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外周血Lac、HO-1、sRAGE、CRP/ALB水平变化与腹腔感染致脓毒症患者预后的关系
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作者 张程 《中外医药研究》 2024年第27期141-144,共4页
目的:探究外周血乳酸(Lac)、血红素氧化酶-1(HO-1)、可溶性晚期糖基化终末产物受体(sRAGE)、C反应蛋白/白蛋白(CRP/ALB)水平变化与腹腔感染致脓毒症患者预后的关系。方法:选取新疆医科大学附属中医医院2021年2月—2024年2月接收的86例... 目的:探究外周血乳酸(Lac)、血红素氧化酶-1(HO-1)、可溶性晚期糖基化终末产物受体(sRAGE)、C反应蛋白/白蛋白(CRP/ALB)水平变化与腹腔感染致脓毒症患者预后的关系。方法:选取新疆医科大学附属中医医院2021年2月—2024年2月接收的86例腹腔感染致脓毒症患者作为观察组,并以60名健康体检人员作为对照组。比较两组外周血Lac、HO-1、sRAGE、CRP/ALB水平,根据观察组预后情况分为死亡组和生存组,比较两亚组外周血Lac、HO-1、sRAGE、CRP/ALB水平,分析外周血Lac、HO-1、sRAGE、CRP/ALB水平与腹腔感染致脓毒症患者病情及预后的相关性,采用受试者工作特征(ROC)曲线探究外周血Lac、HO-1、sRAGE、CRP/ALB水平对腹腔感染致脓毒症患者预后的预测效能。结果:观察组外周血Lac、sRAGE、CRP/ALB水平高于对照组,HO-1水平低于对照组(P<0.001)。生存组外周血Lac、sRAGE、CRP/ALB水平低于死亡组,HO-1水平高于死亡组(P<0.001)。外周血Lac、sRAGE、CRP/ALB水平与腹腔感染致脓毒症患者病情及预后呈正相关(P<0.001);外周血HO-1水平与腹腔感染致脓毒症患者病情及预后呈负相关(P<0.001)。外周血Lac、HO-1、sRAGE、CRP/ALB水平均对腹腔感染致脓毒症患者预后有一定预测价值(AUC>0.5),其cut-off值分别为3.05mmol/L、70.26μg/L、881.24pg/mL、7.29。结论:外周血Lac、HO-1、sRAGE、CRP/ALB水平变化与腹腔感染致脓毒症患者预后有一定相关性,上述指标水平可以为脓毒症患者治疗提供参考。 展开更多
关键词 乳酸 血红素氧化酶-1 可溶性晚期糖基化终末产物受体 c反应蛋白 白蛋白 腹腔感染 脓毒症
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糖尿病患者GHbA_(1C)水平与肾脏微血管病变的相关性研究 被引量:1
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作者 罗蓉 李卓成 阎德文 《放射免疫学杂志》 CAS 2004年第3期185-186,共2页
目的 :探讨糖尿病病人糖化血红蛋白 (GlycosylatedHemoglobinA1C,GHbA1C)的水平与糖尿病肾脏微血管病变的关系。方法 :采用亲和层析法检测糖化血红蛋白 (GHbA1C)、RIA法检测尿微量白蛋白 (mAlb)和β2 -微球蛋白 (β2 -m)。结果 :当糖尿... 目的 :探讨糖尿病病人糖化血红蛋白 (GlycosylatedHemoglobinA1C,GHbA1C)的水平与糖尿病肾脏微血管病变的关系。方法 :采用亲和层析法检测糖化血红蛋白 (GHbA1C)、RIA法检测尿微量白蛋白 (mAlb)和β2 -微球蛋白 (β2 -m)。结果 :当糖尿病患者血GHbA1C正常时 ,其尿mAlb及 β2 -m水平与正常人相比无明显差异 (P >0 0 5 ) ,但随着血GHbA1C水平的增高 ,其尿mAlb及 β2 -m水平随之明显高于正常人 (P <0 0 1) ,并随血GHbA1C水平的升高呈逐步上升趋势 ;糖尿病患者血GHbA1C水平与尿mAlb及 β2 -m水平之间呈明显的正向关系 ,不同血GHbA1C水平患者之间的尿mAlb及 β2 -m水平之间也存在显著差异 (P <0 0 1)。结论 :GH bA1C水平与糖尿病肾脏微血管病变密切相关 ,联合检测GHbA1C、mAlb及 β2 -m ,对于糖尿病肾病的早期预防及诊断有重要意义。 展开更多
关键词 糖尿病 ghba1c 肾脏 微血管病 糖化血红蛋白 ghba1c
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糖尿病患者GH、GHbA_(1C)与肾脏微血管病变的关系探讨 被引量:2
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作者 蔡发成 姚映斐 张金池 《放射免疫学杂志》 CAS 2005年第3期196-197,共2页
目的:探讨糖尿病患者生长激素(GH)、糖化血红蛋白(GHbA1C)水平与糖尿病肾脏微血管病变的关系。方法:采用放射免疫分析(RIA)检测GH和β2-m;用层析法检测GHbA1C;用电极法测定空腹血糖(FBG)。结果:GH、GHbA1C、β2-m及FBG水平糖尿病控制组... 目的:探讨糖尿病患者生长激素(GH)、糖化血红蛋白(GHbA1C)水平与糖尿病肾脏微血管病变的关系。方法:采用放射免疫分析(RIA)检测GH和β2-m;用层析法检测GHbA1C;用电极法测定空腹血糖(FBG)。结果:GH、GHbA1C、β2-m及FBG水平糖尿病控制组较差组>控制较好组>正常对照组,两两比较均为(P<0.01)。结论:GH水平的增高与糖尿病肾脏微血管病变密切相关,GH、GHbA1C、β2-m及FBG联检对糖尿病肾病的预防及诊断有重要意义。 展开更多
关键词 肾脏微血管病变 ghba1c 糖尿病患者 关系探讨 空腹血糖(FBG) 生长激素(GH) 糖化血红蛋白 Β2-M 放射免疫分析 电极法测定 正常对照组 糖尿病控制 糖尿病肾病 两两比较 重要意义 水平 层析法 检测
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成人糖尿病患者FBG、PG2h、GHbA_1C和INS的检测 被引量:1
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作者 常新剑 贾春生 +1 位作者 邢志华 郝丽萍 《标记免疫分析与临床》 CAS 2001年第1期3-5,共3页
探讨成人糖尿病胰岛功能减退的原因。将成人糖尿病患者 92例分为A组 (5 0例 ,胰岛功能良好 )和B组(4 2例 ,胰岛功能较差 )。A组中 ,A1组 30例 ,用正规治疗控制血糖 ;A2 组 2 0例 ,未用正规治疗控制血糖。B组中 ,B1组 2 2例 ,在饮食控制... 探讨成人糖尿病胰岛功能减退的原因。将成人糖尿病患者 92例分为A组 (5 0例 ,胰岛功能良好 )和B组(4 2例 ,胰岛功能较差 )。A组中 ,A1组 30例 ,用正规治疗控制血糖 ;A2 组 2 0例 ,未用正规治疗控制血糖。B组中 ,B1组 2 2例 ,在饮食控制、运动疗法基础上加用胰岛素控制血糖 ;B2 组 2 0例 ,在同样基础上加用磺脲类药物控制血糖。疗程均为 3- 5年。结果表明 :A1组血糖得到控制 ,A2 组胰岛功能减退 ;B1组胰岛功能恢复至正常 ,B2 组胰岛功能未得到改善。胰岛素水平分析 ,A2 与A1,A2 与A ,B2 与B1,B1与B对比 ,P均小于 0 .0 1;A1与A ,B2 与B对比 ,P均大于 0 .0 5。成人糖尿病胰岛功能减退的原因有 :(1)高血糖的毒性作用。 (2 )胰岛功能较差时应用磺脲类药物 ,加重了存活胰岛 β细胞分泌负担 ,使胰岛 展开更多
关键词 成人 糖尿病 血糖 胰岛素 碘脲类药物 FBG PG2h ghba1c NIS
