Comparative efficacy of oral glucose solution versus non-nutritive sucking for pain relief in neonates during nociceptive procedures： a systematic review

Background and aims： The comparative efficacy of glucose solution （GS） versus non-nutritive sucking （NNS） for pain re- lief in neonate remains controversial. This systematic review was consequently performed to objectively investigate the analgesic effect of Oral GS related to NNS in newborns during nociceptive procedures. Methods： All potential records were searched in PubMed, Web of Science, EMBASE, and the Cochrane Library to capture the randomized controlled trials comparing GS with NNS in terms of pain scores in neonates through January 2017. Two independent investigators screened the identified articles, extracted the data, and assessed the methodological quality of the included studies. All statistical analyses were completed by using Review Manager （RevMan） version 5.3.0. Results： Four studies, involving 248 neonates, were incorporated into these statistical analyses. For reducing pain scores, no statistical difference was detected when GS compared to NNS （4 trials; mean difference [MD], 0.75; 95% confidence interval [CI], -0.77 to 2.27; P = 0.33）. Conclusion： Both the GS and NNS reduced the pain scores in neonates who undergoing Hepatitis B vaccination and venipuncture, but the NNS is more convenience than GS to some extent. Considered the limited evidences, more randomized controlled trials with high-quality, large-scale and appropriate measures time are warranted to further establish the comparative efficacy of these two options.

Process development for producing a food-grade glucose solution from rice straws

In this paper, processes for producing a food-grade glucose solution through enzymatic hydrolysis of celluloserich solids obtained from rice straws are presented. The rice straws were pretreated by acid-catalyzed steam explosion, and the reaction efficiency, toxicity control, and process economic feasibility were studied. Mass transfer resistance to the hydrolysis reaction was reduced by grinding with glass beads. A higher glucose concentration could be obtained by feeding more cellulose in the hydrolysis reaction; however, this also resulted in the production of undesired byproducts. Thus, a soaking process for the cellulose solids in water was developed to effectively reduce the generation of byproducts in the hydrolysis reaction. The resulting food-grade glucose solution can provide 414 kilocalories per liter, and could be used during a food-shortage crisis in the future.The current production cost is estimated to be 0.82 USD·L^(-1).

N-butyl-2-cyanoacrylate, iso-amyl-2-cyanoacrylate and hypertonic glucose with 72% chromated glycerin in gastric varices

cyanoacrylate and a mixture of 72% chromated glycerinwith hypertonic glucose solution in management ofgastric varices.METHODS： Ninety patients with gastric varicespresented to Endoscopy Unit of Ain Shams UniversityHospital were included. They were randomly allocatedinto three groups; each group included 30 patients treatedwith intravariceal sclerosant injections in biweeklysessions till complete obturation of gastric varices;Group I （n-butyl-2-cyanoacrylate; Histoacryl？）, GroupII （iso-amyl-2-cyanoacrylate; Amcrylate？） and GroupIII （mixture of 72% chromated glycerin; Scleremo？with glucose solution 25%）. All the procedures wereperformed electively without active bleeding. Recruitedpatients were followed up for 3 mo.RESULTS： 26% of Scleremo group had bleeding duringpuncture vs 3.3% in each of the other two groups withsignificant difference, （P 〈 0.05）. None of Scleremogroup had needle obstruction vs 13.3% in each of theother two groups with no significant difference, （P 〉0.05）. Rebleeding occurred in 13.3% of Histoacryl andAmcrylate groups vs 0% in Scleremo group with nosignificant difference. The in hospital mortality was 6.6%in both Histoacryl and Amcrylate groups, while it was0% in Scleremo group with no significant difference. Inthe first and second sessions, the amount of Scleremoneeded for obturation was significantly high, while the amount of Histoacryl was significantly low. Scleremo was the less costly of the two treatments. CONCLUSION： All used sclerosant substances showed efficacy and success in management of gastric varices with no significant differences except in total amount,cost and bleeding during puncture.

Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress

BACKGROUND：Liver ischemia reperfusion（IR）injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver surgery.Pentoxifylline（PTX）and hypertonic saline solution（HTS）have been identified to have beneficial effects against IR injury.This study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR injury.METHODS： Male Wistar rats were allocated into three groups. Control rats underwent 60 minutes of partial liver ischemia, HTS rats were treated with 0.4 mL/kg of intravenous 7.5% NaCl 15 minutes before reperfusion, and HPTX group were treated with 7.5% NaC1 plus 25 mg/kg of PTX 15 minutes before reperfusion. Samples were collected after reperfusion for determination of ALT, AST, TNF-α, IL-6, IL-10, mitochondrial respiration, lipid peroxidation, pulmonary permeability and myeloperoxidase. RESULTS： HPTX significantly decreased TNF-α 30 minutes after reperfusion. HPTX and HTS significantly decreased ALT,AST, IL-6, mitochondrial dysfunction and pulmonary myelo- peroxidase 4 hours after reperfusion. Compared with HTS only, HPTX significantly decreased hepatic oxidative stress 4 hours after reperfusion and pulmonary permeability 4 and 12 hours after reperfusion. CONCLUSION： This study showed that PTX added the beneficial effects of HTS on liver IR injury through decreases of hepatic oxidative stress and pulmonary permeability.

Application of Ji Desheng Snake Pills Combined with Hypertonic Glucose External Application in Treating Drug-Induced Superficial Phlebitis Caused by Parenteral Nutrition

Objective: The efficacy of Ji Desheng snake pills combined with hypertonic glucose external application in treating drug-induced superficial phlebitis caused by parenteral nutrition (PN) is observed. Methods: Fifty-two cases of drug-induced superficial phlebitis after peripheral parenteral nutrition (PPN) were selected, which were randomly divided into experimental group and control group in accordance with the phlebitis grading. In the experimental group, Ji Desheng snake pills were crushed to make a paste with 50% glucose solution, which was then applied to the affected area of phlebitis, the surface was covered with clean gauze, and properly fixed with tape or bandage. The drug was replaced once a day. In the control group, the gauze soaked with 50% magnesium sulfate solution was used, which was applied to the affected part three times a day in wet, and the efficacy was observed respectively on the 1st, 3rd, 5th and 7th days after applying the drug. Results: On the 1st and 3rd days after treatment, the observed effective rate of the experimental group was higher than that of the control group (42.31% vs. 15.38% and 76.92% vs. 46.15%, respectively). The difference was statistically significant (p th and 7th days after treatment, there was no statistical significance with respect to the efficacy between the experimental group and the control group (p > 0.05). Conclusion: The significant efficacy could be found in early stage after drug-induced superficial phlebitis was treated by Ji Desheng snake pills combined with hypertonic glucose external application, which was superior to that of the traditional treatment of wet application by using gauze soaked in 50% magnesium sulfate solution.

Ji Desheng Snake Pills Combined with Hypertonic Glucose External Application in the Treatment of Stage III and IV Pressure Injuries

Background: As a common surgical disease, pressure injury has become a long-standing problem in clinical treatment and nursing process. This research was conducted to explore the feasibility of Ji Desheng Snake Pills combined with hypertonic glucose external application in the treatment of stage III and IV pressure injuries. Methods: Patients with stage III and IV pressure injuries, who received treatment in our hospital between December 2018 and December 2019 were selected and divided into experimental group, conventional treatment group, and control group, 30 cases for each. The three groups received Ji Desheng Snake Pills combined with hypertonic glucose external application, moist dressing external application and surgical dressing change, respectively. The safety, therapeutic effect and cost benefit of the three treatment methods were compared. Results: There were no adverse reactions in the three groups of patients. The PUSH scores of the experimental group and the conventional treatment group were significantly lower than that of the control group on the 14th, 21th, and 28th days, and the result was statistically significant (p < 0.05), while there was no significant difference between the experimental group and the conventional treatment group (p > 0.05). The wound healing rates of the experimental group (70.14 ± 8.27%) and the conventional treatment group (73.99 ± 7.15%) were significantly higher than that of the control group (43.25 ± 8.53%) on the 28th day, with statistical significance (p < 0.05);there was no significant difference between the experimental group and the conventional treatment group (p > 0.05). The total treatment costs of the three groups were 569.73 ± 78.12 yuan, 1043.40 ± 135.31 yuan, and 186.47 ± 30.29 yuan. The cost of the conventional treatment group was the highest, followed by the experimental group, and the control group was the lowest. The result was statistically significant (p < 0.05). Conclusion: In the treatment of stage III and IV pressure injuries, there was no significant difference in the safety and therapeutic effect between the experimental group (Ji Desheng Snake Pills combined with hypertonic glucose external application) and the conventional treatment group (moist dressing external application), but the experimental group had better cost benefit.

