目的:通过问卷调查评估正颌患者治疗过程中健康相关生命质量指数的变化,初步探讨正颌外科治疗对正颌患者健康相关生命质量状况的影响,为今后正颌治疗提供一定的参考依据。方法:于正颌外科治疗安放矫治器前(T1)-正颌外科手术前1周(T2)-...目的:通过问卷调查评估正颌患者治疗过程中健康相关生命质量指数的变化,初步探讨正颌外科治疗对正颌患者健康相关生命质量状况的影响,为今后正颌治疗提供一定的参考依据。方法:于正颌外科治疗安放矫治器前(T1)-正颌外科手术前1周(T2)-正颌外科术后正畸完成后1周(T3),采用改良的正颌患者生命质量问卷(Health-related quality of life,HRQOL)对58例正颌患者进行问卷调查,PEMS3.1软件包对正颌治疗三阶段四因子分及HRQOL总分进行统计分析。结果:HRQOL总分及颜面、口颌功能、社交因子分T3阶段明显低于T1、T2(P<0.01),正颌治疗后患者HRQOL改善明显,但自我关注因子分改变未见统计学差异;T1～T2,各因子未见统计学差异。结论:正颌外科治疗能明显改善正颌患者的健康相关生命质量水平,但患者自我关注水平不随身体、心理和社交生活质量的改善而降低,在临床治疗中要合理引导患者的审美观和心理状态,以达到更好的治疗结果。展开更多
目的:评估儿童急性淋巴细胞白血病(acute lymphocytic leukemia,ALL)经长期化疗后与健康相关的生存质量(health-re-lated quality of life,HRQL),并分析影响其部分的相关因素。方法:分析2013年1月至2019年6月在南通大学附属医院确诊为AL...目的:评估儿童急性淋巴细胞白血病(acute lymphocytic leukemia,ALL)经长期化疗后与健康相关的生存质量(health-re-lated quality of life,HRQL),并分析影响其部分的相关因素。方法:分析2013年1月至2019年6月在南通大学附属医院确诊为ALL的108例患儿临床资料,按照中国儿童白血病协作组(Chinese Children Leukemia Group,CCLG)-ALL-2008或中国儿童癌症协作组(Chinese Children Cancer Group,CCCG)-ALL-2015方案按序规范治疗,后随诊于南通大学附属医院。以健康儿童和同胞为双对照组,通过自设调查表和中文版儿童生存质量普适性核心量表(PedsQL 4.0)对ALL患儿进行调查分析。结果:ALL患儿的生存质量评分低于健康儿童组和同胞组,呈显著性差异(P<0.05)。患儿性格类型、家庭教育方式、填表时年龄、结束化疗后时间、确诊时危险分级为相关因素。结论:ALL患儿HRQL低于健康儿童组和同胞组,影响因素包括临床和社会学方面,应尽早筛查目标人群,针对性采取措施,提高其生存质量。展开更多
Background： The aim of this study was to evaluate the impact of jejunostomy during esophagectomy for cancer on postoperative health-related quality of life（HRQL）.Methods： We evaluate all consecutive patients who u...Background： The aim of this study was to evaluate the impact of jejunostomy during esophagectomy for cancer on postoperative health-related quality of life（HRQL）.Methods： We evaluate all consecutive patients who underwent esophagectomy for cancer at the surgical oncology unit of the Veneto Institute of Oncology（IOV-IRCCS） between January 2008 and March 2014. The primary outcome was HRQL, which was assessed using nine scales of EORTC C30 and OES18 questionnaires. General linear models were estimated to evaluate mean score difference（MD） of each selected scale in patients with and without jejunostomy, adjusting for clinically relevant confounders. The secondary outcomes were morbidity, hospital stay, postoperative weight loss and postoperative albumin impairment. Results： Jejunostomy was performed in 40 on 109 patients（41.3%） who participated in quality of life investigation. A clinically and statistically significantly worse eating at admission（P=0.009） became not clinically significant at 3 months after surgery（MD =9.1）. Jejunostomy was associated to clinically and statistically significantly poorer emotional function（EF） at 3 months after surgery（MD =-15.6; P=0.04）. Hospital stay was longer in jejunostomy group（median, 20 vs. 17 days, P=0.02）.Conclusions： In our series patients who had a jejunostomy during esophagectomy had been selected for their risk for postoperative complication. However, their postoperative outcome was actually similar compared to those without jejunostomy. Nevertheless, jejunostomy was associated to clinically and statistically significantly poorer EF at 3 months after surgery. Therefore, patient candidate to esophagectomy and feeding jejunostomy should receive additional psychological support.展开更多