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HIV-1 Env gp120 C2V5 Potential N-Linked Glycosylation Site(s) (PNGs) Variations and Amino Acid Length Polymorphisms among Infected Family Members
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作者 Duri Kerina Felicity Zvanyadza Gumbo +5 位作者 Knut Ivans Kristiansen Munyaradzi Paul Mapingure Simba Rusakaniko Mike Zvavahera Chirenje Babill Stray-Pedersen Fredrik Müller 《Advances in Infectious Diseases》 2011年第1期1-13,共13页
Objective: To ascertain the role of HIV-1 gp120 env PNGs variations and sequence length polymorphism following transmission events as possible supporting forensic evidence to determine directionality of HIV transmissi... Objective: To ascertain the role of HIV-1 gp120 env PNGs variations and sequence length polymorphism following transmission events as possible supporting forensic evidence to determine directionality of HIV transmission. Method: An observational study of HIV-1 infected family members, where median and range values of the amino acid lengths and PNGs for the genotyped C2V5 region were calculated. Wilcoxon rank-sum test was used to determine differences in these parameters between different family members. Results: For heterosexual transmission, two mothers had longer C3 sequences relative to that of their spouses;p=0.006 and=0.025 whilst the opposite was observed for one mother, p = 0.028. No clear trends were observed for PNGs. Index children had longer C2V5 amino acid sequences compared to their mothers p = 0.013, 0.040, 0.043 for families 205, 375, 567 respectively. Second siblings “V4 and V5 sequences were generally shorter relative to the maternal ones p = 0.039 and 0.028, respectively. Adults had longer V3 amino acid sequences compared to children;p = 0.018. Similar trends were also observed regarding PNGs within the entire C2V5 region, C3 and V4 sub-regions;p= 0.0025, 0.005 and 0.008, respectively. First siblings’ C2V5 and C3 sequence lengths were significantly longer relative to those of the second siblings;p = 0.005 and 0.007, respectively. Conclusion: Our results are suggestive that HIV-1 env C2V5 amino acid length polymorphism and PNGs tend to increase with age and HIV disease progression. Though sensitive and should be cautiously handled, it is tempting to propose the direc-tionality of the HIV transmission events with respect to C3 sequence length polymorphisms. Correlating HIV-1 env C2V5 amino acid length polymorphism and age of infection may be the first step towards a possible valuable piece of forensic evidence which may be useful in criminalisation of willful HIV infections. However, bigger studies are war-ranted to substantiate the authenticity of this potentially useful application. 展开更多
关键词 HIV-1 Env120 c2V5 glycosylATION Amino Acid Length Polymorphism PARENT to child Transmission
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补肾活血方对气阴两虚兼血瘀型DN患者血清胰岛素样生长因子-1、超敏C反应蛋白及血液流变学的影响 被引量:5
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作者 赵伟杰 王苗苗 《世界中医药》 CAS 2018年第9期2151-2154,共4页
目的:探讨补肾活血方对气阴两虚兼血瘀型糖尿病肾病(DN)患者血清胰岛素样生长因子-1(IGF-1)、超敏C反应蛋白(hs-CRP)及血液流变学的影响。方法:选取2015年5月至2016年9月安阳市中医院收治的早期DN患者86例,根据治疗方法,分为对照组和观... 目的:探讨补肾活血方对气阴两虚兼血瘀型糖尿病肾病(DN)患者血清胰岛素样生长因子-1(IGF-1)、超敏C反应蛋白(hs-CRP)及血液流变学的影响。方法:选取2015年5月至2016年9月安阳市中医院收治的早期DN患者86例,根据治疗方法,分为对照组和观察组,每组43例。对照组给予常规治疗,并口服贝纳普利,在对照组的基础上,观察组给予补肾活血方治疗。治疗12周后,观察2组的疗效,并对比治疗前后空腹血糖(FBG)、餐后血糖(PBG)、糖化血清蛋白(GSP)、血清IGF-1、血清hs-CRP及血液流变学指标。结果:2组的总有效率比较,差异有统计学意义(P<0.05);与治疗前比较,2组治疗后的FBG、PBG、UAER及GSP均显著性下降(P<0.05),且观察组下降程度更大(P<0.05);与治疗前比较,2组治疗后的血清IGF-1、hs-CRP均下降(P<0.05),且观察组下降程度更大(P<0.05);与治疗前比较,对照组治疗后的血液流变学指标差异无统计学意义(P>0.05),观察组治疗后的血液流变学指标显著降低(P<0.05),2组差异有统计学意义(P<0.05)。结论:补肾活血方治疗气阴两虚兼血瘀型糖尿病肾病患者的临床疗效较好,有效控制血糖,降低血清IGF-1、hs-CRP含量,抑制炎性反应,促进血液循环。 展开更多
