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THE CENTRAL DISTRIBUTION OF ADRENOMEDULLIN AND ITS EFFECTS ON BLOOD PRESSURE AND HEART RATE IN RATS 被引量:2
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作者 魏英杰 李倩虹 +4 位作者 宋良文 赵东 张肇康 何瑞荣 汤健 《Chinese Medical Sciences Journal》 CAS CSCD 1996年第1期1-7,共7页
The present study was designed to make certain whether there exists adrenomedullin (ADM) in the rat central nervous system and evaluated the hemodynamic actions of intracerebroventricular administration (ICVA) of hum... The present study was designed to make certain whether there exists adrenomedullin (ADM) in the rat central nervous system and evaluated the hemodynamic actions of intracerebroventricular administration (ICVA) of human ADM[13-52]. By immunohistochemistry (ABC method),We found that there was a discrete localization of ADM-positive immunoreactivity in the rat central system including cerebral cortex,paraventricular tissues, hypothalamus, cerebella cortex, mesencephalon and medulla oblongata. By reverse transcription-polymerase chain reaction(RT-PCR) analysis, rat ADM mRNA was found to be expressed in rat brain. These above results of immunohistochemistry and RT-PCR suggest that ADM exists in the rat brain. We also found that centrally administered ADM[13-52]in a dose of 0.4 to 3. 2 nmol/kg provoked marked, prolonged and dosedependent increases in mean arterial blood pressure (MABP) and heart rate (HR). To clarify the mechanisms of the hemodynamic changes induced by centrally administered ADM [13-52]. the effect of centrally administered ADM [13-52] on renal sympathetic nerve activity (RSNA) was studied. The result showed that centrally administered ADM [13-52] ( 1. 6 nmol/kg) provoked a marked increase in RSNA .therefore .the increases in MABP and HR induced by centrally administered ADM [13-52]might be due to the stimulation of central sympathetic mechanism. In addtion,we also compared the relationship of activity and structure among the different fragments of ADM. In conclusion, ADMexists in the rat brain, and it may play an important role in the central control of cardiovascular system. 展开更多
关键词 adrenomedullin[13-52] blood pressure heart rate
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Blood Pressure and Heart Rate Measurements Using Photoplethysmography with Modified LRCN 被引量:1
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作者 Chih-Ta Yen Cheng-Hong Liao 《Computers, Materials & Continua》 SCIE EI 2022年第4期1973-1986,共14页
In this study,single-channel photoplethysmography(PPG)signals were used to estimate the heart rate(HR),diastolic blood pressure(DBP),and systolic blood pressure(SBP).A deep learning model was proposed using a long-ter... In this study,single-channel photoplethysmography(PPG)signals were used to estimate the heart rate(HR),diastolic blood pressure(DBP),and systolic blood pressure(SBP).A deep learning model was proposed using a long-term recurrent convolutional network(LRCN)modified from a deep learning algorithm,the convolutional neural network model of the modified inception deep learning module,and a long short-term memory network(LSTM)to improve the model’s accuracy of BP and HR measurements.The PPG data of 1,551 patients were obtained from the University of California Irvine Machine Learning Repository.How to design a filter of PPG signals and how to choose the loss functions for deep learning model were also discussed in the study.Finally,the stability of the proposed model was tested using a 10-fold cross-validation,with an MAE±SD of 2.942±5.076 mmHg for SBP,1.747±3.042 mmHg for DBP,and 1.137±2.463 bpm for the HR.Compared with its existing counterparts,the model entailed less computational load and was more accurate in estimating SBP,DBP,and HR.These results established the validity of the model. 展开更多
关键词 Photoplethysmography(PPG)signal deep learning blood pressure systolic blood pressure(SBP) diastolic blood pressure(DBP) heart rate(HR)
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Predictive Value of Blood Pressure,Heart Rate,and Blood Pressure/Heart Rate Ratio in a Chinese Subpopulation with Vasovagal Syncope
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作者 Zhuzhi Wen Jingying Hou +4 位作者 Zun Mai Huifen Huang Yangxin Chen Dengfeng Geng Jingfeng Wang 《Cardiovascular Innovations and Applications》 2021年第1期193-205,共13页
Objective:The head-up tilt test(HUTT)is widely used but is time-consuming and not cost-effective to evaluate patients with vasovagal syncope(VVS).The present study aims to verify the hypothesis that ambulatory blood p... Objective:The head-up tilt test(HUTT)is widely used but is time-consuming and not cost-effective to evaluate patients with vasovagal syncope(VVS).The present study aims to verify the hypothesis that ambulatory blood pressure(BP)monitoring(ABPM)and the simplistic tilt test may be potential alternatives to the HUTT.Methods:The study consecutively enrolled 360 patients who underwent the HUTT to evaluate VVS.BP),heart rate(HR),and BP/HR ratios derived from ABPM and the simplistic tilt test were evaluated to predict the presence,pattern,and stage of syncope during the HUTT.Results:Mixed response was the commonest pattern,and syncope occurred frequently with infusion of isoproterenol at a rate of 3μg/min.During the simplistic tilt test,the cardioinhibitory group had higher tilted BP/HR ratios than the vasodepressor group,while the vasodepressor group had a faster tilted HR and a larger HR difference than the cardioinhibitory group.The higher the BP/HR ratio in the tilted position,the higher the isoproterenol dosage needed to induce a positive response.During ABPM,BP/HR ratios were signifi cantly higher in the cardioinhibitory group than in the vasodepressor group.The higher the ABPM-derived BP,the higher the dosage of isoproterenol needed to induce syncope.There were signifi cant correlations in BP/HR ratios between ABPM and the supine position in the vasodepressor group,while signifi cant correlation was found only for the diastolic BP/HR ratio between ABPM and the tilted position in the cardioinhibitory group.The mixed pattern shared correlative features of the other two patterns.Conclusion:ABPM and the simplistic tilt test might be used as promising alternatives to the HUTT in VVS evaluation in clinical settings. 展开更多
