The most recent new emerging infection is the H5N6 inl uenza virus infection. This infection has just been reported from China in early May 2014. The disease is believed to be a cross species infection. All indexed ca...The most recent new emerging infection is the H5N6 inl uenza virus infection. This infection has just been reported from China in early May 2014. The disease is believed to be a cross species infection. All indexed cases are from China. Of interest, the H5N6 inl uenza virus is the primary virus for avian. The avian H5N6 inl uenza virus in avian population is a low virulent strain. However, the clinical manifestation in human seems severe. In this mini-review, the authors summarize and discuss on this new emerging inl uenza.展开更多
AIM： To compare the one-day quadruple therapy with a standard 7-d triple therapy for H pylori eradication in a rural population of China. METHODS： A total of 396 patients with 13C-urea breath test positive for H pyl...AIM： To compare the one-day quadruple therapy with a standard 7-d triple therapy for H pylori eradication in a rural population of China. METHODS： A total of 396 patients with 13C-urea breath test positive for H pylori were assigned into two groups： 239 patients received one-day quadruple therapy （amoxicillin 2000 mg qid; metronidazole 500 mg qid; bismuth citrate 900 mg qid and lansoprazole 60 mg once daily） and 157 patients received 7-d standard triple therapy （amoxicillin 1000 mg bid; clarithromycin 500 mg bid and lansoprazole 30 mg bid）. All the patients underwent a 13C-UBT to assess the eradication of Hpylori infection six weeks after treatment. RESULTS： Two hundred and twenty-nine patients completed the one-day therapy （95.8%） and 148 patients completed the 7-d therapy （94.2%）. The oneday therapy eradicated H pylori infection in 64 patients （27.95%）. In contrast, 103 patients （69.59%） were Hpylori negative after the 7-d therapy （P 〈 0.01）. CONCLUSION： This pilot study suggests there is no beneficial effect of the one-day therapy in treatment ofHpylori infection compared with the 7-d standard therapy.展开更多
AIM:To evaluate the performance of commercially available immunochromatographic (ICT) and immunoblot tests covering the current infection marker CIM and conventional ELISA for the diagnosis of H pylori infection in ad...AIM:To evaluate the performance of commercially available immunochromatographic (ICT) and immunoblot tests covering the current infection marker CIM and conventional ELISA for the diagnosis of H pylori infection in adult dyspeptic patients. METHODS:Consecutive non-treated dyspeptic patients undergoing diagnostic endoscopy were tested for H pylori infection by culture, rapid urease test, and histology of gastric biopsy specimens. Serum from 61 H pylori infected and 21 non-infected patients were tested for anti-H pylori IgG antibodies by commercial ELISA (AccuBindTM ELISA, Monobind, USA), ICT (Assure H pylori Rapid Test, Genelabs Diagnostics, Singapore), and immunoblot (Helico Blot 2.1, Genelabs Diagnostics, Singapore) assays. ICT and immunoblot kits cover CIM among other parameters and their performance with and without CIM was evaluated separately. RESULTS:Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of ELISA were 96.7%, 42.8%, 83.1%, 81.8%, and 82.9%, of ICT were 90.1%, 80.9%, 93.2%, 73.9%, and 87.8%, of ICT with CIM were 88.5%, 90.4%, 96.4%, 73.0%, and 89.0%, of immunoblot were 98.3%, 80.9%, 93.7%, 94.4%, and 93.9%, and of immunoblot with CIM were 98.3%, 90.4%, 96.7%, 95.0%, and 96.3%, respectively. CONCLUSION:Immunoblot with CIM had the best performance. ICT with CIM was found to be more specific and accurate than the conventional ELISA and may be useful for non-invasive diagnosis of H pylori infection.展开更多
It is known that patients infected with H pylori can spontaneously become free from infection, and that the reverse change can occur. The time-scale of these conversions is expressed as percentages per year. Since the...It is known that patients infected with H pylori can spontaneously become free from infection, and that the reverse change can occur. The time-scale of these conversions is expressed as percentages per year. Since they have been investigated in terms of serology, the changes are called sero-reversion and sero-conversion respectively. Using serological evidence to investigate these phenomena is open to the criticisms that positive serology can be present in the absence of all other evidence of infection, and that a time-lag of 6-12 mo or longer can occur between eradication of the infection and sero-reversion. Investigations using direct evidence of current infection are sparse. The few that exist suggest that some individuals can seroconvert or sero- revert within six to twelve weeks. If these findings are confirmed, it means that some patients have an ability that is variable in time to resist, or spontaneously recover from, H pylori infection. Evidence suggests that the deciding factor of susceptibility is the level of gastric secretion of acid.展开更多
