Unveiling DNA methylation in Alzheimer’s disease:a review of array-based human brain studies

The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA methylation.This review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer’s disease neuropathology.The examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer’s disease progression.The entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the hippocampus.Notably,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal cortex.Further,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory processes.The complex role of BIN1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation patterns.Despite the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease pathology.Future research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.

Theoretical Transplantation into Translation Studies——An Analysis on the Pragmatic Application of Hofstede’s

The deepening process of globalization has given rise to restless cultural exchanges among people from different regions of the world through newspapers,books,and other written media.However,the significant differences in languages and cultures have become an insurmountable gap in intercultural communication.To lubricate cultural exchanges,new translation theories that focus on the transformation of different cultural concepts shall be introduced and adopted.This paper aims to extract applicable notions from Hofstede’s Cultural Dimensions for pragmatic translation studies by laying emphasis on its pragmatic value through case study.By such theoretical transplantation,valuable suggestions are proposed to tackle cultural misunderstandings and conflicts encountered amid cultural exchanges.

A Survey of English Translation Studies of Lu You’s Poetry Based on the Data Analysis of Domestic Academic Journals (2001-2022)

This article presents a comprehensive analysis of the current state of research on the English translation of Lu You’s poetry, utilizing a data sample comprising research papers published in the CNKI Full-text Database from 2001 to 2022. Employing rigorous longitudinal statistical methods, the study examines the progress achieved over the past two decades. Notably, domestic researchers have displayed considerable interest in the study of Lu You’s English translation works since 2001. The research on the English translation of Lu You’s poetry reveals a diverse range of perspectives, indicating a rich body of scholarship. However, several challenges persist, including insufficient research, limited translation coverage, and a noticeable focus on specific poems such as “Phoenix Hairpin” in the realm of English translation research. Consequently, there is ample room for improvement in the quality of research output on the English translation of Lu You’s poems, as well as its recognition within the academic community. Building on these findings, it is argued that future investigations pertaining to the English translation of Lu You’s poetry should transcend the boundaries of textual analysis and encompass broader theoretical perspectives and research methodologies. By undertaking this shift, scholars will develop a more profound comprehension of Lu You’s poetic works and make substantive contributions to the field of translation studies. Thus, this article aims to bridge the gap between past research endeavors and future possibilities, serving as a guide and inspiration for scholars to embark on a more nuanced and enriching exploration of Lu You’s poetry as well as other Chinese literature classics.

Anderson's Cognitive Theory and Learning Strategy Studies in Second Language Acquisition

Second language acquisition can not be understood without addressing the interaction between language and cognition. Cognitive theory can extend to describe learning strategies as complex cognitive skills. Theoretical developments in Anderson’s production systems cover a broader range of behavior than other theories, including comprehension and production of oral and written texts as well as comprehension, problem solving, and verbal learning.Thus Anderson’s cognitive theory can be served as a rationale for learning strategy studies in second language acquisition.

LC-MS/MS法测定大鼠血浆中S,S,S-三丁基三硫代磷酸酯质量浓度及其毒物动力学研究

目的 建立LC-MS/MS法测定大鼠血浆中S,S,S-三丁基三硫代磷酸酯的质量浓度,并用于大鼠体内的毒物动力学研究。方法 采用沉淀蛋白法进行血浆样品前处理,以丙酸倍氯米松为内标。色谱柱为Agilent Zorbax SB C_(18)(50 mm×2.1 mm, 3.5μm)柱,流动相为水(含体积分数0.1%甲酸)-乙腈/甲醇(体积比1∶1),梯度洗脱,流速为0.8 mL·min^(-1)。质谱检测采用ESI源,正离子化方式,多反应监测模式(MRM)进行扫描检测。结果 血浆中S,S,S-三丁基三硫代磷酸酯线性范围为2~800μg·L^(-1),线性良好(r≥0.99),批内、批间RSD均在±15%内,准确度在85%~115%内。高、中、低质量浓度总体提取回收率为89.0%,变异系数为1.1%。结论 本方法适用于大鼠血浆中S,S,S-三丁基三硫代磷酸酯质量浓度的准确测定和动力学研究。