Background: Chronic disease can have physical and psychological effects which affect social functioning. These effects can be better understood from the perspective of parent and child by the use of health-related qua...Background: Chronic disease can have physical and psychological effects which affect social functioning. These effects can be better understood from the perspective of parent and child by the use of health-related quality of life (HRQL) measures. Various HRQL measures are now available, of which generic health measures have been the most widely used. These permit comparison between different diseases and also the normal population. Objectives: To cross-validate a new generic HRQL proxy measure for children, the Children’ s Life Quality Index (CLQI), with an established speciality-specific dermatological questionnaire, the Children’ s Dermatology Life Quality Index (CDLQI), in a group of children with chronic skin diseases. The impairment of HRQL in the same group of children with skin disease was then compared with that associated with other common chronic childhood diseases using the CLQI. Methods: The CDLQI was completed by 379 children aged 5- 16 years with skin disease of more than 6 months’ duration. Their parents (n = 379) and parents of 161 children aged 5- 16 years with other chronic diseases were also asked to complete a proxy measure, the CLQI. Results: Using linear regression analysis, the CLQI and the CDLQI scores showed a strong linear association (rs = 0.72, P < 0.001) and on a Bland-Altman plot, reasonably good agreement (expressing scores out of 100, the 95% limits of agreement were from - 25.5/100 to 26.7/100). In the child’ s opinion psoriasis and atopic dermatitis (AD) caused the greatest impairment (CDLQI scores of 30.6% and 30.5% ), followed by urticaria (20% ) and acne (18% ). Using the generic CLQI (scored 0- 36), from the parental perspective the highest score was for AD (33% ), followed by urticaria (28% ), psoriasis (27% ) and alopecia (19% ). Comparing this with children with other chronic diseases, those with cerebral palsy had the highest score (38% ), followed in descending order by those with generalized AD (33% ), renal disease (33% ), cystic fibrosis (32% ), urticaria (28% ), asthma (28% ) and psoriasis (27% ). Diseases such as epilepsy (24% ) and enuresis (24% ) scored higher than diabetes (19% ), localized eczema (19% ), alopecia (19% ) and acne (16% ). Conclusions: Using the CLQI we have shown that HRQL impairment in children with chronic skin disease is at least equal to that experienced by children with many other chronic diseases of childhood, with AD and psoriasis having the greatest impact on HRQL among chronic skin disorders and only cerebral palsy scoring higher than AD. Cross-validation of the CLQI with the CDLQI in the group of children with skin disease demonstrates a strong linear association and good agreement between the two.展开更多
Background/Aims: Hepatitis C (HCV) infected patients have significant health-related quality of life (HRQL) impairment which worsens during anti-viral therapy. Our aim was to examine the association of HRQL with treat...Background/Aims: Hepatitis C (HCV) infected patients have significant health-related quality of life (HRQL) impairment which worsens during anti-viral therapy. Our aim was to examine the association of HRQL with treatment-induced depression and anemia. Methods: Two hundred and seventy-one HCV patients who received pegylated interferon alfa 2b and ribavirin were included. Data on HRQL, depressive symptoms, laboratory values and socio-demographic characteristics were collected. Results: Mean age was 47.1± 6.5, 69% were male, and 73% were White. HCV patients’ HRQL declined during anti-viral therapy but returned to or exceeded baseline levels within 24 weeks of completion. Anemia and depression were both associated with HRQL impairment. The effects of depression on HRQL were strong; once