Helicobacter pylori(H.pylori)infection is one of the most common chronic bacterial infections all over the world.University students are a group with strong comprehensive ability.Their cognition and behavior can exert...Helicobacter pylori(H.pylori)infection is one of the most common chronic bacterial infections all over the world.University students are a group with strong comprehensive ability.Their cognition and behavior can exert great impact on society.However,up to now,reports on the awareness and attitudes regarding H.pylori infection among university students are scarce.This study aimed to survey dietary,habits,knowledge,and attitudes towards H.pylori infection.A total of 5794 participants,including undergraduates,postgraduates,and doctoral students,were recruited from the top 100 universities in China.A selfconstructed questionnaire was used to assess the knowledge and attitudes of students toward H.pylori infection and its impact.In our study,most of the population preferred dining in the canteen(69.6%),whereas 20.6% chose restaurants or takeaway.Up to 24.1% of the respondents had at least one lifestyle habit associated with H.pylori colonization.Almost half had at least one digestive symptom related to H.pylori infection.Most students were aware of its association with gastritis(84.4%)and peptic ulcer(86.6%).However,only half of them were aware of its association with gastric cancer(57.9%).Furthermore,only 14.1% of the respondents had been tested for H.pylori,and 25.1% of them tested positive.The H.pylori-detection rate was higher in Hunan province compared with Guangdong and Jilin provinces.Regarding knowledge of H.pylori,65.4% of the respondents had known about it,and 24.3% correctly answered all questions.When comparing the acquisition of H.pylori knowledge between tested and untested students,32.5% of the tested participants answered all questions correctly,which was significantly higher than the untested group(13.1%).There was no significant difference between genders in H.pylori knowledge and detection.University students are highly educated population.If they were fully aware of the harm of H.pylori infection,their parents,friends,and even future families would benefit,thus reducing the incidence of H.pylori infection,as well as gastric cancer and healthcare finances.This survey not only investigated but also spread the awareness of H.pylori among university students,which is of great medical,economic and sociological importance.展开更多
文摘The most recent new emerging infection is the H5N6 inl uenza virus infection. This infection has just been reported from China in early May 2014. The disease is believed to be a cross species infection. All indexed cases are from China. Of interest, the H5N6 inl uenza virus is the primary virus for avian. The avian H5N6 inl uenza virus in avian population is a low virulent strain. However, the clinical manifestation in human seems severe. In this mini-review, the authors summarize and discuss on this new emerging inl uenza.
基金Supported by a grant from International Digestive Cancer Alliance and Peking University School of Oncology
文摘AIM： To compare the one-day quadruple therapy with a standard 7-d triple therapy for H pylori eradication in a rural population of China. METHODS： A total of 396 patients with 13C-urea breath test positive for H pylori were assigned into two groups： 239 patients received one-day quadruple therapy （amoxicillin 2000 mg qid; metronidazole 500 mg qid; bismuth citrate 900 mg qid and lansoprazole 60 mg once daily） and 157 patients received 7-d standard triple therapy （amoxicillin 1000 mg bid; clarithromycin 500 mg bid and lansoprazole 30 mg bid）. All the patients underwent a 13C-UBT to assess the eradication of Hpylori infection six weeks after treatment. RESULTS： Two hundred and twenty-nine patients completed the one-day therapy （95.8%） and 148 patients completed the 7-d therapy （94.2%）. The oneday therapy eradicated H pylori infection in 64 patients （27.95%）. In contrast, 103 patients （69.59%） were Hpylori negative after the 7-d therapy （P 〈 0.01）. CONCLUSION： This pilot study suggests there is no beneficial effect of the one-day therapy in treatment ofHpylori infection compared with the 7-d standard therapy.
