AIM:To investigate the incidence of gastroesophageal reflux disease(GERD) and its related risk factors in Uygur and Han Chinese adult in Urumqi,China.METHODS:A population-based cross-sectional survey was undertaken in...AIM:To investigate the incidence of gastroesophageal reflux disease(GERD) and its related risk factors in Uygur and Han Chinese adult in Urumqi,China.METHODS:A population-based cross-sectional survey was undertaken in a total of 972 Uygur(684 male and 288 female) aged from 24 to 61 and 1023 Han Chinese(752 male and 271 female) aged from 23 to 63 years.All participants were recruited from the residents who visited hospital for health examination from November 2011 to May 2012.Each participant signed an informed consent and completed a GERD questionnaire(GerdQ) and a lifestyle-food frequency questionnaire survey.Participants whose Gerd Q score was ≥ 8 and met one of the following requirements would be enrolled into this research:(1) being diagnosed with erosive esophagitis(EE) or Barrett's esophagus(BE) by endoscopy;(2) negative manifestation under endoscopy(non-erosive reflux disease,NERD) with abnormal acid reflux revealed by 24-h esophageal pH monitoring;and(3) suffering from typical heartburn and regurgitation with positive result of proton pump inhibitor test.RESULTS:According to Gerd Q scoring criteria,340 cases of Uygur and 286 cases of Han Chinese were defined as GERD.GERD incidence in Uygur was significantly higher than in Han Chinese(35% vs 28%,χ2 = 11.09,P < 0.005),Gerd Q score in Uygur was higher than in Han Chinese(7.85 ± 3.1 vs 7.15 ± 2.9,P < 0.005),and Gerd Q total score in Uygur male was higher than in female(8.15 ± 2.8 vs 6.85 ± 2.5,P < 0.005).According to normalized methods,304(31%) cases of Uygur were diagnosed with GERD,including 89 cases of EE,185 cases of NERD and 30 cases of BE;256(25%) cases of Han Chinese were diagnosed with GERD,including 90 cases of EE,140 cases of NERD and 26 cases of BE.GERD incidence in Uygur was significantly higher than in Han Chinese(31% vs 25%,χ2 = 9.34,P < 0.005) while the incidences were higher in males of both groups than in females(26% vs 5% in Uygur,χ2 = 35.95,P < 0.005,and 19.8% vs 5.2% in Han,χ2 = 5.48,P < 0.025).GERD incidence in Uygur male was higher than in Han Chinese male(26% vs 19.8%,χ2 = 16.51,P < 0.005),and incidence of NERD in Uygur was higher than in Han Chinese(χ2 = 10.06,P < 0.005).Occupation(r = 0.623),gender(r = 0.839),smoking(r = 0.322),strong tea(r = 0.658),alcohol drinking(r = 0.696),meat-based diet(mainly meat)(r = 0.676) and body mass index(BMI)(r = 0.567) were linearly correlated with GERD in Uygur(r = 0.833,P = 0.000);while gender(r = 0.957),age(r = 0.016),occupation(r = 0.482),strong tea(r = 1.124),alcohol drinking(r = 0.558),meat diet(r = 0.591) and BMI(r = 0.246) were linearly correlated with GERD in Han Chinese(r = 0.786,P = 0.01).There was no significant difference between Gerd Q scoring and three normalized methods for the diagnosis of GERD.CONCLUSION:GERD is highly prevalent in adult in Urumqi,especially in Uygur.Male,civil servant,smoking,strong tea,alcohol drinking,meat diet and BMI are risk factors correlated to GERD.展开更多
We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinj...We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinjiang Uygur and Han Chinese populations, by using polymerase chain reaction-restriction enzyme digestion analysis. Results showed that there were no statistically significant differences in the distributions of the -455G/A genotype and allele frequency between the Uygurs and the Han. Plasma fibrinogen levels in cerebral infarction patients among the Uygurs and the Han were higher than those among healthy subjects. In particular, the frequencies of the -455G/A AA and -148C/T TT genotypes were significantly higher than in healthy subjects. Individuals carrying the A or T allele had a higher incidence of cerebral infarction compared with those carrying the G or C allele. Our experimental findings indicate that the -148C/T and -455G/A polymorphisms are associated with cerebral infarction in Xinjiang Uygur and Han Chinese subjects. The susceptibility- conferring alleles are -148T and -455A, and the susceptibility-conferring genotype is -455G/A + AA.展开更多
AIM: To investigate the relevant prognostic factors and their differences between colorectal cancer (CRC) patients of Chinese Han and Hui ethnicities in the Beijing region.
