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Development and Validation of an LC-MS/MS Method for Determination of Catalpol and Harpagide in Small Volume Rat Plasma: Application to a Pharmacokinetic Study 被引量:1
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作者 Shuangmin Chen Yijun Ren +3 位作者 Xi Xu Dandan Li Wenlian Li Zhenzhen Liu 《Yangtze Medicine》 2018年第2期95-107,共13页
A rapid and sensitive liquid chromatography-tandem mass chromatography (LC-MS/MS) method has been developed and validated for simultaneous determination of catalpol and harpagide in rat plasma. The samples were extrac... A rapid and sensitive liquid chromatography-tandem mass chromatography (LC-MS/MS) method has been developed and validated for simultaneous determination of catalpol and harpagide in rat plasma. The samples were extracted by one-step protein precipitation and separated on a SunFireTM C18 column (100 mm × 2.1 mm, 3.5 &mu;m;Waters) using acetonitrile-10 mM ammonium formate as mobile phase at a flow rate 0.3 mL/min in gradient mode. The analytes were detected without interference in Multiple Reaction Monitoring (MRM) mode with negative electrospray ionization. Linear responses were obtained for catalpol ranging from 20 to 5000 ng/mL and harpagide ranging from 10 to 2500 ng/mL. Coefficients of correlation (r) for the calibration curves were more than 0.99 for both analytes. Intra- and inter-day accuracy and precision were within the acceptable limits of less than 15.0% at all concentrations. The quantitation method was successfully applied for simultaneous estimation of catalpol and harpagide after oral administration of Zeng Ye Decoction. 展开更多
关键词 LC-MS/MS PHARMACOKINETICS CATALPOL harpagide Zeng Ye DECOCTION
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Harpagide Inhibits Microglial Activation and Protects Dopaminergic Neurons as Revealed by Nanoelectrode Amperometry
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作者 Fu-Li Zhang Yun Tang +2 位作者 Hong Jiang Xiao-Ke Yang Wei-Hua Huang 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2021年第8期2188-2194,共7页
Parkinson's disease(PD)is one of the most comm on n euroge nerative diseases(NDDs),characterized as less n eurotra nsmitter release and loss of dopaminergic(DAergic)neurons with microglial inflammatory response as... Parkinson's disease(PD)is one of the most comm on n euroge nerative diseases(NDDs),characterized as less n eurotra nsmitter release and loss of dopaminergic(DAergic)neurons with microglial inflammatory response as a key player.Natural product harpagide with anti-inflammatory function is a potential therapeutic drug of PD,but its role towards microglial activation and inflammation-mediated neuronal injury remained unsure. 展开更多
关键词 Nanotechnology Reactive oxygen species Vesicles harpagide NEUROCHEMISTRY
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Two New Iridoid Glycosides from Caryopteris mongholica 被引量:1
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作者 Yong Hong ZHANG Dong Liang CHENG (Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000) 《Chinese Chemical Letters》 SCIE CAS CSCD 2000年第4期319-322,共4页
Two new iridoid glucosides were isolated from the whole plant of Caryopteris mongholica Bunge. On the basis of chemical and spectral evidence, they were determined as 8-acetyl-6'-O-(p-coumaroyl)harpagide and 6'... Two new iridoid glucosides were isolated from the whole plant of Caryopteris mongholica Bunge. On the basis of chemical and spectral evidence, they were determined as 8-acetyl-6'-O-(p-coumaroyl)harpagide and 6'-O-(p-coumaroyl)antirrinoside, respectively. 展开更多
关键词 Caryopteris mongholica verbanaceae 8-acetyl-6 '-O-(p-coumaroyl)harpagide 6 '-O-(p-coumaroyl)antirrinoside
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