关键词 Vasovagal syncope head-up tilt test simplistic tilt test ambulatory blood pressure monitoring blood pressure/heart rate ratio
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Cardiovascular age of aviation personnel: based on the principal component analysis of heart rate and blood pressure variability
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作者 牛有国 王守岩 +2 位作者 张玉海 王兴邦 张立藩 《Journal of Medical Colleges of PLA(China)》 CAS 2004年第1期64-70,共7页
Objective: To introduce a method to calculate cardiovascular age, a new, accurate and much simpler index for assessing cardiovascular autonomic regulatory function, based on statistical analysis of heart rate and bloo... Objective: To introduce a method to calculate cardiovascular age, a new, accurate and much simpler index for assessing cardiovascular autonomic regulatory function, based on statistical analysis of heart rate and blood pressure variability (HRV and BPV) and baroreflex sensitivity (BRS) data. Methods: Firstly, HRV and BPV of 89 healthy aviation personnel were analyzed by the conventional autoregressive (AR) spectral analysis and their spontaneous BRS was obtained by the sequence method. Secondly, principal component analysis was conducted over original and derived indices of HRV, BPV and BRS data and the relevant principal components, PCi orig and PCi deri (i=1, 2, 3,...) were obtained. Finally, the equation for calculating cardiovascular age was obtained by multiple regression with the chronological age being assigned as the dependent variable and the principal components significantly related to age as the regressors. Results: The first four principal components of original indices accounted for over 90% of total variance of the indices, so did the first three principal components of derived indices. So, these seven principal components could reflect the information of cardiovascular autonomic regulation which was embodied in the 17 indices of HRV, BPV and BRS exactly with a minimal loss of information. Of the seven principal components, PC2 orig , PC4 orig and PC2 deri were negatively correlated with the chronological age ( P <0 05), whereas the PC3 orig was positively correlated with the chronological age ( P <0 01). The cardiovascular age thus calculated from the regression equation was significantly correlated with the chronological age among the 89 aviation personnel ( r =0.73, P <0 01). Conclusion: The cardiovascular age calculated based on a multi variate analysis of HRV, BPV and BRS could be regarded as a comprehensive indicator reflecting the age dependency of autonomic regulation of cardiovascular system in healthy aviation personnel. 展开更多
关键词 flying personnel heart rate variability blood pressure variability baroreflex sensitivity age principal components analysis multiple regression analysis
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Effects of Impaired Glucose Metabolism on Heart Rate Variability and Blood Pessure Variability in Essential Hpertensive Patients 被引量:4
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作者 王钢 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2006年第6期654-656,共3页
To investigate the effects of impaired glucose metabolism (IGM) on cardiovascular autonomic nervous systems in essential hypertensive (EH) patients by comparing heart rate variability (HRV) and blood pressure va... To investigate the effects of impaired glucose metabolism (IGM) on cardiovascular autonomic nervous systems in essential hypertensive (EH) patients by comparing heart rate variability (HRV) and blood pressure variability (BPV) in EH patients with or without type 2 diabetes mellitus (T2DM). Simultaneous 24-h recordings of ambulatory ECG and blood pressure monitoring were performed in 36 male old patients with simple EH and 33 male old patients with EH combined with T2DM. HRV analysis included time domain parameters such as SDNN, SDANN, SDNNi, rMSSD and pNN50, and total spectral power (TP) of HRV, which mainly consists of VLF, LF and HF component along with LF/HF ratio, was also obtained. The value of ambulatory blood pressure was represented as the mean blood pressure (mean systolic/mSBP, diastolic/mDBP and pulse pressure/mPP) during different periods (24 h/24 h, day time/d and night time/n). Standard deviation (SD) as well as coefficient of variance (CV) of blood pressure during each above-mentioned period were obtained to reflect the long-term BPV. Our result showed that SDNN, SDNNi, SDANN, rMSSD, PNN50, TP and HF of HRV in cases of EH with T2DM were all significantly lower than those in simple EH subjects (P〈0.05). No significant differences in VLF or LF was found between the two groups (P〉0.05), while LF/HF ratio was significantly higher in EH with T2DM