关键词 补肾活血方 糖尿病肾病 胰岛素样生长因子-1 超敏c反应蛋白 血液流变学 血糖 糖化血清蛋白 炎性反应
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Glycated hemoglobin A1C and diabetes mellitus in critically ill patients 被引量:3
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作者 Hai-yan Zhang Cai-jun Wu Chun-sheng Li 《World Journal of Emergency Medicine》 CAS 2013年第3期201-204,共4页
BACKGROUND:Hyperglycemia has been detected in many critically ill patients in the department of emergency medicine.But its mechanism and prognosis have not been well elucidated.In this study,we measured the serum leve... BACKGROUND:Hyperglycemia has been detected in many critically ill patients in the department of emergency medicine.But its mechanism and prognosis have not been well elucidated.In this study,we measured the serum level of glycated hemoglobin A1C(HbA1c) in critically ill patients to evaluate the effects of hyperglycemia on the prognosis of the patients.METHODS:A total of 826 critically ill patients,who had been treated at the Department of Emergency Medicine of Chaoyang Hospital during October 2006 and November 2007,were divided into a diabetes mellitus group(n=184) and a non-diabetes mellitus group(642) according to whether they had diabetes mellitus.Fasting glucose and HbA1 c were measured in all patients.Those in the diabetes mellitus group were further assigned to a drug therapy subgroup and a non-drug therapy subgroup;the serum level of HbA1 c and its relationship with short-term outcome were evaluated.RESULTS:Fasting glucose increased in 78.8% of the patients(88.6%in the diabetes mellitus group,and 75.9%in the non-diabetes mellitus group,P<0.05),and HbA1 c was elevated in 45.5% of the patients(78.3% in the diabetes mellitus group,and 36.1%in the non-diabetes mellitus group,P<0.01).Fasting glucose,HbA1 c and 28-day mortality were improved more significantly(P<0.01) in the drug therapy subgroup than in the non-drug therapy subgroup.The 28-day mortality was more significantly different in patients with fasting blood glucose >8.33 mmol/L than in those with fasting blood glucose <8.33 mmol/L.CONCLUSIONS:Hyperglycemia of critically ill patients could not totally attribute to stress response,especially in those who have no history of diabetes mellitus.Prognosis of hyperglycemia may vary among critically ill patients. 展开更多
关键词 glycosylated hemoglobin A1c Diabetes mellitus HYPERGLYcEMIA PROGNOSIS critically ill patients
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Utility of a hemoglobin A1C obtained at the first prenatal visit
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作者 Lisa E Moore Diana Clokey 《World Journal of Obstetrics and Gynecology》 2014年第3期130-133,共4页
AIM: To evaluate the utility of the hemoglobin A1C (HbA1C) at the frst prenatal visit as a triaging tool in patients at high risk for gestational diabetes (GDM).METHODS: The HbA1C was obtained at the frst prenat... AIM: To evaluate the utility of the hemoglobin A1C (HbA1C) at the frst prenatal visit as a triaging tool in patients at high risk for gestational diabetes (GDM).METHODS: The HbA1C was obtained at the frst prenatal visit prior to 20 wk. Women with a HbA1C ≥ 6.5% (group one) were instructed on diet and daily self-monitoring