城市轨道交通S型曲线夹直线与长直线地段振动对比试验研究

夹直线在一定程度上可以保证线型连续和行车平顺,但过短的夹直线长度会导致振动叠加,影响旅客舒适度和列车运行的稳定性,增加运营维护成本。本文通过对城市轨道交通S型曲线夹直线与长直线地段振动对比试验研究,从时域、时频域、振动加速度级及地面Z振级等方面对获得的数据进行分析,解释了夹直线段振动叠加的产生机理,验证了车体垂向加速度峰值在缓直点处会出现峰值提前现象,并阐述了夹直线段的振动叠加现象对地面环境振动的影响。结论如下:车辆在通过S型曲线线形变化点时产生的冲击振动会通过钢轨以弹性波的形式向前传播,与车辆在夹直线段行驶产生的振动叠加;由于弹性波的形式传播的速度远高于车辆行驶速度,因此会导致夹直线段出现振动加速度峰值提前现象;S型曲线夹直线的垂向振动加速度的优势频率要高于长直线段,且更向高频分散;S型曲线夹直线产生的振动叠加现象不会对地面环境振动产生影响。

Anatomic location of the first dorsal extensor compartment for surgical De-Quervain’s tenosynovitis release:A cadaveric study

BACKGROUND De-Quervain’s tenosynovitis is a disorder arising from the compression and irritation of the first dorsal extensor compartment of the wrist.Patients who fail conservative treatment modalities are candidates for surgical release.However,risks with surgery include damage to the superficial radial nerve and an incomplete release due to inadequate dissection.Currently,there is a paucity of literature demonstrating the exact anatomic location of the first dorsal extensor compartment in reference to surface anatomy.Thus,this cadaveric study was performed to determine the exact location of the first extensor compartment and to devise a reliable surgical incision to prevent complications.AIM To describe the location of the first dorsal compartment in relation to bony surface landmarks to create replicable surgical incisions.METHODS Six cadaveric forearms,including four left and two right forearm specimens were dissected.Dissections were performed by a single fellowship trained upper extremity orthopaedic surgeon.Distance of the first dorsal compartment from landmarks such as Lister’s tubercle,the wrist crease,and the radial styloid were calculated.Other variables studied included the presence of the superficial radial nerve overlying the first dorsal compartment,additional compartment subsheaths,number of abductor pollicis longus(APL)tendon slips,and the presence of a pseudo-retinaculum.RESULTS Distance from the radial most aspect of the wrist crease to the extensor retinaculum was 5.14 mm±0.80 mm.The distance from Lister’s tubercle to the distal aspect of the extensor retinaculum was 13.37 mm±2.94 mm.Lister’s tubercle to the start of the first dorsal compartment was 18.43 mm±2.01 mm.The radial styloid to the initial aspect of the extensor retinaculum measured 2.98 mm±0.99 mm.The retinaculum length longitudinally on average was 26.82 mm±3.34 mm.Four cadaveric forearms had separate extensor pollicis brevis compartments.The average number of APL tendon slips was three.A pseudo-retinaculum was present in four cadavers.Two cadavers had a superficial radial nerve that crossed over the first dorsal compartment and retinaculum proximally(7.03 mm and 13.36 mm).CONCLUSION An incision that measures 3 mm proximal from the radial styloid,2 cm radial from Lister’s tubercle,and 5 mm proximal from the radial wrist crease will safely place surgeons at the first dorsal compartment.

Real world studies are essential for drug therapy in Parkinson's disease

Prospective real-world data from large patient samples, which re- port on the long-term effectiveness of the employed different drug therapies, are rare in Parkinson＇s disease （PD）. The non interven- tional ＂Transdermal Rotigotine User Surveillance Study＂ （TRUST） trial represents such a real-world study. It investigated long-term treatment with different dopamine substituting treatment regimens in 2195 PD patients （Mfiller et al., 2018）. Participation in TRUST meant that the treating neurologists were only asked to document and modify the dopaminergic drug regimen without any prior PD patient selection criteria. Thus this unique trial design reflects the real world of patient maintenance.