depression scores were included other factors were no longer significant. Patients’ depressive symptoms tended to increase during the initial half of treatment regimen. Those with higher body mass index (BMI), cirrhosis, and women reported more HRQL impairments. HRQL scales were generally not associated with alcohol abuse, age, race, ALT and HCV RNA levels. Conclusions: Antiviral therapy for HCV is associated with diminished HRQL. Although anemia and depression were associated with this impairment, depression was the most consistent predictor. Future studies are needed to see whether proactive management of these side effects can improve patients’ HRQL and the efficacy of antiviral therapy for hepatitis C.展开更多
文摘目的:通过问卷调查评估正颌患者治疗过程中健康相关生命质量指数的变化,初步探讨正颌外科治疗对正颌患者健康相关生命质量状况的影响,为今后正颌治疗提供一定的参考依据。方法:于正颌外科治疗安放矫治器前(T1)-正颌外科手术前1周(T2)-正颌外科术后正畸完成后1周(T3),采用改良的正颌患者生命质量问卷(Health-related quality of life,HRQOL)对58例正颌患者进行问卷调查,PEMS3.1软件包对正颌治疗三阶段四因子分及HRQOL总分进行统计分析。结果:HRQOL总分及颜面、口颌功能、社交因子分T3阶段明显低于T1、T2(P<0.01),正颌治疗后患者HRQOL改善明显,但自我关注因子分改变未见统计学差异;T1～T2,各因子未见统计学差异。结论:正颌外科治疗能明显改善正颌患者的健康相关生命质量水平,但患者自我关注水平不随身体、心理和社交生活质量的改善而降低,在临床治疗中要合理引导患者的审美观和心理状态,以达到更好的治疗结果。
文摘目的:评估儿童急性淋巴细胞白血病(acute lymphocytic leukemia,ALL)经长期化疗后与健康相关的生存质量(health-re-lated quality of life,HRQL),并分析影响其部分的相关因素。方法:分析2013年1月至2019年6月在南通大学附属医院确诊为ALL的108例患儿临床资料,按照中国儿童白血病协作组(Chinese Children Leukemia Group,CCLG)-ALL-2008或中国儿童癌症协作组(Chinese Children Cancer Group,CCCG)-ALL-2015方案按序规范治疗,后随诊于南通大学附属医院。以健康儿童和同胞为双对照组,通过自设调查表和中文版儿童生存质量普适性核心量表(PedsQL 4.0)对ALL患儿进行调查分析。结果:ALL患儿的生存质量评分低于健康儿童组和同胞组,呈显著性差异(P<0.05)。患儿性格类型、家庭教育方式、填表时年龄、结束化疗后时间、确诊时危险分级为相关因素。结论:ALL患儿HRQL低于健康儿童组和同胞组,影响因素包括临床和社会学方面,应尽早筛查目标人群,针对性采取措施,提高其生存质量。
基金supported by Current Research Fund from Italian Ministry of Health to Carlo Castoro grant from Berlucchi Foundation （Brescia, Italy） to Carlo Castoro
文摘Background： The aim of this study was to evaluate the impact of jejunostomy during esophagectomy for cancer on postoperative health-related quality of life（HRQL）.Methods： We evaluate all consecutive patients who underwent esophagectomy for cancer at the surgical oncology unit of the Veneto Institute of Oncology（IOV-IRCCS） between January 2008 and March 2014. The primary outcome was HRQL, which was assessed using nine scales of EORTC C30 and OES18 questionnaires. General linear models were estimated to evaluate mean score difference（MD） of each selected scale in patients with and without jejunostomy, adjusting for clinically relevant confounders. The secondary outcomes were morbidity, hospital stay, postoperative weight loss and postoperative albumin impairment. Results： Jejunostomy was performed in 40 on 109 patients（41.3%） who participated in quality of life investigation. A clinically and statistically significantly worse eating at admission（P=0.009） became not clinically significant at 3 months after surgery（MD =9.1）. Jejunostomy was associated to clinically and statistically significantly poorer emotional function（EF） at 3 months after surgery（MD =-15.6; P=0.04）. Hospital stay was longer in jejunostomy group（median, 20 vs. 17 days, P=0.02）.Conclusions： In our series patients who had a jejunostomy during esophagectomy had been selected for their risk for postoperative complication. However, their postoperative outcome was actually similar compared to those without jejunostomy. Nevertheless, jejunostomy was associated to clinically and statistically significantly poorer EF at 3 months after surgery. Therefore, patient candidate to esophagectomy and feeding jejunostomy should receive additional psychological support.