文摘AIM:To evaluate the performance of commercially available immunochromatographic (ICT) and immunoblot tests covering the current infection marker CIM and conventional ELISA for the diagnosis of H pylori infection in adult dyspeptic patients. METHODS:Consecutive non-treated dyspeptic patients undergoing diagnostic endoscopy were tested for H pylori infection by culture, rapid urease test, and histology of gastric biopsy specimens. Serum from 61 H pylori infected and 21 non-infected patients were tested for anti-H pylori IgG antibodies by commercial ELISA (AccuBindTM ELISA, Monobind, USA), ICT (Assure H pylori Rapid Test, Genelabs Diagnostics, Singapore), and immunoblot (Helico Blot 2.1, Genelabs Diagnostics, Singapore) assays. ICT and immunoblot kits cover CIM among other parameters and their performance with and without CIM was evaluated separately. RESULTS:Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of ELISA were 96.7%, 42.8%, 83.1%, 81.8%, and 82.9%, of ICT were 90.1%, 80.9%, 93.2%, 73.9%, and 87.8%, of ICT with CIM were 88.5%, 90.4%, 96.4%, 73.0%, and 89.0%, of immunoblot were 98.3%, 80.9%, 93.7%, 94.4%, and 93.9%, and of immunoblot with CIM were 98.3%, 90.4%, 96.7%, 95.0%, and 96.3%, respectively. CONCLUSION:Immunoblot with CIM had the best performance. ICT with CIM was found to be more specific and accurate than the conventional ELISA and may be useful for non-invasive diagnosis of H pylori infection.
文摘It is known that patients infected with H pylori can spontaneously become free from infection, and that the reverse change can occur. The time-scale of these conversions is expressed as percentages per year. Since they have been investigated in terms of serology, the changes are called sero-reversion and sero-conversion respectively. Using serological evidence to investigate these phenomena is open to the criticisms that positive serology can be present in the absence of all other evidence of infection, and that a time-lag of 6-12 mo or longer can occur between eradication of the infection and sero-reversion. Investigations using direct evidence of current infection are sparse. The few that exist suggest that some individuals can seroconvert or sero- revert within six to twelve weeks. If these findings are confirmed, it means that some patients have an ability that is variable in time to resist, or spontaneously recover from, H pylori infection. Evidence suggests that the deciding factor of susceptibility is the level of gastric secretion of acid.
基金funded by the Development and Reform Commission of Hunan Province to Yuqian Zhou(Grant No.2021-212-17).
文摘Helicobacter pylori(H.pylori)infection is one of the most common chronic bacterial infections all over the world.University students are a group with strong comprehensive ability.Their cognition and behavior can exert great impact on society.However,up to now,reports on the awareness and attitudes regarding H.pylori infection among university students are scarce.This study aimed to survey dietary,habits,knowledge,and attitudes towards H.pylori infection.A total of 5794 participants,including undergraduates,postgraduates,and doctoral students,were recruited from the top 100 universities in China.A selfconstructed questionnaire was used to assess the knowledge and attitudes of students toward H.pylori infection and its impact.In our study,most of the population preferred dining in the canteen(69.6%),whereas 20.6% chose restaurants or takeaway.Up to 24.1% of the respondents had at least one lifestyle habit associated with H.pylori colonization.Almost half had at least one digestive symptom related to H.pylori infection.Most students were aware of its association with gastritis(84.4%)and peptic ulcer(86.6%).However,only half of them were aware of its association with gastric cancer(57.9%).Furthermore,only 14.1% of the respondents had been tested for H.pylori,and 25.1% of them tested positive.The H.pylori-detection rate was higher in Hunan province compared with Guangdong and Jilin provinces.Regarding knowledge of H.pylori,65.4% of the respondents had known about it,and 24.3% correctly answered all questions.When comparing the acquisition of H.pylori knowledge between tested and untested students,32.5% of the tested participants answered all questions correctly,which was significantly higher than the untested group(13.1%).There was no significant difference between genders in H.pylori knowledge and detection.University students are highly educated population.If they were fully aware of the harm of H.pylori infection,their parents,friends,and even future families would benefit,thus reducing the incidence of H.pylori infection,as well as gastric cancer and healthcare finances.This survey not only investigated but also spread the awareness of H.pylori among university students,which is of great medical,economic and sociological importance.
