Objective To evaluate and analyze the preventive and therapeutic effects of Gushudan on osteoporosis in rats after administrated prednisolone and investigate the mechanisms by study Osteoblast-like cells.Methods 60 Wi...Objective To evaluate and analyze the preventive and therapeutic effects of Gushudan on osteoporosis in rats after administrated prednisolone and investigate the mechanisms by study Osteoblast-like cells.Methods 60 Wistar male rats were divided into 6 groups:normal control group,model control group,Gushudan Prescription groups of 3,1,0.3 g/kg dose,Gushukang 1 g·kg-1 group.The effect was observed by measuring the levels of blood calcium,blood phosphorus,blood BGP content,bone calcium,bone phosphorus,bone density and bone biomechanics.Results After 8 weeks,Gushudan significantly increases the bone density,bone biomechanics,blood BGP content,bone calcium,bone phosphorus in model control group rats.Conclusions Gushudan can increases bone density,bone biomechanics,blood BGP content,bone calcium and bone phosphorus induced by prednisolone.These results suggest that Gushudan has a distinct preventive and therapeutic effect on osteoporosis rats caused by administrated prednisolone.展开更多
文摘Objective To evaluate and analyze the preventive and therapeutic effects of Gushudan on osteoporosis in rats after administrated prednisolone and investigate the mechanisms by study Osteoblast-like cells.Methods 60 Wistar male rats were divided into 6 groups:normal control group,model control group,Gushudan Prescription groups of 3,1,0.3 g/kg dose,Gushukang 1 g·kg-1 group.The effect was observed by measuring the levels of blood calcium,blood phosphorus,blood BGP content,bone calcium,bone phosphorus,bone density and bone biomechanics.Results After 8 weeks,Gushudan significantly increases the bone density,bone biomechanics,blood BGP content,bone calcium,bone phosphorus in model control group rats.Conclusions Gushudan can increases bone density,bone biomechanics,blood BGP content,bone calcium and bone phosphorus induced by prednisolone.These results suggest that Gushudan has a distinct preventive and therapeutic effect on osteoporosis rats caused by administrated prednisolone.