Nenropsychiatric symptoms are common in patients with Parkinson's disease(PD)and they are likely to outweigh the motor symptoms and become a major factor affecting the quality of life of PD patients.However,the st...Nenropsychiatric symptoms are common in patients with Parkinson's disease(PD)and they are likely to outweigh the motor symptoms and become a major factor affecting the quality of life of PD patients.However,the studies focusing on the non-motor symptoms in Chinese PD patients from different ethnicity are scarce.The aim of this retrospective study was to investigate neuropsychiatric symptoms and cognitive impairment in Chinese PD patients from Han and Hui populations from central China.Seventy-two Han Chinese PD patients(Han PD group)and 71 age-and sex-matched Hui Chinese PD patients(Hui PD group)were enrolled from Zhongnan Hospital of Wuhan University between Sept.2011 and Aug.2014 in the study.The neuropsychiatric symptoms and cognitive impairment were assessed using Neuropsychiatric Inventory(NPI)and Mini Mental State Examination(MMSE).We found that the proportion of depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were higher in the Han PD group than in the Hui PD group(P<0.05 or P<0.01).But the proportion of delusion,hallucination,agitation,disinhibition,aberrant motor behavior and change in appetite were not significantly different between the Han PD group and the Hui PD group(P>0.05).The total mean scores of the MMSE from patients in the Han PD group were similar to those in the Hui PD group(P>0.05).However,the subscale scores of recall domain and language domain in the Han PD group were significantly different from those in the Hui PD group(P<0.05).No significant difference was noted in the orientation,memory and calculation domains between the two PD groups(P>0.05).This study first showed the recall domain and language domain were different between the Han PD patients and the Hui PD patients.Depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were less presented in the Hui PD patients.All these differences may be related to the different ethnicity,which would be helpful for clinical physicians to recognize the different non-motor symptoms in Chinese PD patients with different ethnicity.展开更多
When Han rioters came crashing through the gates of the Xinjiang Medical University (XMU) in the region's capital, students and teachers from the same ethnic group formed a wall to protect their Uygur fellows from ...When Han rioters came crashing through the gates of the Xinjiang Medical University (XMU) in the region's capital, students and teachers from the same ethnic group formed a wall to protect their Uygur fellows from the mob.展开更多
Kaposi's sarcoma-associated herpesvirus(KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma(KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high ...Kaposi's sarcoma-associated herpesvirus(KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma(KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in China's Mainland. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China. In this work, we focused on the populations in the Kashgar region and Urumqi area, where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjiang, and to determine risk factors that may affect KSHV infection rates or KS incidence. We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined that advancing age, low education level, and stationary population status affect KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants.展开更多
