子宫内膜癌组织CTGF、TWIST1、NCAPH的表达与临床病理特征及预后的关系

目的 探讨子宫内膜癌组织中结缔组织生长因子(CTGF)、TWIST1和非平滑肌细胞凝聚素Ⅰ复合亚单位H(NCAPH)蛋白的表达,以及与肿瘤临床病理特征及患者预后的关系。方法 回顾性分析2017年1月至2019年1月于南通大学附属海安医院行全子宫切除术140例患者的临床资料,其中术后病理证实为子宫内膜癌68例(子宫内膜癌组)、不典型增生42例(不典型增生组)和正常子宫内膜30例(正常组)。采用免疫组化染色法检测3组CTGF、TWIST1和NCAPH蛋白的阳性表达率,分析其与子宫内膜癌患者的肿瘤病理特征和预后的关系。结果 子宫内膜癌组CTGF、TWIST1和NCAPH蛋白的阳性表达率均明显高于不典型增生组和正常组,差异有统计学意义(P<0.05),而不典型增生组和正常组上述指标比较差异无统计学意义(P>0.05)。子宫内膜癌组CTGF、TWIST1和NCAPH蛋白的阳性表达率与患者年龄、肿瘤分化程度和病理类型无相关性(P>0.05),而与肿瘤临床分期、淋巴结转移和肿瘤肌层浸润深度密切相关(P<0.05)。Kaplan-Meier生存分析显示,子宫内膜癌组CTGF、TWIST1和NCAPH阳性表达患者的累积总生存率均明显低于阴性表达患者(P<0.05)。单因素和多因素COX回归分析显示,国际妇产科联盟(FIGO)分期Ⅲ~Ⅳ期、淋巴结转移阳性、CTGF、TWIST1和NCAPH阳性表达是患者死亡的独立危险因素(P<0.05)。结论 子宫内膜癌患者组织CTGF、TWIST1和NCAPH表达上调可能与肿瘤发生和发展密切相关,三者可作为预测生存预后的重要生物标志物。

Severe Novel Influenza A(H1N1) in Shanghai:Clinical Features, Therapeutic Management and Risk Factors for Mortality

Objective To analyze the clinical features,therapeutic management and risk factors for mortality of patients with severe novel A(H1N1)influenza in Shanghai,China.Methods All patients were diagnosed by influenza A(H1N1)virus mRNA detection.Chest CT scan,routine blood,hepatic function,humoral and cellular immunity,sputum smears,and sputum cultures were performed.Logistic analysis was applied to identify risk factors for mortality.Results Total of 68 patients were enrolled in this study,the primary clinical symptoms including cough(66,97.1%),expectoration(41,60.3%),and polypnea(41,60.3%).Altogether,37(54.4%)and 11(16.2%)patients were infected with bacterial and fungal,respectively.CT scan demonstrated that 67(98.6%)patients had pneumonia.Oxygen therapy,oseltamivir,antibiotic and antifungal drugs were performed in 68(100%),66(97.1%),39(57.4%),and 11(16.2%)patients,respectively.Finally,4 of 68 patients died.Logistic analysis demonstrated that there was a significant correlation between the percentage of neutrophils and mortality before therapy and direct bilirubin content and mortality after therapy,respectively.Conclusions Patients with severe H1N1 influenza were susceptible to bacterial and/or fungal infection.The risk factors for mortality may be associated with pre-therapeutic neutrophil percentage and post-therapeutic direct bilirubin content.