patients than in simple EH subjects (P〈0.01). Moreover, dmSBP, 24 h-mPP and dmPP were all significantly higher in EH with T2DM patients than in simple EH subjects (P〈0.05), while nmSBP, 24 h-mSBP, 24 h-mDBP, dmDBP, nmDBP or nmPP showed no significant difference between this two groups of patients (P〉0.05). And dSBPSD, dSBPCV and 24 h-SBPSD were all significantly higher in EH with T2DM patients than in simple EH subjects (P〈0.05), while the other BPV indexes showed no significant difference between this two groups (P〉0.05). It is concluded that the cardiovascular autonomic nervous systems in EH patients was further impaired by T2DM, displaying lowering of HRV and enlargement of BPV, which in turn induced abnormal structural and functional changes of cardiovascular systems. Therefore, improving cardiovascular autonomic nervous systems might reduce the occurrence of cardiovascular complications in the EH patients with IGM. 展开更多
关键词 impaired glucose metabolism (IGM) essential hypertensive(EH) heart rate variability(HRV) blood pressure
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Blood pressure and stature in Helicobacter pylori positive and negative persons 被引量:9
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作者 Marcela Kopacova Ilona Koupil +7 位作者 Bohumil Seifert Miluska Skodova Fendrichova Jana Spirkova Viktor Vorisek Stanislav Rejchrt Tomas Douda Ilja Tacheci Jan Bures 《World Journal of Gastroenterology》 SCIE CAS 2014年第19期5625-5631,共7页
To evaluate vital signs and body indices in Helicobacter pylori (H. pylori) positive and negative persons. A total of 22 centres entered the study. They were spread over the whole country, corresponding well to the ge... To evaluate vital signs and body indices in Helicobacter pylori (H. pylori) positive and negative persons. A total of 22 centres entered the study. They were spread over the whole country, corresponding well to the geographical distribution of the Czech population. A total of 1818 subjects (aged 5-98 years) took part in the study, randomly selected out of 38147 subjects. H. pylori infection was investigated by means of a 13C-urea breath test. Data on height, weight, systolic and diastolic blood pressure and heart rate were collected at the clinics of general practitioners. The overall prevalence of H. pylori infection was 30.4% (402/1321) in adults (&#x02265; 18 year-old) and 5.2% (26/497) in children and adolescents (&#x02264; 17 year-old). Once adjusted for age and gender, only a difference in body mass index remained statistically significant with H. pylori positive adults showing an increase of 0.6 kg/m<sup>2</sup> in body mass index. Once adjusted for age and gender, we found a difference in height between H. pylori positive and H. pylori negative children and adolescents. On further adjustment for place of residence, this difference became statistically significant, with H. pylori positive children and adolescents being on average 3.5 cm shorter. H. pylori positive adults were significantly older compared to H. pylori negative subjects. Once adjusted for age and gender, H. pylori infection had no impact on body weight, body mass index and vital signs either in adults or children and adolescents. Chronic H. pylori infection appeared to be associated with short stature in children. H. pylori infection did not influence blood pressure, body weight and body mass index either in adults or children and adolescents. 展开更多
关键词 EPIDEMIOLOGY Helicobacter pylori Czech Republic 13C-urea breath test blood pressure heart rate Weight STATURE Body mass index
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Power Spectral Analysis of Heart Rate Variability of Driver Fatigue 被引量:2
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作者 焦昆 李增勇 +1 位作者 陈铭 王成焘 《Journal of Donghua University(English Edition)》 EI CAS 2005年第1期11-15,共5页
This investigation was to evaluate the driving fatigue based on power spectral analysis of heart rate variability (HRV) under vertical vibration. Forty healthy male subjects (29.7±3.5 years) were randomly divided... This investigation was to evaluate the driving fatigue based on power spectral analysis of heart rate variability (HRV) under vertical vibration. Forty healthy male subjects (29.7±3.5 years) were randomly divided into two groups, Group A (28.8±4.3 years) and Group B (30.6±2.7 years). Group A (experiment group) was required to perform the simulated driving and Group B (control group) kept calm for 90 min. The frequency domain indices of HRV such as low frequency (0.04 0.15 Hz, LF), high frequency (0.150.4 Hz, HF), LF/HF together with the indices of hemodynamics such as blood pressure (BP) and heart rate (HR) of the subjects between both groups were calculated and analyzed after the simulated driving. There were significances of the former indices between both groups (P<0.05). All the data collected after experiment of Group A was observed the remarkable linear correlation (P<0.05) and parameters and errors of their linear regression equation were stated (α=0.05, P<0.001) in this paper, respectively. The present study investigated that sympathetic activity of the subjects enhanced after the simulated driving while parasympathetic activities decreased. The sympathovagal balance was also improved. As autonomic function indictors of HRV reflected fatigue level, quantitative evaluation of driving mental fatigue from physiological reaction could be possible. 展开更多
关键词 driving fatigue heart rate variability blood pressure heart rate VIBRATION correlation.