of blood glucose. Women with a HbA1C between 5.7%-6.4% (group two) were offered testing or daily self-monitoring of blood glucose. Women with a HbA1C 〈 5.7% (group three) were tested at 24-28 wk. Patients were tested for GDM using the two step testing and Carpenter and Coustan values as cutoffs. Medication was started if patients failed to meet glycemic goals of fasting ≤ 95 mg/dL (5.3 mmol/L) and 2 h postprandial ≤ 120 mg/dL (6.7 mmol/L).RESULTS: In group one (n = 16), 15/16 (95%) re-quired medication to achieve euglycemia. The mean gestational age at which medication was required was early at 14 ± 6 wk. Postpartum, 14/16 patients (87%) remained diabetic. Group two contained 82 patients. Sixty-sixpatients (80%) were given a diagnosis of GDM and 52 patients (64%) required medication. The mean gestational age at which medication was started in group two was 20 ± 7.8 wk. There were 205 patients in group three, 18 patients (8.7%) were diagnosed with GDM and 13 patients (6%) required medication. In comparison to group three, patients in group one were 220 times more likely to require medication (95%CI: 26.9- 〉 999, P 〈 0.0001). Patients in group two were 26 times more likely to require medication (95%CI: 12.5-54.3, P 〈 0.0001). 展开更多
关键词 Gestational diabetes PREGNANcY Hemoglo-bin A1c glycosylated hemoglobin
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16例暴发性1型糖尿病患者临床特点分析 被引量:5
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作者 林乐韦华 全会标 +4 位作者 陈道雄 陈开宁 刘海蔚 方团育 莫泽纬 《中国全科医学》 CAS CSCD 北大核心 2016年第21期2567-2571,共5页
目的分析16例暴发性1型糖尿病(FT1DM)患者的临床资料,提高临床医师对FT1DM的认识。方法选取2008年1月—2015年5月海南省人民医院收治住院的FT1DM患者16例。记录患者发病时临床症状;抽取肘静脉血,检测血糖、糖化血红蛋白(HbA1c)、D-3羟... 目的分析16例暴发性1型糖尿病(FT1DM)患者的临床资料,提高临床医师对FT1DM的认识。方法选取2008年1月—2015年5月海南省人民医院收治住院的FT1DM患者16例。记录患者发病时临床症状;抽取肘静脉血,检测血糖、糖化血红蛋白(HbA1c)、D-3羟丁酸、总二氧化碳(CO_2)、血肌酐(Scr)、肌酸激酶(CK)、血淀粉酶、血常规、胰岛相关自身抗体〔谷氨酸脱羧酶抗体(GADAb)、胰岛细胞抗体(ICA)、胰岛素自身抗体(IAA)〕水平。患者在酮症或酮症酸中毒纠正后1~3 d,检测空腹C肽(FCP)和餐后2 h C肽(PCP)水平。对患者进行长期随访。结果 2008年1月—2015年5月,16例FT1DM患者占同期所有住院糖尿病患者(22 999例)的0.70‰,占住院1型糖尿病患者(457例)的3.5%。16例患者起病急骤,病程为12 h^6 d。临床症状上,15例患者出现恶心、呕吐,8例出现腹痛,6例伴上呼吸道感染,6例出现意识障碍,5例出现多饮、多尿,5例伴发热;血糖水平均明显升高(17.0~46.1 mmol/L);Hb A1c接近正常(5.6%~8.2%);FCP水平降低(<0.003~0.090 nmol/L);PCP水平降低(<0.003~0.160 nmol/L);动脉血pH值降低(6.92~7.30);血清D-3羟丁酸水平升高(5.18~9.69mmol/L);总CO2降低(1.0~20.0 mmol/L);12例Scr水平升高(94~275μmol/L);7例CK水平升高(263~5 373U/L);9例血淀粉酶水平升高(110~436 U/L);14例白细胞计数(WBC)升高〔(13.3~31.9)×10~9/L〕;胰岛β细胞功能几乎衰竭,迅速发展为糖尿病酮症酸中毒。入院后患者经积极补液扩容、小剂量胰岛素静脉滴注、纠正电解质紊乱抢救后,病情均好转。在酮症酸中毒纠正后继续胰岛素泵或基础+餐时胰岛素强化治疗,出院后沿用住院期间胰岛素强化治疗方案至今。8例患者门诊随访3~34个月,复查FCP、PCP仍接近于入院时水平。结论 FT1DM患者占同期所有住院糖尿病患者的0.70‰,占住院1型糖尿病患者的3.5%。FT1DM起病急骤、代谢紊乱严重,常合并多系统损害,部分患者以消化道或上呼吸道症状起病。患者胰岛β细胞功能呈完全且不可逆损害,预后差,需终身胰岛素替代治疗,应引起重视。 展开更多
关键词 糖尿病 1 血糖 血红蛋白A 糖基化 c 糖尿病酮症酸中毒
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儿童1型糖尿病血清T细胞亚群与胰岛功能的相关性 被引量:7
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作者 张改秀 王蕾 +4 位作者 杜建 胡东阳 张明衬 郭婷婷 张晓盼 《山西医科大学学报》 CAS 2017年第6期615-618,共4页
目的分析1型糖尿病初发患儿外周血T细胞亚群(CD4^+、CD8^+、CD4^+/CD8^+)变化特点;探讨1型糖尿病初发患儿外周血T细胞亚群与胰岛功能的关系。方法选择2010-05~2013-12山西省儿童医院确诊的T1DM初发患儿43例,25例健康体检儿童为对照组。... 目的分析1型糖尿病初发患儿外周血T细胞亚群(CD4^+、CD8^+、CD4^+/CD8^+)变化特点;探讨1型糖尿病初发患儿外周血T细胞亚群与胰岛功能的关系。方法选择2010-05~2013-12山西省儿童医院确诊的T1DM初发患儿43例,25例健康体检儿童为对照组。采用流式细胞技术测定血清CD4^+、CD8^+、CD4^+/CD8^+T细胞亚群,并对两组结果进行比较。对T1DM初发患儿T细胞亚群与糖化血红蛋白、C肽(C-P)水平进行相关性分析。结果 T1DM组患儿外周血CD4^+T细胞、CD4^+/CD8^+T细胞明显高于对照组(P<0.05),CD8^+T细胞明显低于对照组,差异有统计学意义(P<0.05)。T1DM患儿外周血CD4^+T细胞与Hb A1c呈正相关(r=0.261,P<0.05),与C-P呈负相关(r=-0.270,P<0.05);CD8^+T细胞与Hb A1c无明显相关性(r=-0.156,P>0.05),与C-P水平呈正相关(r=0.162,P<0.05);CD4^+/CD8^+T细胞与Hb A1c无明显相关性(r=0.200,P>0.05),与C-P水平呈负相关(r=-0.243,P<0.05)。结论 T1DM的发病过程存在T淋巴细胞亚群失衡,CD4^+T细胞异常激活、CD8^+T细胞缺陷和CD4^+/CD8^+T细胞比值增高。CD4^+及CD4^+/CD8^+T细胞与C肽呈负相关,CD8^+T细胞与C肽呈正相关。 展开更多