RADIOFREQUENCY ABLATION USING HYPERTONIC SALINE SOLUTION INSTILLATION: AN EX VIVO STUDY

Objective To determine whether radiofrequency ablation using hypertonic saline solution instillation can increase the extent of thermally mediated coagulation in ex vivo pig liver tissue. Methods Fifty-six radiofrequency ablation lesions were produced in fresh ex vivo pig’s liver. According to different saline solutions, the lesions were divided into six groups: 25% acetic acid, 18% NaCl, 10% NaCl, 5% NaCl, 0.9% NaCl, and distilled water. After radiofrequency ablation, the lesions size and morphology were measured and compared.Results Using different instillation, the volume of coagulation necrosis was different: 25% acetic acid >18% NaCl >10% NaCl >5% NaCl >0.9% NaCl>distilled water. Conclusion Radiofrequency ablation using hypertonic saline solution instillation can increase the volume of radiofrequency ablation induced necrosis.

Variable change in renal function by hypertonic saline

AIM: To investigate the effects of hypertonic saline in the neurocritical care population.METHODS: We retrospectively reviewed our hospital's use of hypertonic saline(HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change(Cr), and HS formulation(3% Na Cl, 3% Na Cl/sodium acetate mix, and 23.4% Na Cl) to patients receiving normal saline or lactated ringers. The patients(n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data. RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation Ⅱ scores and GlasgowComa Scale scores occurred between different saline formulations. No significant correlation of Cl- or Na+ with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury(TBI) patients demonstrated moderate correlation between Na+ and Cr of 0.45. Stroke patients demonstrated weak correlations between Na+ and Cr, and Cl- and Cr(0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl- and Cr at 0.29.CONCLUSION: Cr directly correlates with Na+ or Cl- in stroke, Na+ in TBI, and Cl- in other populations. Prospective comparison of HS and renal function is needed.

Effect of hypertonic saline solution on the left ventricular functions of isolated hearts from burned rats

Objective: To study the effect of hypertonic saline solution on the left ventricular functions of isolated hearts from burned rats. Methods: Thirty six Wistar rats were used and divided into 4 groups: (1) normal hearts perfused with isotonic Krebs Henseleit solution; (2) normal hearts perfused with Krebs Henseleit solution which contained 215 mmol/L Na +; (3) hearts of rats suffered from 25% TBSA third degree burn and perfused with isotonic Krebs Henseleit solution; (4) hearts of the burned rats perfused with Krebs Henseleit solution which contained 215 mmol/L Na +. The systolic and diastolic functions of the left ventricle were observed.Results: During perfusion, there were very short periods of decrease in heart systolic and diastolic functions at first, but they recovered very soon and even became stronger than normal both in the normal and burned rats. The systolic and diastolic functions of the hearts increased very significantly when the perfusion solution was changed to isotonic solution from the hypertonic solutions. The effect of the hypertonic saline solution on the ventricular systolic and diastolic improvements was stronger in the hearts of the burned rats than that in the normal hearts. Conclusions: Hypertonic saline solution can directly affect myocardium and significantly improve the ventricular systolic and diastolic functions, especially in the hearts of the burned rats.

Effect of hypertonic saline resuscitation on heme oxygenase-1 mRNA expression and apoptosis of the intestinal mucosa in a rat model of hemorrhagic shock

Background Massive blood loss due to trauma is the leading cause of death in trauma patients and military combatants. The fluid category of resuscitation for hypotensive trauma patients is open to debate. This study was conducted to investigate the early effects of hypertonic and isotonic saline solutions on heme oxygenase-1 （HO-1） mRNA expression and apoptosis in the intestinal mucosa of rats with hemorrhagic shock. Methods A model of severe hemorrhagic shock was established in 21 Sprague-Dawley rats. The rats were randomly divided into sham, normal saline resuscitation （NS）, and hypertonic saline resuscitation （HTS） groups, with 7 in each group. We assessed and compared the HO-1 mRNA expression and apoptosis in the small intestinal mucosa of rats after hemorrhagic shock and resuscitation using the SYBR Green I fluorescence quantitative reverse transcriptase polymerase chain reaction, fluorescein-iso-thiocyanate-annexin V/propidium iodide double staining, and flow cytometry. Results In the early stage of hemorrhagic shock and resuscitation, marked apoptosis occurred in the small intestinal mucosa from both the NS and HTS groups. The apoptotic rate in the NS group was higher than that in the HTS group （P 〈0.01）. Among the three groups, HO-1 mRNA mucosa from the HTS group had the highest level of expression; however, the differences were not significant. There was a significant negative correlation between HO-1 mRNA expression and apoptosis in the small intestinal mucosa from the NS and HTS groups after hemorrhagic shock and resuscitation. Conclusions In this rat model of severe hemorrhagic shock, HTS resuscitation with a small volume is more effective than NS resuscitation in reducing apoptosis of the intestinal mucosa. Further, HO-1 mRNA over-expression in the intestinal mucosa may be one of the molecular mechanisms of HTS in the resuscitation of hemorrhagic shock.