本文报道49例Hb G Coushatta在我国西北部的分布情况。新疆和甘肃的发生率为0.57‰和0.43‰,高于陕西的发生率0.07‰。维吾尔、哈萨克、柯尔克孜和回族的发生率为0.66‰—1.74‰,高于汉族的发生率0.45‰。Hb G Coushatta基因流呈由北向...本文报道49例Hb G Coushatta在我国西北部的分布情况。新疆和甘肃的发生率为0.57‰和0.43‰,高于陕西的发生率0.07‰。维吾尔、哈萨克、柯尔克孜和回族的发生率为0.66‰—1.74‰,高于汉族的发生率0.45‰。Hb G Coushatta基因流呈由北向南和向西漂移和特点,结合国内外有关资料进行分析,这种变异体起源于东北亚地区,为古代游牧民族的遗传标志。展开更多
基金Supported by Research Fund of the Education Department of Shaanxi Province,China,No. 09JK710
文摘AIM:To investigate the incidence of gastroesophageal reflux disease(GERD) and its related risk factors in Uygur and Han Chinese adult in Urumqi,China.METHODS:A population-based cross-sectional survey was undertaken in a total of 972 Uygur(684 male and 288 female) aged from 24 to 61 and 1023 Han Chinese(752 male and 271 female) aged from 23 to 63 years.All participants were recruited from the residents who visited hospital for health examination from November 2011 to May 2012.Each participant signed an informed consent and completed a GERD questionnaire(GerdQ) and a lifestyle-food frequency questionnaire survey.Participants whose Gerd Q score was ≥ 8 and met one of the following requirements would be enrolled into this research:(1) being diagnosed with erosive esophagitis(EE) or Barrett's esophagus(BE) by endoscopy;(2) negative manifestation under endoscopy(non-erosive reflux disease,NERD) with abnormal acid reflux revealed by 24-h esophageal pH monitoring;and(3) suffering from typical heartburn and regurgitation with positive result of proton pump inhibitor test.RESULTS:According to Gerd Q scoring criteria,340 cases of Uygur and 286 cases of Han Chinese were defined as GERD.GERD incidence in Uygur was significantly higher than in Han Chinese(35% vs 28%,χ2 = 11.09,P < 0.005),Gerd Q score in Uygur was higher than in Han Chinese(7.85 ± 3.1 vs 7.15 ± 2.9,P < 0.005),and Gerd Q total score in Uygur male was higher than in female(8.15 ± 2.8 vs 6.85 ± 2.5,P < 0.005).According to normalized methods,304(31%) cases of Uygur were diagnosed with GERD,including 89 cases of EE,185 cases of NERD and 30 cases of BE;256(25%) cases of Han Chinese were diagnosed with GERD,including 90 cases of EE,140 cases of NERD and 26 cases of BE.GERD incidence in Uygur was significantly higher than in Han Chinese(31% vs 25%,χ2 = 9.34,P < 0.005) while the incidences were higher in males of both groups than in females(26% vs 5% in Uygur,χ2 = 35.95,P < 0.005,and 19.8% vs 5.2% in Han,χ2 = 5.48,P < 0.025).GERD incidence in Uygur male was higher than in Han Chinese male(26% vs 19.8%,χ2 = 16.51,P < 0.005),and incidence of NERD in Uygur was higher than in Han Chinese(χ2 = 10.06,P < 0.005).Occupation(r = 0.623),gender(r = 0.839),smoking(r = 0.322),strong tea(r = 0.658),alcohol drinking(r = 0.696),meat-based diet(mainly meat)(r = 0.676) and body mass index(BMI)(r = 0.567) were linearly correlated with GERD in Uygur(r = 0.833,P = 0.000);while gender(r = 0.957),age(r = 0.016),occupation(r = 0.482),strong tea(r = 1.124),alcohol drinking(r = 0.558),meat diet(r = 0.591) and BMI(r = 0.246) were linearly correlated with GERD in Han Chinese(r = 0.786,P = 0.01).There was no significant difference between Gerd Q scoring and three normalized methods for the diagnosis of GERD.CONCLUSION:GERD is highly prevalent in adult in Urumqi,especially in Uygur.Male,civil servant,smoking,strong tea,alcohol drinking,meat diet and BMI are risk factors correlated to GERD.
