Background: In developing countries like Nigeria, with poor socio-economic, early marriage, poor acceptance of contraception, poor spacing of pregnancies, high fertility rate and poor maternal and child health indices...Background: In developing countries like Nigeria, with poor socio-economic, early marriage, poor acceptance of contraception, poor spacing of pregnancies, high fertility rate and poor maternal and child health indices, leading to poor maternal-child outcome. There is a need to investigate the pattern of serum lipid changes during pregnancy in Nigeria women as hyperlipidemia may lead to poor maternal outcome. Materials and methods: A total of one hundred and forty (140) subjects between the ages of 20 and 45 years with mean age 29.74 ± 6.5 years of the study population. Group 1: the control comprises of thirty-five (35) healthy non pregnant subjects with mean age of 26.84 ± 5.2 volunteers of Nigeria origin. Group 2: the test involved one hundred and five (105) apparently healthy pregnant Nigerian women sub-divided into three groups;X, Y and Z each made of thirty-five (35) subjects distributed into 1st, 2nd and 3rd trimester of pregnancy respectively. The TG assay was analyzed using enzymatic spectrophotometric method as described by Biosystems. Results: The result analysis showed a significant increase (p ≤ 0.05) in the TG level during the first trimester of pregnancy when compared with control as shown in Table 1. There was a significant increase (p ≤ 0.05) in the TG levels during the second trimester of pregnancy when compared with that of the control subjects. During the third trimester of pregnancy there was a significant increase in TG levels when compared with the control subjects. Conclusion: This work revealed that the most dramatic change in the lipid profile in normal pregnancy is serum hypertriglyceridemia, which may be as high as two-three folds in the third trimester over the levels in non pregnant subjects. The estimation of lipid profile is strongly recommended as part of the laboratory investigations during pregnancy. Since studies in recent past have incriminated abnormal lipid metabolism during pregnancy in the pathogenesis of atherosclerotic, ischemia heart disease, intrauterine growth disease, intrauterine growth retardation and hypertension.展开更多
The consequence of a monstrous and diffuse evolution of the usual epithelial hyperplasia of pregnancy, gravidic gigantomastia is a disabling pathology. Rarely, it poses a problem for management and its etiology is sti...The consequence of a monstrous and diffuse evolution of the usual epithelial hyperplasia of pregnancy, gravidic gigantomastia is a disabling pathology. Rarely, it poses a problem for management and its etiology is still undetermined. In spite of a benign condition, it is nonetheless a serious one because of the complications associated with excessive growth, the weight of the mammary gland and the compromise of breastfeeding function (through destruction of the nipple-areolar plate and surgery). We report a case of bilateral gravidic gigantomastia in a 31-year-old woman to discuss the diagnostic and therapeutic aspects.展开更多
Complications arising from neglected umbilical hernia are not uncommon in pregnancy, more especially in developing countries with characteristically poor health seeking behaviour and less encouraging attitude towards ...Complications arising from neglected umbilical hernia are not uncommon in pregnancy, more especially in developing countries with characteristically poor health seeking behaviour and less encouraging attitude towards surgical intervention for un-complicated medical conditions. The report is on a 34-year-old para 8 who presented with prolonged labour and an irreducible herniated gravid uterus complicating a neglected congenital umbilical hernia. The patient was resuscitated. She had spontaneous vaginal delivery while preparation was being made for an elective caesarean section.展开更多
Incarcerated gravid uterus is a rare obstetric condition that contributes to pregnancy-related adverse outcomes,especially if the uterus remains incarcerated and the condition goes undiagnosed until delivery.An effect...Incarcerated gravid uterus is a rare obstetric condition that contributes to pregnancy-related adverse outcomes,especially if the uterus remains incarcerated and the condition goes undiagnosed until delivery.An effective diagnosis of this condition is benefited from pelvic examination combined with imaging methods and based on suspected symptoms.We present a case of ultrasound-assisted instrument reposition of an incarcerated gravid uterus at mid-gestation and discuss its clinical characteristics,diagnosis,imaging features,and treatment.We believe that once manual reduction fails,the use of instruments will undoubtedly be a better choice.展开更多