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The Effect of Baroreflex Function on Blood Pressure Variability 被引量:1
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作者 Xiufang Wei Xinhui Fang +4 位作者 Lina Ren Yanyan Meng Zixin Zhang Yongquan Wang Guoxian Qi 《International Journal of Clinical Medicine》 2013年第9期378-383,共6页
Objective: The aim of this study was to assess the relationship of blood pressure variability (BPV) and heart rate variability (HRV) to investigate the effect of baroreflex function on blood pressure variability. Meth... Objective: The aim of this study was to assess the relationship of blood pressure variability (BPV) and heart rate variability (HRV) to investigate the effect of baroreflex function on blood pressure variability. Methods: This study consisted of 111 subjects, including 32 normotensives and 79 hypertensives. All the subjects were given two concurrent tests: 24-hour Holter ECG and ambulatory blood pressure monitoring. According to standard deviation of normal-to-normal sinus RR intervals (SDNN) derived from the Holter ECG, the hypertensives were divided into two groups: an HRV normal group with SDNN > 100 ms and an HRV abnormal group with 展开更多
关键词 blood pressure VARIABILITY heart rate VARIABILITY BAROREFLEX FUNCTION HYPERTENSION
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Impact of metabolism-related mutations on the heart rate of gastric cancer patients after peritoneal lavage
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作者 Yan Yuan Shuang Yao +1 位作者 Guang-Hua Luo Xiao-Ying Zhang 《World Journal of Clinical Cases》 SCIE 2021年第6期1318-1328,共11页
BACKGROUND During surgery for gastric cancer,peritoneal lavage using warm distilled water can cause temporary hemodynamic changes.AIM To examine the associations between changes in heart rate and single nucleotide pol... BACKGROUND During surgery for gastric cancer,peritoneal lavage using warm distilled water can cause temporary hemodynamic changes.AIM To examine the associations between changes in heart rate and single nucleotide polymorphisms(SNPs).METHODS This was a prospective observational study of patients with gastric cancer who underwent gastrectomy and peritoneal hypotonic lavage at the Third Afliated Hospital of Soochow University from March 2018 to March 2019.Related SNPs were selected,and the verified exons were analyzed.Heart rate and blood pressure(BP)were measured before and after lavage.The patients were grouped as heart rate change≥30%vs<30%.Comparison and regression analyses of the selected SNPs were performed between the two groups.RESULTS According to the inclusion/exclusion criteria,194 patients were included in the analysis.Of these patients,138 were male,with a mean age of 65.9±0.8 years,and 56 were female,with a mean age of 65.0±1.3 years.Heart rate dropped by 0%-10%in 65 participants,by 10%-15%in 29,by 15%-20%in 23,by 20%-50%in 39,by 50%-100%in four,six had a cardiac arrest,and 28 had an increase in heart rate.Considering the possible impact of exonic SNPs on the phenotypes,TEP1(rs938886),TEP1(rs1713449),and RECQL5(rs820196)were analyzed.The haplotype analysis suggested that the haplotypes CTT[odds ratio(OR)=2.018,95%confidence interval(CI):1.012-4.025,P=0.0430]and GCC(OR=2.293,95%CI:1.174-4.477,P=0.0131)of TEP1(rs938886),TEP1(rs1713449),and RECQL5(rs820196)increased the risk of a drop in heart rate>30%.CONCLUSION The TEP1(rs938886),TEP1(rs1713449),and RECQL5(rs820196)SNPs were associated with changes in heart rate≥30%during intraperitoneal lavage using distilled water after gastrectomy for gastric cancer. 展开更多
关键词 Gastric cancer Peritoneal lavage Distilled water heart rate Singlenucleotide polymorphism blood pressure
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Efectsofmoxonidineinjectedintorostralventrolateralmedulaonbloodpressure,heartrate,andrenalsympatheticnerveactivityinrats 被引量:3
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作者 许彦芳 何瑞荣 《中国药理学报》 CSCD 1997年第5期415-418,共4页
目的:观察延髓腹外侧头端(RVLM)注射莫索尼定(Mox)对麻醉大鼠血压(BP)、心率(HR)及肾交感神经放电(RSNA)的影响.方法:麻醉大鼠RVLM注射1μLMox1,10,100μmol·L-1,同步记录B... 目的:观察延髓腹外侧头端(RVLM)注射莫索尼定(Mox)对麻醉大鼠血压(BP)、心率(HR)及肾交感神经放电(RSNA)的影响.方法:麻醉大鼠RVLM注射1μLMox1,10,100μmol·L-1,同步记录BP,HR及RSNA.结果:Mox1,10,100μmol·L-1分别使BP从139±10kPa降至130±17kPa(P<005),138±18kPa至114±15kPa(P<001),and139±19kPa至94±17kPa(P<001).Mox不影响HR.Mox1μmol·L-1增加RSNA50%(P<005),10μmol·L-1对RSNA无影响(P>005),100μmol·L-1则降低RSNA23%(P<005).在缓冲神经切断大鼠,Mox10μmol·L-1抑制RSNA50%(P<005),明显不同于缓冲神经完整的动物(P<001).结论:麻醉大鼠RVLM注射Mox可降低BP,但不影响HR。 展开更多
关键词 莫索尼定 延髓 交感神经系统 血压 心率
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High frequency heart rate variability evoked by repetitive transcranial magnetic stimulation over the medial prefrontal cortex: A preliminary investigation on brain processing of acute stressor-evoked cardiovascular reactivity
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作者 Eduardo Manuel Goncalves Saul Neves de Jesus 《Open Journal of Psychiatry》 2013年第4期335-344,共10页
