Objective Here, we explored molecular changes that could potentially mediate healing effects of Gua Sha — a method employed by the Chinese traditional medicine with proven track records of safe and efficient applicat...Objective Here, we explored molecular changes that could potentially mediate healing effects of Gua Sha — a method employed by the Chinese traditional medicine with proven track records of safe and efficient applications dating back to ancient times as well as support from randomized controlled trials performed by modern medical studies — yet remaining almost entirely unexplored by the modern-day high-throughput methods of the-omics sciences.Methods We investigated transcriptome changes occurring shortly after Gua Sha treatment in the whole blood of healthy volunteers using bulk RNA-seq analysis. We applied various analytical tools to identify genes with consistent expression changes in multiple individuals in response to Gua Sha and their networks.Results We found that while the changes were very subtle and individual-specific, we could identify consistent upregulation of three histone genes. Further analysis of the potential regulatory networks of these histone genes revealed the enrichment of functions involved in the immune response and inflammation.Conclusion The significance of these results in the context of potential effects of Gua Sha and the next steps in exploring the molecular mechanisms of action of this technique are discussed.展开更多
Guangzhou Dayun Motorcycle Co.,Ltd(hereaf-ter referred to as Guangzhou Dayun)is a new-type modern motorcycle company which combines R&D,manufacture,sales,services and imports&exports.It served as the supplier ...Guangzhou Dayun Motorcycle Co.,Ltd(hereaf-ter referred to as Guangzhou Dayun)is a new-type modern motorcycle company which combines R&D,manufacture,sales,services and imports&exports.It served as the supplier of motorcycle for the 2008 Bei-展开更多
As cross-cultural communication gains growing popularity in our global world,heavy emphasis has been placed on a better understanding of cultural differences among countries.Gua Sha is such a movie that epitomizes the...As cross-cultural communication gains growing popularity in our global world,heavy emphasis has been placed on a better understanding of cultural differences among countries.Gua Sha is such a movie that epitomizes the existing cultural differences between China and America.It is to firstly make a brief introduction of the plot and then analyze the causes of various cultural conflicts and finally put forward some suggestions to help avoid these conflicts in cross-cultural communication.展开更多
Although forests play important roles in the hydrological cycle,there is little information that relates the water retention capacity of litter in areas under passive restoration,especially in Cerrado savannas.This st...Although forests play important roles in the hydrological cycle,there is little information that relates the water retention capacity of litter in areas under passive restoration,especially in Cerrado savannas.This study relates litter levels to water holding capacity and effective water retention among forest fragments under different passive restoration stages:46,11,and 8 years to better understand litter hydrological functions in the Cerrado.Water retention capacity and effective water retention capacity of litters(unstructured materials,branches and leaves)in the field were monitored on a monthly basis.Total litter accumulation at 46 years was significantly higher than that of the other succession stages.Unstructured litter mass was significantly higher than that of leaves and branches.The 46-year stage had the highest water holding capacity in the leaf fraction,followed by unstructured material and branches.Although the water holding capacity was lower in the oldest resto-ration,this site showed the highest efficiency under field conditions.The process was quickly reestablished,as the 11-year restoration showed results closer to that for the 46-year stage in comparison to the area at 8 years.Thus,passive restoration plays a key role in soil water mainte-nance due to the influence of litter in Cerrado savannas.Deforestation and the imminent need of restoring degraded sites,highlight the need for further studies focused on bet-ter understanding of the process of forest restoration and its temporal effect on soil water recovery dynamics.展开更多