Risk Factors Contributing to Microbiological Contamination of Boreholes and Hand Dug Wells Water in the Vina Division, Adamawa, Cameroon

This study examined the sanitary conditions of public boreholes and hand dug wells water in relation to pathogenic bacteria isolated in water samples. To assess the suitability of drinking water, sanitary inspection of surroundings of the sources was conducted, membrane filtration technic was used to trap the microorganisms in the water sample and other standard microbiological technics were applied to check the heterotrophic plate counts, total coliforms, fecal coliforms and some pathogenic bacteria in the samples. It was observed that there were no delineated protection zones around many boreholes (61.19%) and in almost all hand dug wells;thus, hand dug wells were pruned to more contamination than boreholes. Heterotrophic plate counts of boreholes were significantly different between (p < 0.0001) zones in dry and rainy seasons. Total coliforms per 100 ml varied significantly (p < 0.001) between the two seasons both in boreholes and hand dug wells. Fecal coliforms were significantly absent in some boreholes, but significantly present in all hand dug wells with the presence of E. coli 157H in some. Risk assessment of factors contributing to water contamination showed that: pumps manipulation with feet, other sources of contamination such as wastewater dumps, within 10m were significantly associated to boreholes contamination with Salmonella spp, Staphylococcus aureuse, fecal coliform (p = 0.01);in hand dug wells, presence of latrine or septic tank soak-away within 10 m of the wells, poor depth and lack of internal lining, uncapped wells, presence of trees near the wells, animal and birds feces, were significant and associated to contamination with Salmonela spp., B. cepaceae, S. aureus E. coli 1 (p < 0.05). Generally water collection points are marked with very poor sanitary conditions and this situation may not change unless the contaminating risk factors are fixed and sanitary measures are taken.

H pylori infection and other risk factors associated with peptic ulcers in Turkish patients: A retrospective study

AIM: To identify and evaluate the relative impact of H pylori infection and other risk factors on the occurrence of gastric ulcer (GU), duodenal ulcer (DU) and gastritis in Turkish patients. METHODS: A total of 4471 patients (48.3% female) out of 4863 attended the Samatya hospital in Istanbul (June 1999 - October 2003) were included. The records of H pylori status (CLO-test), endoscopic f indings of GU, DU and gastritis, personal habits (smoking, alcohol intake) and medication [non-steroidal anti-inflammatory drugs (NSAIDs), aspirin intake] were analyzed using multi-way frequency analysis. RESULTS: We have found that GU in the presence of H pylori had significant association with aspirin (P = 0.0001), alcohol (P = 0.0090) and NSAIDs (P = 0.0372). DU on the other hand had significant association with aspirin/ smoking/NSAIDs (P = 0.0259), aspirin/alcohol (P = 0.0002) and aspirin/smoking (P = 0.0233), also in the presence of H pylori. In the absence of H pylori GU had significant association with alcohol/NSAIDs (P = 0.0431), and NSAIDs (P = 0.0436). While DU in the absence of H pylori had significant association with smoking/alcohol/ NSAIDs (P = 0.0013), aspirin/NSAIDs (P = 0.0334), aspirin/alcohol (P = 0.0360). CONCLUSION: In the presence of H pylori, aspirin, alcohol and NSAIDs intake act as an independent risk factors that had an augmenting impact on the occurrence of GU and only together on the occurrence of DU in Turkish patients.