Introduction: Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for brain stimulation. Repetitive TMS (rTMS) over the medial Prefrontal Cortex (mPFC), Broadman Area 10 (BA10) may stimulate transynapt... Introduction: Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for brain stimulation. Repetitive TMS (rTMS) over the medial Prefrontal Cortex (mPFC), Broadman Area 10 (BA10) may stimulate transynaptically perigenual Anterior Cingulate Cortex (pACC, BA 33), insula, amigdala, hypothalamus and connected branches of the Autonomic Nervous System (ANS) involved in stressorevoked cardiovascular reactivity. Stressors are associated with an increase in sympathetic cardiac control, a decrease in parasympathetic control, or both, and, consequently, an increase in systolic/stroke volume, total vascular impedance/resistance and heart rate, a decrease of baroreflex sensitivity, i.e., an increase in blood pressure/arterial tension. Objectives and Aims: The present work aims, using TMS and accordingly to Gianaros modeling, based on functional neuroimaging studies and previous neuroanatomical data from animal models, to probe the connectivity of brain systems involved in stressor-evoked cardiovascular reactivity and to explore TMS potential as a tool for detection and stratification of individual differences concerning this reactivity and hemorreological risk factors correlated with the development of Coronary Heart Disease (CHD). Methods: Both subjects, a 52 years old male and a 40 years old female with previous increased Low Frequency (LF)/High Frequency (HF) Heart Rate Variability (HRV) ratios (respectively, 4.209/3.028) without decompensated cardiorespiratory symptoms, gave informed consent, and ethico-legal issues have been observed. Electroencephalographic (EEG) monitoring has been performed for safety purposes. Immediately after administration, over the mPFC, of 15 pulses of rTMS, during 60 second, with an inductive electrical current, at the stimulating coil, of 85.9 Ampère per μsecond and 66 Ampère per μsecond, respectively, for male and female subjects (a “figure-of-eight” coil and magnetic stimulator MagLite, Dantec/Medtronic, have been used), HRV spectrum analysis (cStress software) has been performed (during 5 minutes, in supine position). Results: In both subjects, LF power, HF power and LF/HF ratio results, before and after rTMS administration, pointed towards sympathetic attenuation and parasympathetic augmentation (respectively, in male/female subject: decreased LF power—65.1 nu/69.3 nu, before rTMS;56.1 nu/41.6 nu, after rTMS;increased HF power—15.5 nu/22.9 nu, before rTMS;30.9 nu/45.5 nu, after rTMS). Conclusions: In this preliminary investigation, the existence of a link between “mind” and heart’s function has been put in evidence, through a reversible “virtual” lesion, of brain systems involved in cardiovascular control, caused by TMS. Repetitive TMS over mPFC decreased brain function involved in stressorevoked cardiovascular reactivity, suggesting the importance of TMS in the management of stress-related cardiovascular disorders. 展开更多
关键词 Repetitive Transcranial Magnetic Stimulation (rTMS) Medial Prefrontal Cortex (mPFC) Anterior Cingulate Cortex (ACC) Amigdala Autonomic Nervous System (ANS) heart’s Conducting System Acute Sressor-Evoked Cardiovascular (blood pressure) Reactivity heart rate Variability (HRV)
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辅酶Q10片辅助美托洛尔治疗高血压合并室性心律失常的效果
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作者 肖普 王蔚蔚 《罕少疾病杂志》 2025年第1期82-84,共3页
目的 探究辅酶Q10片辅助美托洛尔在高血压合并室性心律失常患者中的应用效果。方法 采用回顾性研究,收集2021年1月至2023年12月医院接受美托洛尔治疗的52例高血压合并室性心律失常患者病历资料,纳入对照组;收集医院同期接受辅酶Q10片辅... 目的 探究辅酶Q10片辅助美托洛尔在高血压合并室性心律失常患者中的应用效果。方法 采用回顾性研究,收集2021年1月至2023年12月医院接受美托洛尔治疗的52例高血压合并室性心律失常患者病历资料,纳入对照组;收集医院同期接受辅酶Q10片辅助美托洛尔治疗的52例高血压合并室性心律失常患者病历资料,纳入观察组,全部患者临床资料均保存完整。查阅患者病历资料,比较两组治疗效果,治疗前后血压指标、心率指标及心电图指标、心肌损伤指标,以及用药不良反应发生情况。结果 观察组总有效率为96.15%,高于对照组总有效率84.62%,差异有统计学意义(P<0.05);治疗后,两组舒张压与收缩压均降低,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组心率、窦性心律失常频次、QT间期离散度(QTd)、QT校正离散度(QTcd)均下降,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、肌红蛋白(Myo)均降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 辅酶Q10片辅助美托洛尔治疗高血压合并室性心律失常患者的临床效果显著,可以有效降低患者血压,改善心律失常症状,促进心肌细胞修复,且安全性好。 展开更多
关键词 高血压 室性心律失常 美托洛尔 辅酶Q10片 血压 心率 不良反应
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Stochastic resonance whole body vibration increases perceived muscle relaxation but not cardiovascular activation:A randomized controlled trial 被引量:4
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作者 Achim Elfering Christian Burger +1 位作者 Volker Schade Lorenz Radlinger 《World Journal of Orthopedics》 2016年第11期758-765,共8页