The rainfall induced landslides and debris flows are the major disasters in China, as well in Europe, South America, Japan and Australia. This paper proposes a new type of joint probability prediction model—Double La...The rainfall induced landslides and debris flows are the major disasters in China, as well in Europe, South America, Japan and Australia. This paper proposes a new type of joint probability prediction model—Double Layer Nested Multivariate Compound Extreme Value Distribution (DLNMCEVD) to predict landslides and debris flows triggered by rainfall. The outer layer of DLNMCEVD is predicting the joint probabilities of different combinations for rainfall characteristics, air temperature and humidity, which should be considered as external load factors with geological and geotechnical characteristics as resistance factors for reliability analysis of slope stability in the inner layer of model. For the reliability and consequence analysis of rainfall-induced slope failure, the Global Uncertainty Analysis and Global Sensitivity Analysis (GUA & GSA) should be taken into account for input-output iterations. Finally, based on the statistics prediction by DLNMCEVD, the geological hazards prevention alarm and regionalization can be provided in this paper.展开更多
Objective： Gua Sha and Blood-letting at the acupoints were Chinese traditional therapies for heatstroke. The purpose of present study was to assess the therapeutic effect of Gua Sha on the DU Meridian and Bladder Mer...Objective： Gua Sha and Blood-letting at the acupoints were Chinese traditional therapies for heatstroke. The purpose of present study was to assess the therapeutic effect of Gua Sha on the DU Meridian and Bladder Meridian combined with Blood-letting acupoints at Shixuan （EX-UE 11） and Weizhong （BL 40） on heatstroke. Methods： Anesthetized rats, immediately after the onset of heatstroke, were divided into four major groups： Gua Sha group, Blood-letting group, Gua Sha combined with Blood-letting group and model group. They were exposed to ambient temperature of 43℃ to induce heatstroke. Another group of rats were exposed to room temperature （26℃） and used as normal control group. Their survival times were measured. In addition, their physiological and biochemical parameters were continuously monitored. Results： When rats underwent heatstroke, their survival time values were found to be 21-25 min. Treatment of Gua Sha combined with Blood- letting greatly improved the survival time （230 ± 22 rain） during heatstroke. All heatstoke animals displayed and activated coagulation evidenced by increased prothrombin time （PT）, activated partial thromboplastin time （aPTT）, D-dimer, and decreased platelet count, protein C. Furthermore, the animals displayed systemic inflammation evidenced by increased the serum levels of cytokines interleukin-1β （IL-1β）, tumor necrosis factor α （TNF-α） and malondialdehyde （MDA）. Biochemical markers evidenced by cellular ischemia and injury/dysfunction included increased plasma levels of blood urea nitrogen （BUN）, creatinine, serum glutamic oxaloacetic transaminase （SGOT）, serum glutamic pyruvic transaminase （SGPT）, and alkaline phosphatase （ALP） were all elevated during heatstroke. Core temperatures （Tco） were also increased during heatstroke. In contrast, the values of mean arterial pressure were significantly lower during heatstroke. These heatstroke reactions were all significantly suppressed by treatment of Gua Sha and Blood-letting, especially the combination therapy. Conclusion： Gua Sha combined with Blood-letting after heatstroke may improve survival by ameliorating systemic inflammation, hypercoagulable state, and tissue ischemia and injury in multiple organs.展开更多
OBJECTIVE: To investigate the analgesic effect of Gua Sha and its underlying mechanism in rats with noncompressive lumbar disk herniation induced by autologous nucleus pulposus.METHODS: A rat model of noncompressive l...OBJECTIVE: To investigate the analgesic effect of Gua Sha and its underlying mechanism in rats with noncompressive lumbar disk herniation induced by autologous nucleus pulposus.METHODS: A rat model of noncompressive lumbar disk herniation was established and rats were randomly divided into model group, sham group, and Gua Sha group(24 in each group). Gua Sha was performed from the 5 th day after the surgery, once every other day, 3 times for a course of treatment,and totally 3 courses. The thermal withdrawal latency was evaluated using the intelligent hot plate one day before the surgery, and on days 4(the day before the treatment), 10(the end of the firstcourse), 16(the end of the second course) and 