结直肠癌中NCAPH、AGGF1及TM4SF1的表达及与预后的相关性

目的:探讨结直肠癌(colorectal cancer,CRC)中非染色体结构维持蛋白凝缩蛋白复合体I亚单位H(non-SMC condensin I complex subunit H,NCAPH)、G补缀FHA域血管新生因子1(angiogenic factor with G and FHA domains 1,AGGF1)及跨膜4L六家族成员1(transmembrane-4-L-six-family-1,TM4SF1)蛋白质表达之间的关系及临床意义。方法:收集145例CRC术后标本和30例癌旁正常黏膜组织标本,采用免疫组织化学法检测CRC和癌旁正常黏膜组织中NCAPH、AGGF1及TM4SF1蛋白质的表达情况,分析其表达与各种临床病理因素的关系以及三者之间的相关性。结果:在CRC和癌旁组织中,NCAPH、AGGF1及TM4SF1的阳性表达率分别为55.2%、53.1%、60.7%和3.3%、6.6%、0,差异均有统计学意义(均P<0.001)。3种蛋白质的表达均与CRC的组织学分化和TNM分期有关(均P<0.001);NCAPH和TM4SF1的表达均与CRC的淋巴结转移有关(均P<0.05);NCAPH和AGGF1的表达均与CRC组织脉管侵犯有关(均P<0.05);AGGF1和TM4SF1的表达均与CRC的肿瘤浸润深度有关(均P<0.01)。TM4SF1的表达分别与NCAPH和AGGF1的表达呈正相关(r值分别为0.311和0.517,均P<0.001);同时,AGGF1与NCAPH的表达亦呈正相关(r=0.291,P=0.001)。Kaplan-Meier生存分析表明:NCAPH、AGGF1及TM4SF1的表达上调均与患者的生存率有关,NCAPH、AGGF1及TM4SF1阳性的患者生存率明显低于三者阴性患者(均P<0.05)。多因素分析表明:TNM分期、NCAPH、AGGF1及TM4SF1的表达和肿瘤脉管侵犯均是影响CRC根治术后患者预后的独立因素(均P<0.05)。结论:CRC组织中NCAPH、AGGF1及TM4SF1的表达上调与CRC的分化程度、转移和预后等因素相关,这些指标的联合检测可能作为判断CRC进展及患者预后的重要指标。

Factors Associated with Death Due to 2009 Influenza A (H1N1) Virus Infection and Acute Respiratory Distress Syndrome in Beijing, 2009-2011

Objective Patients with H1N1 virus infection were hospitalized and quarantined, and some of them developed into acute respiratory failure, and were transfered to the medical intensive care unit of Beijing Ditan Hospital, Capital Medical University in Beijing, China. Methods The clinical features and preliminary epidemiologic findings among 30 patients with confirmed H1N1 virus infection who developed into acute respiratory failure for ventilatory support were investigated. Results A total of 30 patients(37.43 ± 18.80 years old) with 2009 influenza A(H1N1) related acute respiratory distress syndrome(ARDS) received treatment with mechanical ventilation, 15 cases of whom were male and 17 cases died of ARDS. Fatal cases were significantly associated with an APACHE Ⅱ score(P = 0.016), but not with PaO 2 /FIO 2(P = 0.912) and chest radiograph(P = 0.333). The most common complication was acute renal failure(n = 9). Five patients received extracorporeal membrane oxygenation(ECMO), 3 of whom died and the others survived. The major causes of death were multiple organ dysfunction syndrome(MODS)(39%), intractable respiratory failure(27%) and sepsis(20%). Conclusions Most patients with respiratory failure due to influenza A(H1N1) virus infection were young, with a high mortality, particularly associated with APACHE Ⅱ score, secondary infection of lung or type 2 diabetes mellitus.

多环芳烃中苯并[g,h,i]苝与特发性膜性肾病的关联

目的:探索多环芳烃(PAHs)中苯并[g,h,i]苝(BghiP)与特发性膜性肾病(IMN)之间的相关性及其可能机制。方法:选取2020年6月至2020年9月经郑州大学第一附属医院肾内科肾活检病理证实的IMN30例和继发性膜性肾病(SMN)10例,留取患者空腹血标本并检测血液中PAHs及转化生长因子β1(TGF-β1)含量,分析BghiP与临床指标和TGF-β1之间的关系。结果:IMN组与SMN组患者血液中PAHs 16种主要成分平均浓度结果提示,IMN组患者BghiP平均浓度最高(约1.259μg/mL),且显著高于SMN组患者(P=0.004)。IMN组患者BghiP浓度与24h尿蛋白、血清抗磷脂酶A2受体(PLA2R)抗体、总胆固醇呈正相关(r值分别为0.401、0.404、0.483,P值分别为0.028、0.027、0.007),与血清总蛋白、白蛋白呈负相关(r值分别为-0.550、-0.440,P值分别为0.002、0.015),另外,BghiP与TGF-β1呈正相关(r=0.558,P=0.001),线性回归分析结果提示,BghiP浓度每升高1μg/mL,TGF-β1浓度便升高0.112 ng/mL(P=0.001)。结论:IMN患者血液中BghiP浓度较高,可能与IMN的发生发展相关;TGF-β1可能参与BghiP导致的IMN发生和发展。