Letter from Li Peng Chairman of the Standing Committee of the National People's Congress, To China Society for Human Rights Studies

China Society for Human Rights Studies, I would like to extend my warm greetings to the launch of your Human Rights magazine. Enjoying human rights fully is a lofty goal long pursued after by human race. Over the years when they carried out revolution, construction and reforms, the Chinese people have struggled indomitably and strived incessantly to achieve this goal. Progress made in this regard has caught worldwide attention. When struggling for, safeguarding, promoting and developing human rights, the Chinese people have always combined the universality prin-

Analytical, Spectral, Thermal and Molecular Modeling Studies of Hg2+-2,3-Butanedionemonoxime Girard’s T Hydrazone Complex and Its Application

The coordination behavior of 2,3-butanedionemonoxime Girard’s T hydrazone (L1) towards Hg2+ ion has been investigated. The structure of Hg2+ complex, [Hg(L1)Cl]Cl·5H2O, is elucidated using elemental analyses, spectral (IR, UV-visible, 1H-NMR and mass) and TGA measurements. IR spectrum suggests that L1 behaves in a bidentate manner through the azomethine groups. The molecular modeling of L1 and its Hg2+ complex has been investigated. The bond lengths, bond angles, HOMO and LUMO have been calculated. The thermal behavior and kinetic parameters are determined using Coats-Redfern method. The use of L1 for preconcentration and separation via flotation of Hg2+ complex and determination using cold vapor atomic spectrometry (CVAAS) is described. The effects on the percentage of recovered Hg2+ by pH of sample solutions, oleic acid (HOL) concentration, Hg2+ and L1 concentrations are studied in details. The method is applied for the determination of the total Hg2+ (mg·mL-1) in natural water samples.

Studies on the seed production properties of Hunong 5s/Teqing 2

From Nongken 58s/Laser 4 // Xiandang, aphotoperiod-sensitive genic male sterile indicarice line, Hunong 5s was developed, and au-thorized by Hubei Province in 1992, and by theCommittee of the State Science Foundation ofChina in 1993. Hunong 5s was crossed to a in-dica restorer line Teqing 2 to produce a two-line Fhybrid Hunong 5s/Teqing 2. Growth and blossom characteristics of thetwo parents and the seed production propertieswere studied in this experiment. The resultswere as follows: Hunong 5s and Teqing 2 wereboth medium-maturing rice in Jingsha, Hubei,and their photo-thermo-growing properties

Studies on the Evolutionary Laws and Maintaining Mechanism of Renewability of the Yellow River's Water Resources

The Yellow River has a vast catchment area and historically it is the mother river of the Chinese nation. Now it serves as one of the main theatres for the on-going national campaign to develop China's western hinterland.……

The Normative Enlightenment of China's Human Rights Studies from the Space-Time Dimensions of the Chinese Dream

In order to gradually build a theoretical system of human rights with Chinese characteristics that conforms to the development of the times through rigorous academic research, researchers need to break through the basic think- ing tendency of ＂from idea to idea＂ step by step and finally establish the fundamental research orientation of ＂specifying human rights stud- ies.＂ Through comprehensive and systematic analysis and sorting out various basic concepts relating to human rights, researchers also need to finally establish a solid foundation and prerequisite for fruitful academic study.

Scholars Discuss Hu Jintao's Letter to China Society for Human Rights Studies

Hu Jintao, general secretary of the Central Committee of the Communist Party of ,China and state president,recently wrote a letter to the China Society for Human Rights Studies （CSHRS）. The letter was published on December 10, 2008. Social circles have responded enthusiastically to the letter. On December 16, 2008 the society held a forum where participants discussed important ideas Hu expresses in his letter.