22(the end of the third course). On days 4, 10, 16 and22, six rats in each group were picked randomly and their blood samples were drawn to assess the expression of interleukin-1β(IL-1β), interleukin-6(IL-6) and tumor necrosis factor-alpha(TNF-α).RESULTS: Compared to rats in the sham group, the application of nucleus pulposus to right L5 dorsal root ganglion induced prolonged thermal hyperalgesia, and up-regulated the expression of IL-1β,IL-6 and TNF-α in serum(P < 0.01). The therapy of Gua Sha attenuated thermal hyperalgesia potently,inhibited the expression of IL-1β, IL-6 and TNF-α in a time-dependent manner(P < 0.01). There were no significant differences in the thermal withdrawal latency and the expression of inflammatory cytokines between the sham and Gua Sha groups at the end of the treatment(P > 0.01).CONCLUSION: The current study showed that Gua Sha might alleviate thermal hyperalgesia in rats with lumbar disc herniation induced by autologous nucleus pulposus via inhibiting the expression of proinflammatory cytokins.展开更多
OBJECTIVE: To evaluate the effect of Gua Sha therapy on weightlifting training.METHODS: The sample size was calculated by conducting a pilot study. A total of 44 male weightlifters were randomly assigned to either the...OBJECTIVE: To evaluate the effect of Gua Sha therapy on weightlifting training.METHODS: The sample size was calculated by conducting a pilot study. A total of 44 male weightlifters were randomly assigned to either the Gua Sha group(n = 15), sham scraping group(n = 14), or control group(n = 14). The participants in the Gua Sha group and sham scraping group received 16 sessions of Gua Sha therapy during normal weightlifting training for 8 weeks. No treatment was applied to participants in the control group. The effectiveness of Gua Sha therapy was evaluated by measuring weightlifting ability, the rating of perceived exertion(RPE) of snatch and clean and jerk(85% of1 repetition maximum), and creatinine kinase(CK),blood urea nitrogen(BUN), and immunoglobulin A levels.RESULTS: Gua Sha therapy treatment significantly increased weightlifting ability in participants in the Gua Sha group(P < 0.01). The RPE values of snatch and clean and jerk were significantly lower in the Gua Sha group and sham scraping groups compared with the control group(P < 0.05). CK levels were lower and immunoglobulin A levels were significantly higher in the Gua Sha group compared with sham scraping group and control group(both P < 0.05). BUN levels tended to be reduced only in the Gua Sha group. A close correlation between CK levels and the RPE was found in the Gua Sha group.CONCLUSION: Gua Sha therapy can facilitate weightlifting ability, reduce the RPE, and inhibit muscle injury by promoting recovery from fatigue caused by normal weightlifting training. Gua Sha therapy could be an effective treatment to complement normal weightlifting training.展开更多
We were attracted by a news in Washington Post talking about the effects of Gua Sha （刮痧） on pain relief in the United States. Once there was a film telling culture conflicts between Eastern and Western world deriv...We were attracted by a news in Washington Post talking about the effects of Gua Sha （刮痧） on pain relief in the United States. Once there was a film telling culture conflicts between Eastern and Western world derived from Gua Sha in 2000, in which the Chinese parents were sued as child abuse evidenced by the appearance of petechiae and ecchymosis （Sha） on the child＇s back. Now about 12 years later Gua Sha has been one of the complementary therapies widely accepted in the United States mirrored by more and more clinic-visits and several evidence-based studies published in peer-reviewed journals.展开更多
On the afternoon of April 27, the CPAFFC, the China- EU Association (CEUA), the Guangdong Provincial People’s Association for Friendship with Foreign Countries (GPPAFFC) and the Delegation of the European Commission ...On the afternoon of April 27, the CPAFFC, the China- EU Association (CEUA), the Guangdong Provincial People’s Association for Friendship with Foreign Countries (GPPAFFC) and the Delegation of the European Commission of the European Union jointly held a debate on the global impact brought about by the 15+10 enlargement of European Union in Zhongshan University, Guangzhou.展开更多
It is known that, in the 12th five year plan, Guizhou will be built into a major base for deep processing of resources. Non-ferrous metals, one of the eight pillar industries in Guizhou, will focus on deep processing.
