目的探讨肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病的疗效及对β2-MG、CRP、HCY水平影响。方法选取医院治疗的84例肾病综合征合并类固醇糖尿病炎患者,随机分为两组各42例。对照组患者给予舒洛地特,治疗组在对照组基础上口...目的探讨肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病的疗效及对β2-MG、CRP、HCY水平影响。方法选取医院治疗的84例肾病综合征合并类固醇糖尿病炎患者,随机分为两组各42例。对照组患者给予舒洛地特,治疗组在对照组基础上口服肾炎康复片,两组患者均持续治疗6个月。对比两组患者的临床疗效、中医症候积分、Scr、ALB、BUN、24 h UPE水平、2 h PG、FBG、HbA1c和FINS水平、β2-MG、CRP、HCY水平、补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平。结果治疗后,治疗组总有效率较高(P<0.05);两组患者治疗前中医证候积分差异无统计学意义(P>0.05);两组患者治疗后腰脊酸痛、疲倦乏力、面浮肢肿、肢体困重等证候评分显著降低(P<0.05);并且治疗组腰脊酸痛、疲倦乏力、面浮肢肿、肢体困重评分明显低于对照组(P<0.05);两组患者治疗前Scr、ALB、BUN、24 h UPE水平差异无统计学意义(P>0.05);两组患者治疗后Scr、BUN、24 h UPE显著降低,ALB水平明显升高(P<0.05);并且治疗组改善较多(P<0.05);两组患者治疗前2 h PG、FBG、HbA1c和FINS水平差异无统计学意义(P>0.05);两组患者治疗后2 h PG、FBG、HbA1c和FINS水平显著降低(P<0.05);并且治疗组2 h PG、FBG、HbA1c明显低于对照组(P<0.05),治疗组患者FINS水平低于对照组,但但差异无统计学意义(P>0.05);两组患者治疗前β2-MG、CRP、HCY水平差异无统计学意义(P>0.05);治疗后两组患者β2-MG、CRP、HCY水平显著降低(P<0.05);并且治疗组降低较多(P<0.05);两组患者治疗前补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平差异无统计学意义(P>0.05);对照组患者治疗前后补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平变化无统计学意义(P>0.05);治疗组患者治疗后补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平高于对照组,但差异无统计学意义(P>0.05)。结论采用肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病具有较好的治疗效果,能够改善血清β2-MG、CRP、HCY水平,安全性较高,值得在临床上推广应用。展开更多
BACKGROUND Acute ischemic stroke(AIS)is mainly caused by cerebral blood flow disorders,which further leads to ischemic brain necrosis or encephalomalacia.The role of homocysteine(Hcy),an independent risk factor for ca...BACKGROUND Acute ischemic stroke(AIS)is mainly caused by cerebral blood flow disorders,which further leads to ischemic brain necrosis or encephalomalacia.The role of homocysteine(Hcy),an independent risk factor for cardiovascular disease,in the development of atherosclerosis is gradually revealed.However,studies are still rare and little is known about the relationship of Hcy level with the prognosis.AIM To explore the relationship between Hcy level and prognosis in elderly patients with AIS after thrombolytic therapy with recombinant tissue plasminogen activator(rtPA).METHODS A total of 120 patients with acute ischemic stroke who were admitted to Jingzhou Central Hospital and underwent recombinant tissue plasminogen activator treatment were randomly selected from January 2017 to December 2018.They were divided into two groups according to the level of Hcy,with 60 patients in each group.Patients with Hcy≥18.54 umol/L were included into a high-level group and those with Hcy<18.54 umol/L were included into a low-level group.The outcomes were analyzed in the two groups after the treatment.RESULTS The National institute of Health Stroke Scale(NIHSS)scores were significantly higher in the high-level group than in the low-level group before and 1 h after the treatment(P<0.05).There was no significant difference in NIHSS scores between the two groups at 12 and 24 h after the treatment(P>0.05).The Modified Rankin scale(MRS)scores were significantly higher in the high-level group than in the low-level group before and 1 h after the treatment(P<0.05).There was no significant difference in MRS scores between the two groups at 12 and 24 h after the treatment(P>0.05).NIHSS and MRS scores were positively correlated with the prognosis after thrombolytic therapy(P<0.05).CONCLUSION The level of Hcy is closely related to the prognosis of elderly patients with acute ischemic stroke,and after rtPA treatment,the prognosis of elderly patients is improved significantly.展开更多
