This paper considers the design problem of static output feedback H ∞ controllers for descriptor linear systems with linear matrix inequality (LMI) approach. Necessary and sufficient conditions for the existence of...This paper considers the design problem of static output feedback H ∞ controllers for descriptor linear systems with linear matrix inequality (LMI) approach. Necessary and sufficient conditions for the existence of a static output feedback H ∞ controller are given in terms of LMIs. Furthermore, the design method of H ∞ controllers is provided using the solutions to the LMIs.展开更多
Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report...Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.展开更多
针对电动助力转向(Electric power steering,EPS)系统存在系统模型、干扰等不确定性,以及对系统动态特性的要求,提出EPS系统混合H2/H∞控制器。在EPS系统及整车2自由度数学模型基础上,以驾驶员获得良好的转向路感、系统具有卓越的鲁棒...针对电动助力转向(Electric power steering,EPS)系统存在系统模型、干扰等不确定性,以及对系统动态特性的要求,提出EPS系统混合H2/H∞控制器。在EPS系统及整车2自由度数学模型基础上,以驾驶员获得良好的转向路感、系统具有卓越的鲁棒性和较小的力矩波动为控制目标,构建系统的状态空间方程和增广被控对象矩阵,运用H∞方法极小化系统中各种干扰对被控输出的影响,并在此基础之上应用H2方法对系统进行优化。EPS系统路感仿真结果表明,基于混合H2/H∞控制的EPS系统,综合了H2控制和H∞控制的优点,具有较好的鲁棒性能和鲁棒稳定性,可有效抑制路面随机激励、转矩传感器量测、模型参数不确定等所引起的各种干扰和噪声,使驾驶员获得满意的路感。展开更多
文摘This paper considers the design problem of static output feedback H ∞ controllers for descriptor linear systems with linear matrix inequality (LMI) approach. Necessary and sufficient conditions for the existence of a static output feedback H ∞ controller are given in terms of LMIs. Furthermore, the design method of H ∞ controllers is provided using the solutions to the LMIs.
基金supported by the National Natural Science Foundation of China,Nos.82171429,81771384a grant from Wuxi Municipal Health Commission,No.1286010241190480(all to YS)。
文摘Interferon regulatory factor 7 plays a crucial role in the innate immune response.However,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains unknown.Here we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial cells.Both the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 phenotype.In addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and YM1.Taken together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.
文摘针对电动助力转向(Electric power steering,EPS)系统存在系统模型、干扰等不确定性,以及对系统动态特性的要求,提出EPS系统混合H2/H∞控制器。在EPS系统及整车2自由度数学模型基础上,以驾驶员获得良好的转向路感、系统具有卓越的鲁棒性和较小的力矩波动为控制目标,构建系统的状态空间方程和增广被控对象矩阵,运用H∞方法极小化系统中各种干扰对被控输出的影响,并在此基础之上应用H2方法对系统进行优化。EPS系统路感仿真结果表明,基于混合H2/H∞控制的EPS系统,综合了H2控制和H∞控制的优点,具有较好的鲁棒性能和鲁棒稳定性,可有效抑制路面随机激励、转矩传感器量测、模型参数不确定等所引起的各种干扰和噪声,使驾驶员获得满意的路感。