AIM To investigate the acute effects of stochastic resonance whole body vibration(SR-WBV), including muscle relaxation and cardiovascular activation.METHODS Sixty-four healthy students participated. The participants w... AIM To investigate the acute effects of stochastic resonance whole body vibration(SR-WBV), including muscle relaxation and cardiovascular activation.METHODS Sixty-four healthy students participated. The participants were randomly assigned to sham SR-WBV training at a low intensity(1.5 Hz) or a verum SR-WBV training at a higher intensity(5 Hz). Systolic blood pressure(SBP), diastolic blood pressure(DBP), heart rate(HR) and selfreported muscle relaxation were assessed before and immediately after SR-WBV.RESULTS Two factorial analyses of variance(ANOVA) showed a significant interaction between pre- vs post-SR-WBVmeasurements and SR-WBV conditions for muscle relaxation in the neck and back [F(1,55) = 3.35, P = 0.048, η2 = 0.07]. Muscle relaxation in the neck and back increased in verum SR-WBV, but not in sham SR-WBV. No significant changes between pre- and post-training levels of SBD, DBD and HR were observed either in sham or verum SR-WBV conditions. With verum SR-WBV, improved muscle relaxation was the most significant in participants who reported the experience of back, neck or shoulder pain more than once a month(P < 0.05).CONCLUSION A single session of SR-WBV increased muscle relaxation in young healthy individuals, while cardiovascular load was low. An increase in musculoskeletal relaxation in the neck and back is a potential mediator of pain reduction in preventive worksite SR-WBV trials. 展开更多
关键词 MUSCULOSKELETAL system Prevention blood pressure heart rate Low back PAIN
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Acute Toxicity and Cardio-Respiratory Effects of 2-Deoxy-D-Glucose: A Promising Radio Sensitiser
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作者 R.VIJAYARAGHAVAN DEO KUMAR +7 位作者 SN DUBE R.SINGH KS.PANDEY BC.BAG MP.KAUSHIK K.SEKHAR BS.DWARAKANATH T.RAVINDRANATH 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2006年第2期96-103,共8页
Objective To evaluate the acute toxicity of 2-deoxy-D-glucose (2DG) by oral (p.o.) and intravenous (i.v.) routes, and also the cardio-respiratory effects following high doses of 2DG in animal models. Methods The... Objective To evaluate the acute toxicity of 2-deoxy-D-glucose (2DG) by oral (p.o.) and intravenous (i.v.) routes, and also the cardio-respiratory effects following high doses of 2DG in animal models. Methods The LD50 of 2DG (in water) was determined in rats and mice by p.o. route and in mice by i.v. route. The effect of 2-DG (250 mg/kg, 500 mg/kg, and 1000 mg/kg, i.v.) was studied on various cardio-respiratory parameters viz., mean arterial blood pressure, heart rate and respiratory rate in anaesthetised rats. The effect of 2DG (500 mg/kg, 1000 mg/kg, and 2000 mg/kg, p.o.) was also studied on various respiratory parameters viz., respiratory rate and tidal volume in conscious rats and mice using a computer program. Results The p.o. LD50 of 2DG was found to be 〉8000 mg/kg in mice and rats, and at this dose no death was observed. The LD50 in mice by i.v. route was found to be 8000 mg/kg. At this dose 2 out of 4 mice died and the death occurred within 6 h. A significant increase in the body weight was observed after p.o. administration of 2DG in rats at 500 mg/kg, 1000 mg/kg, and 2000 mg/kg doses. There was no significant change in the body weight at 4000 mg/kg and 8000 mg/kg by the p.o. route in rats and up to 8000 mg/kg by p.o. as well as i.v. routes in mice. Intravenous administration of 2DG (250 mg/kg, 500 mg/kg, and 1000 mg/kg) in anaesthetised rats showed a time-dependent decrease in the mean arterial blood pressure. There was no change in the heart rate in any of the treatment groups. The tidal volume was not changed significantly by p.o administration in conscious rats, but a significant decrease in the respiratory frequency at 500 mg/kg and 1000 mg/kg doses was observed. In the mice also there was no change in the tidal volume after p.o, administration, but the respiratory frequency decreased significantly at 2000 mg/kg dose. Conclusion 2DG is a safe compound but can cause a fall in the blood pressure and a decrease in respiratory frequency at high doses. 展开更多
关键词 2-deoxy-D-glucose Glucose analogue Radio sensitizer Acute toxicity blood pressure heart rate RESPIRATION
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Relationship between nucleus tractus solitarii and effect of guanabenz on plasma renin activity in rats
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作者 张永胜 张家新 +1 位作者 余传林 刘菊芳 《Journal of Medical Colleges of PLA(China)》 CAS 1992年第1期49-51,共3页
Microinjection of 0.5μg guanabenz(GB)into the nucleus tractus solitarii(NTS)orintravenous(i.v.)injection of 10μg/kg of GB significantly lowered plasma renin activity(PRA).blood pressure(BP)and heart rate(HR)in rats ... Microinjection of 0.5μg guanabenz(GB)into the nucleus tractus solitarii(NTS)orintravenous(i.v.)injection of 10μg/kg of GB significantly lowered plasma renin activity(PRA).blood pressure(BP)and heart rate(HR)in rats i.v.10 μg/kg GB,after the bilateral NIS were de-stroyed by electric current(1 mA 20s),did not decrease PRA,BP and HR.These findings suggestthat the inhibitory action of GB on PRA,BP and HR is related to the activation of alpha-2adrenoceptors in the NTS. 展开更多