关键词 1型糖尿病 T细胞亚群 胰岛功能 糖化血红蛋白 c
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Utility of different glycemic control metrics for optimizing management of diabetes 被引量:7
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作者 Klaus-Dieter Kohnert Peter Heinke +1 位作者 Lutz Vogt Eckhard Salzsieder 《World Journal of Diabetes》 SCIE CAS 2015年第1期17-29,共13页
The benchmark for assessing quality of long-term glycemic control and adjustment of therapy is currently glycated hemoglobin(Hb A1c). Despite its importance as an indicator for the development of diabeticcomplications... The benchmark for assessing quality of long-term glycemic control and adjustment of therapy is currently glycated hemoglobin(Hb A1c). Despite its importance as an indicator for the development of diabeticcomplications, recent studies have revealed that this metric has some limitations; it conveys a rather complex message, which has to be taken into consideration for diabetes screening and treatment. On the basis of recent clinical trials, the relationship between Hb A1 c and cardiovascular outcomes in long-standing diabetes has been called into question. It becomes obvious that other surrogate and biomarkers are needed to better predict cardiovascular diabetes complications and assess efficiency of therapy. Glycated albumin, fructosamin, and 1,5-anhydroglucitol have received growing interest as alternative markers of glycemic control. In addition to measures of hyperglycemia, advanced glucose monitoring methods became available. An indispensible adjunct to Hb A1 c in routine diabetes care is selfmonitoring of blood glucose. This monitoring method is now widely used, as it provides immediate feedback to patients on short-term changes, involving fasting, preprandial, and postprandial glucose levels. Beyond the traditional metrics, glycemic variability has been identified as a predictor of hypoglycemia, and it might also be implicated in the pathogenesis of vascular diabetes complications. Assessment of glycemic variability is thus important, but exact quantification requires frequently sampled glucose measurements. In order to optimize diabetes treatment, there is a need for both key metrics of glycemic control on a day-to-day basis and for more advanced, user-friendly monitoring methods. In addition to traditional discontinuous glucose testing, continuous glucose sensing has become a useful tool to reveal insufficient glycemic management. This new technology is particularly effective in patients with complicated diabetes and provides the opportunity to characterize glucose dynamics. Several continuous glucose monitoring(CGM) systems, which have shown usefulness in clinical practice, are presently on the market. They can broadly be divided into systems providing retrospective or real-time information on glucose patterns. The widespread clinical application of CGM is still hampered by the lack of generallyaccepted measures for assessment of glucose profiles and standardized reporting of glucose data. In this article, we will discuss advantages and limitations of various metrics for glycemic control as well as possibilities for evaluation of glucose data with the special focus on glycemic variability and application of CGM to improve individual diabetes management. 展开更多