The depression of the passenger car market was most marked in some top provinces. The top 5 provinces, accounting for nearly 40% of the total passenger car market in China's Mainland, all saw growth rate lower tha...The depression of the passenger car market was most marked in some top provinces. The top 5 provinces, accounting for nearly 40% of the total passenger car market in China's Mainland, all saw growth rate lower than the national average rate in April 2008 except Shandong. Decreases were even展开更多
基金supported by the National Natural Science Foundation of China [Grant No. 32170619 to PK and Grant No. 32000462 to FQ]the Research Fund for International Senior Scientists from the National Natural Science Foundation of China [Grant No. 32150710525 to PK]+1 种基金the Natural Science Foundation of Fujian Province,China [Grant No. 2020J02006 to PK]the Scientific Research Funds of Huaqiao University [Grant No. 15BS101 to PK and Grant No. 22BS114 to FQ]。
文摘Objective Here, we explored molecular changes that could potentially mediate healing effects of Gua Sha — a method employed by the Chinese traditional medicine with proven track records of safe and efficient applications dating back to ancient times as well as support from randomized controlled trials performed by modern medical studies — yet remaining almost entirely unexplored by the modern-day high-throughput methods of the-omics sciences.Methods We investigated transcriptome changes occurring shortly after Gua Sha treatment in the whole blood of healthy volunteers using bulk RNA-seq analysis. We applied various analytical tools to identify genes with consistent expression changes in multiple individuals in response to Gua Sha and their networks.Results We found that while the changes were very subtle and individual-specific, we could identify consistent upregulation of three histone genes. Further analysis of the potential regulatory networks of these histone genes revealed the enrichment of functions involved in the immune response and inflammation.Conclusion The significance of these results in the context of potential effects of Gua Sha and the next steps in exploring the molecular mechanisms of action of this technique are discussed.
文摘Guangzhou Dayun Motorcycle Co.,Ltd(hereaf-ter referred to as Guangzhou Dayun)is a new-type modern motorcycle company which combines R&D,manufacture,sales,services and imports&exports.It served as the supplier of motorcycle for the 2008 Bei-
文摘As cross-cultural communication gains growing popularity in our global world,heavy emphasis has been placed on a better understanding of cultural differences among countries.Gua Sha is such a movie that epitomizes the existing cultural differences between China and America.It is to firstly make a brief introduction of the plot and then analyze the causes of various cultural conflicts and finally put forward some suggestions to help avoid these conflicts in cross-cultural communication.
基金This work is supported by the International Paper Co.from Brazil(Process 23112.000670/2015-59)by Brazilian National Council for Scientific and Technological Development(CNPq)in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil(CAPES)-Finance Code 001.
文摘Although forests play important roles in the hydrological cycle,there is little information that relates the water retention capacity of litter in areas under passive restoration,especially in Cerrado savannas.This study relates litter levels to water holding capacity and effective water retention among forest fragments under different passive restoration stages:46,11,and 8 years to better understand litter hydrological functions in the Cerrado.Water retention capacity and effective water retention capacity of litters(unstructured materials,branches and leaves)in the field were monitored on a monthly basis.Total litter accumulation at 46 years was significantly higher than that of the other succession stages.Unstructured litter mass was significantly higher than that of leaves and branches.The 46-year stage had the highest water holding capacity in the leaf fraction,followed by unstructured material and branches.Although the water holding capacity was lower in the oldest resto-ration,this site showed the highest efficiency under field conditions.The process was quickly reestablished,as the 11-year restoration showed results closer to that for the 46-year stage in comparison to the area at 8 years.Thus,passive restoration plays a key role in soil water mainte-nance due to the influence of litter in Cerrado savannas.Deforestation and the imminent need of restoring degraded sites,highlight the need for further studies focused on bet-ter understanding of the process of forest restoration and its temporal effect on soil water recovery dynamics.