文摘目的探讨肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病的疗效及对β2-MG、CRP、HCY水平影响。方法选取医院治疗的84例肾病综合征合并类固醇糖尿病炎患者,随机分为两组各42例。对照组患者给予舒洛地特,治疗组在对照组基础上口服肾炎康复片,两组患者均持续治疗6个月。对比两组患者的临床疗效、中医症候积分、Scr、ALB、BUN、24 h UPE水平、2 h PG、FBG、HbA1c和FINS水平、β2-MG、CRP、HCY水平、补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平。结果治疗后,治疗组总有效率较高(P<0.05);两组患者治疗前中医证候积分差异无统计学意义(P>0.05);两组患者治疗后腰脊酸痛、疲倦乏力、面浮肢肿、肢体困重等证候评分显著降低(P<0.05);并且治疗组腰脊酸痛、疲倦乏力、面浮肢肿、肢体困重评分明显低于对照组(P<0.05);两组患者治疗前Scr、ALB、BUN、24 h UPE水平差异无统计学意义(P>0.05);两组患者治疗后Scr、BUN、24 h UPE显著降低,ALB水平明显升高(P<0.05);并且治疗组改善较多(P<0.05);两组患者治疗前2 h PG、FBG、HbA1c和FINS水平差异无统计学意义(P>0.05);两组患者治疗后2 h PG、FBG、HbA1c和FINS水平显著降低(P<0.05);并且治疗组2 h PG、FBG、HbA1c明显低于对照组(P<0.05),治疗组患者FINS水平低于对照组,但但差异无统计学意义(P>0.05);两组患者治疗前β2-MG、CRP、HCY水平差异无统计学意义(P>0.05);治疗后两组患者β2-MG、CRP、HCY水平显著降低(P<0.05);并且治疗组降低较多(P<0.05);两组患者治疗前补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平差异无统计学意义(P>0.05);对照组患者治疗前后补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平变化无统计学意义(P>0.05);治疗组患者治疗后补体C3、IgG和CD^(+)_(4)/CD^(+)_(8)水平高于对照组,但差异无统计学意义(P>0.05)。结论采用肾炎康复片联合舒洛地特治疗肾病综合征合并类固醇糖尿病具有较好的治疗效果,能够改善血清β2-MG、CRP、HCY水平,安全性较高,值得在临床上推广应用。
文摘BACKGROUND Acute ischemic stroke(AIS)is mainly caused by cerebral blood flow disorders,which further leads to ischemic brain necrosis or encephalomalacia.The role of homocysteine(Hcy),an independent risk factor for cardiovascular disease,in the development of atherosclerosis is gradually revealed.However,studies are still rare and little is known about the relationship of Hcy level with the prognosis.AIM To explore the relationship between Hcy level and prognosis in elderly patients with AIS after thrombolytic therapy with recombinant tissue plasminogen activator(rtPA).METHODS A total of 120 patients with acute ischemic stroke who were admitted to Jingzhou Central Hospital and underwent recombinant tissue plasminogen activator treatment were randomly selected from January 2017 to December 2018.They were divided into two groups according to the level of Hcy,with 60 patients in each group.Patients with Hcy≥18.54 umol/L were included into a high-level group and those with Hcy<18.54 umol/L were included into a low-level group.The outcomes were analyzed in the two groups after the treatment.RESULTS The National institute of Health Stroke Scale(NIHSS)scores were significantly higher in the high-level group than in the low-level group before and 1 h after the treatment(P<0.05).There was no significant difference in NIHSS scores between the two groups at 12 and 24 h after the treatment(P>0.05).The Modified Rankin scale(MRS)scores were significantly higher in the high-level group than in the low-level group before and 1 h after the treatment(P<0.05).There was no significant difference in MRS scores between the two groups at 12 and 24 h after the treatment(P>0.05).NIHSS and MRS scores were positively correlated with the prognosis after thrombolytic therapy(P<0.05).CONCLUSION The level of Hcy is closely related to the prognosis of elderly patients with acute ischemic stroke,and after rtPA treatment,the prognosis of elderly patients is improved significantly.
