Routine pelvic examinations in women prescribed oral contraceptive pills (OCPs) for acne management are scrutinized to assess their impact on dermatological outcomes versus gynecological health. A synthesis of clinica...Routine pelvic examinations in women prescribed oral contraceptive pills (OCPs) for acne management are scrutinized to assess their impact on dermatological outcomes versus gynecological health. A synthesis of clinical trials, patient surveys, and medical guidelines reveals that these routine exams do not significantly enhance the effectiveness of acne treatment with OCPs but are linked to increased patient discomfort and false-positive results. Evidence suggests that routine pelvic examinations do not significantly impact the effectiveness of acne management with OCPs but are associated with increased patient discomfort and higher rates of false-positive results. The analysis indicates that a more personalized approach, focusing on selective pelvic examinations based on individual risk factors and clinical symptoms, may offer a more practical and patient-centered alternative. The review advocates for a reexamination of existing guidelines to better align with a model of individualized care, emphasizing the need for further research to optimize best practices at the intersection of dermatological and gynecological care. Adopting a personalized approach to pelvic examinations could substantially improve patient care by minimizing unnecessary interventions and discomfort while maintaining the efficacy of acne treatment with oral contraceptive pills.展开更多
This paper reviews the research progress of Guizhi Fuling Pill in the clinical application of gynecology,such as the treatment of uterine leiomyoma,ovarian cyst,infertility and dysmenorrhea,in order to provide further...This paper reviews the research progress of Guizhi Fuling Pill in the clinical application of gynecology,such as the treatment of uterine leiomyoma,ovarian cyst,infertility and dysmenorrhea,in order to provide further research ideas for clinical researchers.展开更多
Objective:Tocompare the clinical efficacyand safety of oral administration of BuxueYimuPills(BYP),ferrous sulfate(FS),and the combination of BYP and FS on gynecological anemia,and investigate the mechanisms using netw...Objective:Tocompare the clinical efficacyand safety of oral administration of BuxueYimuPills(BYP),ferrous sulfate(FS),and the combination of BYP and FS on gynecological anemia,and investigate the mechanisms using network pharmacology.Methods:A randomized,controlled,multi-center clinical trial was conducted.Totally 150 patients with hemoglobin of 70-110 g/L due to gynecological conditions were recruited and randomized(using the block randomization method)into Buxue Yimu Pills group(24 g/d),oral iron group(FS Tablets,0.9 g/d),and combined treatment group(BYP,24g/d plus FS Tablets,0.9 g/d),50 patients in each group.At the enrollment and 4-week treatment,complete blood count,serum iron indexes were evaluated.Adverse events,liver and renal functions,as well as blood coagulation were observed.Network pharmacology was conducted to identify the active ingredients and explore the potential mechanisms of BYP.Results:Ten(20%)and 7(14%)participants discontinued the therapy due to gastrointestinal symptoms in oral iron and combination treatment groups.All 3 groups showed elevated hemoglobin.The patients in the iron group exhibited typically elevated in serum iron and ferritin and decreased in total iron-binding capacity.No change in iron indexes was observed in BYP group.The patients in the combination treatment group neither showed significant changes in serum ferritin nortotal iron-binding capacity.No significant adverse reactions were observed in the BYP group.The network pharmacology identified 27 bioactive compounds and 145 targets of BYP on gynecological anemia.Biological processes and pathways including regulation of inflammation,hormone,angiogenesis and hemostasis,responsetodecreased oxygen levels,effects on myeloma cell,and responseto metal ions were identified.Conclusion:BYP contributes to the practical improvement on gynecological anemia potentially through multi-target mechanisms and optimized iron re-distribution.展开更多
目的:基于网络药理学方法,初步探讨红花如意丸治疗妇科疾病的作用机制。方法:依托中药系统药理学数据库和分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)、中草药综合数据库(tradi...目的:基于网络药理学方法,初步探讨红花如意丸治疗妇科疾病的作用机制。方法:依托中药系统药理学数据库和分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)、中草药综合数据库(traditional Chinese medicine database@Taiwan,TDT)以及中国知网(CNKI),检索红花如意丸中主要药物所含的化学成分、作用靶点以及相关疾病,构建"化合物-靶点"网络、"靶点-疾病"网络、"药物-化合物-靶点-疾病"网络、蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络和"靶点-通路"网络,研究红花如意丸治疗妇科疾病的作用机制。结果:"化合物-靶点"网络中包含73个化合物和99个相应靶点,关键靶点涉及前列腺素内过氧化物合成酶2、前列腺素内过氧化物合成酶1和热休克蛋白90等;PPI网络中包含97个蛋白,关键蛋白涉及丝裂原活化蛋白激酶1(mitogen-activated protein kinase 1,MAPK1)、丝裂原活化蛋白激酶8(mitogen-activated protein kinase 8,MAPK8)和肿瘤蛋白p53(tumor protein p53,TP53)等;基因本体(gene ontology,GO)条目37个,其中生物过程相关的条目22个,分子功能相关的条目7个,细胞组成相关的条目8个;京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路14条,涉及神经活性配体-受体相互作用通路、恶性肿瘤的途径、雌激素信号通路和钙离子信号通路等。结论:本研究结果初步阐释了红花如意丸治疗妇科疾病的基本药理作用及其作用机制,为进一步深入揭示其作用机制奠定了良好的基础。展开更多
文摘Routine pelvic examinations in women prescribed oral contraceptive pills (OCPs) for acne management are scrutinized to assess their impact on dermatological outcomes versus gynecological health. A synthesis of clinical trials, patient surveys, and medical guidelines reveals that these routine exams do not significantly enhance the effectiveness of acne treatment with OCPs but are linked to increased patient discomfort and false-positive results. Evidence suggests that routine pelvic examinations do not significantly impact the effectiveness of acne management with OCPs but are associated with increased patient discomfort and higher rates of false-positive results. The analysis indicates that a more personalized approach, focusing on selective pelvic examinations based on individual risk factors and clinical symptoms, may offer a more practical and patient-centered alternative. The review advocates for a reexamination of existing guidelines to better align with a model of individualized care, emphasizing the need for further research to optimize best practices at the intersection of dermatological and gynecological care. Adopting a personalized approach to pelvic examinations could substantially improve patient care by minimizing unnecessary interventions and discomfort while maintaining the efficacy of acne treatment with oral contraceptive pills.