文摘The rainfall induced landslides and debris flows are the major disasters in China, as well in Europe, South America, Japan and Australia. This paper proposes a new type of joint probability prediction model—Double Layer Nested Multivariate Compound Extreme Value Distribution (DLNMCEVD) to predict landslides and debris flows triggered by rainfall. The outer layer of DLNMCEVD is predicting the joint probabilities of different combinations for rainfall characteristics, air temperature and humidity, which should be considered as external load factors with geological and geotechnical characteristics as resistance factors for reliability analysis of slope stability in the inner layer of model. For the reliability and consequence analysis of rainfall-induced slope failure, the Global Uncertainty Analysis and Global Sensitivity Analysis (GUA & GSA) should be taken into account for input-output iterations. Finally, based on the statistics prediction by DLNMCEVD, the geological hazards prevention alarm and regionalization can be provided in this paper.
基金Supported by a grant from Administration of Traditional Chinese Medicine of Zhejiang Province(No.2009YB023)
文摘Objective： Gua Sha and Blood-letting at the acupoints were Chinese traditional therapies for heatstroke. The purpose of present study was to assess the therapeutic effect of Gua Sha on the DU Meridian and Bladder Meridian combined with Blood-letting acupoints at Shixuan （EX-UE 11） and Weizhong （BL 40） on heatstroke. Methods： Anesthetized rats, immediately after the onset of heatstroke, were divided into four major groups： Gua Sha group, Blood-letting group, Gua Sha combined with Blood-letting group and model group. They were exposed to ambient temperature of 43℃ to induce heatstroke. Another group of rats were exposed to room temperature （26℃） and used as normal control group. Their survival times were measured. In addition, their physiological and biochemical parameters were continuously monitored. Results： When rats underwent heatstroke, their survival time values were found to be 21-25 min. Treatment of Gua Sha combined with Blood- letting greatly improved the survival time （230 ± 22 rain） during heatstroke. All heatstoke animals displayed and activated coagulation evidenced by increased prothrombin time （PT）, activated partial thromboplastin time （aPTT）, D-dimer, and decreased platelet count, protein C. Furthermore, the animals displayed systemic inflammation evidenced by increased the serum levels of cytokines interleukin-1β （IL-1β）, tumor necrosis factor α （TNF-α） and malondialdehyde （MDA）. Biochemical markers evidenced by cellular ischemia and injury/dysfunction included increased plasma levels of blood urea nitrogen （BUN）, creatinine, serum glutamic oxaloacetic transaminase （SGOT）, serum glutamic pyruvic transaminase （SGPT）, and alkaline phosphatase （ALP） were all elevated during heatstroke. Core temperatures （Tco） were also increased during heatstroke. In contrast, the values of mean arterial pressure were significantly lower during heatstroke. These heatstroke reactions were all significantly suppressed by treatment of Gua Sha and Blood-letting, especially the combination therapy. Conclusion： Gua Sha combined with Blood-letting after heatstroke may improve survival by ameliorating systemic inflammation, hypercoagulable state, and tissue ischemia and injury in multiple organs.
基金Supported by National Natural Science Foundation of China:Differential proteomics-based research on the intervention effects,and mechanism of scraping therapy,treating lumbar disc herniation(No.81473791)Natural Science Foundation of Basic Research Program in Jiangsu Province:Proteomics research on the intervention effects,and mechanism of scraping therapy for lumbar disc herniation based on i TRAQ technology(No.BK20141464)
文摘OBJECTIVE: To investigate the analgesic effect of Gua Sha and its underlying mechanism in rats with noncompressive lumbar disk herniation induced by autologous nucleus pulposus.METHODS: A rat model of noncompressive lumbar disk herniation was established and rats were randomly divided into model group, sham group, and Gua Sha group(24 in each group). Gua Sha was performed from the 5 th day after the surgery, once every other day, 3 times for a course of treatment,and totally 3 courses. The thermal withdrawal latency was evaluated using the intelligent hot plate one day before the surgery, and on days 4(the day before the treatment), 10(the end of the firstcourse), 16(the end of the second course) and 22(the end of the third course). On days 4, 10, 16 and22, six rats in each group were picked randomly and their blood samples were drawn to assess the expression of interleukin-1β(IL-1β), interleukin-6(IL-6) and tumor necrosis factor-alpha(TNF-α).RESULTS: Compared to rats in the sham group, the application of nucleus pulposus to right L5 dorsal root ganglion induced prolonged thermal hyperalgesia, and up-regulated the expression of IL-1β,IL-6 and TNF-α in serum(P < 0.01). The therapy of Gua Sha attenuated thermal hyperalgesia potently,inhibited the expression of IL-1β, IL-6 and TNF-α in a time-dependent manner(P < 0.01). There were no significant differences in the thermal withdrawal latency and the expression of inflammatory cytokines between the sham and Gua Sha groups at the end of the treatment(P > 0.01).CONCLUSION: The current study showed that Gua Sha might alleviate thermal hyperalgesia in rats with lumbar disc herniation induced by autologous nucleus pulposus via inhibiting the expression of proinflammatory cytokins.