基金supported by the National Natural Science Foundation of China, No. 81060097
文摘We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinjiang Uygur and Han Chinese populations, by using polymerase chain reaction-restriction enzyme digestion analysis. Results showed that there were no statistically significant differences in the distributions of the -455G/A genotype and allele frequency between the Uygurs and the Han. Plasma fibrinogen levels in cerebral infarction patients among the Uygurs and the Han were higher than those among healthy subjects. In particular, the frequencies of the -455G/A AA and -148C/T TT genotypes were significantly higher than in healthy subjects. Individuals carrying the A or T allele had a higher incidence of cerebral infarction compared with those carrying the G or C allele. Our experimental findings indicate that the -148C/T and -455G/A polymorphisms are associated with cerebral infarction in Xinjiang Uygur and Han Chinese subjects. The susceptibility- conferring alleles are -148T and -455A, and the susceptibility-conferring genotype is -455G/A + AA.
文摘AIM: To investigate the relevant prognostic factors and their differences between colorectal cancer (CRC) patients of Chinese Han and Hui ethnicities in the Beijing region.
文摘Nenropsychiatric symptoms are common in patients with Parkinson's disease(PD)and they are likely to outweigh the motor symptoms and become a major factor affecting the quality of life of PD patients.However,the studies focusing on the non-motor symptoms in Chinese PD patients from different ethnicity are scarce.The aim of this retrospective study was to investigate neuropsychiatric symptoms and cognitive impairment in Chinese PD patients from Han and Hui populations from central China.Seventy-two Han Chinese PD patients(Han PD group)and 71 age-and sex-matched Hui Chinese PD patients(Hui PD group)were enrolled from Zhongnan Hospital of Wuhan University between Sept.2011 and Aug.2014 in the study.The neuropsychiatric symptoms and cognitive impairment were assessed using Neuropsychiatric Inventory(NPI)and Mini Mental State Examination(MMSE).We found that the proportion of depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were higher in the Han PD group than in the Hui PD group(P<0.05 or P<0.01).But the proportion of delusion,hallucination,agitation,disinhibition,aberrant motor behavior and change in appetite were not significantly different between the Han PD group and the Hui PD group(P>0.05).The total mean scores of the MMSE from patients in the Han PD group were similar to those in the Hui PD group(P>0.05).However,the subscale scores of recall domain and language domain in the Han PD group were significantly different from those in the Hui PD group(P<0.05).No significant difference was noted in the orientation,memory and calculation domains between the two PD groups(P>0.05).This study first showed the recall domain and language domain were different between the Han PD patients and the Hui PD patients.Depression,anxiety,apathy,irritability,euphoria and night time behavior disturbances were less presented in the Hui PD patients.All these differences may be related to the different ethnicity,which would be helpful for clinical physicians to recognize the different non-motor symptoms in Chinese PD patients with different ethnicity.
文摘When Han rioters came crashing through the gates of the Xinjiang Medical University (XMU) in the region's capital, students and teachers from the same ethnic group formed a wall to protect their Uygur fellows from the mob.
基金supported by research grants from the National Natural Science Foundation of China (U1603117 81560473+5 种基金 81560442)Doctoral Foundation Technology Research and Achievements Transformation Program of Xinjiang production and Construction Corps (2014BB021 2015AD003)the United States National Institutes of Health Fogarty International Center (D43 TW001492)NCI (CA75903)NCRR COBRE (RR15635) to C. Wood
文摘Kaposi's sarcoma-associated herpesvirus(KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma(KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in China's Mainland. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China. In this work, we focused on the populations in the Kashgar region and Urumqi area, where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjiang, and to determine risk factors that may affect KSHV infection rates or KS incidence. We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined that advancing age, low education level, and stationary population status affect KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants.
文摘本文报道49例Hb G Coushatta在我国西北部的分布情况。新疆和甘肃的发生率为0.57‰和0.43‰,高于陕西的发生率0.07‰。维吾尔、哈萨克、柯尔克孜和回族的发生率为0.66‰—1.74‰,高于汉族的发生率0.45‰。Hb G Coushatta基因流呈由北向南和向西漂移和特点,结合国内外有关资料进行分析,这种变异体起源于东北亚地区,为古代游牧民族的遗传标志。