关键词 MARKERS of glycemic control hemoglobina1c POSTPRANDIAL GLUcOSE Risk of HYPERGLYcEMIA andhypoglycemia continuous GLUcOSE monitoring Glycemicvariability GLUcOSE dynamics STANDARDIZATION DIABETESMELLITUS
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联合检测C反应蛋白及糖化血红蛋白对妊娠期糖尿病筛查的价值 被引量:1
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作者 李文忠 肖文珺 《中国民族民间医药》 2015年第1期106-106,共1页
目的:探讨C反应蛋白(CRP)和糖化血红蛋白(GHb Alc)联合检测在妊娠期糖尿病(GDM)筛查中的应用价值。方法:选取GDM患者100例作为观察组和健康孕产妇100例为对照组,两组均对CRP和GHb Alc水平进行检测,比较两组CRP和GHb Alc阳性率。结果:观... 目的:探讨C反应蛋白(CRP)和糖化血红蛋白(GHb Alc)联合检测在妊娠期糖尿病(GDM)筛查中的应用价值。方法:选取GDM患者100例作为观察组和健康孕产妇100例为对照组,两组均对CRP和GHb Alc水平进行检测,比较两组CRP和GHb Alc阳性率。结果:观察组CRP和GHb Alc阳性率分别为95.0%、65.0%,明显大于对照组(P<0.05);观察组CRP和GHb Alc联合检测的阳性率为64.0%,对照组CRP和GHb Alc联合检测的阴性率为78.0%。结论:CRP和GHb Alc的联合检测在妊娠期糖尿病患者的筛查中具有一定的应用价值。 展开更多
关键词 妊娠期糖尿病 cRP ghba1c 联合检测
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冠心病患者血浆NT-proBNP和GHbA1c水平与冠状动脉病变程度的相关性 被引量:1
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作者 李想 《中华心脏与心律电子杂志》 2017年第3期149-152,共4页
目的探讨冠心病患者血浆NT-proBNP和GHbA1c水平与冠状动脉病变程度之间的关系。方法选取2016年8月至2017年8月期间在钟祥市人民医院就诊经冠状动脉造影检查确诊的冠心病患者130例,根据冠状动脉病变程度分为单支病变组(n=50)、双支病变组... 目的探讨冠心病患者血浆NT-proBNP和GHbA1c水平与冠状动脉病变程度之间的关系。方法选取2016年8月至2017年8月期间在钟祥市人民医院就诊经冠状动脉造影检查确诊的冠心病患者130例,根据冠状动脉病变程度分为单支病变组(n=50)、双支病变组(n=35)和多支病变组(n=45),同时选取性别、年龄相匹配的健康体检者30例作为对照组,测定全部研究对象的血浆NT-proBNP和GHbA1c水平,分析冠心病患者血浆NT-proBNP和GHbA1c水平与冠状动脉病变程度之间的关系。结果 (1)单支病变组、双支病变组和多支病变组的血浆NT-proBNP水平均高于对照组[(531.87±272.06)ng/L,(922.15±288.93)ng/L,(2 486.73±1 794.52)ng/L vs(47.18±26.19)ng/L],差异均有统计学意义(P<0.05),且随着病变支数的增加,血浆NT-proBNP水平升高。(2)单支病变组、双支病变组和多支病变组的血浆GHbA1c水平均高于对照组[(6.87±0.47)%,(7.53±0.42)%,(9.65±0.51)%vs(5.49±0.32%],差异均有统计学意义(P<0.05),且随着病变支数的增加,血浆GHbA1c水平升高。(3)相关性分析,血浆NT-proBNP和GHbA1c水平与冠状动脉病变支数均呈正相关(r=0.241,0.363,P<0.05)。结论冠心病患者血浆NT-proBNP和GHbA1c水平与冠状动脉病变程度呈正相关,可以作为评估冠心病患者预后的重要指标。 展开更多
关键词 冠心病 NT-PROBNP ghba1c 冠状动脉病变程度 相关性
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糖尿病GHbA1C升高与合并脑梗塞60例观察
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作者 王建光 张云卿 +3 位作者 刘艳 刘翠妮 刘翠香 周卫波 《按摩与康复医学》 2010年第34期30-30,共1页
目的:观察糖尿病糖化血红蛋白(GHbA1C)升高与糖尿病合并脑梗塞发生、复发的关系。结果:GHbA1C越高,糖尿病合并脑梗塞发生率越高,复发率越高。
关键词 糖尿病 脑梗塞 糖化血红蛋白(ghba1c)
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糖尿病性眼肌瘫痪患者血糖、糖化血红蛋白、血脂水平和血液流变学的变化及其关系 被引量:8
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作者 姚向荣 吕云利 +4 位作者 赵波 廖军 刘吉耀 贾存玮 张全华 《临床神经病学杂志》 CAS 北大核心 2011年第4期288-290,共3页
目的探讨糖尿病性眼肌瘫痪患者血糖、糖化血红蛋白(HbA1c)和血液流变学、血脂水平的变化及其关系。方法对36例糖尿病性眼肌瘫痪患者(糖尿病组)与36名健康对照者(正常对照组)进行血HbA1c、空腹血糖(FBG)和餐后2 h血糖(2h-PG)、血液流变... 目的探讨糖尿病性眼肌瘫痪患者血糖、糖化血红蛋白(HbA1c)和血液流变学、血脂水平的变化及其关系。方法对36例糖尿病性眼肌瘫痪患者(糖尿病组)与36名健康对照者(正常对照组)进行血HbA1c、空腹血糖(FBG)和餐后2 h血糖(2h-PG)、血液流变学、血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)检测;并进行相关性分析。结果糖尿病组红细胞变形指数与血HDL水平显著低于正常对照组(均P<0.01),HbA1c、FBG、2h-PG水平及其他血液流变学指标和血脂显著高于正常对照组(均P<0.01)。糖尿病组血糖、HbA1c水平与全血黏度(低切、中切、高切)、血浆黏度呈正相关(r=0.42~0.86;均P<0.05),与红细胞变形指数呈负相关(r=-0.53、-0.79;均P<0.01)。结论糖尿病性眼肌瘫痪患者血糖、HbA1c、血脂水平增高,血液流变学异常;高血糖是其血脂和血液流变学异常的重要因素。 展开更多
关键词 糖尿病性眼肌瘫痪 血糖 糖化血红蛋白 血液流变学 血脂
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苦荞麦对糖尿病大鼠血糖 蛋白非酶糖基化反应的影响 被引量:8
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作者 刘洋 柳春 +1 位作者 近藤隆一郎 松原惠理 《辽宁中医药大学学报》 CAS 2009年第5期195-197,共3页
