青光眼(POAG)治疗的一线选择,中国目前已有关于其疗效的评价,但国内的研究结果均为单中心临床研究,所用的治疗参数不统一,治疗效果也存在争议,尚缺乏SLT对中国POAG患者治疗的多中心临床研究评估结果。目的观察SLT治疗中国POAG患者的安全性和有效性。方法采用前瞻性、多中心、自身对照临床研究设计。对纳入的年龄≥18岁的POAG患者62例62眼采用LumenisSelecta Duet或Lumenis Selecta II激光治疗仪进行360°房角标准化SLT治疗,共100个激光脉冲,即每个象限激发25个点,预置脉冲时间为3ns,光斑大小为400μm,治疗能量以下方小梁为标准,从0.6mJ开始,调整激光能量至见气泡出现,在该能量基础上降低0.1mJ。激光治疗后1h、1d、2周、4周、3个月、6个月时进行随访,疗效观察指标包括眼压、眼压降低值、眼压降低20%和30%的患眼眼数及百分比;安全性观察指标包括出现结膜充血、前房闪辉等局部不良反应的眼数。结果患者SLT术前基线眼压为(25.7±2.6)mmHg(1mmHg=0.133kPa),术后1d、2周、4周、3个月、6个月眼压均明显下降,差异均有统计学意义(P〈0.001),术后1d眼压最低,为(16.5±4.5)mmHg;术后4周~6个月眼压趋于稳定。SLT术后1d~6个月眼压下降值平均为5.3~9.2mmHg。眼压下降20%的眼数术后ld最多,占83.9%,眼压降低30%者占58.1%;术后2周~6个月,眼压下降20%和30%的眼数趋于稳定,术后6个月眼压降低20%的眼数占56.5%,降低30%的术眼占27.4%。结论SLT对于中国POAG患者的治疗是安全、有效的。 展开更多
关键词 青光眼 原发性开角型 手术 眼压 生理功能 激光 选择性激光小梁成形术 方法 安全性 有效性 多中心临床研究
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