目的综合评价HIV-Ⅰ宫内传播发生的危险因素。方法计算机检索MIDLINE及中国生物医学文献数据库,手工检索和引文检索作为补充。对纳入的文献进行质量评价后提取数据信息。采用专用软件Rev Man 4.2.2完成系统评价过程。结果本次研究纳入文...目的综合评价HIV-Ⅰ宫内传播发生的危险因素。方法计算机检索MIDLINE及中国生物医学文献数据库,手工检索和引文检索作为补充。对纳入的文献进行质量评价后提取数据信息。采用专用软件Rev Man 4.2.2完成系统评价过程。结果本次研究纳入文献8篇,HIV-Ⅰ宫内传播组CD4+细胞计数低于未传播组,WMD=-164.58 95%CI为(-203.64,-125.51);宫内传播组的CD4+/CD8比率低于未传播组,WMD=-0.17,95%的可信区间(-0.22,-0.13);HIV-Ⅰ宫内传播组血清病毒载量高于未传播组,WMD=1.08 95%的置信区间为(0.36,1.81);宫内传播组的低体重婴儿的发生率高于未传播组。宫内传播组的出生体重低于未传播组的出生体重。宫内传播组的胎盘感染及相关疾病高于未传播组。结论母体的免疫状况、病毒水平、胎盘炎症及其他疾病的发生、及胎儿因素等都与宫内感染有关,其中母体免疫状况、病毒水平是HIV-Ⅰ宫内感染的发生的高危因素。另外母体胎盘炎性疾病、其他疾病、早产、低出生体重与HIV-Ⅰ宫内感染的发生也有关系。展开更多
To explore the spatial genetic structure of two HIV-Ⅰ-resistant polymorphisms （CCR2-64 Ⅰ and SDF1-3＇A） alleles in the population of Shandong Province, China. Methods Using the techniques of spatial stratified sam...To explore the spatial genetic structure of two HIV-Ⅰ-resistant polymorphisms （CCR2-64 Ⅰ and SDF1-3＇A） alleles in the population of Shandong Province, China. Methods Using the techniques of spatial stratified sampling and spatial statistics, the spatial genetic structure of the locus （CCR2-64 Ⅰ and SDF1-3＇A）, which was shown to be important co-receptor for HIV infection, was quantified from the populations of 36 sampled counties of Shandong Province, and a total of 3147 and 3172 samples were taken for testing CCR2-64Ⅰ and SDF1-3＇A respectively from individuals without known history of HIV-Ⅰ infection and AIDS symptoms. Results There were significantly spatial genetic structures of the two alleles at different spatial distance classes on the scale of populations, but on the scale of individuals, no spatial structure was found in either the whole area of Shandong Province or the area of each sampled county. Although the change of frequencies of the two alleles with geographic locations in Shandong Province both showed gradual increase trends, their changing directions were inverse. The frequency of CCR2-64Ⅰallele gradually increased from the southwest to the northeast, while the frequency of SDF1-3＇A allele gradually increased from the northeast to the southwest. However the RH to AIDS of combined types of their different genotypes did not represent obvious geographic diversity on the whole area of the Province. Conclusion The frequency of allele usually has some spatial genetic structures or spatial autocorrelation with different spatial distance classes, but the genotypes of individuals have random distribution in the same geographic area. Evaluating spatial distribution of the genetic susceptibility of HIV （AIDS） to CCR2-64Ⅰand SDF1-3＇A alleles, should focus on the frequencies of combined genotypes of CCR2 and SDFI based on the two-locus genotypes of each individual rather than the frequencies of CCR2-641 and SDF1-3＇A alleles.展开更多
文摘目的综合评价HIV-Ⅰ宫内传播发生的危险因素。方法计算机检索MIDLINE及中国生物医学文献数据库,手工检索和引文检索作为补充。对纳入的文献进行质量评价后提取数据信息。采用专用软件Rev Man 4.2.2完成系统评价过程。结果本次研究纳入文献8篇,HIV-Ⅰ宫内传播组CD4+细胞计数低于未传播组,WMD=-164.58 95%CI为(-203.64,-125.51);宫内传播组的CD4+/CD8比率低于未传播组,WMD=-0.17,95%的可信区间(-0.22,-0.13);HIV-Ⅰ宫内传播组血清病毒载量高于未传播组,WMD=1.08 95%的置信区间为(0.36,1.81);宫内传播组的低体重婴儿的发生率高于未传播组。宫内传播组的出生体重低于未传播组的出生体重。宫内传播组的胎盘感染及相关疾病高于未传播组。结论母体的免疫状况、病毒水平、胎盘炎症及其他疾病的发生、及胎儿因素等都与宫内感染有关,其中母体免疫状况、病毒水平是HIV-Ⅰ宫内感染的发生的高危因素。另外母体胎盘炎性疾病、其他疾病、早产、低出生体重与HIV-Ⅰ宫内感染的发生也有关系。
文摘To explore the spatial genetic structure of two HIV-Ⅰ-resistant polymorphisms （CCR2-64 Ⅰ and SDF1-3＇A） alleles in the population of Shandong Province, China. Methods Using the techniques of spatial stratified sampling and spatial statistics, the spatial genetic structure of the locus （CCR2-64 Ⅰ and SDF1-3＇A）, which was shown to be important co-receptor for HIV infection, was quantified from the populations of 36 sampled counties of Shandong Province, and a total of 3147 and 3172 samples were taken for testing CCR2-64Ⅰ and SDF1-3＇A respectively from individuals without known history of HIV-Ⅰ infection and AIDS symptoms. Results There were significantly spatial genetic structures of the two alleles at different spatial distance classes on the scale of populations, but on the scale of individuals, no spatial structure was found in either the whole area of Shandong Province or the area of each sampled county. Although the change of frequencies of the two alleles with geographic locations in Shandong Province both showed gradual increase trends, their changing directions were inverse. The frequency of CCR2-64Ⅰallele gradually increased from the southwest to the northeast, while the frequency of SDF1-3＇A allele gradually increased from the northeast to the southwest. However the RH to AIDS of combined types of their different genotypes did not represent obvious geographic diversity on the whole area of the Province. Conclusion The frequency of allele usually has some spatial genetic structures or spatial autocorrelation with different spatial distance classes, but the genotypes of individuals have random distribution in the same geographic area. Evaluating spatial distribution of the genetic susceptibility of HIV （AIDS） to CCR2-64Ⅰand SDF1-3＇A alleles, should focus on the frequencies of combined genotypes of CCR2 and SDFI based on the two-locus genotypes of each individual rather than the frequencies of CCR2-641 and SDF1-3＇A alleles.