Background:Dengue is a global disease,transmitted by the Aedes vectors.In 2018,there were 80615 dengue cases with 147 deaths in Malaysia.Currently,the nationwide surveillance programs are dependent on Aedes larval sur...Background:Dengue is a global disease,transmitted by the Aedes vectors.In 2018,there were 80615 dengue cases with 147 deaths in Malaysia.Currently,the nationwide surveillance programs are dependent on Aedes larval surveys and notifications of lab-confirmed human infections.The existing,reactive programs appear to lack sensitivity and proactivity.More efficient dengue vector surveillance/control methods are needed.Methods:A parallel,cluster,randomized controlled,interventional trial is being conducted for 18 months in Damansara Damai,Selangor,Malaysia,to determine the efficacy of using gravid oviposition sticky(GOS)trap and dengue non-structural 1(NS1)antigen test for early surveillance of dengue among Aedes mosquitoes to reduce dengue outbreaks.Eight residential apartments were randomly assigned into intervention and control arms.GOS traps are set at the apartments to collect Aedes weekly,following which dengue NS1 antigen is deteaed in these mosquitoes.When a dengue-positive mosquito is detected,the community will be advised to execute vector search-and-destroy and protective measures.The primary outcome concerns the the percentage change in the(i)number of dengue cases and(ii)durations of dengue outbreaks.Whereas other outcome measures include the change in density threshold of Aedes and changes in dengue-related knowledge,attitude and practice among cluster inhabitants.Discussion:This is a proactive and early dengue surveillance in the mosquito vector that does not rely on notification of dengue cases.Surveillance using the GOS traps should be able to efficiently provide sufficient coverage for multistorey dwellings where population per unit area is likely to be higher.Furthermore,trapping dengue-infected mosquitoes using the GOS trap,helps to halt the dengue transmission carried by the mosquito.It is envisaged that the results of this randomized controlled trial will provide a new proactive,cheap and targeted surveillance tool for the prevention and control of dengue outbreaks.Trial registration:This is a parallel-cluster,randomized controlled,interventional trial,registered at ClinicalTrials.gov(ID:NCT03799237),on 8th January 2019(retrospectively registered).展开更多
文摘Background: In developing countries like Nigeria, with poor socio-economic, early marriage, poor acceptance of contraception, poor spacing of pregnancies, high fertility rate and poor maternal and child health indices, leading to poor maternal-child outcome. There is a need to investigate the pattern of serum lipid changes during pregnancy in Nigeria women as hyperlipidemia may lead to poor maternal outcome. Materials and methods: A total of one hundred and forty (140) subjects between the ages of 20 and 45 years with mean age 29.74 ± 6.5 years of the study population. Group 1: the control comprises of thirty-five (35) healthy non pregnant subjects with mean age of 26.84 ± 5.2 volunteers of Nigeria origin. Group 2: the test involved one hundred and five (105) apparently healthy pregnant Nigerian women sub-divided into three groups;X, Y and Z each made of thirty-five (35) subjects distributed into 1st, 2nd and 3rd trimester of pregnancy respectively. The TG assay was analyzed using enzymatic spectrophotometric method as described by Biosystems. Results: The result analysis showed a significant increase (p ≤ 0.05) in the TG level during the first trimester of pregnancy when compared with control as shown in Table 1. There was a significant increase (p ≤ 0.05) in the TG levels during the second trimester of pregnancy when compared with that of the control subjects. During the third trimester of pregnancy there was a significant increase in TG levels when compared with the control subjects. Conclusion: This work revealed that the most dramatic change in the lipid profile in normal pregnancy is serum hypertriglyceridemia, which may be as high as two-three folds in the third trimester over the levels in non pregnant subjects. The estimation of lipid profile is strongly recommended as part of the laboratory investigations during pregnancy. Since studies in recent past have incriminated abnormal lipid metabolism during pregnancy in the pathogenesis of atherosclerotic, ischemia heart disease, intrauterine growth disease, intrauterine growth retardation and hypertension.