TACE联合索拉菲尼治疗晚期肝癌患者的疗效及对血清VEGF、CTGF、HIF-1α及OPN水平的影响

目的 探讨经肝动脉灌注化疗栓塞术（transcatheter arterial chemoembolization,TACE）联合索拉菲尼对晚期肝癌（hepatocellular carcinoma,HCC）患者的临床疗效及对血清血管内皮生长因子（vascular endothelial growth factor,VEGF）、结缔组织生长因子（connective tissue growth factor,CTGF）、缺氧诱导因子1α（hypoxia inducible factor 1α,HIF-1α）及骨桥蛋白（osteopontin,OPN）水平的影响。方法 选取2013年9月~2014年12月台州市肿瘤医院收治的HCC患者113例,按照随机数字法分为对照组（n=56）和试验组（n=57）,对照组采用TACE治疗,试验组采用TACE联合索拉菲尼治疗。分别于术前及术后1、3、7 d采用间接酶联免疫吸附测定法检测并比较2组患者血清VEGF、CTGF、HIF-1α及OPN水平,并进行Spearman相关性分析;统计2组远期临床疗效及不良反应发生情况。结果 术后1 d 2组患者血清VEGF、CTGF、HIF-1α及OPN水平较术前显著升高（P〈0.01）;术后1 d至7 d 2组患者血清各因子水平均呈下降趋势（P〈0.05）,且2组间差异有统计学意义（P〈0.05）;HIF-1α水平与VEGF、CTGF及OPN水平均呈显著正相关（r=0.951,r=0.954,r=0.929,P〈0.05）;试验组中位生存时间及1年生存率较对照组显著增加（P〈0.01）;试验组手足反应、脱发及腹泻发生率显著高于对照组（P〈0.05）,2组间其他各项不良反应发生率差异无统计学意义。结论 TCAE联合索拉菲尼较单独TACE可显著降低HCC患者VEGF、CTGF、HIF-1α、OPN水平,延长患者生存期,且不增加不良反应。

H型高血压患者肾损害危险因素的多因素Logistic回归分析

目的探讨H型高血压患者肾损害的危险因素,为有效预防患者出现肾损害提供参考。方法回顾性分析2016年1月至2017年1月在我院诊治的186例H型高血压患者的临床资料,根据患者肾小球滤过率(GFR)将患者分为正常组(GFR≥90 mL/L,共148例)和损伤组(GFR<90 mL/L,共38例)。对两组患者的性别、年龄、病程、收缩压、视黄醇结合蛋白、血同型半胱氨酸(Hcy)、胱抑素C(Cys-C)、β2微球蛋白(β2-MG)、血肌酐、尿酸等进行比较分析,对导致H型高血压患者发生肾损害的因素进行多因素Logistic回归分析。结果单因素分析结果显示,H型高血压损伤组患者的Hcy、Cys-C、β2-MG表达水平均显著高于正常组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,Hcy>20.13μmol/L、Cys-C>1.83 mg/L、β2-MG>3.12 mg/L是H型高血压患者发生肾损害的独立危险因素(P<0.05)。结论Hcy、Cys-C、β2-MG水平升高与H型高血压患者的肾损害密切相关,对患者进行检测,及早采取针对性干预措施,可能有助于预防肾损伤,改善预后。

Effects of resistance training on cardiovascular health in non-obese active adolescents

