肝细胞癌(HCC)是世界范围内发病率非常高的恶性肿瘤之一。HBV和HCV感染是肝细胞癌发生的主要致病因素。乙型肝炎病毒x蛋白(hepatitis B virus x protein,HBx)是HBV基因组x区编码的一种多功能蛋白,在肝细胞癌发生中起重要作用。HBV抗原...肝细胞癌(HCC)是世界范围内发病率非常高的恶性肿瘤之一。HBV和HCV感染是肝细胞癌发生的主要致病因素。乙型肝炎病毒x蛋白(hepatitis B virus x protein,HBx)是HBV基因组x区编码的一种多功能蛋白,在肝细胞癌发生中起重要作用。HBV抗原表达可引起氧化应激(oxidative stress,OS)致DNA损伤(DNA damage)。研究发现DNA损伤反应的异常是肿瘤发生早期的重要机制。本文重点就HBx对DNA损伤反应的影响及这一影响作用与肝细胞癌发生关系的研究进展做一综述。展开更多
Occult hepatitis B virus(HBV)infection(OBI)is a challenging pathobiological and clinical issue that has been widely debated for several decades.By definition,OBI is characterized by the persistence of HBV DNA in the l...Occult hepatitis B virus(HBV)infection(OBI)is a challenging pathobiological and clinical issue that has been widely debated for several decades.By definition,OBI is characterized by the persistence of HBV DNA in the liver tissue(and in some cases also in the serum)in the absence of circulating HBV surface antigen(HBsAg).Many epidemiological and molecular studies have indicated that OBI is an important risk factor for hepatocellular carcinoma(HCC)development.OBI may exert direct pro-oncogenic effects through the activation of the same oncogenic mechanisms that are activated in the course of an HBsAg-positive infection.Indeed,in OBI as in HBV-positive infection,HBV DNA can persist in the hepatocytes both integrated into the host genome as well as free episome,and may maintain the capacity to produce proteins-mainly X protein and truncated preS-S protein-provided with potential transforming properties.Furthermore,OBI may indirectly favor HCC development.It has been shown that the persistence of very low viral replicative activity during OBI may induce mild liver necro-inflammation continuing for life,and substantial clinical evidence indicates that OBI canaccelerate the progression of liver disease towards cirrhosis that is considered the most important risk factor for HCC development.展开更多
文摘肝细胞癌(HCC)是世界范围内发病率非常高的恶性肿瘤之一。HBV和HCV感染是肝细胞癌发生的主要致病因素。乙型肝炎病毒x蛋白(hepatitis B virus x protein,HBx)是HBV基因组x区编码的一种多功能蛋白,在肝细胞癌发生中起重要作用。HBV抗原表达可引起氧化应激(oxidative stress,OS)致DNA损伤(DNA damage)。研究发现DNA损伤反应的异常是肿瘤发生早期的重要机制。本文重点就HBx对DNA损伤反应的影响及这一影响作用与肝细胞癌发生关系的研究进展做一综述。
文摘Occult hepatitis B virus(HBV)infection(OBI)is a challenging pathobiological and clinical issue that has been widely debated for several decades.By definition,OBI is characterized by the persistence of HBV DNA in the liver tissue(and in some cases also in the serum)in the absence of circulating HBV surface antigen(HBsAg).Many epidemiological and molecular studies have indicated that OBI is an important risk factor for hepatocellular carcinoma(HCC)development.OBI may exert direct pro-oncogenic effects through the activation of the same oncogenic mechanisms that are activated in the course of an HBsAg-positive infection.Indeed,in OBI as in HBV-positive infection,HBV DNA can persist in the hepatocytes both integrated into the host genome as well as free episome,and may maintain the capacity to produce proteins-mainly X protein and truncated preS-S protein-provided with potential transforming properties.Furthermore,OBI may indirectly favor HCC development.It has been shown that the persistence of very low viral replicative activity during OBI may induce mild liver necro-inflammation continuing for life,and substantial clinical evidence indicates that OBI canaccelerate the progression of liver disease towards cirrhosis that is considered the most important risk factor for HCC development.