关键词 GUANABENZ HYPOTHALAMUS RENIN blood pressure heart rate RATS
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Analysis of hemodynamic responses to resistance exercise performed with different intensities and recovery intervals
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作者 Dihogo Gama de Matos Felipe José Aidar +6 位作者 Mauro Lucio Mazini Filho Rosimar da Silva Salgueiro Jordana Cristina de Oliveira Ingi P. Klain Robert C. Hickner André Luis Carneiro Estélio Henrique Martin Dantas 《Health》 2013年第2期159-165,共7页
This aim of the present study was to analyze the hemodynamic responses during resistance exercise performed at different intensities and with different recovery intervals. This study was conducted on twenty-four appar... This aim of the present study was to analyze the hemodynamic responses during resistance exercise performed at different intensities and with different recovery intervals. This study was conducted on twenty-four apparently healthy male individuals (25.50 ± 3.72 years and 76.50 ± 4.50 kg) experienced in strength training. The volunteers performed a 1RM test to determine the training load for the study. Blood pressure and Rate Pressure Product were measured before and at the end of the exercise training. The only significant difference observed was in SBP during strength training at 70% intensity (121.7 ± 8.68, p = 0.039), which was lower than SBP at the remaining intensities of 80% (126.3 ± 7.11) and 90% (127.1 ± 7.51). It was concluded that strength training performed at different intensities and recovery intervals did not significantly alter most variables, changing only the SBP due to the intensity employed. 展开更多
关键词 Strength Training (ST) blood pressure (BP) heart rate (HR) rate pressure Product (RPP)
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Studies of anthropometric indicators and their relationship with metabolic variables
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作者 Antonia Dalla Pria Bankoff Leandro Calixto Zago 《Open Journal of Preventive Medicine》 2014年第2期64-68,共5页
The purpose of this work is to identify in the anthropometrical indicators used here in this study the percentage of body fat, the body mass index (BMI) and the waist-hip ratio (WHR), which present a correlation with ... The purpose of this work is to identify in the anthropometrical indicators used here in this study the percentage of body fat, the body mass index (BMI) and the waist-hip ratio (WHR), which present a correlation with the metabolic variables of heart rate, blood pressure (systolic and diastolic) and double product. A population of 69 subjects averaging 41.7 ± 6.6 years old had their data registered by applying the Bruce Protocol modified to calculate metabolic variables;to obtain the percentage of fat, the formula of Petroski was used. The data collected received statistical treatment by the “Statistical 5.0” program with correlation being made by the calculation of the simple coefficient of Pearson “r” by means of a statistical significance test (p < 0.05). In the results, heart rate appeared to be correlated essentially with the intensity of force, associating itself with the percentage of fat and the BMI. Blood pressure presented a good correlation with the BMI, principally in the female group. In the male group, the anthropometrical indicator that had major associations with blood pressure was the WHR, showing an association between the pattern of male body fat distribution (android) and blood pressure. The double-product had a major correlation with the BMI;however, this variable really reflects the work of the myocardium since the BMI is the only indicator used here that includes lean mass in its values. The time spent on the treadmill was correlated in a negative way only with the percentage of fat;in other words, the greater the percentage, the lesser time spent on the treadmill. 展开更多
关键词 ANTHROPOMETRY Body FAT heart rate blood pressure
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Physical and Psychological Effects of the Shiatsu Stimulation in the Sitting Position
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作者 Shinpei Oki Koichi Ouchi +1 位作者 Mayumi Watanabe Nozomu Mandai 《Health》 2017年第8期1264-1272,共9页