AIM:To determine the benefits of a 10-wk resistance training programme on cardiovascular health in nonobese and active adolescents.METHODS:This is a pragmatic randomised controlled intervention.The study was carried out in a Hong Kong Government secondary school.Thirty-eight lean and active boys and girls were randomised to either the resistance training group or the control group.Students in the resistance training group received in-school 10-wk supervised resistance training twice per week,with each session lasting 70 min.Main outcome measures taken before and after training included brachial endothelial dependent flow-mediated dilation,body composition,fasting serum lipids,fasting glucose and insulin,high sensitive C-reactive protein,24-h ambulatory blood pressure and aerobic fitness.RESULTS:The only training related change was in endothelial dependent flow-mediated dilation which increased from 8.5%to 9.8%.A main effect of time and an interaction(P<0.005) indicated that this improvement was a result of the 10-wk resistance training.Main effects for time(P<0.05) in a number of anthropometric,metabolic and vascular variables were noted;however,there were no significant interactions indicating the change was more likely an outcome of normal growth and development as opposed to a training effect.CONCLUSION:Ten weeks of resistance training in school appears to have some vascular benefit in active,lean children.

H指数、G指数在学科外文期刊采访中的参考意义——以统计学外文期刊采访为例

随着外文期刊价格的不断提升,高校图书馆面临着外文期刊采访的困境,采用何种科学有效的方法采购外文期刊,是当今高校图书馆采访人员亟需解决的问题。为更科学、合理地进行统计学外文期刊采访,采用影响因子与H指数及G指数相结合的期刊采访策略,对于评定某一领域期刊、改进期刊采访策略有一定的参考价值。

基于g-h分布的股票收益率风险价值研究

以我国上证综指收益率序列为研究对象,分析了其分布及特性。针对上证指数收益率不服从正态分布,具有"有偏、尖峰、厚尾"的特性,提出了基于g-h分布假设的VaR计算方法,并与正态假设、Logistic假设、Student-t假设和历史模拟法计算的VaR进行了比较,结果表明基于g-h分布假设下的VaR对收益率数据的风险描述最为准确,计算结果优于其它3种分布。

H型高血压的临床研究现状及药物治疗进展

随着临床对高血压发病机制和危险因素研究的深入,发现了更多和高血压患者发生心血管事件相关的危险因子。半胱氨酸是近年来新发现的危险因素,高血压合并同型半胱氨酸血症被临床定义为H型高血压。本文就针对H型高血压的流行病特点、发病机制,与慢性肾病、心脑血管疾病的联系,治疗方法等进行阐述。

基于G-H分布的copula-SMR方法

将阿基米德copula应用于谱风险度量(SMR),提出了一种新的风险度量方法(copula-SMR方法)。选取G-H分布对边缘分布进行建模,采用极大似然估计对给定的阿基米德copula进行参数估计,选择能更好拟合实际数据的copula函数,运用二次规划方法,计算相应的谱风险值,确定了在不同期望收益率下最优投资组合。

Macrosomia at the Center Hospital of Montelimar (France): 141 Cases Report

Introduction: Macrosomia is usually defined by the delivery of a child over 4000 g at term. Because of the margins of error, the obstetrician must take into account, in addition to ultrasound, the constitutional and acquired factors of the mother in order to be able to prevent the complications expected during the delivery of a large fetus. Material and method: We carried out a cross-sectional, descriptive, 12-month study in a level 2 hospital in southern France (Montélimar). The aim of the study was to assess the prevalence of macrosomia, to identify the epidemiological characteristics of the patients, to specify the management of obstetrics and complications in this hospital. Results: We recorded 141 births with a weight greater than or equal to 4000 g. That is a rate of 7.95%. The average age of our patients is 30 years. Half of them had a BMI of less than 25 and were not diabetic. 75% of the patients gave birth by a low-dose route. The sex ratio of the children is male to female 2:1. The main maternal complications were the perineovaginal tears (39 cases) and the hemorrhages of the deliverance (6 cases). Conclusion: The delivery of macrosomia is not uncommon at the Hospital Center of Montélimar. It predominates among Caucasians. Usual risk factors have rarely been found. Overall management was without major complications for both the mother and the child.