Hypertonic saline resuscitation maintains a more balanced profile of T-lymphocyte subpopulations in a rat model of hemorrhagic shock

Objective: To investigate the potential and early effect of hypertonic saline resuscitation on T-lymphocyte sub- populations in rats with hemorrhagic shock. Methods: A model of rat with severe hemorrhagic shock was established in 18 Sprague-Dawley (SD) rats. The rats were randomly divided into Sham group, HTS group (hypertonic saline resuscitation group) and NS group (normal saline resuscitation group). Each group contained 6 rats. The CD4+ and CD8+ subpopulations of T-lymphocytes in peripheral blood were detected respectively before shock and after resuscitation by double antibody labelling and flow cytometry. Results: In the early stage after hemorrhagic shock, fluid resuscitation and emergency treatment, the CD4+ lymphocytes of peripheral blood in HTS and NS groups markedly increased. Small volume resuscitation with HTS also induced peripheral CD8+ lymphocytes to a certain extent, whereas NS resuscitation showed no effect in this respect. Consequently, compared with Sham and HTS groups, CD4+/CD8+ ratio of peripheral blood in NS group was obviously increased, and showed statistically differences. Conclusion: In this model of rat with severe hemorrhagic shock, small volume resuscitation with HTS is more effective than NS in reducing immunologic disorders and promoting a more balanced profile of T-lymphocyte subpopula- tions regulating network.

Hypertonic saline resuscitation reduces apoptosis of intestinal mucosa in a rat model of hemorrhagic shock

Objective: To investigate the early effects of hypertonic and isotonic saline solutions on apoptosis of intestinal mucosa in rats with hemorrhagic shock. Methods: A model of rat with severe hemorrhagic shock was established in 21 Sprague-Dawley (SD) rats. The rats were randomly divided into the sham group, normal saline resuscitation (NS) group, and hypertonic saline resuscitation (HTS) group, with 7 in each group. We detected and compared the apoptosis in small intestinal mucosa of rats after hemorrhagic shock and resuscitation by terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL), FITC (fluo- rescein-iso-thiocyanate)-Annexin V/PI (propidium iodide) double staining method, and flow cytometry. Results: In the early stage of hemorrhagic shock and resuscitation, marked apoptosis of small intestinal mucosa in the rats of both NS and HTS groups was observed. The numbers of apoptotic cells in these two groups were significantly greater than that in the sham group (P<0.01). In the HTS group, the apoptic cells significantly decreased, compared with the NS group (P<0.01). Conclusion: In this rat model of severe hemorrhagic shock, the HTS resuscitation of small volume is more effective than the NS resuscitation in reducing apoptosis of intestinal mucosa in rats, which may improve the prognosis of trauma.

Mathematical Model for Diabetes Mellitus with Impulsive Injections of Glucose-insulin

Impulsive injections of glucose and insulin analogues are very important strategies for the control of diabetes mellitus. We mainly imitate diabetes patients take insulin before eating, and eating approximately as a pulse blood glucose injection, as a result, a new mathematical model with impulsive injections of both glucose and insulin at different fixed times is formulated in this paper. Using the discrete dynamical system determined by the stroboscopic map, we show that the existence and uniqueness of a positive globally asymptotically stable periodic solution for type I diabetes. By impulsive comparison theorem, we obtain the glucose concentration level of the system is uniformly bounded above and below for type Ⅱ diabetes. Numerical analysis verifies our theoretical results.

