AIM: To investigate the chemical constituents of aerial parts of Gynura divaricata(L.)DC.METHODS: Chemical constituents were isolated with multi-chromatographic methods.Their structures were determined by spectral ana...AIM: To investigate the chemical constituents of aerial parts of Gynura divaricata(L.)DC.METHODS: Chemical constituents were isolated with multi-chromatographic methods.Their structures were determined by spectral analysis and chemical evidence.RESULTS: 10 compounds were obtained and identified as quercetin(Ⅰ),3-O-β-Dglucopyranosyl quercetin(Ⅱ),3-O-β-D-(6→1) glucopyranosyl-αL-rhamnosyl quercetin(Ⅲ),3-O-β-D-(6→1)glucopyranosyl-α-L-rhamnosyl kaemferol(Ⅳ),epi-friedelinol(Ⅴ),epi-friedelinol acetatd(Ⅵ),β-sitosterol(Ⅶ),stigmasterol(Ⅷ),adenosine(Ⅸ) and uridine(Ⅹ).CONCLUSION: All these compounds were isolated from this plant for the first time.展开更多
The pyrrolizidine alkaloids(PAs) in leaf of Gynura divaricata(L.) DC.was analyzed by LC-MSn technique.The result shows that two hepatotoxic pyrrolizidine alkaloids(HPAs) are detected from the methanol extract of G.div...The pyrrolizidine alkaloids(PAs) in leaf of Gynura divaricata(L.) DC.was analyzed by LC-MSn technique.The result shows that two hepatotoxic pyrrolizidine alkaloids(HPAs) are detected from the methanol extract of G.divaricata leaf,with relative molecular weight of 335 and 365,respectively and lower content.The constituent with relative molecular weight 335 is a retronecine-type alkaloid,and identified as integerrimine;another constituent with relative molecular weight 365 is an otonecine-type alkaloid,speculated to be isomer of usaramine or 18-hydroxyinterrimine.展开更多
基金supported by the Scientific Research Fund of Fujian Provincial Department of Science &Technology(No.2008Y0086)the Traditional Chinese Medicine Research Fund of Fujian Provincial Public Health Bureau(No.wzy0606),China
文摘AIM: To investigate the chemical constituents of aerial parts of Gynura divaricata(L.)DC.METHODS: Chemical constituents were isolated with multi-chromatographic methods.Their structures were determined by spectral analysis and chemical evidence.RESULTS: 10 compounds were obtained and identified as quercetin(Ⅰ),3-O-β-Dglucopyranosyl quercetin(Ⅱ),3-O-β-D-(6→1) glucopyranosyl-αL-rhamnosyl quercetin(Ⅲ),3-O-β-D-(6→1)glucopyranosyl-α-L-rhamnosyl kaemferol(Ⅳ),epi-friedelinol(Ⅴ),epi-friedelinol acetatd(Ⅵ),β-sitosterol(Ⅶ),stigmasterol(Ⅷ),adenosine(Ⅸ) and uridine(Ⅹ).CONCLUSION: All these compounds were isolated from this plant for the first time.
文摘The pyrrolizidine alkaloids(PAs) in leaf of Gynura divaricata(L.) DC.was analyzed by LC-MSn technique.The result shows that two hepatotoxic pyrrolizidine alkaloids(HPAs) are detected from the methanol extract of G.divaricata leaf,with relative molecular weight of 335 and 365,respectively and lower content.The constituent with relative molecular weight 335 is a retronecine-type alkaloid,and identified as integerrimine;another constituent with relative molecular weight 365 is an otonecine-type alkaloid,speculated to be isomer of usaramine or 18-hydroxyinterrimine.