目的:研究苦荞麦提取物对STZ诱导的糖尿病大鼠血糖、蛋白非酶糖基化反应的影响。方法:用链脲左菌素(STZ)诱导糖尿病大鼠模型,并于第3周开始给予苦荞麦高、中、低(200,100,50mg/kg·d)剂量和氨基胍(100mg/kg·d)剂量处理12周。... 目的:研究苦荞麦提取物对STZ诱导的糖尿病大鼠血糖、蛋白非酶糖基化反应的影响。方法:用链脲左菌素(STZ)诱导糖尿病大鼠模型,并于第3周开始给予苦荞麦高、中、低(200,100,50mg/kg·d)剂量和氨基胍(100mg/kg·d)剂量处理12周。上述动物于第12周末尾部取血,用血糖仪测定大鼠即时血糖。用酶联免疫吸附分析法(ELISA)测定糖化血红蛋白含量。用荧光分光光度法测定晚期糖基化终末产物含量。计量资料采用SPSS14.0进行方差分析。结果:苦荞麦高、中剂量明显降低糖尿病大鼠血糖、抑制糖基化产物的形成(P<0.01),并且苦荞麦高剂量组的治疗效果优于氨基胍组。结论:中药苦荞麦的提取物具有降低血糖、抑制大鼠体内蛋白非酶糖基化反应的作用。 展开更多
关键词 苦荞麦 血糖(BG) 糖化血红蛋白(ghba1c) 晚期糖基化终末产物(AGEs)
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Possible FDA-approved drugs to treat Ebola virus infection 被引量:4
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作者 Shu Yuan 《Infectious Diseases of Poverty》 SCIE 2015年第1期199-208,198,共11页
There is currently no effective treatment for the Ebola virus(EBOV)thus far.Most drugs and vaccines developed to date have not yet been approved for human trials.Two FDA-approved c-AbI1 tyrosine kinase inhibitors Glee... There is currently no effective treatment for the Ebola virus(EBOV)thus far.Most drugs and vaccines developed to date have not yet been approved for human trials.Two FDA-approved c-AbI1 tyrosine kinase inhibitors Gleevec and Tasigna block the release of viral particles;however,their clinical dosages are much lower than the dosages required for effective EBOV suppression.Anα-1,2-glucosidase inhibitor Miglustat has been shown to inhibit EBOV particle assembly and secretion.Additionally,the estrogen receptor modulators Clomiphene and Toremifene prevent membrane fusion of EBOV and 50-90%of treated mice survived after Clomiphene/Toremifene treatments.However,the uptake efficiency of Clomiphene by oral administration is very low.Thus,I propose a hypothetical treatment protocol to treat Ebola virus infection with a cumulative use of both Miglustat and Toremifene to inhibit the virus effectively and synergistically.EBOV infection induces massive apoptosis of peripheral lymphocytes.Also,cytolysis of endothelial cells triggers disseminated intravascular coagulation(DIC)and subsequent multiple organ failures.Therefore,blood transfusions and active treatments with FDA-approved drugs to treat DIC are also recommended. 展开更多
关键词 Ebola virus infection Disseminated intravascular coagulation glycosylation inhibitors Miglustat Niemann-Pick c1 inhibitors TOREMIFENE
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Effect of Health Education Based on Integrative Therapy of Chinese and Western Medicine for Adult Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Study 被引量:6
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作者 SHI Mai LIU Zhao-lan +6 位作者 ZHU Yan-bo XU Mei-yan DUAN Xue-ying SHI Hui-mei JIANG Bo ZHANG Xiao-mei YU Xiao-han 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2018年第2期94-102,共9页
Objective: To investigate the effects of health education based on integrative therapy of Chinese and Western medicine for type 2 diabetes mellitus(T2DM) from the aspects of knowledge, attitude and practice(KAP),... Objective: To investigate the effects of health education based on integrative therapy of Chinese and Western medicine for type 2 diabetes mellitus(T2DM) from the aspects of knowledge, attitude and practice(KAP), health-related quality of life(HRQo L), body mass index(BMI) and glucose control. Methods: Patients were individually randomized into intervention group(receiving integrative education, n=120) and control group(receiving usual education, n=120). The primary outcome was the changes in glycosylated hemoglobin A1c(HbA1c) levels after 3, 6, 9 and 12 months from baseline. Hierarchical linear