Purpose: In this study, we investigated physical and psychological effects of the shiatsu (finger pressure) stimulation in a sitting position. Subjects and Methods: A crossover test was conducted on 20 subjects (avera... Purpose: In this study, we investigated physical and psychological effects of the shiatsu (finger pressure) stimulation in a sitting position. Subjects and Methods: A crossover test was conducted on 20 subjects (average 34.5 ± 7.6 years old;male = 10, female = 10). First they were randomly divided into two groups: Group A (shiatsu stimulation/control) and group B (control/shiatsu stimulation). They had shiatsu stimulation (Namikoshi basic methods in the sitting position, five minutes). At the same time, POMS (profile of mood states), SBP (systolic blood pressure, DBP (diastolic blood pressure) and HR (heart rate) were measured. Results: Physical result—Compared to the baseline, the shiatsu stimulation showed statistical decreased SBP and HR while the control (no shiatsu stimulation) did not. Psychological result (POMS)— Compared to the baseline, the stimulation showed significant change in all six mood states (Tension-Anxiety, Depression-Dejection, Fatigue and Confusion decreased while Vigor elevated). Male showed statistical decrease in Tension-Anxiety, Depression-Dejection, Anger, Fatigue and Confusion as well as significant increase in Vigor. Female only showed decrease in Depression-Dejection and Anger. Discussion and Conclusion: The shiatsu stimulation in the sitting position could modulate autonomic nerve system and it could affect human body. Gender differences were found in physiological effect. 展开更多
关键词 Shiatsu STIMULATION POMS blood pressure heart rate
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Re-Parameterization the Logistic Model in Assessing Changes in the Baroreceptor Reflex
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作者 Shande Chen Xiangrong Shi 《Neuroscience & Medicine》 2011年第2期110-116,共7页
The logistic model is frequently used to describe the nonlinear relationship between systemic arterial pressure (SAP) and carotid sinus pressure (CSP). In this paper, we propose using maximum gain and saturation as pa... The logistic model is frequently used to describe the nonlinear relationship between systemic arterial pressure (SAP) and carotid sinus pressure (CSP). In this paper, we propose using maximum gain and saturation as parameters in the logistic model. By this method, the estimates and standard errors together with confidence intervals for maximum gain and saturation are direct outputs from the curve fitting, which also makes it easy to perform various hypotheses testing on these quantities. The method is illustrated by real life data from a study on the carotid baroreflex function during infusion of sodium nitroprusside, in which seven healthy, young men who were clinically proved to be free from any disease were studied. Their heart rate, arterial blood pressure and central venous pressure were measured. Neck pressure and neck suction protocol was carried out to selectively elicit changes in CSP and the responsiveness of SAP. Data were analyzed and compare before and after nitroprusside infusion. Our results showed that nitroprusside significantly decreased arterial blood pressure and central venous pressure, and significantly increased heart rate, and significantly augmented maximum gain of the carotid baroreflex function. 展开更多
关键词 blood pressure CAROTID SINUS pressure heart rate mathematical model maximum gain NITROPRUSSIDE operating range
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Autonomic and cardiovascular effects of pentobarbital anesthesia during trigeminal stimulation in cats
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作者 Hiroshi Hanamoto Hitoshi Niwa +1 位作者 Mitsutaka Sugimura Yoshinari Morimoto 《International Journal of Oral Science》 SCIE CAS CSCD 2012年第1期24-29,共6页
Stimulation of the trigeminal nerve can elicit various cardiovascular and autonomic responses;however,the effects of anesthesia with pentobarbital sodium on these responses are unclear.Pentobarbital sodium was infused... Stimulation of the trigeminal nerve can elicit various cardiovascular and autonomic responses;however,the effects of anesthesia with pentobarbital sodium on these responses are unclear.Pentobarbital sodium was infused intravenously at a nominal rate and the lingual nerve was electrically stimulated at each infusion rate.Increases in systolic blood pressure(SBP) and heart rate(HR) were evoked by lingual nerve stimulation at an infusion rate between 5 and 7 mg?kg 21 ?h 21.This response was associated with an increase in the low-frequency band of SBP variability(SBP-LF).As the infusion rate increased to 10 mg?kg 21 ?h 21 or more,decreases in SBP and HR were observed.This response was associated with the reduction of SBP-LF.In conclusion,lingual nerve stimulation has both sympathomimetic and sympathoinhibitory effects,depending on the depth of pentobarbital anesthesia.The reaction pattern seems to be closely related to the autonomic balance produced by pentobarbital anesthesia. 展开更多
关键词 autonomic nervous system blood pressure and heart rate variability hemodynamics trigeminal depressor response
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