文摘Background: Chronic disease can have physical and psychological effects which affect social functioning. These effects can be better understood from the perspective of parent and child by the use of health-related quality of life (HRQL) measures. Various HRQL measures are now available, of which generic health measures have been the most widely used. These permit comparison between different diseases and also the normal population. Objectives: To cross-validate a new generic HRQL proxy measure for children, the Children’ s Life Quality Index (CLQI), with an established speciality-specific dermatological questionnaire, the Children’ s Dermatology Life Quality Index (CDLQI), in a group of children with chronic skin diseases. The impairment of HRQL in the same group of children with skin disease was then compared with that associated with other common chronic childhood diseases using the CLQI. Methods: The CDLQI was completed by 379 children aged 5- 16 years with skin disease of more than 6 months’ duration. Their parents (n = 379) and parents of 161 children aged 5- 16 years with other chronic diseases were also asked to complete a proxy measure, the CLQI. Results: Using linear regression analysis, the CLQI and the CDLQI scores showed a strong linear association (rs = 0.72, P < 0.001) and on a Bland-Altman plot, reasonably good agreement (expressing scores out of 100, the 95% limits of agreement were from - 25.5/100 to 26.7/100). In the child’ s opinion psoriasis and atopic dermatitis (AD) caused the greatest impairment (CDLQI scores of 30.6% and 30.5% ), followed by urticaria (20% ) and acne (18% ). Using the generic CLQI (scored 0- 36), from the parental perspective the highest score was for AD (33% ), followed by urticaria (28% ), psoriasis (27% ) and alopecia (19% ). Comparing this with children with other chronic diseases, those with cerebral palsy had the highest score (38% ), followed in descending order by those with generalized AD (33% ), renal disease (33% ), cystic fibrosis (32% ), urticaria (28% ), asthma (28% ) and psoriasis (27% ). Diseases such as epilepsy (24% ) and enuresis (24% ) scored higher than diabetes (19% ), localized eczema (19% ), alopecia (19% ) and acne (16% ). Conclusions: Using the CLQI we have shown that HRQL impairment in children with chronic skin disease is at least equal to that experienced by children with many other chronic diseases of childhood, with AD and psoriasis having the greatest impact on HRQL among chronic skin disorders and only cerebral palsy scoring higher than AD. Cross-validation of the CLQI with the CDLQI in the group of children with skin disease demonstrates a strong linear association and good agreement between the two.
文摘Background/Aims: Hepatitis C (HCV) infected patients have significant health-related quality of life (HRQL) impairment which worsens during anti-viral therapy. Our aim was to examine the association of HRQL with treatment-induced depression and anemia. Methods: Two hundred and seventy-one HCV patients who received pegylated interferon alfa 2b and ribavirin were included. Data on HRQL, depressive symptoms, laboratory values and socio-demographic characteristics were collected. Results: Mean age was 47.1± 6.5, 69% were male, and 73% were White. HCV patients’ HRQL declined during anti-viral therapy but returned to or exceeded baseline levels within 24 weeks of completion. Anemia and depression were both associated with HRQL impairment. The effects of depression on HRQL were strong; once depression scores were included other factors were no longer significant. Patients’ depressive symptoms tended to increase during the initial half of treatment regimen. Those with higher body mass index (BMI), cirrhosis, and women reported more HRQL impairments. HRQL scales were generally not associated with alcohol abuse, age, race, ALT and HCV RNA levels. Conclusions: Antiviral therapy for HCV is associated with diminished HRQL. Although anemia and depression were associated with this impairment, depression was the most consistent predictor. Future studies are needed to see whether proactive management of these side effects can improve patients’ HRQL and the efficacy of antiviral therapy for hepatitis C.