“H型”高血压与脑卒中患者脑血管事件再发风险的关系

目的探讨高血压患者的血浆同型半胱氨酸水平与缺血性脑血管事件再发风险的关系。方法对100例脑卒中患者进行随访,Cox生存回归分析高血压患者高血浆同型半胱氨酸与脑血管事件再发风险的关系。结果随访3年过程中,100例初发生脑血管事件,25例脑卒中复发。与同型半胱氨酸水平最低组比较,校正年龄、性别、吸烟、饮酒等传统危险因素后,高同型半胱氨酸显著增加初发脑卒中患者的缺血性脑血管事件再发风险(风险比1.54,95%可信区间为1.18～2.21)和脑卒中复发风险(风险比1.74,95%可信区间为1.3～2.3)。亚型分析显示,不仅在初发脑梗死组,而且在初发脑出血组中,高同型半胱氨酸水平与3年内的脑血管事件再发风险均显著相关。结论高血压患者血浆同型半胱氨酸水平升高是卒中复发和脑血管事件再发风险增加的独立危险因素。

南京市鼓楼区H型高血压患病率及相关危险因素的横断面研究

目的了解南京市鼓楼区H型高血压患病率及相关危险因素。方法采用多阶段随机抽样原则,收集5个社区的高血压病患者,采用自行设计问卷进行问卷调查及相关实验室检查。结果筛查纳入1 148例原发性高血压病患者,诊断为H型高血压842例,占73.33%,其中女性为62.94%,男性为77.72%。多因素logistic回归分析显示:男性(OR=3.305,95%CI:1.887~5.376)、年龄(OR=1.082,95%CI:1.042~1.098)、吸烟(OR=1.951,95%CI:1.198~3.322)、BMI升高(OR=1.184,95%CI:1.110~1.253)、低密度脂蛋白升高(OR=1.612,95%CI:1.248~2.112)、eGFR降低(OR=0.978,95%CI:0.968~0.989)以及未进行有效锻炼(OR=1.876,95%CI:1.192~2.952;OR=3.331,95%CI:1.816~6.002)与H型高血压患病有统计学关联。结论南京市鼓楼区高血压人群中H型高血压发生率较高,应根据相关危险因素特征,开展针对性预防及制定治疗方案。

H型高血压合并射血分数保留心力衰竭患者发生颈动脉硬化的危险因素分析

目的研究H型高血压合并射血分数保留心力衰竭(心衰)患者发生颈动脉硬化的危险因素。方法选取2015年1月至2019年1月于秦皇岛市第一医院心内科门诊就诊以及住院治疗的H型高血压合并射血分数保留心衰患者200例作为观察对象。将所有患者按照是否发生颈动脉硬化分为硬化组(89例)与非硬化组(111例)。分别比较两组基本资料,各项生化指标水平,并做多因素Logistic回归分析。结果硬化组年龄≥60岁、病程≥5年、吸烟、血糖控制效果差、睡眠呼吸暂停综合征人数占比相比非硬化组较高(均P<0.05)。硬化组与非硬化组在总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平方面对比,前者更高,而硬化组与非硬化组在高密度脂蛋白胆固醇(HDL-C)水平方面对比,前者更低(P均<0.05)。经多因素Logistic回归分析可得:年龄、病程、吸烟、血糖控制效果差、睡眠呼吸暂停综合征、TG、TC、LDL-C均是H型高血压合并射血分数保留心衰患者发生颈动脉硬化的独立危险因素,而HDL-C为保护性因素(P均<0.05)。结论随着年龄、病程的不断延长,血糖控制效果差、睡眠呼吸暂停综合征,TG、TC、LDL-C水平逐渐升高,HDL-C水平的逐渐降低,均可能会增加H型高血压合并射血分数保留心衰患者发生颈动脉硬化的风险。临床工作中应针对上述因素予以相关干预,继而达到降低颈动脉硬化发生风险的目的。