腹腔镜术前口服高糖溶液对结直肠癌患者的影响

目的探讨结直肠癌患者腹腔镜术前口服高糖溶液对术后胃肠功能、炎症水平及胰岛素抵抗的影响。方法选择2020年5月至2022年7月南京中医药大学附属连云港市中医院收治的78例结直肠癌患者为研究对象,利用随机数字表法将其分为两组,观察组39例,对照组39例。观察组男20例、女19例,年龄38~75(56.65±8.43)岁,Dukes分期:Ⅰ期21例,Ⅱ期18例;对照组男19例、女20例,年龄39~74(55.79±8.39)岁,Dukes分期:Ⅰ期22例,Ⅱ期17例。对照组采用常规治疗,观察组术前采用高糖溶液口服。比较两组患者的术后胃肠功能、炎症水平、胰岛素抵抗指数及并发症情况。采用独立样本t检验、配对t检验和χ^(2)检验。结果治疗后,观察组术后肛门排气时间、术后首次排便时间、住院时间分别为(23.97±2.85)h、(14.35±5.43)h、(5.69±0.87)d,均短于对照组(34.68±3.94)h、(21.06±7.47)h、(9.52±1.14)d,差异均有统计学意义(均P<0.05);治疗后,观察组患者肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平分别是(141.85±30.29)ng/L、(8.69±2.05)mg/L、(7.34±0.93)ng/L,均低于对照组(182.46±33.37)ng/L、(15.33±2.78)mg/L、(9.97±1.54)ng/L,差异均有统计学意义(均P<0.05);治疗后,观察组胰岛素抵抗指数(5.14±0.31),低于对照组(7.75±0.96),差异有统计学意义(P<0.05);治疗后,观察组并发症总发生率为10.25%(4/39),低于对照组的28.21%(11/39),差异有统计学意义(P<0.05)。结论腹腔镜术前口服高糖溶液能有效改善结直肠癌患者术后的胃肠功能,降低患者炎症水平,改善患者胰岛素抵抗,降低并发症发生率,值得推广。

应用于葡萄糖溶液检测的人工电磁超表面结构设计

提出了一种用于葡萄糖浓度检测的电磁近场聚焦人工超表面结构。经人工超表面反射的电磁波近场聚焦位置对介电常数具有高敏感性,据此能够对不同浓度的葡萄糖溶液进行检测。该结构尺寸为400 mm×400 mm×1 mm,由20×20个具有不同电磁波反射相位差的异构人工超表面单元组成。为验证设计的可行性,对不同浓度值的葡萄糖溶液进行了实验测试,结果表明:葡萄糖浓度值的改变将导致溶液相对介电常数的改变,进而对聚焦位置产生显著的影响,溶液相对介电常数变化的检测灵敏度为0.027%。

4种糖类对西瓜嫁接苗生长及砧木萌蘖的影响

用D-核糖、山梨糖、葡萄糖、蔗糖4种糖溶液,在嫁接后10 d对葫芦砧西瓜嫁接苗均匀喷雾,研究4种糖溶液对嫁接苗生长及葫芦侧芽萌蘖的抑制效果。结果表明:4种糖溶液喷雾处理均能显著降低砧木侧芽萌发率和平均叶面积;在处理后14、28 d,葡萄糖处理的接穗株高、叶绿素含量均最高,D-核糖处理与对照无显著性差异,山梨糖处理效果最差。用葡萄糖溶液对葫芦砧西瓜嫁接苗喷雾,不仅能抑制砧木侧芽萌蘖,也能促进嫁接苗生长。

急诊外科中静脉快速滴注高渗盐液对脑外伤并休克患者预后的影响

目的探讨急诊外科中静脉快速滴注高渗盐液对脑外伤并休克患者预后的影响。方法选取2020年10月至2023年10月我院急诊外科收治的84例脑外伤并休克患者为研究对象,以随机数字表法将其分为观察组(n=42,静脉快速滴注高渗盐液)和对照组(n=42,甘露醇+碳酸氢钠注射液)。比较两组的生命体征、格拉斯哥昏迷评分(GCS)、美国国立卫生研究院卒中量表(NIHSS)、简易智力状态检查量表(MMSE)评分及临床疗效。结果治疗30 min后、治疗2 h后,观察组的呼吸频率、心率(HR)、尿量优于对照组(P<0.05)。治疗1周后,观察组的GCS、MMSE评分高于对照组,NIHSS评分低于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。结论静脉快速滴注高渗盐液能有效促进脑外伤并休克患者的生命体征改善和神经功能恢复。