文摘This paper reviews the research progress of Guizhi Fuling Pill in the clinical application of gynecology,such as the treatment of uterine leiomyoma,ovarian cyst,infertility and dysmenorrhea,in order to provide further research ideas for clinical researchers.
文摘Objective:Tocompare the clinical efficacyand safety of oral administration of BuxueYimuPills(BYP),ferrous sulfate(FS),and the combination of BYP and FS on gynecological anemia,and investigate the mechanisms using network pharmacology.Methods:A randomized,controlled,multi-center clinical trial was conducted.Totally 150 patients with hemoglobin of 70-110 g/L due to gynecological conditions were recruited and randomized(using the block randomization method)into Buxue Yimu Pills group(24 g/d),oral iron group(FS Tablets,0.9 g/d),and combined treatment group(BYP,24g/d plus FS Tablets,0.9 g/d),50 patients in each group.At the enrollment and 4-week treatment,complete blood count,serum iron indexes were evaluated.Adverse events,liver and renal functions,as well as blood coagulation were observed.Network pharmacology was conducted to identify the active ingredients and explore the potential mechanisms of BYP.Results:Ten(20%)and 7(14%)participants discontinued the therapy due to gastrointestinal symptoms in oral iron and combination treatment groups.All 3 groups showed elevated hemoglobin.The patients in the iron group exhibited typically elevated in serum iron and ferritin and decreased in total iron-binding capacity.No change in iron indexes was observed in BYP group.The patients in the combination treatment group neither showed significant changes in serum ferritin nortotal iron-binding capacity.No significant adverse reactions were observed in the BYP group.The network pharmacology identified 27 bioactive compounds and 145 targets of BYP on gynecological anemia.Biological processes and pathways including regulation of inflammation,hormone,angiogenesis and hemostasis,responsetodecreased oxygen levels,effects on myeloma cell,and responseto metal ions were identified.Conclusion:BYP contributes to the practical improvement on gynecological anemia potentially through multi-target mechanisms and optimized iron re-distribution.
文摘目的:基于网络药理学方法,初步探讨红花如意丸治疗妇科疾病的作用机制。方法:依托中药系统药理学数据库和分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)、中草药综合数据库(traditional Chinese medicine database@Taiwan,TDT)以及中国知网(CNKI),检索红花如意丸中主要药物所含的化学成分、作用靶点以及相关疾病,构建"化合物-靶点"网络、"靶点-疾病"网络、"药物-化合物-靶点-疾病"网络、蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络和"靶点-通路"网络,研究红花如意丸治疗妇科疾病的作用机制。结果:"化合物-靶点"网络中包含73个化合物和99个相应靶点,关键靶点涉及前列腺素内过氧化物合成酶2、前列腺素内过氧化物合成酶1和热休克蛋白90等;PPI网络中包含97个蛋白,关键蛋白涉及丝裂原活化蛋白激酶1(mitogen-activated protein kinase 1,MAPK1)、丝裂原活化蛋白激酶8(mitogen-activated protein kinase 8,MAPK8)和肿瘤蛋白p53(tumor protein p53,TP53)等;基因本体(gene ontology,GO)条目37个,其中生物过程相关的条目22个,分子功能相关的条目7个,细胞组成相关的条目8个;京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路14条,涉及神经活性配体-受体相互作用通路、恶性肿瘤的途径、雌激素信号通路和钙离子信号通路等。结论:本研究结果初步阐释了红花如意丸治疗妇科疾病的基本药理作用及其作用机制,为进一步深入揭示其作用机制奠定了良好的基础。