Studies on cell culture and PAS reaction of se-cretory cell from S.meridionalis Chen

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基于PDSA循环的教师课例研修模式及应用实证

PDSA(计划—执行—审视—改进)循环是一种质量管理行动框架,因其能有效地发现并解决问题,逐渐在教育领域获得不断实践和发展。为解决当前课例研修运行模式和活动设计的规范性和实效性不足等问题,在PDSA循环的指导下,重构了教师课例研修模式,开展了两轮PDSA课例研修活动,并使用准实验研究和课堂观察相结合的方法验证了基于PDSA循环的教师课例研修模式的应用效果。研究结果表明,基于PDSA循环的教师课例研修既提高了学生学习兴趣和满意度,也提升了教师信息化教学能力。

基于B/S架构的勤工助学系统设计与实现

勤工助学是高校学生资助工作的重要组成部分,是提高学生综合素质和资助家庭经济困难学生的有效途径,是实现全程育人、方位育人的有效平台。将信息技术运用到高校学生勤工助学管理中,不仅能够有效提高管理效率,降低人工成本,还可以更加高效地解决贫困生与岗位匹配的问题。因此,文章运用B/S架构模式,结合SSM框架、jsp技术、MySQL数据库和Tomcat服务器,设计并实现了勤工助学系统。并且根据每一个学生需求,使用协同过滤算法,进行个性化岗位推荐,提高岗位的匹配度。

Chiral asymmetry of anti-symmetric coordinates studied by the Raman differential bond polarizability of S-phenylethylamine

The Raman optical activity （ROA） study on S-phenylethylamine is presented by the intensity analyses via bond polarizability and differential bond polarizability. Ample information concerning the physical picture of this chiral system is obtained, and its ROA mechanism is constructed. Especially, we propose that the asymmetric modes and/or the off-diagonal elements of the electronic polarizability tensor are the potential keys to the exploration of ROA.

基于D-S证据理论和贝叶斯网络的煤与瓦斯突出事故致因研究

为探究煤矿煤与瓦斯突出事故发生机理及影响因素,从人、机、环、管4个方面选取诱发煤与瓦斯突出事故的因素,借助D-S证据理论和贝叶斯网络对事故进行致因风险研究;基于DS证据理论融合专家知识得出网络结构,并通过贪婪搜索算法对网络结构进行优化修正;采用EM算法进行参数学习,获取相关因素间的条件概率和后验概率,同时寻找导致事故发生的关键因素和识别敏感性因素,得出最大风险源链并加以分析。结果表明:导致煤与瓦斯突出最主要的致因因素是环境因素(87.4%),其次是管理因素(84.7%)、机械因素(80.3%)和人为因素(82.7%);矿井煤体结构、地质赋存条件差、未做防突措施,安全隐患排查不到位、瓦斯超限、监测系统不完善和通风设施不足是诱发煤矿煤与瓦斯突出事故发生的重要影响因素。

Inflammatory Bowel Disease Patients’Risk of Developing Prostate Cancer:A Meta-Analysis

Background:Inflammatory bowel disease(IBD)has been linked to an increased risk of prostate cancer(PC)in numerous studies.However,the exact relationship between them remains conflicting.In this meta-analysis,we focus on determining the relationship between PC incidence and IBD.Methods:A comprehensive literature search was conducted up until January 2022,selecting 14 studies,comprising 127,323 subjects with IBD,at the beginning of the study,among which 61,985 were patients with ulcerative colitis(UC)and 37,802 were with Crohn’s disease(CD).The studies reported the differences between subjects with IBD and controls with regard to the incidence of PC.In order to investigate the relationship between IBD and the prevalence of PC,we estimated the odds ratio(OR)with 95%confidence intervals(CIs).Results:IBD significantly increased the incidence of PC(OR,3.46;95%CI,1.40-8.54,P=0.007)compared to controls.UC significantly increased the incidence of PC(OR,1.43;95%CI,1.03-1.98,P=0.03)compared to controls.Yet,no significant difference was observed between CD and controls in relation to PC incidence(OR,0.89;95%CI,0.75-1.06,P=0.18).Conclusion:IBD,particularly UC,may increase the risk of developing PC.This relationship prompts us to advocate for increased PC and IBD screening to reduce the risk for possible complications that could occur in these subjects.