Objective: To discuss the curative effect of H-UPPP in the treatment of adult OSAS patients and its influence on serum inflammatory medium. Method: A total of 118 cases of adult OSAS patients, who were treated in our ...Objective: To discuss the curative effect of H-UPPP in the treatment of adult OSAS patients and its influence on serum inflammatory medium. Method: A total of 118 cases of adult OSAS patients, who were treated in our hospital between June,2014 and July, 2016, were selected and retrospective analysis was performed for their surgical methods, and these patients were divided into control group(n=57) with UPPP treatment and study group (n=61) with H-UPPP treatment. Curative effect, ventilation resistance and systemic inflammation differences in both groups were compared. Results: Clinical treatment effective rate in study group was significantly higher than that in control group. One month after surgery, Zrs, Rc, R5, R20 levels in both groups were lower than those before surgery, and the decrease degree in study group was greater than that in control group;12 h after surgery, proinflammatory mediator contents such as hs-CRP, IL-1β, IL-6, IL-17, IL-23 in the serum of both groups were higher than those before surgery, and the increase degree in study group was lower than that in control group. Conclusion: Curative effect of H-UPPP in the treatment of adult OSAS patients was superior that UPPP's, and early postoperative inflammation response of H-UPPP was lighter, and H-UPPP also has advantages in surgical high efficiency and minimally invasive.展开更多
目的研究对合并鼻部和口咽部阻塞性睡眠呼吸暂停低通气量综合征,同时完成改良鄂咽成形手术(H-UPPP)和鼻内窥镜手术,探讨一次完成多平面手术对OSAHS患者的治疗方法。方法32例OSAHS的患者,年龄23～45岁,平均34.3岁,其中男30例,女2例,体重...目的研究对合并鼻部和口咽部阻塞性睡眠呼吸暂停低通气量综合征,同时完成改良鄂咽成形手术(H-UPPP)和鼻内窥镜手术,探讨一次完成多平面手术对OSAHS患者的治疗方法。方法32例OSAHS的患者,年龄23～45岁,平均34.3岁,其中男30例,女2例,体重指数为21.8～35.7 kg/m2,术前睡眠呼吸暂停低通气指数(apnea and hypopnea index,AHI)15.4～39.7次/h,平均25.7次/h,最低血氧饱和度67～87,平均77术前鼻咽镜检查阻塞平面均位于鼻腔和口咽部,舌根和会厌均无狭窄。术前均行CT断层扫描鼻腔和口咽部明确诊断狭窄平面以确定个性化术士,手术全麻鼻腔插管现行鼻内镜手术术后硅胶管压迫支撑,再行H-UPPP手术。结果术后一周、两个月、六个月复查PTT睡眠监测,32例患者总有效100%。展开更多
文摘Objective: To discuss the curative effect of H-UPPP in the treatment of adult OSAS patients and its influence on serum inflammatory medium. Method: A total of 118 cases of adult OSAS patients, who were treated in our hospital between June,2014 and July, 2016, were selected and retrospective analysis was performed for their surgical methods, and these patients were divided into control group(n=57) with UPPP treatment and study group (n=61) with H-UPPP treatment. Curative effect, ventilation resistance and systemic inflammation differences in both groups were compared. Results: Clinical treatment effective rate in study group was significantly higher than that in control group. One month after surgery, Zrs, Rc, R5, R20 levels in both groups were lower than those before surgery, and the decrease degree in study group was greater than that in control group;12 h after surgery, proinflammatory mediator contents such as hs-CRP, IL-1β, IL-6, IL-17, IL-23 in the serum of both groups were higher than those before surgery, and the increase degree in study group was lower than that in control group. Conclusion: Curative effect of H-UPPP in the treatment of adult OSAS patients was superior that UPPP's, and early postoperative inflammation response of H-UPPP was lighter, and H-UPPP also has advantages in surgical high efficiency and minimally invasive.
文摘目的研究对合并鼻部和口咽部阻塞性睡眠呼吸暂停低通气量综合征,同时完成改良鄂咽成形手术(H-UPPP)和鼻内窥镜手术,探讨一次完成多平面手术对OSAHS患者的治疗方法。方法32例OSAHS的患者,年龄23～45岁,平均34.3岁,其中男30例,女2例,体重指数为21.8～35.7 kg/m2,术前睡眠呼吸暂停低通气指数(apnea and hypopnea index,AHI)15.4～39.7次/h,平均25.7次/h,最低血氧饱和度67～87,平均77术前鼻咽镜检查阻塞平面均位于鼻腔和口咽部,舌根和会厌均无狭窄。术前均行CT断层扫描鼻腔和口咽部明确诊断狭窄平面以确定个性化术士,手术全麻鼻腔插管现行鼻内镜手术术后硅胶管压迫支撑,再行H-UPPP手术。结果术后一周、两个月、六个月复查PTT睡眠监测,32例患者总有效100%。