超声引导下高渗葡萄糖注射对于距腓前韧带慢性损伤的疗效研究

目的 研究超声引导下高渗葡萄糖注射对于距腓前韧带慢性损伤患者的治疗效果,为临床保守治疗距腓前韧带慢性损伤提供相关经验。方法选取单侧踝关节扭伤慢性疼痛患者60例,将患者随机分为A组、B组,A组注射高渗葡萄糖治疗,B组行超短波联合肌内效贴布治疗,分别评估患者治疗前与治疗后1、3个月和6个月的距腓前韧带超声表现、视觉模拟评分(Visual Analogue Scale,VAS)和美国足踝外科医师协会(American Orthopedic Foot and Ankle Society,AOFAS)后足评分。结果 2组治疗期间VAS评分结果显示,时间效应、组间效应和交互作用差异均有统计学意义(F组别=34.276,F时间=369.061,F交互=23.759,P均<0.001)。2组治疗期间AOFAS评分结果显示,时间效应、组间效应和交互作用差异均有统计学意义(F组别=97.236,F时间=322.951,F交互=11.175,P均<0.001)。A组治疗后1、3个月和6个月的VAS评分均较前改善,差异具有统计学意义(P均<0.001);A组治疗后1、3个月和6个月的AOFAS评分均较前改善,差异具有统计学意义(P均<0.001);B组治疗后1、3个月和6个月的VAS评分均较前改善,差异具有统计学意义(P均<0.001);B组治疗后1、3个月和6个月的AOFAS评分均较前改善,差异具有统计学意义(P均<0.001);治疗后1个月、3个月、6个月,A组VAS分数均比B组低,且差异有统计学意义(P=0.010、<0.001、<0.001);治疗后1、3个月和6个月,A组AOFAS分数均比B组高,且差异有统计学意义(P均<0.001)。结论 对于距腓前韧带慢性损伤患者,超声引导下行高渗葡萄糖注射治疗安全、有效,值得临床进一步推广。

通络开痹片联合高渗葡萄糖关节腔内注射治疗膝骨关节炎的临床疗效

目的探讨通络开痹片联合高渗葡萄糖关节腔内注射治疗膝骨关节炎(knee osteoarthritis,KOA)的疗效。方法选取2023年1月至12月赣州市中医院收治的82例KOA患者,根据随机数字表法将其分为对照组和观察组,每组各41例。对照组患者给予双氯芬酸钠口服+玻璃酸钠关节腔内注射治疗,观察组患者给予通络开痹片口服+高渗葡萄糖关节腔内注射治疗;两组患者均治疗8周。比较两组患者的临床疗效、视觉模拟评分法(visual analogue scale,VAS)评分、Lysholm膝关节评分和炎症因子水平。结果观察组患者的治疗总有效率显著高于对照组(χ^(2)=6.187,P<0.001)。治疗8周后,两组患者的VAS评分、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)、基质金属蛋白酶3(matrix metalloproteinase 3,MMP-3)水平均显著低于本组治疗前,Lysholm膝关节评分均显著高于本组治疗前(P<0.05),且观察组患者的VAS评分、TNF-α、IL-1β、MMP-3水平显著低于对照组,Lysholm膝关节评分显著高于对照组(P<0.05)。结论通络开痹片联合高渗葡萄糖关节腔内注射有助于KOA患者缓解膝关节疼痛、降低炎症因子水平并改善膝关节功能,治疗效果确切。

高渗盐液用于重度脑外伤并休克的临床急救效果研究

目的比较重度脑外伤并休克患者急救中采取不同方式降低颅内压的临床效果。方法对2021年1月至2023年12月晋江市安海医院收治的100例重度脑外伤并休克患者进行回顾性研究。根据急救方式的不同,将患者分为观察组与对照组,观察组采用高渗盐液,对照组采用甘露醇,每组各50例。比较两组患者脑损伤相关指标、炎症因子、抢救效率。结果治疗前,两组患者颅内压、脑氧摄取率、S100B蛋白均无显著差异(P>0.05);治疗后,两组患者颅内压、脑氧摄取率、S100B蛋白水平均降低(P<0.05),且观察组颅内压、脑氧摄取率、S100B蛋白水平低于对照组(P<0.05)。治疗前,两组患者血清白介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平均无显著差异(P>0.05);治疗后,两组患者IL-6、CRP、TNF-α水平均降低(P<0.05),且观察组IL-6、CRP、TNF-α水平低于对照组(P<0.05)。观察组抢救成功率也显著高于对照组(P<0.05)。结论高渗盐液用于重度脑外伤并休克的急诊治疗中,可有效改善脑损伤,减少炎症因子释放,降低患者死亡率。