models(HLMs) were used to assess within-group changes in outcomes over time and between-group differences in patterns of change. Secondary outcomes were KAP scores, HRQo L scores and BMI after 6 and 12 months, paired-sample t test was used to assess within-group changes in outcomes in 6 and 12 months, independent-sample t test was used to assess between-group differences in patterns of change. Results: HbA1c decreased statistically from baseline to 3 months, from 3 to 6 months, from 6 to 9 months and from 9 to 12 months in the intervention group(all P〈0.01); and decreased significantly from baseline to 3 months, and from 3 to 6 months in the control group(P〈0.01). There were significant between-group differences from baseline to 3 months(P=0.044), from 6 to 9 months(P〈0.01) and from 9 to 12 months(P〈0.01). Significant improvements in the intervention group along with significant between-group differences were found in KAP and HRQo L scores respectively(all P〈0.05). The number in the intervention group of normal weight increased from 56 at baseline to 81(6 months), 94(12 months), the number in the control group were 63(baseline), 69(6 months), 70(12 months), the χ~2 of hierarchical analysis of BMI were 6.93(P=0.075), 10.31(P=0.016), 15.53(P〈0.01), respectively. Conclusion: Health education based on integrative therapy of Chinese and Western medicine is beneficial to the control of T2DM and should be recommended for T2DM. 展开更多
关键词 type 2 diabetes mellitus health education chinese medicine glycosylated hemoglobin A1c health-related quality of life
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益气养阴活血汤联合西药治疗冠心病合并糖尿病随机平行对照研究 被引量:7
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作者 黄洪伟 《实用中医内科杂志》 2016年第3期55-57,共3页
[目的]观察益气养阴活血汤联合西药治疗冠心病合并糖尿病疗效。[方法]使用随机平行对照方法,将108例住院及门诊患者按掷骰子法简单随机分为两组。对照组54例格列美脲,2mg/次,1次/d;阿卡波糖,50mg/次,3次/d;辛伐他汀,10mg/次,1次/d;阿司... [目的]观察益气养阴活血汤联合西药治疗冠心病合并糖尿病疗效。[方法]使用随机平行对照方法,将108例住院及门诊患者按掷骰子法简单随机分为两组。对照组54例格列美脲,2mg/次,1次/d;阿卡波糖,50mg/次,3次/d;辛伐他汀,10mg/次,1次/d;阿司匹林,50mg/次,1次/d;氯吡格雷,75mg/次,1次/d。治疗组54例益气养阴活血汤(丹参、黄芪各18g,川芎、葛根、党参、麦冬、熟地各12g,五味子、白芍、甘草-炙各8g),1剂/d,水煎400m L,早晚口服,200m L/次;西药治疗同对照组。连续治疗15d为1疗程。观测临床症状、FIB、D-D、CRP、FPG、2h PG、GHb A1c、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组基本控制12例,显效23例,有效16例,无效3例,总有效率94.44%。对照组基本控制5例,显效19例,有效15例,无效15例,总有效率72.22%。治疗组疗效优于对照组(P〈0.01)。相关指标两组均有改善(P〈0.01),治疗组改善优于对照组(P〈0.01)。[结论]益气养阴活血汤联合西药治疗冠心病合并糖尿病疗效满意,无严重不良反应,值得推广。 展开更多
关键词 冠心病合并糖尿病 心悸 消渴 益气养阴活血汤 格列美脲 阿卡波糖 辛伐他汀 阿司匹林 氯吡格雷 FIB D-D cRP FPG 2hPG ghba1c 中西医结合治疗 随机平行对照研究
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2型糖尿病(痰瘀)中医证候积分与人口学资料、病程和生化指标相关研究 被引量:3
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作者 李鹏辉 《实用中医内科杂志》 2018年第4期1-3,65,共4页
[目的]观察2型糖尿病(痰瘀)中医证候积分与人口学资料(性别、年龄,身高、体质量、体质量指数-BMI)及糖尿病病程和对应生化指标(血清TGF-β_1、ox-LDL和FPG、(HbA1c、TC、TG、HDL-C、LDL-C)相关性。[方法]使用前瞻性设计方法,选择74例2... [目的]观察2型糖尿病(痰瘀)中医证候积分与人口学资料(性别、年龄,身高、体质量、体质量指数-BMI)及糖尿病病程和对应生化指标(血清TGF-β_1、ox-LDL和FPG、(HbA1c、TC、TG、HDL-C、LDL-C)相关性。[方法]使用前瞻性设计方法,选择74例2型糖尿病(痰瘀),男41例,女33例。观测中医症候积分,空腹血糖(FPG)、糖化血红蛋白((HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清TGF-β_1、ox-LDL,分析中医证候积分与检测指标相关性。[结果]2型糖尿病(痰瘀)中医证候积分与TGF-β_1、ox-LDL、(HbA1c、FBG呈正相关(P<0.05);2型糖尿病(痰瘀)TGF-β_1、ox-LDL明显高于对照组(P<0.05)。[结论]2型糖尿病(痰瘀)中医证候积分与(HbA1c、FBG正相关,TGF-β_1、ox-LDL升高。 展开更多
关键词 2型糖尿病 痰瘀 中医证候积分 性别 年龄 身高 体质量 体质量指数-BMI 病程 TGF-β1 ox-LDL 空腹血糖(FPG) 糖化血红蛋白(HbA1c) 总胆固醇(Tc) 甘油三酯(TG) 高密度脂蛋白胆固醇(HDL-c) 低密度脂蛋白胆固醇(LDL-c) 相关研究
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