Cord blood transplantation （CBT） from unrelated donors has increasingly been performed worldwide during the last decade. The immaturity of lymphocytes in cord blood permits HLA-mismatching between donors and recipie...Cord blood transplantation （CBT） from unrelated donors has increasingly been performed worldwide during the last decade. The immaturity of lymphocytes in cord blood permits HLA-mismatching between donors and recipients and reduces the severity of graft-versus-host disease （GVHD）. However, the relatively small dose of the cord blood nucleated cells is associated with a high frequency of engraftment failure.15 But re-transplantation with stem cells from the original donor is impossible.展开更多
基金This study was partially supported by the"211"Program of China.
文摘Cord blood transplantation （CBT） from unrelated donors has increasingly been performed worldwide during the last decade. The immaturity of lymphocytes in cord blood permits HLA-mismatching between donors and recipients and reduces the severity of graft-versus-host disease （GVHD）. However, the relatively small dose of the cord blood nucleated cells is associated with a high frequency of engraftment failure.15 But re-transplantation with stem cells from the original donor is impossible.