基金Supported by Beijing Municipal Science and Technology Commission,China(grant to BJ,No.Z121107001012148)the Science Technology Project in the Education Department of Jiangxi Province(No.GJJ170811)
文摘OBJECTIVE: To evaluate the effect of Gua Sha therapy on weightlifting training.METHODS: The sample size was calculated by conducting a pilot study. A total of 44 male weightlifters were randomly assigned to either the Gua Sha group(n = 15), sham scraping group(n = 14), or control group(n = 14). The participants in the Gua Sha group and sham scraping group received 16 sessions of Gua Sha therapy during normal weightlifting training for 8 weeks. No treatment was applied to participants in the control group. The effectiveness of Gua Sha therapy was evaluated by measuring weightlifting ability, the rating of perceived exertion(RPE) of snatch and clean and jerk(85% of1 repetition maximum), and creatinine kinase(CK),blood urea nitrogen(BUN), and immunoglobulin A levels.RESULTS: Gua Sha therapy treatment significantly increased weightlifting ability in participants in the Gua Sha group(P < 0.01). The RPE values of snatch and clean and jerk were significantly lower in the Gua Sha group and sham scraping groups compared with the control group(P < 0.05). CK levels were lower and immunoglobulin A levels were significantly higher in the Gua Sha group compared with sham scraping group and control group(both P < 0.05). BUN levels tended to be reduced only in the Gua Sha group. A close correlation between CK levels and the RPE was found in the Gua Sha group.CONCLUSION: Gua Sha therapy can facilitate weightlifting ability, reduce the RPE, and inhibit muscle injury by promoting recovery from fatigue caused by normal weightlifting training. Gua Sha therapy could be an effective treatment to complement normal weightlifting training.
文摘We were attracted by a news in Washington Post talking about the effects of Gua Sha （刮痧） on pain relief in the United States. Once there was a film telling culture conflicts between Eastern and Western world derived from Gua Sha in 2000, in which the Chinese parents were sued as child abuse evidenced by the appearance of petechiae and ecchymosis （Sha） on the child＇s back. Now about 12 years later Gua Sha has been one of the complementary therapies widely accepted in the United States mirrored by more and more clinic-visits and several evidence-based studies published in peer-reviewed journals.
文摘On the afternoon of April 27, the CPAFFC, the China- EU Association (CEUA), the Guangdong Provincial People’s Association for Friendship with Foreign Countries (GPPAFFC) and the Delegation of the European Commission of the European Union jointly held a debate on the global impact brought about by the 15+10 enlargement of European Union in Zhongshan University, Guangzhou.
文摘It is known that, in the 12th five year plan, Guizhou will be built into a major base for deep processing of resources. Non-ferrous metals, one of the eight pillar industries in Guizhou, will focus on deep processing.
文摘The depression of the passenger car market was most marked in some top provinces. The top 5 provinces, accounting for nearly 40% of the total passenger car market in China's Mainland, all saw growth rate lower than the national average rate in April 2008 except Shandong. Decreases were even