文摘The consequence of a monstrous and diffuse evolution of the usual epithelial hyperplasia of pregnancy, gravidic gigantomastia is a disabling pathology. Rarely, it poses a problem for management and its etiology is still undetermined. In spite of a benign condition, it is nonetheless a serious one because of the complications associated with excessive growth, the weight of the mammary gland and the compromise of breastfeeding function (through destruction of the nipple-areolar plate and surgery). We report a case of bilateral gravidic gigantomastia in a 31-year-old woman to discuss the diagnostic and therapeutic aspects.
文摘Complications arising from neglected umbilical hernia are not uncommon in pregnancy, more especially in developing countries with characteristically poor health seeking behaviour and less encouraging attitude towards surgical intervention for un-complicated medical conditions. The report is on a 34-year-old para 8 who presented with prolonged labour and an irreducible herniated gravid uterus complicating a neglected congenital umbilical hernia. The patient was resuscitated. She had spontaneous vaginal delivery while preparation was being made for an elective caesarean section.
文摘Incarcerated gravid uterus is a rare obstetric condition that contributes to pregnancy-related adverse outcomes,especially if the uterus remains incarcerated and the condition goes undiagnosed until delivery.An effective diagnosis of this condition is benefited from pelvic examination combined with imaging methods and based on suspected symptoms.We present a case of ultrasound-assisted instrument reposition of an incarcerated gravid uterus at mid-gestation and discuss its clinical characteristics,diagnosis,imaging features,and treatment.We believe that once manual reduction fails,the use of instruments will undoubtedly be a better choice.
基金This work is supported by the Ministry of Higher Educaion Malaysia(FRGS-MRSA M0013-2017).
文摘Background:Dengue is a global disease,transmitted by the Aedes vectors.In 2018,there were 80615 dengue cases with 147 deaths in Malaysia.Currently,the nationwide surveillance programs are dependent on Aedes larval surveys and notifications of lab-confirmed human infections.The existing,reactive programs appear to lack sensitivity and proactivity.More efficient dengue vector surveillance/control methods are needed.Methods:A parallel,cluster,randomized controlled,interventional trial is being conducted for 18 months in Damansara Damai,Selangor,Malaysia,to determine the efficacy of using gravid oviposition sticky(GOS)trap and dengue non-structural 1(NS1)antigen test for early surveillance of dengue among Aedes mosquitoes to reduce dengue outbreaks.Eight residential apartments were randomly assigned into intervention and control arms.GOS traps are set at the apartments to collect Aedes weekly,following which dengue NS1 antigen is deteaed in these mosquitoes.When a dengue-positive mosquito is detected,the community will be advised to execute vector search-and-destroy and protective measures.The primary outcome concerns the the percentage change in the(i)number of dengue cases and(ii)durations of dengue outbreaks.Whereas other outcome measures include the change in density threshold of Aedes and changes in dengue-related knowledge,attitude and practice among cluster inhabitants.Discussion:This is a proactive and early dengue surveillance in the mosquito vector that does not rely on notification of dengue cases.Surveillance using the GOS traps should be able to efficiently provide sufficient coverage for multistorey dwellings where population per unit area is likely to be higher.Furthermore,trapping dengue-infected mosquitoes using the GOS trap,helps to halt the dengue transmission carried by the mosquito.It is envisaged that the results of this randomized controlled trial will provide a new proactive,cheap and targeted surveillance tool for the prevention and control of dengue outbreaks.Trial registration:This is a parallel-cluster,randomized controlled,interventional trial,registered at ClinicalTrials.gov(ID:NCT03799237),on 8th January 2019(retrospectively registered).