H型高血压患者发生射血分数保留心力衰竭的危险因素分析

目的探讨H型高血压患者发生射血分数保留心力衰竭(HFpEF)的相关危险因素,为预防HFpEF发生提供参考依据。方法回顾性分析2015年1月至2019年1月于秦皇岛市第一医院心血管内科门诊就诊及住院治疗的200例H型高血压发生HFpEF患者的临床资料,作为研究组,选取同期80例H型高血压合并射血分数正常非心衰患者记为对照组。比较两组患者基本临床信息的差异情况,并采用Logistic逐步回归分析H型高血压患者发生HFpEF的危险因素。结果两组性别构成比、年龄、吸烟史、高血压分级以及合并肥胖症、糖尿病、冠状动脉粥样硬化性心脏病(冠心病)、慢性阻塞性肺疾病(COPD)、心房纤颤(房颤)、睡眠呼吸暂停综合征(SAHS)率比较,差异均有统计学意义(P<0.05),组间左室射血分数(LVEF)、左室舒张末期内径(LVDd)、左室舒张期末室间隔厚度(IVST)、左房容积(LAV)和N末端脑钠肽前体(NT-proBNP)水平比较差异也有统计学意义(P<0.01)。多因素Logistic回归分析显示,女性、高龄、吸烟、高血压Ⅲ级、肥胖症、糖尿病、冠心病、COPD均是H型高血压患者发生HFpEF的危险因素。结论高龄、女性、高血压分级较高及合并肥胖症、糖尿病、冠心病、COPD疾病等因素会增加H型高血压患者发生HFpEF的风险,应结合患者上述因素的具备情况采取相应预防治疗等干预措施,努力降低HFpEF发生风险。

H型高血压病痰瘀互结证相关因素的临床分析

[目的]探讨H型高血压病痰瘀互结证与临床常见危险因素的相关性,探讨不同性别间多种相关危险因素间可能存在的差异。[方法]选取高血压病合并高同型半胱氨酸血症(HHcy)患者215例,按中医证型分为两个亚组,痰瘀互结证组117例,非痰瘀互结证组98例(对照组)。分别测定同型半胱氨酸(Hcy)、甘油三酯(TG)、总胆固醇(TC)、载脂蛋白a(Lpa)、空腹血糖(FPG)、血尿酸(UA)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、体重指数(BMI)、腹围(AC),对各项检测结果进行统计学分析。[结果]1)两组间在Hcy、TG、TC、Lpa、FPG、UA检测指标水平方面比较,差异无统计学意义(P>0.05),LDL、HDL、BMI、AC检测指标水平方面比较,差异有统计学意义(P<0.05)。2)两组男性患者对比,Hcy、TG、TC、Lpa、FPG、UA、HDL检测指标水平方面比较,差异无统计学意义(P>0.05),LDL、BMI、AC检测指标水平对比,差异有统计学意义(P<0.05),其中两组男性患者BMI指数比较,差异明显有统计学意义(P<0.01)。3)两组女性患者对比,Hcy、TG、TC、Lpa、UA、HDL、LDL、BMI、AC检测指标水平方面比较,差异无统计学意义(P>0.05),两组女性患者FPG水平比较,差异有统计学意义(P<0.05)。[结论]1)LDL、HDL水平、肥胖(BMI≥28)可能是H型高血压病痰瘀互结证的相关危险因素。2)男性H型高血压病痰瘀互结证患者可能更易出现超重(25<BMI<28)或肥胖(BMI≥28)和LDL水平升高;而女性患者可能逐渐表现出空腹血糖(FPG)的改变。